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Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.

Publication ,  Journal Article
Luo, H; Tan, C; Adhikari, S; Plassman, BL; Kamer, AR; Sloan, FA; Schwartz, MD; Qi, X; Wu, B
Published in: Curr Alzheimer Res
2021

OBJECTIVE: Both diabetes mellitus (DM) and poor oral health are common chronic conditions and risk factors of Alzheimer's disease and related dementia among older adults. This study assessed the effects of DM and complete tooth loss (TL) on cognitive function, accounting for their interactions. METHODS: Longitudinal data were obtained from the 2006, 2012, and 2018 waves of the Health and Retirement Study. This cohort study included 7,805 respondents aged 65 years or older with 18,331 person-year observations. DM and complete TL were self-reported. Cognitive function was measured by the Telephone Interview for Cognitive Status. Random-effect regressions were used to test the associations, overall and stratified by sex. RESULTS: Compared with older adults without neither DM nor complete TL, those with both conditions (b = -1.35, 95% confidence interval [CI]: -1.68, -1.02), with complete TL alone (b = -0.67, 95% CI: -0.88, -0.45), or with DM alone (b = -0.40, 95% CI: -0.59, -0.22), had lower cognitive scores. The impact of having both conditions was significantly greater than that of having DM alone (p < .001) or complete TL alone (p = 0.001). Sex-stratified analyses showed the effects were similar in males and females, except having DM alone was not significant in males. CONCLUSION: The co-occurrence of DM and complete TL poses an additive risk for cognition. Healthcare and family-care providers should pay attention to the cognitive health of patients with both DM and complete TL. Continued efforts are needed to improve older adults' access to dental care, especially for individuals with DM.

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Published In

Curr Alzheimer Res

DOI

EISSN

1875-5828

Publication Date

2021

Volume

18

Issue

13

Start / End Page

1023 / 1031

Location

United Arab Emirates

Related Subject Headings

  • Tooth Loss
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Female
  • Diabetes Mellitus
  • Cohort Studies
  • Cognition Disorders
  • Cognition
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Luo, H., Tan, C., Adhikari, S., Plassman, B. L., Kamer, A. R., Sloan, F. A., … Wu, B. (2021). Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function. Curr Alzheimer Res, 18(13), 1023–1031. https://doi.org/10.2174/1567205019666211223093057
Luo, Huabin, Chenxin Tan, Samrachana Adhikari, Brenda L. Plassman, Angela R. Kamer, Frank A. Sloan, Mark D. Schwartz, Xiang Qi, and Bei Wu. “Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.Curr Alzheimer Res 18, no. 13 (2021): 1023–31. https://doi.org/10.2174/1567205019666211223093057.
Luo H, Tan C, Adhikari S, Plassman BL, Kamer AR, Sloan FA, et al. Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function. Curr Alzheimer Res. 2021;18(13):1023–31.
Luo, Huabin, et al. “Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.Curr Alzheimer Res, vol. 18, no. 13, 2021, pp. 1023–31. Pubmed, doi:10.2174/1567205019666211223093057.
Luo H, Tan C, Adhikari S, Plassman BL, Kamer AR, Sloan FA, Schwartz MD, Qi X, Wu B. Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function. Curr Alzheimer Res. 2021;18(13):1023–1031.

Published In

Curr Alzheimer Res

DOI

EISSN

1875-5828

Publication Date

2021

Volume

18

Issue

13

Start / End Page

1023 / 1031

Location

United Arab Emirates

Related Subject Headings

  • Tooth Loss
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Female
  • Diabetes Mellitus
  • Cohort Studies
  • Cognition Disorders
  • Cognition
  • Aged