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Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Publication ,  Journal Article
Chuang, Y-F; Breitner, JCS; Chiu, Y-L; Khachaturian, A; Hayden, K; Corcoran, C; Tschanz, J; Norton, M; Munger, R; Welsh-Bohmer, K; Zandi, PP ...
Published in: Neurobiol Aging
November 2014

Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1 years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.

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Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

November 2014

Volume

35

Issue

11

Start / End Page

2429 / 2435

Location

United States

Related Subject Headings

  • Sodium Chloride Symporter Inhibitors
  • Risk
  • Neurology & Neurosurgery
  • Male
  • Incidence
  • Humans
  • Follow-Up Studies
  • Female
  • Diuretics, Potassium Sparing
  • Cohort Studies
 

Citation

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Chuang, Y.-F., Breitner, J. C. S., Chiu, Y.-L., Khachaturian, A., Hayden, K., Corcoran, C., … Cache County Investigators, . (2014). Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study. Neurobiol Aging, 35(11), 2429–2435. https://doi.org/10.1016/j.neurobiolaging.2014.05.002
Chuang, Yi-Fang, John C. S. Breitner, Yen-Ling Chiu, Ara Khachaturian, Kathleen Hayden, Chris Corcoran, JoAnn Tschanz, et al. “Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.Neurobiol Aging 35, no. 11 (November 2014): 2429–35. https://doi.org/10.1016/j.neurobiolaging.2014.05.002.
Chuang Y-F, Breitner JCS, Chiu Y-L, Khachaturian A, Hayden K, Corcoran C, et al. Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study. Neurobiol Aging. 2014 Nov;35(11):2429–35.
Chuang, Yi-Fang, et al. “Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.Neurobiol Aging, vol. 35, no. 11, Nov. 2014, pp. 2429–35. Pubmed, doi:10.1016/j.neurobiolaging.2014.05.002.
Chuang Y-F, Breitner JCS, Chiu Y-L, Khachaturian A, Hayden K, Corcoran C, Tschanz J, Norton M, Munger R, Welsh-Bohmer K, Zandi PP, Cache County Investigators. Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study. Neurobiol Aging. 2014 Nov;35(11):2429–2435.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

November 2014

Volume

35

Issue

11

Start / End Page

2429 / 2435

Location

United States

Related Subject Headings

  • Sodium Chloride Symporter Inhibitors
  • Risk
  • Neurology & Neurosurgery
  • Male
  • Incidence
  • Humans
  • Follow-Up Studies
  • Female
  • Diuretics, Potassium Sparing
  • Cohort Studies