Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.

Publication ,  Journal Article
Qi, X; Zhu, Z; Plassman, BL; Wu, B
Published in: J Am Med Dir Assoc
October 2021

OBJECTIVES: To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. DESIGN: Longitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were pooled using random-effects models. The dose-response associations were assessed using generalized least squares spline models. SETTING AND PARTICIPANTS: Adults from community, institution, outpatient or in-hospital were included in the meta-analysis. MEASURES: Cognitive impairment and dementia were defined by neuropsychological tests, diagnostic criteria, or medical records. Tooth loss was self-reported or assessed by clinical examinations. RESULTS: Fourteen studies were entered into the meta-analysis, including 34,074 participants and 4689 cases with diminished cognitive function. Participants with more tooth loss had a 1.48 times higher risk of developing cognitive impairment [95% confidence interval (CI) 1.18-1.87] and 1.28 times higher risk of being diagnosed with dementia (95% CI 1.09-1.49); however, the association was nonsignificant for participants using dentures (relative risk = 1.10, 95% CI 0.90-1.11). Eight studies were included in the dose-response analysis, and data supported the use of linear models. Each additional tooth loss was associated with a 0.014 increased relative risk of cognitive impairment and 0.011 elevated relative risks of dementia. Edentulous participants faced a 1.54 times higher risk of cognitive impairment and a 1.40 times higher risk of being diagnosed with dementia. CONCLUSIONS AND IMPLICATIONS: Moderate-quality evidence suggested tooth loss was independently associated with cognitive impairment and dementia; risk of diminished cognitive function increased with incremental numbers of teeth lost. Furthermore, timely prosthodontic treatment with dentures may reduce the progression of cognitive decline related to tooth loss.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Am Med Dir Assoc

DOI

EISSN

1538-9375

Publication Date

October 2021

Volume

22

Issue

10

Start / End Page

2039 / 2045

Location

United States

Related Subject Headings

  • Tooth Loss
  • Humans
  • Geriatrics
  • Dementia
  • Cognitive Dysfunction
  • Cognition
  • Adult
  • 4206 Public health
  • 4205 Nursing
  • 4203 Health services and systems
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Qi, X., Zhu, Z., Plassman, B. L., & Wu, B. (2021). Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia. J Am Med Dir Assoc, 22(10), 2039–2045. https://doi.org/10.1016/j.jamda.2021.05.009
Qi, Xiang, Zheng Zhu, Brenda L. Plassman, and Bei Wu. “Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.J Am Med Dir Assoc 22, no. 10 (October 2021): 2039–45. https://doi.org/10.1016/j.jamda.2021.05.009.
Qi X, Zhu Z, Plassman BL, Wu B. Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia. J Am Med Dir Assoc. 2021 Oct;22(10):2039–45.
Qi, Xiang, et al. “Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.J Am Med Dir Assoc, vol. 22, no. 10, Oct. 2021, pp. 2039–45. Pubmed, doi:10.1016/j.jamda.2021.05.009.
Qi X, Zhu Z, Plassman BL, Wu B. Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia. J Am Med Dir Assoc. 2021 Oct;22(10):2039–2045.
Journal cover image

Published In

J Am Med Dir Assoc

DOI

EISSN

1538-9375

Publication Date

October 2021

Volume

22

Issue

10

Start / End Page

2039 / 2045

Location

United States

Related Subject Headings

  • Tooth Loss
  • Humans
  • Geriatrics
  • Dementia
  • Cognitive Dysfunction
  • Cognition
  • Adult
  • 4206 Public health
  • 4205 Nursing
  • 4203 Health services and systems