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Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.

Publication ,  Journal Article
Steffens, DC; Maytan, M; Helms, MJ; Plassman, BL
Published in: Am J Alzheimers Dis Other Demen
2005

The purpose of this research was to assess the frequency and severity of neuropsychiatric and behavioral symptoms and to examine the association between preexisting medical conditions and specific neuropsychiatric symptoms in demented individuals. We studied 211 demented subjects (87.7 percent male) who were participants in epidemiological studies of dementia. Using the Neuropsychiatric Inventory (NPI), we assessed the frequency and severity of neuropsychiatric symptoms. We collected medical history information during a structured telephone interview. Our analyses focused on determining prevalence of neuropsychiatric symptoms by dementia diagnosis and severity. We also examined the association of history of head injury, alcohol abuse, and stroke with development of neuropsychiatric symptoms. We found that neuropsychiatric symptoms were common, with approximately three-fourths of the subjects exhibiting at least one symptom during the preceding month. Apathy (39.3 percent), agitation (31.8 percent), and aberrant motor behavior (31.1 percent) were the most frequent symptoms. Frequency and severity of symptoms were similar for the all-dementia and Alzheimer's disease-only groups, neuropsychiatric symptoms varied by severity of dementia, but generally not in a consistent ordinal pattern. History of alcohol abuse, head injury, or stroke was associated with presence of specific neuropsychiatric symptoms in dementia. While psychiatric symptoms are common in dementia, they also vary by type and severity of dementia. The finding that certain medical conditions may increase risk for specific types of neuropsychiatric symptoms expands our knowledge of the natural history of dementia and should improve management of dementia in medically ill patients. Our results may also shed light on mechanisms that underlie neuropsychiatric symptoms.

Duke Scholars

Published In

Am J Alzheimers Dis Other Demen

DOI

ISSN

1533-3175

Publication Date

2005

Volume

20

Issue

6

Start / End Page

367 / 373

Location

United States

Related Subject Headings

  • Stroke
  • Severity of Illness Index
  • Risk Factors
  • Psychomotor Disorders
  • Prevalence
  • North Carolina
  • Neuropsychological Tests
  • Mood Disorders
  • Male
  • Logistic Models
 

Citation

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ICMJE
MLA
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Steffens, D. C., Maytan, M., Helms, M. J., & Plassman, B. L. (2005). Prevalence and clinical correlates of neuropsychiatric symptoms in dementia. Am J Alzheimers Dis Other Demen, 20(6), 367–373. https://doi.org/10.1177/153331750502000611
Steffens, David C., Margaret Maytan, Michael J. Helms, and Brenda L. Plassman. “Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.Am J Alzheimers Dis Other Demen 20, no. 6 (2005): 367–73. https://doi.org/10.1177/153331750502000611.
Steffens DC, Maytan M, Helms MJ, Plassman BL. Prevalence and clinical correlates of neuropsychiatric symptoms in dementia. Am J Alzheimers Dis Other Demen. 2005;20(6):367–73.
Steffens, David C., et al. “Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.Am J Alzheimers Dis Other Demen, vol. 20, no. 6, 2005, pp. 367–73. Pubmed, doi:10.1177/153331750502000611.
Steffens DC, Maytan M, Helms MJ, Plassman BL. Prevalence and clinical correlates of neuropsychiatric symptoms in dementia. Am J Alzheimers Dis Other Demen. 2005;20(6):367–373.
Journal cover image

Published In

Am J Alzheimers Dis Other Demen

DOI

ISSN

1533-3175

Publication Date

2005

Volume

20

Issue

6

Start / End Page

367 / 373

Location

United States

Related Subject Headings

  • Stroke
  • Severity of Illness Index
  • Risk Factors
  • Psychomotor Disorders
  • Prevalence
  • North Carolina
  • Neuropsychological Tests
  • Mood Disorders
  • Male
  • Logistic Models