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The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Publication ,  Journal Article
Nicholson, JS; Hudak, EM; Phillips, CB; Chanti-Ketterl, M; O'Brien, JL; Ross, LA; Lister, JJ; Burke, JR; Potter, G; Plassman, BL; Woods, AJ ...
Published in: Contemp Clin Trials
December 2022

BACKGROUND: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially available computerized cognitive training program targeting improved Useful Field of View Training (UFOVT) performance. The primary goal is to test the effectiveness of UFOVT to reduce incidence of clinically defined mild cognitive impairment (MCI) or dementia with a secondary objective to examine if effects are moderated by plasma β-amyloid level or apolipoprotein E e4 (APOE e4) allele status. METHODS/DESIGN: This multisite study utilizes a randomized, controlled experimental design with blinded assessors and investigators. Individuals who are 65 years of age and older are recruited from the community. Eligible participants who demonstrate intact cognitive status (Montreal Cognitive Assessment score > 25) are randomized and asked to complete 45 sessions of either a commercially available computerized-cognitive training program (UFOVT) or computerized games across 2.5 years. After three years, participants are screened for cognitive decline. For those demonstrating decline or who are part of a random subsample, a comprehensive neuropsychological assessment is completed. Those who perform below a pre-specified level are asked to complete a clinical evaluation, including an MRI, to ascertain clinical diagnosis of normal cognition, MCI, or dementia. Participants are asked to provide blood samples for analyses of Alzheimer's disease related biomarkers. DISCUSSION: The PACT study addresses the rapidly increasing prevalence of dementia. Computerized cognitive training may provide a non-pharmaceutical option for reducing incidence of MCI or dementia to improve public health. REGISTRATION: The PACT study is registered at http://Clinicaltrials.govNCT03848312.

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Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

December 2022

Volume

123

Start / End Page

106978

Location

United States

Related Subject Headings

  • Public Health
  • Neuropsychological Tests
  • Humans
  • General Clinical Medicine
  • Cognitive Training
  • Cognitive Dysfunction
  • Cognition Disorders
  • Cognition
  • Alzheimer Disease
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nicholson, J. S., Hudak, E. M., Phillips, C. B., Chanti-Ketterl, M., O’Brien, J. L., Ross, L. A., … Edwards, J. D. (2022). The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial. Contemp Clin Trials, 123, 106978. https://doi.org/10.1016/j.cct.2022.106978
Nicholson, Jody S., Elizabeth M. Hudak, Christine B. Phillips, Marianne Chanti-Ketterl, Jennifer L. O’Brien, Lesley A. Ross, Jennifer J. Lister, et al. “The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.Contemp Clin Trials 123 (December 2022): 106978. https://doi.org/10.1016/j.cct.2022.106978.
Nicholson JS, Hudak EM, Phillips CB, Chanti-Ketterl M, O’Brien JL, Ross LA, et al. The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial. Contemp Clin Trials. 2022 Dec;123:106978.
Nicholson, Jody S., et al. “The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.Contemp Clin Trials, vol. 123, Dec. 2022, p. 106978. Pubmed, doi:10.1016/j.cct.2022.106978.
Nicholson JS, Hudak EM, Phillips CB, Chanti-Ketterl M, O’Brien JL, Ross LA, Lister JJ, Burke JR, Potter G, Plassman BL, Woods AJ, Krischer J, Edwards JD. The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial. Contemp Clin Trials. 2022 Dec;123:106978.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

December 2022

Volume

123

Start / End Page

106978

Location

United States

Related Subject Headings

  • Public Health
  • Neuropsychological Tests
  • Humans
  • General Clinical Medicine
  • Cognitive Training
  • Cognitive Dysfunction
  • Cognition Disorders
  • Cognition
  • Alzheimer Disease
  • 42 Health sciences