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Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.

Publication ,  Journal Article
Plassman, BL; Welsh-Bohmer, KA; Bigler, ED; Johnson, SC; Anderson, CV; Helms, MJ; Saunders, AM; Breitner, JC
Published in: Neurology
April 1997

We examined the relation of APOE-epsilon 4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an epsilon 4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the epsilon 4 groups compared to the group without epsilon 4. Combined with prior reports, these findings suggest that epsilon 4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1997

Volume

48

Issue

4

Start / End Page

985 / 989

Location

United States

Related Subject Headings

  • Twins
  • Reference Values
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hippocampus
  • Genotype
  • Female
  • Cognition
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D., Johnson, S. C., Anderson, C. V., Helms, M. J., … Breitner, J. C. (1997). Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. Neurology, 48(4), 985–989. https://doi.org/10.1212/wnl.48.4.985
Plassman, B. L., K. A. Welsh-Bohmer, E. D. Bigler, S. C. Johnson, C. V. Anderson, M. J. Helms, A. M. Saunders, and J. C. Breitner. “Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.Neurology 48, no. 4 (April 1997): 985–89. https://doi.org/10.1212/wnl.48.4.985.
Plassman BL, Welsh-Bohmer KA, Bigler ED, Johnson SC, Anderson CV, Helms MJ, et al. Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. Neurology. 1997 Apr;48(4):985–9.
Plassman, B. L., et al. “Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.Neurology, vol. 48, no. 4, Apr. 1997, pp. 985–89. Pubmed, doi:10.1212/wnl.48.4.985.
Plassman BL, Welsh-Bohmer KA, Bigler ED, Johnson SC, Anderson CV, Helms MJ, Saunders AM, Breitner JC. Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. Neurology. 1997 Apr;48(4):985–989.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1997

Volume

48

Issue

4

Start / End Page

985 / 989

Location

United States

Related Subject Headings

  • Twins
  • Reference Values
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Hippocampus
  • Genotype
  • Female
  • Cognition