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Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.

Publication ,  Journal Article
Cohen, HJ; Harris, T; Pieper, CF
Published in: Am J Med
February 15, 2003

PURPOSE: This study was performed to determine the effects of markers of inflammation (interleukin 6) and coagulation (D-dimer) on mortality and functional status in older persons. METHODS: Subjects were selected for the Duke Established Populations for Epidemiologic Studies of the Elderly. In 1992, 2569 subjects (age >71 years) were interviewed, of whom 1,723 had interleukin-6 and D-dimer measurements. Values of interleukin 6 and D-dimer were categorized into quartiles. Outcomes were mortality (through 5 years) and functional status (through 4 years). Relative risks were estimated with proportional hazards models that adjusted for potential confounders. RESULTS: The relative risk of mortality was 1.28 (95% confidence interval [CI]: 0.98 to 1.69; P = 0.06) for those with only interleukin-6 levels in the highest quartile, 1.53 (95% CI: 1.18 to 1.97; P = 0.001) for subjects with only D-dimer levels in the highest quartile, and 2.00 (95% CI: 1.53 to 2.62; P = 0.0001) for those with levels of both in the highest quartile, as compared with those who were not in either of the highest quartiles. Those with high interleukin-6 and high D-dimer levels had the greatest declines in all measures of function. CONCLUSION: Activation of the coagulation and inflammatory pathways is associated with mortality and decline in function, and may be part of the explanation for the development of a frailty phenotype in the elderly.

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Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

February 15, 2003

Volume

114

Issue

3

Start / End Page

180 / 187

Location

United States

Related Subject Headings

  • White People
  • Smoking
  • Sex Distribution
  • Pulmonary Disease, Chronic Obstructive
  • North Carolina
  • Neoplasms
  • Multivariate Analysis
  • Male
  • Longitudinal Studies
  • Interleukin-6
 

Citation

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Cohen, H. J., Harris, T., & Pieper, C. F. (2003). Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med, 114(3), 180–187. https://doi.org/10.1016/s0002-9343(02)01484-5
Cohen, Harvey Jay, Tamara Harris, and Carl F. Pieper. “Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.Am J Med 114, no. 3 (February 15, 2003): 180–87. https://doi.org/10.1016/s0002-9343(02)01484-5.
Cohen, Harvey Jay, et al. “Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.Am J Med, vol. 114, no. 3, Feb. 2003, pp. 180–87. Pubmed, doi:10.1016/s0002-9343(02)01484-5.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

February 15, 2003

Volume

114

Issue

3

Start / End Page

180 / 187

Location

United States

Related Subject Headings

  • White People
  • Smoking
  • Sex Distribution
  • Pulmonary Disease, Chronic Obstructive
  • North Carolina
  • Neoplasms
  • Multivariate Analysis
  • Male
  • Longitudinal Studies
  • Interleukin-6