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Carl F. Pieper
Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
carl.pieper@duke.edu
Duke Box 3003, Durham, NC 27710
1513 Busse Bldg, Durham, NC 27710
Research
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At a Glance
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Credentials
Education
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Academic Experience
Current Appointments & Affiliations
Previous Appointments & Affiliations
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Expertise
Global Scholarship
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Research
Selected Grants
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Publications
Selected Publications
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Advising & Mentoring
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Recognition
In the News
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Professional Activities
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Selected Grants
2/3 CTSA K12 Program at Duke University
Research
Mentor ·
Awarded by National Institutes of Health ·
2025 - 2030
Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP)
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2024 - 2028
Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging
Research
Co Investigator ·
Awarded by Tufts Medical Center ·
2022 - 2027
Effect of Acetylcholinesterase inhibitors on Bone Metabolism and Fracture Risk Factors among older adults with mild to moderate Alzheimer's Disease (R21)
Research
Biostatistician ·
Awarded by National Institute on Aging ·
2023 - 2026
Influence of Vision Impairments on Dementia in Stroke Survivors: A Longitudinal Analysis
Research
Advisor ·
Awarded by National Institutes of Health ·
2023 - 2026
Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment
Research
Co Investigator ·
Awarded by University of North Carolina - Chapel Hill ·
2023 - 2026
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2021 - 2026
Behavior and Physiology in Aging
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institute on Aging ·
2015 - 2025
Sickle Cell Disease Functional Assessment Validation and Exercise Pilot Intervention
Research
Advisor ·
Awarded by National Heart, Lung, and Blood Institute ·
2023 - 2025
RFTOP 2022 Domain 5-E003 Strategic Use of Race, Ethnicity, and Social Determinants of Health Data in National Healthcare Safety Network (NHSN) Measures to Promote Health Equity
Research
Senior Statistician ·
Awarded by Centers for Disease Control and Prevention ·
2022 - 2025
Multiplex point-of-care test for diagnosis, prognosis and serology of COVID19
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2021 - 2025
Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2019 - 2025
Temporal Patterns of Spinal Cord Stimulation
Research
Collaborator ·
Awarded by National Institutes of Health ·
2019 - 2024
Duke CTSA (TL1) Year 5
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2018 - 2024
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative)
Research
Biostatistician Investigator ·
Awarded by National Institutes of Health ·
2017 - 2024
Epigenetic Mechanisms Promoting Longevity
Research
Biostatistician ·
Awarded by National Institutes of Health ·
2018 - 2024
Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience
Research
Co Investigator ·
Awarded by Columbia University ·
2019 - 2024
Characterizing frailty in older adults with sickle cell disease using a sickle cell frailty index (FI-SCD)
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2021 - 2023
Healthy Skeletal Muscle, Healthy Brain: Are Kynurenine Metabolites the Link?
Research
Statistician ·
Awarded by National Institutes of Health ·
2020 - 2023
Weight loss and exercise to improve rheumatoid arthritis cardiovascular risk
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2020 - 2023
Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes (K23)
Research
Co-Mentor ·
Awarded by National Institutes of Health ·
2018 - 2023
Addressing Barriers to Adult Hearing Healthcare
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2016 - 2022
MURDOCK COVID-19 Prevalence Study
Research
Statistician ·
Awarded by NC DHHS ·
2021 - 2022
Sustained blood pressure control and progression of multimorbidity
Research
Statistician ·
Awarded by National Institutes of Health ·
2017 - 2022
IPA-Carl Pieper
Research
Biostatistician ·
Awarded by Durham Veterans Affairs Medical Center ·
2019 - 2021
Altitude Study
Research
Statistician ·
Awarded by Naval Sea Systems Command ·
2017 - 2021
The Effect of Exercise Type, Dose, and Intensity on Plasma Amyloid Beta and Tau in Healthy Adults
Research
Statistician ·
Awarded by Dementia Alliance of North Carolina ·
2019 - 2021
IPA-Carl Pieper
Research
Biostatistician ·
Awarded by Durham Veterans Affairs Medical Center ·
2018 - 2021
MURDOCK COVID-19 Prevalence Study
Research
Biostatistician Investigator ·
Awarded by NC DHHS ·
2020 - 2021
Biomarkers of Caloric Restriction in Humans: the CALERIE Biorepository
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2015 - 2021
Mentoring Intervention Development in Fall and Fracture Prevention
Research
Statistician ·
Awarded by National Institutes of Health ·
2015 - 2021
An Enhanced Protein (Dairy) Weight Loss Intervention for Dynapenic Obesity: Impact on Muscle Quality and Composition
Research
Investigator ·
Awarded by Dairy Management, Inc. ·
2015 - 2020
A point-of-care, biomarker-based test to predict non-healing in chronic wounds
Research
Co Investigator ·
Awarded by The Plastic Surgery Foundation ·
2018 - 2020
Point of Care Testing to Improve Monitoring of LVAD Patients
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2018 - 2020
PCORI Duke Subcontract
Research
Principal Investigator ·
Awarded by University of Arkansas for Medical Sciences ·
2017 - 2020
IPA - Richard Sloane - Pieper
Research
Principal Investigator ·
Awarded by Veterans Administration Medical Center ·
2019 - 2019
Does Meal-based Enhancement of Protein Intake Augment Long-term Responses to Sarcopenic Obesity Reduction?
Research
Biostatistician ·
Awarded by National Pork Board ·
2016 - 2018
Pioneering Health Information Technology (R00)
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2012 - 2018
Does Beef Protein Preserve Muscle Mass and Function During Weight Loss in Frail, Obese Older Adults?: A Follow-Up Study
Research
Biostatistician ·
Awarded by National Cattlemen's Beef Association ·
2016 - 2017
Exercise, Nitric Oxide Bioavailability and Arteriovenous Fistula Maturation
Clinical Trial
Co Investigator ·
Awarded by National Institutes of Health ·
2014 - 2017
Improving Quality of Life Measurement in Older Dialysis Patients
Research
Collaborator ·
Awarded by National Institutes of Health ·
2015 - 2017
Adherence to Venous Thromboembolism Prophylaxis Guidelines in Hospitalized Elders
Research
Statistician ·
Awarded by National Institutes of Health ·
2014 - 2016
Assessment of Physical Performance, Walking Mechanics, and the Cost-effectiveness of Revision Total Ankle Replacement
Clinical Trial
Statistician ·
Awarded by Orthopaedic Research and Education Foundation ·
2014 - 2016
Multisite RCT Investigating the Efficacy of Massage in Osteoarthritis
Research
Statistician ·
Awarded by National Institutes of Health ·
2009 - 2016
Measuring and Talking to Patients about the Accuracy of Data used in Patient Outcomes Research
Research
Statistician ·
Awarded by Patient-Centered Outcomes Research Institute ·
2015 - 2016
A High-Protein Weight Loss Treatment for Sarcopenic Obesity
Research
Biostatistician ·
Awarded by National Pork Board ·
2013 - 2015
Clinico-Genomic Assessment of Performance Status in Elderly AML Patients
Research
Statistician ·
Awarded by National Institutes of Health ·
2012 - 2015
Behavior And Physiology In Aging
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
1999 - 2015
Disentangling Late Life Depression, Vascular Lesions and Functional Decline
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2012 - 2015
Pioneering Health Information Quality (K99)
Research
Advisor ·
Awarded by National Institutes of Health ·
2012 - 2015
Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity
Research
Statistician ·
Awarded by National Institutes of Health ·
2011 - 2015
Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
Research
Statistician ·
Awarded by National Institutes of Health ·
2013 - 2015
CALERIE
Clinical Trial
Co Investigator ·
Awarded by National Institutes of Health ·
2009 - 2014
CALERIE Non-competing Extension with Funds
Clinical Trial
Co Investigator ·
Awarded by National Institutes of Health ·
2002 - 2014
IPA-Richard Lawrence Whitley
Research
Principal Investigator ·
Awarded by Durham Veterans Affairs Medical Center ·
2013 - 2014
IPA - Richard Sloane
Research
Principal Investigator ·
Awarded by Veterans Administration Medical Center ·
2012 - 2014
Developing Interventions to Improve Function in Seniors with Comorbid Conditions
Research
Advisor ·
Awarded by National Institutes of Health ·
2008 - 2013
Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease
Research
Collaborator ·
Awarded by National Institutes of Health ·
2007 - 2012
Curriculum Development Centers
Research
Assistant Research Professor ·
Awarded by Department of Health and Human Services ·
2010 - 2012
Subtypes and Trajectories of Depression in Older Adults
Research
Statistician ·
Awarded by National Institutes of Health ·
2007 - 2012
IPA - Richard Sloane
Research
Principal Investigator ·
Awarded by Veterans Administration Medical Center ·
2011 - 2012
IPA - Carl Pieper
Research
Biostatistician ·
Awarded by Veterans Administration Medical Center ·
2010 - 2011
Epidemiology of Dementia in Cache County, Utah (Bridge-Funding Request)
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2002 - 2011
Epidemiology of Dementia in Cache County, Utah
Research
Co Investigator ·
Awarded by National Institutes of Health ·
1994 - 2011
Caffeine and Glucose Regulation
Research
Biostatistician Investigator ·
Awarded by National Institutes of Health ·
2004 - 2010
Mindfulness Based Weight Loss Maintenance
Research
Biostatistician ·
Awarded by National Institutes of Health ·
2006 - 2010
Adapting Marital Therapy in Older Adults with Depression
Research
Statistical Analyst ·
Awarded by National Institutes of Health ·
2006 - 2010
CALERIE
Clinical Trial
Co Investigator ·
Awarded by National Institutes of Health ·
2002 - 2009
IPA - Carl Pieper
Research
Biostatistician ·
Awarded by Veterans Administration Medical Center ·
2008 - 2009
Depression and Physical Functioning in Older Adults (K01)
Research
Biostatistician ·
Awarded by National Institutes of Health ·
2003 - 2009
IPA - Carl Pieper
Research
Biostatistician ·
Awarded by Veterans Administration Medical Center ·
2006 - 2008
Walking Activity and the Burden of Multiple Morbidities
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2005 - 2007
Insulin Resistance and Polycystic Ovary Syndrome
Research
Statistician ·
Awarded by National Institutes of Health ·
2002 - 2007
Surveillance And Analysis Of The UNC Alumni Heart Study
Research
Co Investigator ·
Awarded by National Institutes of Health ·
1996 - 2007
Herpes Zoster and Medications in the Elderly
Research
Investigator ·
Awarded by National Institutes of Health ·
2001 - 2007
Treatment Outcomes of Vascular Depression
Research
Statistician ·
Awarded by National Institutes of Health ·
2001 - 2007
Meditation for High Blood Pressure
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2001 - 2006
Antidepressant Use by Older Adults
Research
Statistician ·
Awarded by National Institutes of Health ·
2002 - 2005
Disability In Nursing Home Residents With Dementia
Research
Co Investigator ·
Awarded by National Institutes of Health ·
1998 - 2004
Living Arrangements and Health Status in Late Life
Research
Statistician ·
Awarded by National Institutes of Health ·
1999 - 2003
Caffeine Effects On Stress Reactivity
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1995 - 2003
Geriatric Depression: Risk Factors For Adverse Outcomes
Research
Statistician ·
Awarded by National Institutes of Health ·
1995 - 2002
Race Differences in Prevalence and Incidence of Dementia
Research
Collaborator ·
Awarded by National Institutes of Health ·
1991 - 2002
Impact of geriatric care in drug related problems.
Research
Co Investigator ·
Awarded by National Institutes of Health ·
1996 - 2001
Phase Ten Year Follow up
Research
Statistician ·
Awarded by National Institutes of Health ·
1997 - 2000
Study Of Depression
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1994 - 2000
Phse Ten Year Follow-Up
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1995 - 1999
Crc/Pe For The Study Of Depression
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1984 - 1999
Geratric Depression: Risk Factors For Adverse Outcome
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1995 - 1999
Claude D Pepper Older Americans Independence Center
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1992 - 1999
Surveillance And Analysis Of The Unc Alumni Heart Study
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1996 - 1999
Suboptimal Drug Use And Health Outcomes In The Elderly
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1997 - 1998
Caffeine Effects On Stress Reactivity
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1995 - 1998
Caffine Effects On Stress Reactivity
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1995 - 1998
Depression In Elderly Cardiac Patients
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1994 - 1998
Cognitive Impairment And Medication Appropriateness
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1993 - 1998
Osteoporosis And Disability In Life Care Community Women
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1992 - 1997
Claude D. Pepper Older Americans Independence Center
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1993 - 1997
Claude D. Pepper Older American Independence Centers
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1992 - 1997
Neuroimaging Of Age Related Cognitive Changes
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1993 - 1996
Osteoporosis And Disability In A Life Care Community
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1993 - 1996
Osteoporosis And Disability In Life-Care Community Women
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1992 - 1996
Research Support Services For Gerontology Center
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1992 - 1994
Renewal Of Established Populations For Epidemiologic Studi
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
1991 - 1992
