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Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.

Publication ,  Journal Article
Paluch, AE; Bajpai, S; Ballin, M; Bassett, DR; Buford, TW; Carnethon, MR; Chernofsky, A; Dooley, EE; Ekelund, U; Evenson, KR; Galuska, DA ...
Published in: Circulation
January 10, 2023

BACKGROUND: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines. METHODS: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance-weighted random effects models. RESULTS: The mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults. CONCLUSIONS: For older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician-patient communication and population health to reduce the risk of CVD.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 10, 2023

Volume

147

Issue

2

Start / End Page

122 / 131

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Coronary Disease
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
 

Citation

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Paluch, A. E., Bajpai, S., Ballin, M., Bassett, D. R., Buford, T. W., Carnethon, M. R., … Steps for Health Collaborative. (2023). Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis. Circulation, 147(2), 122–131. https://doi.org/10.1161/CIRCULATIONAHA.122.061288
Paluch, Amanda E., Shivangi Bajpai, Marcel Ballin, David R. Bassett, Thomas W. Buford, Mercedes R. Carnethon, Ariel Chernofsky, et al. “Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.Circulation 147, no. 2 (January 10, 2023): 122–31. https://doi.org/10.1161/CIRCULATIONAHA.122.061288.
Paluch AE, Bajpai S, Ballin M, Bassett DR, Buford TW, Carnethon MR, et al. Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis. Circulation. 2023 Jan 10;147(2):122–31.
Paluch, Amanda E., et al. “Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.Circulation, vol. 147, no. 2, Jan. 2023, pp. 122–31. Pubmed, doi:10.1161/CIRCULATIONAHA.122.061288.
Paluch AE, Bajpai S, Ballin M, Bassett DR, Buford TW, Carnethon MR, Chernofsky A, Dooley EE, Ekelund U, Evenson KR, Galuska DA, Jefferis BJ, Kong L, Kraus WE, Larson MG, Lee I-M, Matthews CE, Newton RL, Nordström A, Nordström P, Palta P, Patel AV, Pettee Gabriel K, Pieper CF, Pompeii L, Rees-Punia E, Spartano NL, Vasan RS, Whincup PH, Yang S, Fulton JE, Steps for Health Collaborative. Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis. Circulation. 2023 Jan 10;147(2):122–131.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 10, 2023

Volume

147

Issue

2

Start / End Page

122 / 131

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Coronary Disease
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases