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Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.

Publication ,  Journal Article
Harris, BS; Hopkins, MK; Villers, MS; Weber, JM; Pieper, C; Grotegut, CA; Swamy, GK; Hughes, BL; Heine, RP
Published in: AJP Rep
April 2019

Objective  To examine the association between perioperative Beta ( β ))-lactam versus non- β -lactam antibiotics and cesarean delivery surgical site infection (SSI). Study Design  Retrospective cohort of women undergoing cesarean delivery from January 1 to December 31, 2014. All women undergoing cesarean after 34 weeks with a postpartum visit were included. Prevalence of SSI was compared between women receiving β -lactam versus non- β -lactam antibiotics. Bivariate analyses were performed using Pearson's Chi-square, Fisher's exact, or Wilcoxon's rank-sum tests. Logistic regression models were fit controlling for possible confounders. Results  Of the 929 women included, 826 (89%) received β -lactam prophylaxis and 103 (11%) received a non- β -lactam. Among the 893 women who reported a non-type I (low risk) allergy, 819 (92%) received β -lactam prophylaxis. SSI occurred in 7% of women who received β -lactam antibiotics versus 15% of women who received a non- β -lactam ( p  = 0.004). β -Lactam prophylaxis was associated with lower odds of SSI compared with non- β -lactam antibiotics (odds ratio [OR] = 0.43; 95% confidence interval [CI] = 0.22-0.83; p  = 0.01) after controlling for chorioamnionitis in labor, postlabor cesarean, endometritis, tobacco use, and body mass index (BMI). Conclusion   β -Lactam perioperative prophylaxis is associated with lower odds of a cesarean delivery surgical site infection compared with non- β -lactam antibiotics.

Duke Scholars

Published In

AJP Rep

DOI

ISSN

2157-6998

Publication Date

April 2019

Volume

9

Issue

2

Start / End Page

e167 / e171

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harris, B. S., Hopkins, M. K., Villers, M. S., Weber, J. M., Pieper, C., Grotegut, C. A., … Heine, R. P. (2019). Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections. AJP Rep, 9(2), e167–e171. https://doi.org/10.1055/s-0039-1685503
Harris, Benjamin S., Maeve K. Hopkins, Margaret S. Villers, Jeremy M. Weber, Carl Pieper, Chad A. Grotegut, Geeta K. Swamy, Brenna L. Hughes, and R Phillips Heine. “Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.AJP Rep 9, no. 2 (April 2019): e167–71. https://doi.org/10.1055/s-0039-1685503.
Harris BS, Hopkins MK, Villers MS, Weber JM, Pieper C, Grotegut CA, et al. Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections. AJP Rep. 2019 Apr;9(2):e167–71.
Harris, Benjamin S., et al. “Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.AJP Rep, vol. 9, no. 2, Apr. 2019, pp. e167–71. Pubmed, doi:10.1055/s-0039-1685503.
Harris BS, Hopkins MK, Villers MS, Weber JM, Pieper C, Grotegut CA, Swamy GK, Hughes BL, Heine RP. Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections. AJP Rep. 2019 Apr;9(2):e167–e171.
Journal cover image

Published In

AJP Rep

DOI

ISSN

2157-6998

Publication Date

April 2019

Volume

9

Issue

2

Start / End Page

e167 / e171

Location

United States