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Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.

Publication ,  Journal Article
Malmrose, LC; Gray, SL; Pieper, CF; Blazer, DG; Rowe, JW; Seeman, TE; Albert, MS
Published in: J Am Geriatr Soc
July 1993

OBJECTIVE: To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. DESIGN: Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe total chromagen method. Fifteen clearance-estimating equations were evaluated for bias, accuracy, correlation with measured clearance values, and frequency of erroneous placement into renal function categories. Stepwise regression modeling and reliability testing were performed on a split sample to construct and assess a novel creatinine-clearance-estimating equation. SETTING: New Haven, Connecticut, East Boston, Massachusetts, and a five-county region in and around Durham, North Carolina. PARTICIPANTS: A subsample of community-dwelling men and women (age range 70-79 years) from the Established Populations for Epidemiological Studies of the Elderly was screened for physical and cognitive functioning and placed into high-, medium-, and low-functioning groups (n = 1354). High-functioning respondents who provided blood and complete urine samples (n = 762) were included in the present study. RESULTS: In general, estimated creatinine clearance was more closely correlated to measured values in males than in females. Most equations underestimated creatinine clearance, with average bias ranging from -33.1 mL/min to +19.6 mL/min. Predictive accuracy ranged from 18.2 mL/min to 38.0 mL/min. Equations were variable in their erroneous placement of individuals into renal function categories. Regression modeling yielded an equation which contained novel components but failed to provide better estimates of creatinine clearance than those already available. CONCLUSIONS: The equations evaluated here provide unacceptable predictions of creatinine clearance in normally aging individuals. We advocate the use of serum drug concentration measurements when available and encourage investigation into timed urine collections of short duration as alternatives to clearance-estimating equations in the elderly.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

July 1993

Volume

41

Issue

7

Start / End Page

715 / 721

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Male
  • Humans
  • Health Status
  • Geriatrics
  • Female
  • Educational Status
  • Creatinine
  • Aging
  • Aged
 

Citation

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Malmrose, L. C., Gray, S. L., Pieper, C. F., Blazer, D. G., Rowe, J. W., Seeman, T. E., & Albert, M. S. (1993). Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging. J Am Geriatr Soc, 41(7), 715–721. https://doi.org/10.1111/j.1532-5415.1993.tb07459.x
Malmrose, L. C., S. L. Gray, C. F. Pieper, D. G. Blazer, J. W. Rowe, T. E. Seeman, and M. S. Albert. “Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.J Am Geriatr Soc 41, no. 7 (July 1993): 715–21. https://doi.org/10.1111/j.1532-5415.1993.tb07459.x.
Malmrose LC, Gray SL, Pieper CF, Blazer DG, Rowe JW, Seeman TE, et al. Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging. J Am Geriatr Soc. 1993 Jul;41(7):715–21.
Malmrose, L. C., et al. “Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.J Am Geriatr Soc, vol. 41, no. 7, July 1993, pp. 715–21. Pubmed, doi:10.1111/j.1532-5415.1993.tb07459.x.
Malmrose LC, Gray SL, Pieper CF, Blazer DG, Rowe JW, Seeman TE, Albert MS. Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging. J Am Geriatr Soc. 1993 Jul;41(7):715–721.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

July 1993

Volume

41

Issue

7

Start / End Page

715 / 721

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Male
  • Humans
  • Health Status
  • Geriatrics
  • Female
  • Educational Status
  • Creatinine
  • Aging
  • Aged