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Depressive symptomatology and fracture risk in community-dwelling older men and women.

Publication ,  Journal Article
Whitson, HE; Sanders, L; Pieper, CF; Gold, DT; Papaioannou, A; Richards, JB; Adachi, JD; Lyles, KW; CaMos Research Group
Published in: Aging Clin Exp Res
December 2008

BACKGROUND AND AIMS: Previous studies suggest that depression increases risk of falls, low bone mineral density, and fractures. Our aim was to evaluate whether depressive symptomatology alone predicts 5- year clinical fracture risk in older adults. METHODS: In this secondary analysis of a community-based, prospective cohort study including 4175 women and 1652 men in Canada, depressive symptomatology was assessed at baseline by the mental health inventory-5 (MHI-5) and the mental component score (MCS) of the short form 36 questionnaire (SF-36). Fracture events were assessed annually for five years; all reported incident fragility fractures were confirmed radiographically. RESULTS: Depressive symptomatology did not predict time to first fracture in men (hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.45-1.65) or women (HR 1.09, 95% CI 0.86-1.39). Results were similar after controlling for potential confounders. Depressive symptoms were not significantly associated with baseline bone mineral density at the lumbar spine or femoral neck. Women with depressive symptoms were more likely to report falls in the previous month (odds ratio [OR] 1.52, 95% CI 1.12-2.06, p=0.01). This association did not achieve statistical significance in men (OR 1.71, 95% CI 0.96-3.04, p=0.07). CONCLUSION: In this large, community cohort, depressive symptomatology did not predict five-year risk of clinical fracture. Further research is needed to determine if individuals with major depressive disorder (MDD) are at higher fracture risk and whether neuroendocrine or hormonal dysregulation might contribute to such risk in MDD.

Duke Scholars

Published In

Aging Clin Exp Res

DOI

ISSN

1594-0667

Publication Date

December 2008

Volume

20

Issue

6

Start / End Page

585 / 592

Location

Germany

Related Subject Headings

  • Spinal Fractures
  • Sex Distribution
  • Risk Factors
  • Prevalence
  • Predictive Value of Tests
  • Osteoporosis
  • Middle Aged
  • Male
  • Incidence
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Whitson, H. E., Sanders, L., Pieper, C. F., Gold, D. T., Papaioannou, A., Richards, J. B., … CaMos Research Group. (2008). Depressive symptomatology and fracture risk in community-dwelling older men and women. Aging Clin Exp Res, 20(6), 585–592. https://doi.org/10.1007/BF03324888
Whitson, Heather E., Linda Sanders, Carl F. Pieper, Deborah T. Gold, Alexandra Papaioannou, J Brent Richards, Jonathan D. Adachi, Kenneth W. Lyles, and CaMos Research Group. “Depressive symptomatology and fracture risk in community-dwelling older men and women.Aging Clin Exp Res 20, no. 6 (December 2008): 585–92. https://doi.org/10.1007/BF03324888.
Whitson HE, Sanders L, Pieper CF, Gold DT, Papaioannou A, Richards JB, et al. Depressive symptomatology and fracture risk in community-dwelling older men and women. Aging Clin Exp Res. 2008 Dec;20(6):585–92.
Whitson, Heather E., et al. “Depressive symptomatology and fracture risk in community-dwelling older men and women.Aging Clin Exp Res, vol. 20, no. 6, Dec. 2008, pp. 585–92. Pubmed, doi:10.1007/BF03324888.
Whitson HE, Sanders L, Pieper CF, Gold DT, Papaioannou A, Richards JB, Adachi JD, Lyles KW, CaMos Research Group. Depressive symptomatology and fracture risk in community-dwelling older men and women. Aging Clin Exp Res. 2008 Dec;20(6):585–592.
Journal cover image

Published In

Aging Clin Exp Res

DOI

ISSN

1594-0667

Publication Date

December 2008

Volume

20

Issue

6

Start / End Page

585 / 592

Location

Germany

Related Subject Headings

  • Spinal Fractures
  • Sex Distribution
  • Risk Factors
  • Prevalence
  • Predictive Value of Tests
  • Osteoporosis
  • Middle Aged
  • Male
  • Incidence
  • Humans