Overview
Dr. Whitson's research is focused on improving care options and resilience for people with multiple chronic conditions. In particular, she has interest and expertise related to the link between age-related changes in the eye and brain (e.g., How does late-life vision loss impact the aging brain or cognitive outcomes? Is Alzheimer's disease associated with distinctive changes in the retina, and could such changes help diagnose Alzheimer's disease early in its course?). Dr. Whitson leads a collaborative Alzheimer's Disease initiative that brings together investigators from Duke University and the University of North Carolina (UNC) at Chapel Hill, with a bold vision to transform dementia research and care across Eastern North Carolina. Dr. Whitson is also interested in improving health services to better meet the needs of medically complex patients. Within the Duke Aging Center, she leads research efforts aimed at promoting resilience to late-life stressors (e.g., surgery, sensory loss, infection). She has developed a novel rehabilitation model for people with co-existing vision and cognitive deficits, and she is part of a inter-disciplinary team seeking to improve peri-operative outcomes for frail or at-risk seniors who must undergo surgery. As a co-leader of a national resilience collaborative, she seeks to better understand the biological and psychological factors that determine how well we "bounce back" after health stressors.
Current Appointments & Affiliations
Duke School of Medicine Distinguished Professor in Neuroscience
·
2024 - Present
Medicine, Geriatrics and Palliative Care,
Medicine
Professor of Medicine
·
2020 - Present
Medicine, Geriatrics and Palliative Care,
Medicine
Professor in Ophthalmology
·
2020 - Present
Ophthalmology, Vitreoretinal Diseases & Surgery,
Ophthalmology
Professor in Head & Neck Surgery and Communication Sciences
·
2021 - Present
Head and Neck Surgery & Communication Sciences,
Clinical Science Departments
Professor in Neurology
·
2022 - Present
Neurology,
Clinical Science Departments
Director of the Duke Center for the Study of Aging and Human Development
·
2008 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Recent Publications
Frailty Phenotype in Adults with Sickle Cell Disease.
Journal Article J Gerontol A Biol Sci Med Sci · April 2, 2026 BACKGROUND: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty is characterized by decreased physiologic reserve and increased vulnerability to stress ... Full text Link to item CiteClinical Predictors of Resilience following Total Knee Arthroplasty: the PRIME-KNEE Study.
Journal Article J Gerontol A Biol Sci Med Sci · March 30, 2026 BACKGROUND: We aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasi ... Full text Link to item CiteOlfactory cleft biopsy analysis of Alzheimer's disease pathobiology across disease stages.
Journal Article Nat Commun · March 18, 2026 Alzheimer's Disease (AD) is a neurodegenerative condition affecting millions worldwide. Defining early pathobiological events remains challenging, in part due to inaccessibility of neural tissue. Because olfactory neurons are accessible, and olfactory loss ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchCo-Mentor · Awarded by National Institute on Aging · 2024 - 2029Neural Mechanisms Underlying Attentional Resilience in the Aging Brain
ResearchCo Investigator · Awarded by National Institute on Aging · 2024 - 2029View All Grants
Education
Duke University ·
2009
M.H.S.
Cornell University ·
2000
M.D.