Kenneth Ward Lyles
Professor of Medicine
My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.
In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.
In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.
KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates
In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.
In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.
KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Geriatrics, Medicine 1999
- Senior Fellow in the Center for the Study of Aging and Human Development, Center for the Study of Aging and Human Development, Institutes and Centers 1983
Contact Information
- Duke Box 3881, Durham, NC 27710
- Orange Zone , Ground Ffloor, Room 0360, Durham, NC 27710
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kenneth.lyles@duke.edu
(919) 660-7520
- Background
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Education, Training, & Certifications
- M.D., Virginia Commonwealth University 1974
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Previous Appointments & Affiliations
- Vice-chair for Clinical Research in the Department of Medicine, Medicine, Clinical Science Departments 2007 - 2010
- Associate Professor of Medicine with Tenure, Medicine, Geriatrics, Medicine 1990 - 1999
- Expertise
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Subject Headings
- Research
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Selected Grants
- Clinical characteristics, including history of MI and stroke among US Post-Menopausal women initiating treatment with Romosozumab and other anti-osteoporosis therapies awarded by Bendcare, LLC 2022 - 2025
- Trial of Parkinson's And Zoledronic Acid (TOPAZ) Year 3 awarded by California Pacific Medical Center 2020 - 2023
- Prevention of Fractures in Patients with Parkinson's Disease awarded by California Pacific Medical Center 2018 - 2023
- Telemedicine agreement for TOPAZ Clinical Trial awarded by Parkinson Foundation 2020 - 2021
- Mentoring Intervention Development in Fall and Fracture Prevention awarded by National Institutes of Health 2015 - 2021
- An Enhanced Protein (Dairy) Weight Loss Intervention for Dynapenic Obesity: Impact on Muscle Quality and Composition awarded by Dairy Management, Inc. 2015 - 2020
- Prevention of Fractures in Patients with Parkinson's Disease Clinical Data Research Network (CDRN Admin) awarded by California Pacific Medical Center 2018 - 2020
- The Carolinas Center for Medical Excellence Agreement awarded by The Carolinas Center for Medical Excellence 2008 - 2017
- TFWS/GEMSSTAR Professional Development Plan for Richard H. Lee awarded by American Diabetes Association 2014 - 2017
- Behavior And Physiology In Aging awarded by National Institutes of Health 1999 - 2015
- Geriatric Training Regarding Physicians and Dentists awarded by Department of Health and Human Services 1998 - 2007
- Geriatric Academic Career Award (GACA) awarded by Health Resources and Service Administration 2003 - 2006
- Claude D Pepper Older Americans Independence Center awarded by National Institutes of Health 1992 - 1999
- Faculty Training Projects In Geriatric Medicine & Dentistr awarded by National Institutes of Health 1988 - 1999
- Faculty Training Projects In Geratric Medicine And Denistr awarded by National Institutes of Health 1988 - 1999
- Osteoporosis And Disability In Life Care Community Women awarded by National Institutes of Health 1992 - 1997
- Claude D. Pepper Older American Independence Centers awarded by National Institutes of Health 1992 - 1997
- Osteoporosis And Disability In A Life Care Community awarded by National Institutes of Health 1993 - 1996
- Bone Density In Women Exposed To Des In Utero awarded by National Institutes of Health 1992 - 1993
- Glucocorticoid Effects On Mineral Homeostasis In Aging awarded by National Institutes of Health 1991 - 1992
- Estrogen Effects On Mineral Homeostasis In Aging awarded by National Institutes of Health 1988 - 1992
- Estrogen Effects On Mineral Homeostasis In Aging Rats awarded by National Institutes of Health 1987 - 1992
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External Relationships
- Faculty Connection
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lyles, Kenneth W., and Patrick B. Cacchio. “Your mother was right… You should stand up straight.” J Am Geriatr Soc, December 24, 2022. https://doi.org/10.1111/jgs.18168.Full Text Link to Item
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Colón-Emeric, Cathleen S., Richard Lee, Carl F. Pieper, Kenneth W. Lyles, Leah L. Zullig, Richard E. Nelson, Katina Robinson, Ivuoma Igwe, Jyotsna Jadhav, and Robert A. Adler. “Protocol for the models of primary osteoporosis screening in men (MOPS) cluster randomized trial.” Contemp Clin Trials 112 (January 2022): 106634. https://doi.org/10.1016/j.cct.2021.106634.Full Text Link to Item
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Lyles, Kenneth W., Kristal M. Riska, and Sherri L. Smith. “Is silence golden… In this context, not so much.” J Am Geriatr Soc 69, no. 11 (November 2021): 3074–76. https://doi.org/10.1111/jgs.17444.Full Text Link to Item
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Lyles, K. W., D. C. Bauer, C. S. Colon-Emeric, C. F. Pieper, S. R. Cummings, and D. M. Black. “Zoledronic acid reduces the rate of clinical fractures after surgical repair of a hip fracture regardless of the Pretreatment bone mineral density.” Osteoporos Int 32, no. 6 (June 2021): 1217–19. https://doi.org/10.1007/s00198-021-05923-5.Full Text Link to Item
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Tanner, Caroline M., Steven R. Cummings, Michael A. Schwarzschild, Ethan G. Brown, E Ray Dorsey, Alberto J. Espay, Nicholas B. Galifianakis, et al. “The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.” Npj Parkinsons Dis 7, no. 1 (March 1, 2021): 16. https://doi.org/10.1038/s41531-021-00162-1.Full Text Link to Item
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Sagalla, N., C. Colón-Emeric, R. Sloane, K. Lyles, J. Vognsen, and R. Lee. “FRAX without BMD can be used to risk-stratify Veterans who recently sustained a low trauma non-vertebral/non-hip fracture.” Osteoporos Int 32, no. 3 (March 2021): 467–72. https://doi.org/10.1007/s00198-020-05616-5.Full Text Link to Item
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Miller, Marshall G., Kathryn N. Porter Starr, Jamie Rincker, Melissa C. Orenduff, Shelley R. McDonald, Carl F. Pieper, Angela R. Fruik, Kenneth W. Lyles, and Connie W. Bales. “Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.” J Nutr Gerontol Geriatr 40, no. 2–3 (2021): 150–70. https://doi.org/10.1080/21551197.2021.1896615.Full Text Link to Item
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Center, Jacqueline R., Kenneth W. Lyles, and Dana Bliuc. “Bisphosphonates and lifespan.” Bone 141 (December 2020): 115566. https://doi.org/10.1016/j.bone.2020.115566.Full Text Link to Item
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Reid, Ian R., Jonathan R. Green, Kenneth W. Lyles, David M. Reid, Ulrich Trechsel, David J. Hosking, Dennis M. Black, Steven R. Cummings, R Graham G. Russell, and Erik F. Eriksen. “Zoledronate.” Bone 137 (August 2020): 115390. https://doi.org/10.1016/j.bone.2020.115390.Full Text Link to Item
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Ogunwale, Abayomi N., Cathleen S. Colon-Emeric, Richard Sloane, Robert A. Adler, Kenneth W. Lyles, and Richard H. Lee. “Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia.” J Bone Miner Res 35, no. 3 (March 2020): 440–45. https://doi.org/10.1002/jbmr.3916.Full Text Link to Item
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Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.” J Bone Miner Res 34, no. 11 (November 2019): 2045–51. https://doi.org/10.1002/jbmr.3826.Full Text Link to Item
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Colón-Emeric, Cathleen S., Carl F. Pieper, Courtney H. Van Houtven, Janet M. Grubber, Kenneth W. Lyles, Joanne Lafleur, and Robert A. Adler. “Limited Osteoporosis Screening Effectiveness Due to Low Treatment Rates in a National Sample of Older Men.” Mayo Clin Proc 93, no. 12 (December 2018): 1749–59. https://doi.org/10.1016/j.mayocp.2018.06.024.Full Text Link to Item
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Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.” J Clin Endocrinol Metab 103, no. 1 (January 1, 2018): 281–87. https://doi.org/10.1210/jc.2017-01593.Full Text Link to Item
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Lyles, Kenneth W. “Have We Learned How to Use Bisphosphonates Yet?” J Am Geriatr Soc 65, no. 9 (September 2017): 1902–3. https://doi.org/10.1111/jgs.14948.Full Text Link to Item
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Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues.” Osteoporos Int 28, no. 7 (July 2017): 2261–62. https://doi.org/10.1007/s00198-017-4056-6.Full Text Link to Item
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Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders.” Osteoporos Int 28, no. 3 (March 2017): 925–34. https://doi.org/10.1007/s00198-016-3841-y.Full Text Link to Item
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Bethel, M., F. M. Weaver, L. Bailey, S. Miskevics, J. N. Svircev, S. P. Burns, H. Hoenig, K. Lyles, and L. D. Carbone. “Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders.” Osteoporos Int 27, no. 10 (October 2016): 3011–21. https://doi.org/10.1007/s00198-016-3627-2.Full Text Link to Item
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Lee, Richard H., Megan Pearson, Kenneth W. Lyles, Patricia W. Jenkins, and Cathleen Colon-Emeric. “Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture.” Rural Remote Health 16, no. 1 (2016): 3440.Link to Item
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Colón-Emeric, Cathleen, Carl F. Pieper, Janet Grubber, Lynn Van Scoyoc, Merritt L. Schnell, Courtney Harold Van Houtven, Megan Pearson, Joanne Lafleur, Kenneth W. Lyles, and Robert A. Adler. “Correlation of hip fracture with other fracture types: Toward a rational composite hip fracture endpoint.” Bone 81 (December 2015): 67–71. https://doi.org/10.1016/j.bone.2015.07.003.Full Text Link to Item
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Singer, Frederick R., Henry G. Bone, David J. Hosking, Kenneth W. Lyles, Ian R. Reid, and Ethel S. Siris. “Response to letter by Ralston et al.” J Clin Endocrinol Metab 100, no. 6 (June 2015): L47–48. https://doi.org/10.1210/jc.2015-1961.Full Text Link to Item
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Singer, Frederick R., Henry G. Bone, David J. Hoskings, Kenneth W. Lyles, Ian R. Reid, and Ethel S. Siris. “Response to letter.” J Clin Endocrinol Metab 100, no. 5 (May 2015): L38. https://doi.org/10.1210/jc.2015-1713.Full Text Link to Item
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Singer, Frederick R., Henry G. Bone, David J. Hosking, Kenneth W. Lyles, Mohammad Hassan Murad, Ian R. Reid, and Ethel S. Siris. “Response to the letter by Asik M., et al.” J Clin Endocrinol Metab 100, no. 4 (April 2015): L36. https://doi.org/10.1210/jc.2015-1568.Full Text Link to Item
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Yun, H., E. Delzell, K. G. Saag, M. L. Kilgore, M. A. Morrisey, P. Muntner, R. Matthews, et al. “Fractures and mortality in relation to different osteoporosis treatments.” Clinical and Experimental Rheumatology 33, no. 3 (January 1, 2015): 302–9.
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Singer, Frederick R., Henry G. Bone, David J. Hosking, Kenneth W. Lyles, Mohammad Hassan Murad, Ian R. Reid, Ethel S. Siris, and Ethel S. Endocrine Society. “Paget's disease of bone: an endocrine society clinical practice guideline.” J Clin Endocrinol Metab 99, no. 12 (December 2014): 4408–22. https://doi.org/10.1210/jc.2014-2910.Full Text Link to Item
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Magaziner, Jay S., Denise L. Orwig, Kenneth W. Lyles, Lars Nordsletten, Steven Boonen, Jonathan D. Adachi, Chris Recknor, et al. “Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.” J Bone Miner Res 29, no. 12 (December 2014): 2545–51. https://doi.org/10.1002/jbmr.2283.Full Text Link to Item
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Itty, Sujit, Shelley Day, Kenneth W. Lyles, Sandra S. Stinnett, Lejla M. Vajzovic, and Prithvi Mruthyunjaya. “Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.” Retina 34, no. 9 (September 2014): 1779–86. https://doi.org/10.1097/IAE.0000000000000178.Full Text Link to Item
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Lyles, Kenneth W., and Cathleen S. Colon-Emeric. “Does low bone mineral density cause a broken heart?” Jacc Heart Fail 2, no. 4 (August 2014): 390–91. https://doi.org/10.1016/j.jchf.2014.04.002.Full Text Link to Item
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Nassaralla, Claudia, and Kenneth W. Lyles. “Possible way to reduce fracture rates in patients with traumatic spinal cord injury?” Arch Phys Med Rehabil 95, no. 6 (June 2014): 1021–22. https://doi.org/10.1016/j.apmr.2014.02.029.Full Text Link to Item
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Lee, Richard H., Kenneth W. Lyles, Megan Pearson, Karen Barnard, and Cathleen Colón-Emeric. “Osteoporosis screening and treatment among veterans with recent fracture after implementation of an electronic consult service.” Calcif Tissue Int 94, no. 6 (June 2014): 659–64. https://doi.org/10.1007/s00223-014-9849-4.Full Text Link to Item
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Prieto-Alhambra, D., A. Judge, N. K. Arden, C. Cooper, K. W. Lyles, and M. K. Javaid. “Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial.” Osteoporos Int 25, no. 1 (January 2014): 77–83. https://doi.org/10.1007/s00198-013-2420-8.Full Text Link to Item
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White, Heidi K., Gwendolen Buhr, Eleanor McConnell, Robert J. Sullivan, Jack Twersky, Cathleen Colon-Emeric, Mitchell Heflin, et al. “An advanced course in long term care for geriatric medicine fellows.” J Am Med Dir Assoc 14, no. 7 (July 2013): 499–506. https://doi.org/10.1016/j.jamda.2013.02.012.Full Text Link to Item
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Wolfe, Frederick, Marcy B. Bolster, Christopher M. O’Connor, Kaleb Michaud, Kenneth W. Lyles, and Cathleen S. Colón-Emeric. “Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis.” J Bone Miner Res 28, no. 5 (May 2013): 984–91. https://doi.org/10.1002/jbmr.1792.Full Text Link to Item
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Reid, I. R., D. M. Black, R. Eastell, C. Bucci-Rechtweg, G. Su, T. F. Hue, P. Mesenbrink, K. W. Lyles, S. Boonen, and S. HORIZON Pivotal Fracture Trial and HORIZON Recurrent Fracture Trial Steering Committees. “Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams.” J Clin Endocrinol Metab 98, no. 2 (February 2013): 557–63. https://doi.org/10.1210/jc.2012-2868.Full Text Link to Item
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Boonen, Steven, Richard Eastell, Guoqin Su, Peter Mesenbrink, Felicia Cosman, Jane A. Cauley, Ian R. Reid, et al. “Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis.” J Bone Miner Res 27, no. 7 (July 2012): 1487–93. https://doi.org/10.1002/jbmr.1605.Full Text Link to Item
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Colón-Emeric, Cathleen S., and Kenneth W. Lyles. “How much vitamin D should I take?” J Clin Invest 122, no. 5 (May 2012): 1598–99. https://doi.org/10.1172/jci62966.Full Text Link to Item
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Adachi, Jonathan D., Kenneth Lyles, Steven Boonen, Cathleen Colón-Emeric, Lars Hyldstrup, Lars Nordsletten, Carl Pieper, et al. “Subtrochanteric fractures in bisphosphonate-naive patients: results from the HORIZON-recurrent fracture trial.” Calcif Tissue Int 89, no. 6 (December 2011): 427–33. https://doi.org/10.1007/s00223-011-9543-8.Full Text Link to Item
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Boonen, Steven, Eric Orwoll, Jay Magaziner, Cathleen S. Colón-Emeric, Jonathan D. Adachi, Christina Bucci-Rechtweg, Patrick Haentjens, et al. “Once-yearly zoledronic acid in older men compared with women with recent hip fracture.” J Am Geriatr Soc 59, no. 11 (November 2011): 2084–90. https://doi.org/10.1111/j.1532-5415.2011.03666.x.Full Text Link to Item
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Adachi, J. D., K. W. Lyles, C. S. Colón-Emeric, S. Boonen, C. F. Pieper, C. Mautalen, L. Hyldstrup, et al. “Zoledronic acid results in better health-related quality of life following hip fracture: the HORIZON-Recurrent Fracture Trial.” Osteoporos Int 22, no. 9 (September 2011): 2539–49. https://doi.org/10.1007/s00198-010-1514-9.Full Text Link to Item
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Reid, Ian R., Kenneth Lyles, Guoqin Su, Jacques P. Brown, John P. Walsh, Javier del Pino-Montes, Paul D. Miller, et al. “A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years.” J Bone Miner Res 26, no. 9 (September 2011): 2261–70. https://doi.org/10.1002/jbmr.438.Full Text Link to Item
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Colón-Emeric, C., L. Nordsletten, S. Olson, N. Major, S. Boonen, P. Haentjens, P. Mesenbrink, et al. “Association between timing of zoledronic acid infusion and hip fracture healing.” Osteoporos Int 22, no. 8 (August 2011): 2329–36. https://doi.org/10.1007/s00198-010-1473-1.Full Text Link to Item
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Colón-Emeric, Cathleen S., Kenneth W. Lyles, Guoqin Su, Carl F. Pieper, Jay S. Magaziner, Jonathan D. Adachi, Christina M. Bucci-Rechtweg, Patrick Haentjens, Steven Boonen, and Steven HORIZON Recurrent Fracture Trial. “Clinical risk factors for recurrent fracture after hip fracture: a prospective study.” Calcif Tissue Int 88, no. 5 (May 2011): 425–31. https://doi.org/10.1007/s00223-011-9474-4.Full Text Link to Item
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Grbic, John T., Dennis M. Black, Kenneth W. Lyles, David M. Reid, Eric Orwoll, Michael McClung, Christina Bucci-Rechtweg, and Guoqin Su. “The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program.” J Am Dent Assoc 141, no. 11 (November 2010): 1365–70. https://doi.org/10.14219/jada.archive.2010.0082.Full Text Link to Item
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Zammar, Guilherme Roberto, Jatin Shah, Ana Paula Bonilauri Ferreira, Luciana Cofiel, Kenneth W. Lyles, and Ricardo Pietrobon. “Qualitative analysis of the interdisciplinary interaction between data analysis specialists and novice clinical researchers.” Plos One 5, no. 2 (February 24, 2010): e9400. https://doi.org/10.1371/journal.pone.0009400.Full Text Open Access Copy Link to Item
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Boonen, Steven, Dennis M. Black, Cathleen S. Colón-Emeric, Richard Eastell, Jay S. Magaziner, Erik Fink Eriksen, Peter Mesenbrink, Patrick Haentjens, and Kenneth W. Lyles. “Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older.” J Am Geriatr Soc 58, no. 2 (February 2010): 292–99. https://doi.org/10.1111/j.1532-5415.2009.02673.x.Full Text Link to Item
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Lee, Richard H., Kenneth W. Lyles, and Cathleen Colón-Emeric. “A review of the effect of anticonvulsant medications on bone mineral density and fracture risk.” Am J Geriatr Pharmacother 8, no. 1 (February 2010): 34–46. https://doi.org/10.1016/j.amjopharm.2010.02.003.Full Text Link to Item
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Colón-Emeric, Cathleen S., Peter Mesenbrink, Kenneth W. Lyles, Carl F. Pieper, Steven Boonen, Pierre Delmas, Erik F. Eriksen, and Jay Magaziner. “Potential mediators of the mortality reduction with zoledronic acid after hip fracture.” J Bone Miner Res 25, no. 1 (January 2010): 91–97. https://doi.org/10.1359/jbmr.090704.Full Text Link to Item
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Colón-Emeric, Cathleen S., and Kenneth W. Lyles. “Should there be a fracas over FRAX and other fracture prediction tools?: Comment on "A comparison of prediction models for fractures in older women".” Arch Intern Med 169, no. 22 (December 14, 2009): 2094–95. https://doi.org/10.1001/archinternmed.2009.2094.Full Text Link to Item
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Eriksen, Erik Fink, Kenneth W. Lyles, Cathleen S. Colón-Emeric, Carl F. Pieper, Jay S. Magaziner, Jonathan D. Adachi, Lars Hyldstrup, et al. “Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture.” J Bone Miner Res 24, no. 7 (July 2009): 1308–13. https://doi.org/10.1359/jbmr.090209.Full Text Link to Item
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Warriner, Amy H., Ryan C. Outman, Kenneth G. Saag, Sarah D. Berry, Cathleen Colón-Emeric, Kellie L. Flood, Kenneth W. Lyles, S Bobo Tanner, Nelson B. Watts, and Jeffrey R. Curtis. “Management of osteoporosis among home health and long-term care patients with a prior fracture.” South Med J 102, no. 4 (April 2009): 397–404. https://doi.org/10.1097/SMJ.0b013e31819bc1d3.Full Text Link to Item
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White, Heidi K., Charles D. Petrie, William Landschulz, David MacLean, Ann Taylor, Kenneth Lyles, Jeanne Y. Wei, et al. “Effects of an oral growth hormone secretagogue in older adults.” J Clin Endocrinol Metab 94, no. 4 (April 2009): 1198–1206. https://doi.org/10.1210/jc.2008-0632.Full Text Link to Item
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Curtis, Jeffrey R., Juan Xi, Andrew O. Westfall, Hong Cheng, Kenneth Lyles, Kenneth G. Saag, and Elizabeth Delzell. “Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis.” Med Care 47, no. 3 (March 2009): 334–41. https://doi.org/10.1097/MLR.0b013e31818afa1c.Full Text Link to Item
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Whitson, Heather E., Linda Sanders, Carl F. Pieper, Deborah T. Gold, Alexandra Papaioannou, J Brent Richards, Jonathan D. Adachi, Kenneth W. Lyles, and Kenneth W. CaMos Research Group. “Depressive symptomatology and fracture risk in community-dwelling older men and women.” Aging Clin Exp Res 20, no. 6 (December 2008): 585–92. https://doi.org/10.1007/BF03324888.Full Text Link to Item
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Curtis, Jeffrey R., Andrew O. Westfall, Hong Cheng, Kenneth Lyles, Kenneth G. Saag, and Elizabeth Delzell. “Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users.” J Bone Miner Res 23, no. 9 (September 2008): 1435–41. https://doi.org/10.1359/jbmr.080418.Full Text Link to Item
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Lyles, K. W., A. P. Schenck, and C. S. Colón-Emeric. “Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents.” Osteoporos Int 19, no. 8 (August 2008): 1225–33. https://doi.org/10.1007/s00198-008-0569-3.Full Text Link to Item
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Black, Dennis M., Steven Boonen, Pierre Delmas, and Kenneth W. Lyles. “Review of comparative effectiveness of treatments to prevent fractures.” Ann Intern Med 148, no. 11 (June 3, 2008): 885–86. https://doi.org/10.7326/0003-4819-148-11-200806030-00019.Full Text Link to Item
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Colon-Emeric, C. S., K. W. Lyles, and P. Mesenbrink. “Zoledronate, fractures, and mortality after hip fracture [4].” New England Journal of Medicine 358, no. 9 (February 28, 2008): 968–69.
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Logan, William C., Richard Sloane, Kenneth W. Lyles, Barry Goldstein, and Helen M. Hoenig. “Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury.” Arch Phys Med Rehabil 89, no. 2 (February 2008): 237–43. https://doi.org/10.1016/j.apmr.2007.08.144.Full Text Link to Item
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Colon-Emeric, C. S., K. W. Lyles, and P. Mesenbrink. “Zoledronate, fractures, and mortality after hip fracture [4].” New England Journal of Medicine 358, no. 9 (2008): 968–69. https://doi.org/10.1056/NEJMc073292.Full Text
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Pieper, Carl F., Cathleen Colon-Emeric, John Caminis, Kathleen Betchyk, Jie Zhang, Cheri Janning, John Shostak, Meryl S. LeBoff, Robert R. Heaney, and Kenneth W. Lyles. “Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture.” Am J Geriatr Pharmacother 5, no. 4 (December 2007): 335–40. https://doi.org/10.1016/j.amjopharm.2007.12.004.Full Text Link to Item
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Colón-Emeric, Cathleen S., Kenneth W. Lyles, Paul House, Deborah A. Levine, Anna P. Schenck, Jeroan Allison, Joel Gorospe, et al. “Randomized trial to improve fracture prevention in nursing home residents.” Am J Med 120, no. 10 (October 2007): 886–92. https://doi.org/10.1016/j.amjmed.2007.04.020.Full Text Link to Item
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Lyles, K. W. “Bisphosphonates in Paget's disease of bone.” Clinical Reviews in Bone and Mineral Metabolism 5, no. 3 (September 1, 2007): 165–71. https://doi.org/10.1007/s12018-007-9001-3.Full Text
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Gellad, Ziad F., and Kenneth W. Lyles. “Direct-to-consumer advertising of pharmaceuticals.” Am J Med 120, no. 6 (June 2007): 475–80. https://doi.org/10.1016/j.amjmed.2006.09.030.Full Text Link to Item
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Hosking, D., K. Lyles, J. P. Brown, W. D. Fraser, P. Miller, M. D. Curiel, J. P. Devogelaer, et al. “Long-term control of bone turnover in paget's disease with zoledronic acid and risedronate (Journal of Bone and Mineral Research (2007) 22, (142-148)).” Journal of Bone and Mineral Research 22, no. 5 (May 1, 2007): 773. https://doi.org/10.1359/jbmr.061001e.Full Text
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Colón-Emeric, C., K. W. Lyles, D. A. Levine, P. House, A. Schenck, J. Gorospe, M. Fermazin, et al. “Prevalence and predictors of osteoporosis treatment in nursing home residents with known osteoporosis or recent fracture.” Osteoporos Int 18, no. 4 (April 2007): 553–59. https://doi.org/10.1007/s00198-006-0260-5.Full Text Link to Item
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Echols, Melvin R., Katherine S. Garman, and Kenneth W. Lyles. “Clinical diagnostic reasoning.” N Engl J Med 356, no. 12 (March 22, 2007): 1272.Link to Item
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Hosking, David, Kenneth Lyles, Jacques P. Brown, William D. Fraser, Paul Miller, Manuel Diaz Curiel, Jean-Pierre Devogelaer, et al. “Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate.” J Bone Miner Res 22, no. 1 (January 2007): 142–48. https://doi.org/10.1359/jbmr.061001.Full Text Link to Item
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Lyles, K. W., C. S. Colón-Emeric, J. S. Magaziner, J. D. Adachi, C. F. Pieper, C. Mautalen, L. Hyldstrup, et al. “Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture.” N Engl J Med 357 (2007): nihpa40967. https://doi.org/10.1056/NEJMoa074941.Full Text Link to Item
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Siris, Ethel S., Kenneth W. Lyles, Frederick R. Singer, and Pierce J. Meunier. “Medical management of Paget's disease of bone: indications for treatment and review of current therapies.” J Bone Miner Res 21 Suppl 2 (December 2006): P94–98. https://doi.org/10.1359/jbmr.06s218.Full Text Link to Item
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Whitson, Heather E., Bruce Lobaugh, and Kenneth W. Lyles. “Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone.” Bone 39, no. 4 (October 2006): 954–58. https://doi.org/10.1016/j.bone.2006.04.032.Full Text Link to Item
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Levine, Deborah A., Kenneth G. Saag, Linda L. Casebeer, Cathleen Colon-Emeric, Kenneth W. Lyles, and Richard M. Shewchuk. “Using a modified nominal group technique to elicit director of nursing input for an osteoporosis intervention.” J Am Med Dir Assoc 7, no. 7 (September 2006): 420–25. https://doi.org/10.1016/j.jamda.2006.05.004.Full Text Link to Item
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Stone, L. M., and K. W. Lyles. “Osteoporosis in later life.” Generations 30, no. 3 (September 1, 2006): 65–70.
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Whitson, Heather E., Carl F. Pieper, Linda Sanders, Ronnie D. Horner, Pamela W. Duncan, and Kenneth W. Lyles. “Adding injury to insult: fracture risk after stroke in veterans.” J Am Geriatr Soc 54, no. 7 (July 2006): 1082–88. https://doi.org/10.1111/j.1532-5415.2006.00769.x.Full Text Link to Item
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Reid, Ian R., Paul Miller, Kenneth Lyles, William Fraser, Jacques P. Brown, Youssef Saidi, Peter Mesenbrink, et al. “Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease.” N Engl J Med 353, no. 9 (September 1, 2005): 898–908. https://doi.org/10.1056/NEJMoa044241.Full Text Link to Item
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Colón-Emeric, Cathleen S., and Kenneth W. Lyles. “Antiresorptive pharmacotherapy in older women: where the evidence-based medicine rubber meets the geriatrics road.” J Am Geriatr Soc 53, no. 8 (August 2005): 1425–26. https://doi.org/10.1111/j.1532-5415.2005.53412.x.Full Text Link to Item
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Ichikawa, Shoji, Kenneth W. Lyles, and Michael J. Econs. “A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessive.” J Clin Endocrinol Metab 90, no. 4 (April 2005): 2420–23. https://doi.org/10.1210/jc.2004-2302.Full Text Link to Item
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Colón-Emeric, C. S., L. Casebeer, K. Saag, J. Allison, D. Levine, T. T. Suh, and K. W. Lyles. “Barriers to providing osteoporosis care in skilled nursing facilities: Perceptions of medical directors and directors of nursing.” Journal of the American Medical Directors Association 6, no. 3 SUPPL. (January 1, 2005). https://doi.org/10.1016/j.jamda.2005.03.036.Full Text
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Green, Amanda D., Cathleen S. Colón-Emeric, Lori Bastian, Matthew T. Drake, and Kenneth W. Lyles. “Does this woman have osteoporosis?” Jama 292, no. 23 (December 15, 2004): 2890–2900. https://doi.org/10.1001/jama.292.23.2890.Full Text Link to Item
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Gold, Deborah T., Kathy M. Shipp, Carl F. Pieper, Pamela W. Duncan, Salutario Martinez, and Kenneth W. Lyles. “Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial.” J Am Geriatr Soc 52, no. 9 (September 2004): 1471–78. https://doi.org/10.1111/j.1532-5415.2004.52409.x.Full Text Link to Item
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Colón-Emeric, Cathleen S., John Caminis, Theodore T. Suh, Carl F. Pieper, Cheri Janning, Jay Magaziner, Jonathan Adachi, et al. “The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair.” Curr Med Res Opin 20, no. 6 (June 2004): 903–10. https://doi.org/10.1185/030079904125003683.Full Text Link to Item
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Colón-Emeric, Cathleen S., Linda Casebeer, Kenneth Saag, Jeroan Allison, Deborah Levine, Theodore T. Suh, and Kenneth W. Lyles. “Barriers to providing osteoporosis care in skilled nursing facilities: perceptions of medical directors and directors of nursing.” J Am Med Dir Assoc 5, no. 6 (2004): 361–66. https://doi.org/10.1097/01.JAM.0000141950.34986.EE.Full Text Link to Item
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Lyles, Kenneth W., and Cathleen Colón-Emeric. “Treating vitamin D deficiency in long-term care: it should be done yesterday, but how?” J Am Med Dir Assoc 5, no. 6 (2004): 416–17. https://doi.org/10.1097/01.JAM.0000144556.61630.D5.Full Text Link to Item
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Colón-Emeric, Cathleen, Maragatha Kuchibhatla, Carl Pieper, William Hawkes, Lisa Fredman, Jay Magaziner, Sheryl Zimmerman, and Kenneth W. Lyles. “The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies.” Osteoporos Int 14, no. 11 (November 2003): 879–83. https://doi.org/10.1007/s00198-003-1460-x.Full Text Link to Item
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Lyles, Kenneth W. “What is "resistance" in Paget's disease of bone?” Arthritis Rheum 48, no. 8 (August 2003): 2097–99. https://doi.org/10.1002/art.11135.Full Text Link to Item
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Suh, Theodore T., and Kenneth W. Lyles. “Osteoporosis considerations in the frail elderly.” Curr Opin Rheumatol 15, no. 4 (July 2003): 481–86. https://doi.org/10.1097/00002281-200307000-00018.Full Text Link to Item
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Colón-Emeric, Cathleen S., David P. Biggs, Anna P. Schenck, and Kenneth W. Lyles. “Risk factors for hip fracture in skilled nursing facilities: who should be evaluated?” Osteoporos Int 14, no. 6 (July 2003): 484–89. https://doi.org/10.1007/s00198-003-1384-5.Full Text Link to Item
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Lyles, Kenneth W., and Cathleen S. Colón-Emeric. “Can we identify women at high risk of osteoporotic fractures?” J Am Geriatr Soc 50, no. 6 (June 2002): 1161–62. https://doi.org/10.1046/j.1532-5415.2002.50278.x.Full Text Link to Item
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Cohen, Harvey Jay, John R. Feussner, Morris Weinberger, Molly Carnes, Ronald C. Hamdy, Frank Hsieh, Ciaran Phibbs, et al. “A controlled trial of inpatient and outpatient geriatric evaluation and management.” N Engl J Med 346, no. 12 (March 21, 2002): 905–12. https://doi.org/10.1056/NEJMsa010285.Full Text Link to Item
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Staa, T. P. van, P. Selby, H. G. M. Leufkens, K. Lyles, J. M. Sprafka, and C. Cooper. “Incidence and natural history of Paget's disease of bone in England and Wales.” J Bone Miner Res 17, no. 3 (March 2002): 465–71. https://doi.org/10.1359/jbmr.2002.17.3.465.Full Text Link to Item
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Lyles, K. W., E. S. Siris, F. R. Singer, and P. J. Meunier. “A clinical approach to diagnosis and management of Paget's disease of bone.” J Bone Miner Res 16, no. 8 (August 2001): 1379–87. https://doi.org/10.1359/jbmr.2001.16.8.1379.Full Text Link to Item
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Lyles, K. W. “Osteoporosis and depression: shedding more light upon a complex relationship.” J Am Geriatr Soc 49, no. 6 (June 2001): 827–28. https://doi.org/10.1046/j.1532-5415.2001.49162.x.Full Text Link to Item
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Jayaraj, K., S. Martinez, A. Freeman, and K. W. Lyles. “Intraosseous meningioma--a mimicry of Paget's disease?” J Bone Miner Res 16, no. 6 (June 2001): 1154–56. https://doi.org/10.1359/jbmr.2001.16.6.1154.Full Text Link to Item
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Lyles, K. W., E. S. Siris, F. R. Singer, and P. J. Meunier. “Guidelines for the diagnosis and therapy of the Paget's disease of the bone.” Revista Espanola De Enfermedades Metabolicas Oseas 10, no. 1 (January 1, 2001): 28–34.
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Colón-Emeric, C., L. Yballe, R. Sloane, C. F. Pieper, and K. W. Lyles. “Expert physician recommendations and current practice patterns for evaluating and treating men with osteoporotic hip fracture.” J Am Geriatr Soc 48, no. 10 (October 2000): 1261–63. https://doi.org/10.1111/j.1532-5415.2000.tb02599.x.Full Text Link to Item
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Lyles, K. W. “Ask the expert Question and Answer.” Annals of Long Term Care 8, no. 8 (September 11, 2000): 86.
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Colón-Emeric, C. S., R. Sloane, W. G. Hawkes, J. Magaziner, S. I. Zimmerman, C. F. Pieper, and K. W. Lyles. “The risk of subsequent fractures in community-dwelling men and male veterans with hip fracture.” Am J Med 109, no. 4 (September 2000): 324–26. https://doi.org/10.1016/s0002-9343(00)00504-0.Full Text Link to Item
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Nance, M. A., F. Q. Nuttall, M. J. Econs, K. W. Lyles, K. D. Viles, J. M. Vance, M. A. Pericak-Vance, and M. C. Speer. “Heterogeneity in Paget disease of the bone.” Am J Med Genet 92, no. 5 (June 19, 2000): 303–7. https://doi.org/10.1002/1096-8628(20000619)92:5<303::aid-ajmg2>3.0.co;2-e.Full Text Link to Item
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Shipp, K. M., J. L. Purse, D. T. Gold, C. F. Pieper, R. Sloane, M. Schenkman, and K. W. Lyles. “Timed loaded standing: a measure of combined trunk and arm endurance suitable for people with vertebral osteoporosis.” Osteoporos Int 11, no. 11 (2000): 914–22. https://doi.org/10.1007/s001980070029.Full Text Link to Item
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Gold, D. T., B. M. Burchett, K. M. Shipp, C. F. Pieper, and K. W. Lyles. “Factors associated with self-rated health in patients with Paget's disease of bone.” J Bone Miner Res 14 Suppl 2 (October 1999): 99–102. https://doi.org/10.1002/jbmr.5650140221.Full Text Link to Item
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Grauer, A., H. Bone, E. V. McCloskey, M. McClung, D. H. Gutteridge, K. W. Lyles, C. Mautalen, G. Rodan, and S. Wallach. “Discussion: Newer bisphosphonates in the treatment of Paget's disease of bone: where we are and where we want to go.” J Bone Miner Res 14 Suppl 2 (October 1999): 74–78. https://doi.org/10.1002/jbmr.5650140215.Full Text Link to Item
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Purser, J. L., C. F. Pieper, L. G. Branch, K. M. Shipp, D. T. Gold, and K. W. Lyles. “Spinal deformity and mobility self-confidence among women with osteoporosis and vertebral fractures.” Aging (Milano) 11, no. 4 (August 1999): 235–45. https://doi.org/10.1007/BF03339664.Full Text Link to Item
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Buckler, H., W. Fraser, D. Hosking, W. Ryan, M. J. Maricic, F. Singer, M. Davie, et al. “Single infusion of zoledronate in Paget's disease of bone: a placebo-controlled, dose-ranging study.” Bone 24, no. 5 Suppl (May 1999): 81S-85S. https://doi.org/10.1016/s8756-3282(99)00071-x.Full Text Link to Item
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Lewis, T., A. S. Tesh, and K. W. Lyles. “Caring for the patient with paget’s disease of the bone.” Nurse Practitioner 24, no. 7 (January 1, 1999): 50–68. https://doi.org/10.1080/00006205-199907000-00006.Full Text
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Lyles, K. W. “Management of patients with vertebral compression fractures.” Pharmacotherapy 19, no. 1 Pt 2 (January 1999): 21S-24S. https://doi.org/10.1592/phco.19.2.21s.30908.Full Text Link to Item
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Beck, D. A., L. Gray, and K. W. Lyles. “Dementia associated with hyperphosphatemic tumoral calcinosis.” Clin Neurol Neurosurg 100, no. 2 (June 1998): 121–25. https://doi.org/10.1016/s0303-8467(98)00010-9.Full Text Link to Item
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Gold, D. T., K. M. Shipp, and K. W. Lyles. “Managing patients with complications of osteoporosis.” Endocrinol Metab Clin North Am 27, no. 2 (June 1998): 485–96. https://doi.org/10.1016/s0889-8529(05)70018-9.Full Text Link to Item
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Lyles, K. W., D. T. Gold, R. A. Newton, S. Parekh, K. M. Shipp, C. F. Pieper, R. Krishan, and C. C. Carson. “Peyronie's disease is associated with Paget's disease of bone.” J Bone Miner Res 12, no. 6 (June 1997): 929–34. https://doi.org/10.1359/jbmr.1997.12.6.929.Full Text Link to Item
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Arden-Cordone, M., E. S. Siris, K. W. Lyles, A. Knieriem, R. A. Newton, V. Schaffer, and K. Zelenakas. “Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone.” Calcif Tissue Int 60, no. 5 (May 1997): 415–18. https://doi.org/10.1007/s002239900255.Full Text Link to Item
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Gold, D. T., J. Boisture, K. M. Shipp, C. F. Pieper, and K. W. Lyles. “Paget's disease of bone and quality of life.” J Bone Miner Res 11, no. 12 (December 1996): 1897–1904. https://doi.org/10.1002/jbmr.5650111210.Full Text Link to Item
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Siris, E., R. S. Weinstein, R. Altman, J. M. Conte, M. Favus, A. Lombardi, K. Lyles, et al. “Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone.” J Clin Endocrinol Metab 81, no. 3 (March 1996): 961–67. https://doi.org/10.1210/jcem.81.3.8772558.Full Text Link to Item
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Cohen, H. J., and K. W. Lyles. “The duke approach to faculty development in geriatric medicine.” Educational Gerontology 22, no. 1 (January 1, 1996): 23–36. https://doi.org/10.1080/0360127960220104.Full Text
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Lyles, K. W., J. E. Lammers, K. M. Shipp, L. Sherman, C. F. Pieper, S. Martinez, and D. T. Gold. “Functional and mobility impairments associated with Paget's disease of bone.” J Am Geriatr Soc 43, no. 5 (May 1995): 502–6. https://doi.org/10.1111/j.1532-5415.1995.tb06096.x.Full Text Link to Item
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Bohannon, A. D., and K. W. Lyles. “Drug-induced bone disease.” Clin Geriatr Med 10, no. 4 (November 1994): 611–23.Link to Item
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Lyles, K. W., D. T. Gold, K. M. Shipp, C. F. Pieper, S. Martinez, and P. L. Mulhausen. “Association of osteoporotic vertebral compression fractures with impaired functional status.” Am J Med 94, no. 6 (June 1993): 595–601. https://doi.org/10.1016/0002-9343(93)90210-g.Full Text Link to Item
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Lyles, K. W., T. W. Jackson, T. Nesbitt, and L. D. Quarles. “Salmon calcitonin reduces vertebral bone loss in glucocorticoid-treated beagles.” Am J Physiol 264, no. 6 Pt 1 (June 1993): E938–42. https://doi.org/10.1152/ajpendo.1993.264.6.E938.Full Text Link to Item
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Gold, D. T., K. Stegmaier, C. W. Bales, K. W. Lyles, R. E. Westlund, and M. K. Drezner. “Psychosocial functioning and osteoporosis in late life: Results of a multidisciplinary intervention.” Journal of Women’S Health 2, no. 2 (January 1, 1993): 149–55. https://doi.org/10.1089/jwh.1993.2.149.Full Text
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Mitchell, D. R., T. W. Jackson, and K. W. Lyles. “Effects of short-term administration of glucocorticoids on bone metabolism in healthy elderly men.” J Am Geriatr Soc 39, no. 12 (December 1991): 1179–82. https://doi.org/10.1111/j.1532-5415.1991.tb03571.x.Full Text Link to Item
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Quarles, L. D., G. Murphy, M. J. Econs, S. Martinez, B. Lobaugh, and K. W. Lyles. “Uremic tumoral calcinosis: preliminary observations suggesting an association with aberrant vitamin D homeostasis.” Am J Kidney Dis 18, no. 6 (December 1991): 706–10. https://doi.org/10.1016/s0272-6386(12)80614-7.Full Text Link to Item
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Gold, D. T., S. D. Smith, C. W. Bales, K. W. Lyles, R. E. Westlund, and M. K. Drezner. “Osteoporosis in late life: does health locus of control affect psychosocial adaptation?” J Am Geriatr Soc 39, no. 7 (July 1991): 670–75. https://doi.org/10.1111/j.1532-5415.1991.tb03620.x.Full Text Link to Item
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Burkes, E. J., K. W. Lyles, E. A. Dolan, B. Giammara, and J. Hanker. “Dental lesions in tumoral calcinosis.” J Oral Pathol Med 20, no. 5 (May 1991): 222–27. https://doi.org/10.1111/j.1600-0714.1991.tb00423.x.Full Text Link to Item
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Kochersberger, G., R. Westlund, and K. W. Lyles. “The metabolic effects of calcium supplementation in the elderly.” J Am Geriatr Soc 39, no. 2 (February 1991): 192–96. https://doi.org/10.1111/j.1532-5415.1991.tb01625.x.Full Text Link to Item
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Kochersberger, G., C. Bales, B. Lobaugh, and K. W. Lyles. “Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects.” J Gerontol 45, no. 5 (September 1990): M159–62. https://doi.org/10.1093/geronj/45.5.m159.Full Text Link to Item
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Mitchell, D. R., and K. W. Lyles. “Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention.” J Gerontol 45, no. 5 (September 1990): M153–58. https://doi.org/10.1093/geronj/45.5.m153.Full Text Link to Item
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Martinez, S., J. B. Vogler, J. M. Harrelson, and K. W. Lyles. “Imaging of tumoral calcinosis: new observations.” Radiology 174, no. 1 (January 1990): 215–22. https://doi.org/10.1148/radiology.174.1.2294551.Full Text Link to Item
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Gold, D. T., K. W. Lyles, C. W. Bales, and M. K. Drezner. “Teaching patients coping behaviors: an essential part of successful management of osteoporosis.” J Bone Miner Res 4, no. 6 (December 1989): 799–801. https://doi.org/10.1002/jbmr.5650040602.Full Text Link to Item
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Cohen, H. J., and K. W. Lyles. “Geriatrics.” Jama 261, no. 19 (May 19, 1989): 2847–48.Link to Item
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Gold, D. T., C. W. Bales, K. W. Lyles, and M. K. Drezner. “Treatment of osteoporosis. The psychological impact of a medical education program on older patients.” J Am Geriatr Soc 37, no. 5 (May 1989): 417–22. https://doi.org/10.1111/j.1532-5415.1989.tb02637.x.Full Text Link to Item
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Cohen, H. J., and K. W. Lyles. “Geriatrics: Reply.” Journal of the American Medical Association 262, no. 20 (1989): 2834-. https://doi.org/10.1001/jama.262.20.2834.Full Text
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Lyles, K. W., D. L. Halsey, N. E. Friedman, and B. Lobaugh. “Correlations of serum concentrations of 1,25-dihydroxyvitamin D, phosphorus, and parathyroid hormone in tumoral calcinosis.” J Clin Endocrinol Metab 67, no. 1 (July 1988): 88–92. https://doi.org/10.1210/jcem-67-1-88.Full Text Link to Item
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Kochersberger, G., N. J. Buckley, G. S. Leight, S. Martinez, S. Studenski, J. Vogler, and K. W. Lyles. “What is the clinical significance of bone loss in primary hyperparathyroidism?” Arch Intern Med 147, no. 11 (November 1987): 1951–53.Link to Item
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Kochersberger, G. G., and K. W. Lyles. “Skeletal disorders in malignant disease.” Clin Geriatr Med 3, no. 3 (August 1987): 561–74.Link to Item
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Kochersberger, G. G., and K. W. Lyles. “Osteoporosis followed by primary hyperparathyroidism. A reason for continued vigilance.” J Am Geriatr Soc 35, no. 1 (January 1987): 61–65. https://doi.org/10.1111/j.1532-5415.1987.tb01320.x.Full Text Link to Item
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Stead, N. W., and K. W. Lyles. “Adding interest and excitement to geriatric clinical rotations.” N C Med J 47, no. 10 (October 1986): 491–93.Link to Item
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Polisson, R. P., S. Martinez, M. Khoury, R. M. Harrell, K. W. Lyles, N. Friedman, J. M. Harrelson, E. Reisner, and M. K. Drezner. “Calcification of entheses associated with X-linked hypophosphatemic osteomalacia.” N Engl J Med 313, no. 1 (July 4, 1985): 1–6. https://doi.org/10.1056/NEJM198507043130101.Full Text Link to Item
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Harrell, R. M., K. W. Lyles, J. M. Harrelson, N. E. Friedman, and M. K. Drezner. “Healing of bone disease in X-linked hypophosphatemic rickets/osteomalacia. Induction and maintenance with phosphorus and calcitriol.” J Clin Invest 75, no. 6 (June 1985): 1858–68. https://doi.org/10.1172/JCI111900.Full Text Link to Item
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Lyles, K. W., E. J. Burkes, G. J. Ellis, K. J. Lucas, E. A. Dolan, and M. K. Drezner. “Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity.” J Clin Endocrinol Metab 60, no. 6 (June 1985): 1093–96. https://doi.org/10.1210/jcem-60-6-1093.Full Text Link to Item
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Lyles, K. W., E. J. Burkes, C. R. McNamara, J. M. Harrelson, J. P. Pickett, and M. K. Drezner. “The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets.” J Clin Endocrinol Metab 60, no. 4 (April 1985): 711–17. https://doi.org/10.1210/jcem-60-4-711.Full Text Link to Item
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Graham, S. D., S. H. Poulton, B. H. Woodard, K. W. Lyles, D. F. Paulson, and J. Linder. “Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse.” The Prostate 7, no. 4 (January 1, 1985): 369–76. https://doi.org/10.1002/pros.2990070405.Full Text
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Lyles, K. W., and M. K. Drezner. “Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity.” J Clin Endocrinol Metab 54, no. 3 (March 1982): 638–44. https://doi.org/10.1210/jcem-54-3-638.Full Text Link to Item
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Lyles, K. W., A. G. Clark, and M. K. Drezner. “Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia.” Calcif Tissue Int 34, no. 2 (March 1982): 125–30. https://doi.org/10.1007/BF02411222.Full Text Link to Item
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Lyles, K. W., J. M. Harrelson, and M. K. Drezner. “The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia.” J Clin Endocrinol Metab 54, no. 2 (February 1982): 307–15. https://doi.org/10.1210/jcem-54-2-307.Full Text Link to Item
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Sutton, G. P., K. W. Lyles, and R. H. Wiebe. “Steroid secretion and testosterone binding in a woman with an ovarian hilus cell tumor and thyrotoxicosis.” Am J Obstet Gynecol 141, no. 5 (November 1, 1981): 535–38. https://doi.org/10.1016/s0002-9378(15)33274-9.Full Text Link to Item
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Lyles, K. W., and M. K. Drezner. “An overview of calcium homeostasis in humans.” Urol Clin North Am 8, no. 2 (June 1981): 209–26.Link to Item
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Drezner, M. K., K. W. Lyles, M. R. Haussler, and J. M. Harrelson. “Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia.” J Clin Invest 66, no. 5 (November 1980): 1020–32. https://doi.org/10.1172/JCI109930.Full Text Link to Item
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Lyles, K. W., W. R. Berry, M. Haussler, J. M. Harrelson, and M. K. Drezner. “Hypophosphatemic osteomalacia: association with prostatic carcinoma.” Ann Intern Med 93, no. 2 (August 1980): 275–78. https://doi.org/10.7326/0003-4819-93-2-275.Full Text Link to Item
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Drezner, M. K., M. R. Haussler, K. W. Lyles, and J. M. Harrelson. “The role of 1,25-dihydroxycholecalciferol (DHCC) in the pathogenesis and treatment of X-linked hypophosphatemic rickets (XLH).” Clinical Research 27, no. 2 (January 1, 1979).
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Conference Papers
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Sagalla, Nicole, Richard Lee, Richard Sloane, Kenneth Lyles, and Cathleen Colón-Emeric. “Factors Associated With Adherence to Osteoporosis Medications Among Male Veterans.” In Jbmr Plus, 5:e10498, 2021. https://doi.org/10.1002/jbm4.10498.Full Text Link to Item
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Sagalla, Nicole, Richard Lee, Kenneth Lyles, Julie Vognsen, and Cathleen Colón-Emeric. “Extent of and reasons for osteoporosis medication non-adherence among veterans and feasibility of a pilot text message reminder intervention.” In Arch Osteoporos, 16:21, 2021. https://doi.org/10.1007/s11657-021-00889-7.Full Text Link to Item
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