Scholars@Duke
Kenneth Ward Lyles

Kenneth Ward Lyles

Professor of Medicine
Medicine, Geriatrics and Palliative Care
kenneth.lyles@duke.edu
Duke Box 3881, Durham, NC 27710
Orange Zone , Ground Ffloor, Room 0360, Durham, NC 27710

Selected Publications

Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients.

Journal Article Osteoporos Int · January 2024 UNLABELLED: COVID-19 infection has resulted in significant morbidity and mortality globally, especially among older adults. Repurposed drugs have demonstrated activity in respiratory illnesses, including nitrogen-containing bisphosphonates. In this retrosp ... Full text Link to item Cite

Surgical appropriateness nudges: Developing behavioral science nudges to integrate appropriateness criteria into the decision making of spine surgeons.

Journal Article PLoS One · 2024 BACKGROUND: Substantial variation exists in surgeon decision making. In response, multiple specialty societies have established criteria for the appropriate use of spine surgery. Yet few strategies exist to facilitate routine use of appropriateness criteri ... Full text Link to item Cite

Your mother was right… You should stand up straight.

Journal Article J Am Geriatr Soc · February 2023 Full text Link to item Cite

Protocol for the models of primary osteoporosis screening in men (MOPS) cluster randomized trial.

Journal Article Contemp Clin Trials · January 2022 Current guidelines recommend primary osteoporosis screening for at-risk men to reduce the morbidity, mortality, and cost associated with osteoporotic fractures. However, analyses in a national Veterans Health Administration cohort of over 4,000,000 men dem ... Full text Link to item Cite

Is silence golden… In this context, not so much.

Journal Article J Am Geriatr Soc · November 2021 Full text Link to item Cite

Factors Associated With Adherence to Osteoporosis Medications Among Male Veterans.

Conference JBMR Plus · August 2021 Risk factors for nonadherence to osteoporosis medication have been well described for cohorts of women with osteoporosis, but little is known about predictors or mediators of nonadherence in men. We conducted a secondary analysis of a national cohort of ma ... Full text Link to item Cite

Zoledronic acid reduces the rate of clinical fractures after surgical repair of a hip fracture regardless of the Pretreatment bone mineral density.

Journal Article Osteoporos Int · June 2021 UNLABELLED: In patients with surgical repair of a low-trauma hip fracture, zoledronic acid (ZA) reduced the risk of subsequent fractures regardless of pretreatment femoral neck and total hip bone mineral density (BMD). INTRODUCTION: Zoledronic acid reduces ... Full text Link to item Cite

FRAX without BMD can be used to risk-stratify Veterans who recently sustained a low trauma non-vertebral/non-hip fracture.

Journal Article Osteoporos Int · March 2021 UNLABELLED: We evaluated the fracture risk assessment tool (FRAX) without bone mineral density (BMD) in predicting treatment recommendations for patients with a recent low trauma fracture other than hip or vertebral. The concordance, sensitivity, and speci ... Full text Link to item Cite

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.

Journal Article NPJ Parkinsons Dis · March 1, 2021 The Trial of Parkinson's And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414 ) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral trea ... Full text Link to item Cite

Extent of and reasons for osteoporosis medication non-adherence among veterans and feasibility of a pilot text message reminder intervention.

Conference Arch Osteoporos · February 2, 2021 UNLABELLED: We determined the extent of and reasons for non-adherence to oral bisphosphonates among veterans and conducted a pilot text message reminder application aimed at the most commonly cited reason for non-adherence. The intervention was found to be ... Full text Link to item Cite

Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.

Journal Article J Nutr Gerontol Geriatr · 2021 In contrast to recommendations for young and middle-aged adults, intentional weight loss among older adults remains controversial and is inconsistently advised. Recent research suggests that a higher protein diet can mitigate loss of lean mass during perio ... Full text Link to item Cite

Bone Loss

Chapter · January 1, 2021 Breast cancer survivors are at increased risk for bone loss and fragility fractures due to a combination of disease, treatment, and age-related factors. A thorough clinical evaluation including history, physical examination, and laboratory and imaging stud ... Full text Cite

Bisphosphonates and lifespan.

Journal Article Bone · December 2020 Bisphosphonates are first line agents used to treat osteoporosis and reduce fracture rate. They bind to areas of exposed calcium in the skeleton and cause osteoclast apoptosis, thereby leading to a reduction in remodelling rates. They are also used to decr ... Full text Link to item Cite

Zoledronate.

Journal Article Bone · August 2020 Zoledronate is the most potent and most long-acting bisphosphonate in clinical use, and is administered as an intravenous infusion. Its major uses are in osteoporosis, Paget's disease, and in myeloma and cancers to reduce adverse skeletal related events (S ... Full text Link to item Cite

Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia.

Journal Article J Bone Miner Res · March 2020 Acetylcholinesterase inhibitors (AChEIs) have been noted to increase bone density and quality in mice. Human studies are limited but suggest an association with improved bone healing after hip fracture. We examined the relationship between AChEI use and fr ... Full text Link to item Cite

Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.

Journal Article J Bone Miner Res · November 2019 Diabetes mellitus among older men has been associated with increased bone mineral density but paradoxically increased fracture risk. Given the interactions among medication treatment, glycemic control, and diabetes-associated comorbidities, the relative ef ... Full text Link to item Cite

Limited Osteoporosis Screening Effectiveness Due to Low Treatment Rates in a National Sample of Older Men.

Journal Article Mayo Clin Proc · December 2018 OBJECTIVE: To determine the association between dual-energy x-ray absorptiometry (DXA) testing for osteoporosis and subsequent fractures in US male veterans without a previous fracture. PATIENTS AND METHODS: This is a propensity score-matched observational ... Full text Link to item Cite

Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.

Journal Article J Clin Endocrinol Metab · January 1, 2018 INTRODUCTION: Type 2 diabetes mellitus among older women has been associated with increased bone mineral density, but paradoxically with increased fracture risk. Findings among older men have varied, and potential mechanisms have not been fully elucidated. ... Full text Link to item Cite

Have We Learned How to Use Bisphosphonates Yet?

Journal Article J Am Geriatr Soc · September 2017 Full text Link to item Cite

Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders.

Journal Article Osteoporos Int · March 2017 UNLABELLED: Low T-scores at the hip predict incident fractures in persons with a SCI. INTRODUCTION: Persons with a spinal cord injury (SCI) have substantial morbidity and mortality following osteoporotic fractures. The objective of this study was to determ ... Full text Link to item Cite

Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders.

Journal Article Osteoporos Int · October 2016 UNLABELLED: Clinical risk factors for fracture were explored among Veterans with a spinal cord injury. At the end of 11 years of follow-up, the absolute risk of fracture was approximately 20 %. Among the clinical and SCI-related factors explored, a prior h ... Full text Link to item Cite

Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture.

Journal Article Rural Remote Health · 2016 INTRODUCTON: Low-trauma, osteoporotic fractures among older men are associated with a significant increase in morbidity and mortality. Despite effective therapies for osteoporosis, several studies have demonstrated that management and treatment after a low ... Link to item Cite

Correlation of hip fracture with other fracture types: Toward a rational composite hip fracture endpoint.

Journal Article Bone · December 2015 PURPOSE: With ethical requirements to the enrollment of lower risk subjects, osteoporosis trials are underpowered to detect reduction in hip fractures. Different skeletal sites have different levels of fracture risk and response to treatment. We sought to ... Full text Link to item Cite

Response to letter by Ralston et al.

Journal Article J Clin Endocrinol Metab · June 2015 Full text Link to item Cite

Response to letter.

Journal Article J Clin Endocrinol Metab · May 2015 Full text Link to item Cite

Response to the letter by Asik M., et al.

Journal Article J Clin Endocrinol Metab · April 2015 Full text Link to item Cite

Fractures and mortality in relation to different osteoporosis treatments

Journal Article Clinical and Experimental Rheumatology · January 1, 2015 Objective: Few studies have assessed the effectiveness of different drugs for osteoporosis (OP). We aimed to determine if fracture and mortality rates vary among patients initiating different OP medications. Methods: We used the Medicare 5% sample to ident ... Cite

Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · December 2014 Minimizing post-fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic inte ... Full text Link to item Cite

Paget's disease of bone: an endocrine society clinical practice guideline.

Journal Article J Clin Endocrinol Metab · December 2014 OBJECTIVE: The aim of this guideline was to formulate practice guidelines for the diagnosis and treatment of Paget's disease of the bone. PARTICIPANTS: The guideline was developed by an Endocrine Society-appointed Task Force of experts, a methodologist, an ... Full text Link to item Cite

Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.

Journal Article Retina · September 2014 PURPOSE: To compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients. METHODS: Medical records of all patients d ... Full text Link to item Cite

Osteoporosis screening and treatment among veterans with recent fracture after implementation of an electronic consult service.

Journal Article Calcif Tissue Int · June 2014 Fewer than 24% of Veterans received appropriate evaluation and/or treatment for osteoporosis within 6 months of an index fracture. An electronic consult (E-consult) service was implemented at three Veterans Affairs Medical Centers to facilitate the identif ... Full text Link to item Cite

Possible way to reduce fracture rates in patients with traumatic spinal cord injury?

Journal Article Arch Phys Med Rehabil · June 2014 Lower extremity fractures in men with spinal cord injury (SCI) are a major problem. The use of thiazide diuretics, a simple and safe intervention, may be effective in reducing the risk of fracture in patients with traumatic SCI. Furthermore, thiazide diure ... Full text Link to item Cite

Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial.

Journal Article Osteoporos Int · January 2014 UNLABELLED: Patients with cognitive impairment (CI) often do not receive secondary fracture prevention. Use of zoledronic acid led to a similar reduction in re-fracture risk but the survival benefit was limited to those without CI. INTRODUCTION: We tested ... Full text Link to item Cite

An advanced course in long term care for geriatric medicine fellows.

Journal Article J Am Med Dir Assoc · July 2013 Long term care deserves focused attention within a geriatric medicine fellowship curriculum to ensure that graduates are prepared not only for clinical care but also for the leadership, administrative, educational, quality improvement, and health policy as ... Full text Link to item Cite

Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis.

Journal Article J Bone Miner Res · May 2013 Bisphosphonates have been shown to reduce mortality in patients with osteoporotic fractures, but the mechanism is unclear. Bisphosphonates have immunomodulatory effects that may influence the development of vascular disease. We sought to determine if bisph ... Full text Link to item Cite

Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams.

Journal Article J Clin Endocrinol Metab · February 2013 CONTEXT: Annual infusions of zoledronic acid 5 mg over 3 years have been shown to reduce fracture incidence. There is now evidence that the effects of a single dose of zoledronic acid on bone mineral density and bone turnover last for much more than a year ... Full text Link to item Cite

Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis.

Journal Article J Bone Miner Res · July 2012 Oral bisphosphonates reduce fracture risk in osteoporotic patients but are often associated with poor compliance, which may impair their antifracture effects. This post hoc analysis assessed the time to onset and persistence of the antifracture effect of z ... Full text Link to item Cite

How much vitamin D should I take?

Journal Article J Clin Invest · May 2012 Clinical vignette: A 68-year-old woman consults you after a recent bone mineral density screening revealed osteopenia, total hip T score of –1.8. Further evaluation shows her only other abnormal lab value is a serum 25-hydroxyvitamin D [25(OH)D] level of 1 ... Full text Link to item Cite

Subtrochanteric fractures in bisphosphonate-naive patients: results from the HORIZON-recurrent fracture trial.

Journal Article Calcif Tissue Int · December 2011 Our purpose was to characterize the risks of osteoporosis-related subtrochanteric fractures in bisphosphonate-naive individuals. Baseline characteristics of patients enrolled in the HORIZON-Recurrent Fracture Trial with a study-qualifying hip fracture were ... Full text Link to item Cite

Once-yearly zoledronic acid in older men compared with women with recent hip fracture.

Journal Article J Am Geriatr Soc · November 2011 OBJECTIVES: To assess the efficacy of once-yearly zoledronic acid (ZOL) 5 mg in increasing bone mineral density (BMD) in men with a recent hip fracture participating in the Health Outcomes and Reduced Incidence with Zoledronic Acid Once- Yearly Recurrent F ... Full text Link to item Cite

Zoledronic acid results in better health-related quality of life following hip fracture: the HORIZON-Recurrent Fracture Trial.

Journal Article Osteoporos Int · September 2011 UNLABELLED: This study evaluated the benefits of ZOL versus placebo on health-related quality of life (HRQoL) among patients from HORIZON-RFT. At month 24 and end of the study visit, ZOL significantly improved patients' overall health state compared to pla ... Full text Link to item Cite

A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years.

Journal Article J Bone Miner Res · September 2011 Two trials have shown that a single 5-mg infusion of zoledronic acid achieves much higher response rates in Paget disease of bone than risedronate. The duration of this effect is unknown. We have conducted an open follow-up of responders from the two trial ... Full text Link to item Cite

Association between timing of zoledronic acid infusion and hip fracture healing.

Journal Article Osteoporos Int · August 2011 UNLABELLED: Patients in the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly (HORIZON) Recurrent Fracture Trial were assessed for evidence of delayed hip fracture healing. No association was observed between zoledronic acid (ZOL) and ... Full text Link to item Cite

Clinical risk factors for recurrent fracture after hip fracture: a prospective study.

Journal Article Calcif Tissue Int · May 2011 Additional fractures after hip fracture are common, but little is known about the risk factors associated with these events. We determined the clinical risk factors associated with fracture following a low-trauma hip fracture and whether clinical risk fact ... Full text Link to item Cite

The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program.

Journal Article J Am Dent Assoc · November 2010 BACKGROUND: The Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly-Pivotal Fracture Trial found one case of osteonecrosis of the jaw (ONJ) in a patient with postmenopausal osteoporosis (OP) treated with 5 milligrams of zoledronic acid ( ... Full text Link to item Cite

Qualitative analysis of the interdisciplinary interaction between data analysis specialists and novice clinical researchers.

Journal Article PLoS One · February 24, 2010 BACKGROUND: The inherent complexity of statistical methods and clinical phenomena compel researchers with diverse domains of expertise to work in interdisciplinary teams, where none of them have a complete knowledge in their counterpart's field. As a resul ... Full text Open Access Link to item Cite

A review of the effect of anticonvulsant medications on bone mineral density and fracture risk.

Journal Article Am J Geriatr Pharmacother · February 2010 BACKGROUND: Osteoporosis and seizure disorders are common diagnoses in older adults and often occur concomitantly. OBJECTIVE: The goal of this review was to discuss the current hypothesis for the pathogenesis of anticonvulsant-induced bone density loss and ... Full text Link to item Cite

Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older.

Journal Article J Am Geriatr Soc · February 2010 OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc subgroup analysis ... Full text Link to item Cite

Potential mediators of the mortality reduction with zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · January 2010 Zoledronic acid reduces the risk of death by 28% after hip fracture, but the mechanisms are not known. This exploratory analysis sought to identify potential pathways for the reduction in mortality with zoledronic acid after hip fracture. This was a retros ... Full text Link to item Cite

Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · July 2009 Annual infusions of zoledronic acid (5 mg) significantly reduced the risk of vertebral, hip, and nonvertebral fractures in a study of postmenopausal women with osteoporosis and significantly reduced clinical fractures and all-cause mortality in another stu ... Full text Link to item Cite

Effects of an oral growth hormone secretagogue in older adults.

Journal Article J Clin Endocrinol Metab · April 2009 CONTEXT: GH secretion declines with age, possibly contributing to reduced muscle mass, strength, and function. GH secretagogues (GHS) may increase muscle mass and physical performance. OBJECTIVES/DESIGN: We conducted a randomized, double-masked, placebo-co ... Full text Link to item Cite

Management of osteoporosis among home health and long-term care patients with a prior fracture.

Journal Article South Med J · April 2009 Osteoporosis is a growing health concern as the number of senior adults continues to increase worldwide. Falls and fractures are very common among frail older adults requiring home health and long-term care. Preventative strategies for reducing falls have ... Full text Link to item Cite

Improving the prediction of medication compliance: the example of bisphosphonates for osteoporosis.

Journal Article Med Care · March 2009 INTRODUCTION: Administrative claims data have a limited ability to identify persons with high compliance to oral bisphosphonates. We tested whether adding information on compliance with other drugs used to treat chronic, asymptomatic conditions would impro ... Full text Link to item Cite

Depressive symptomatology and fracture risk in community-dwelling older men and women.

Journal Article Aging Clin Exp Res · December 2008 BACKGROUND AND AIMS: Previous studies suggest that depression increases risk of falls, low bone mineral density, and fractures. Our aim was to evaluate whether depressive symptomatology alone predicts 5- year clinical fracture risk in older adults. METHODS ... Full text Link to item Cite

Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users.

Journal Article J Bone Miner Res · September 2008 The relationship between high adherence to oral bisphosphonates and the risk of different types of fractures has not been well studied among adults of different ages. Using claims data from a large U.S. health care organization, we quantified adherence aft ... Full text Link to item Cite

Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents.

Journal Article Osteoporos Int · August 2008 UNLABELLED: Nursing home residents with a history of hip fractures or prior osteoporotic fractures were found to have an increased risk of another osteoporotic fracture over the ensuing two years when compared to nursing home residents with no fracture his ... Full text Link to item Cite

Zoledronate, fractures, and mortality after hip fracture [4]

Journal Article New England Journal of Medicine · February 28, 2008 Cite

Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury.

Journal Article Arch Phys Med Rehabil · February 2008 OBJECTIVE: To measure skeletal fractures in a cohort of veterans with spinal cord dysfunction (SCD) due to multiple sclerosis (MS) or trauma-related spinal cord injury (SCI). DESIGN: Retrospective cohort analysis. SETTING: Database search. PARTICIPANTS: St ... Full text Link to item Cite

Zoledronate, fractures, and mortality after hip fracture [4]

Journal Article New England Journal of Medicine · 2008 Full text Cite

Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture.

Journal Article Am J Geriatr Pharmacother · December 2007 BACKGROUND: Vitamin D deficiency is common in older populations, particularly during the winter months due to low levels of ultraviolet light exposure, and in nursing home residents. OBJECTIVE: The main objective of the current study was to assess the dist ... Full text Link to item Cite

Randomized trial to improve fracture prevention in nursing home residents.

Journal Article Am J Med · October 2007 BACKGROUND: Interventions to improve the fracture prevention in nursing homes are needed. METHODS: Cluster-randomized, single-blind, controlled trial of a multi-modal quality improvement intervention. Nursing homes (n=67) with > or =10 residents with a dia ... Full text Link to item Cite

Bisphosphonates in Paget's disease of bone

Journal Article Clinical Reviews in Bone and Mineral Metabolism · September 1, 2007 Paget's disease of bone is a chronic focal bone remodeling disorder with distinctive geographic occurnece. In the US, 1.8% of people over 60 years of age are affected. At present, 70% of patients are asymptomatic with the most common presenting symptoms be ... Full text Cite

Direct-to-consumer advertising of pharmaceuticals.

Journal Article Am J Med · June 2007 Since the US Food and Drug Administration (FDA) released new guidelines on broadcast direct-to-consumer advertising in 1997, the prevalence of direct-to-consumer advertising of prescription drugs has increased exponentially. The impact on providers, patien ... Full text Link to item Cite

Prevalence and predictors of osteoporosis treatment in nursing home residents with known osteoporosis or recent fracture.

Journal Article Osteoporos Int · April 2007 SUMMARY: We studied nursing home residents with osteoporosis or recent fracture to determine the frequency and predictors of osteoporosis treatment. There was wide variation in performance, and both clinical and systems variables predicted use. This study ... Full text Link to item Cite

Clinical diagnostic reasoning.

Journal Article N Engl J Med · March 22, 2007 Link to item Cite

Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture.

Journal Article N Engl J Med · 2007 BACKGROUND: Mortality is increased after a hip fracture, and strategies that improve outcomes are needed. METHODS: In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic acid (at a d ... Full text Link to item Cite

Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate.

Journal Article J Bone Miner Res · January 2007 UNLABELLED: A single 5-mg infusion of zoledronic acid restores biochemical markers of bone turnover into the reference range in the majority of patients with Paget's disease and maintains biochemical remission for at least 2 years. This effect is largely i ... Full text Link to item Cite

Medical management of Paget's disease of bone: indications for treatment and review of current therapies.

Journal Article J Bone Miner Res · December 2006 Treatment with a potent bisphosphonate is indicated in patients with Paget's disease who have symptoms likely to respond to reduced bone turnover at pagetic sites. In asymptomatic patients with active disease at sites susceptible to local progression and l ... Full text Link to item Cite

Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone.

Journal Article Bone · October 2006 Bisphosphonate therapy is a common and effective treatment for Paget's disease of bone, osteoporosis, hypercalcemia of malignancy and cancer metastatic to bone. Clinically significant hypocalcemia has not been reported in patients with Paget's disease of b ... Full text Link to item Cite

Using a modified nominal group technique to elicit director of nursing input for an osteoporosis intervention.

Journal Article J Am Med Dir Assoc · September 2006 BACKGROUND: Barriers prevent osteoporosis care in nursing homes. Successful interventions designed to circumvent these barriers benefit from target recipient input during development. OBJECTIVE: To elicit suggestions for an osteoporosis quality improvement ... Full text Link to item Cite

Osteoporosis in later life

Journal Article Generations · September 1, 2006 Cite

Adding injury to insult: fracture risk after stroke in veterans.

Journal Article J Am Geriatr Soc · July 2006 OBJECTIVES: To determine fracture risk in U.S. stroke patients and identify patient characteristics that predict highest fracture risk in two complementary cohorts. DESIGN: Secondary analyses of two prospective cohorts. SETTING: Veterans Affairs (VA) Medic ... Full text Link to item Cite

Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease.

Journal Article N Engl J Med · September 1, 2005 BACKGROUND: The advent of bisphosphonates advanced therapy for Paget's disease, but more effective and convenient agents are needed to increase adherence. Zoledronic acid, a bisphosphonate administered as a single intravenous infusion, might meet these nee ... Full text Link to item Cite

A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessive.

Journal Article J Clin Endocrinol Metab · April 2005 Familial tumoral calcinosis is a rare metabolic disorder, characterized by ectopic calcification and hyperphosphatemia. Recently biallelic mutations in the GalNAc transferase 3 (GALNT3) gene were identified in two families with tumoral calcinosis. In the p ... Full text Link to item Cite

Barriers to providing osteoporosis care in skilled nursing facilities: Perceptions of medical directors and directors of nursing

Journal Article Journal of the American Medical Directors Association · January 1, 2005 Objectives: The objectives of this study were to identify the barriers to osteoporosis clinical practice guideline use perceived by Medical Directors (MED DIR) and Directors of Nursing (DON) in skilled nursing facilities; and to describe differences in the ... Full text Cite

Does this woman have osteoporosis?

Journal Article JAMA · December 15, 2004 CONTEXT: Although recent US Preventive Services Task Force guidelines recommend bone densitometry for all women older than 65 years, identifying younger women at increased risk for osteoporosis and women with occult vertebral fractures remains a clinical c ... Full text Link to item Cite

Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial.

Journal Article J Am Geriatr Soc · September 2004 OBJECTIVES: To assess whether group exercise and coping classes reduce physical and psychological impairments and functional disability in older women with prevalent vertebral fractures (VFs). DESIGN: Randomized, controlled trial (modified cross-over) with ... Full text Link to item Cite

The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair.

Journal Article Curr Med Res Opin · June 2004 OBJECTIVE: To present the novel design of a trial testing the safety and efficacy of a yearly bisphosponate, zoledronic acid, in preventing new clinical fractures in patients with recent low trauma hip fracture repair. RESEARCH DESIGN AND METHODS: Randomiz ... Full text Link to item Cite

Barriers to providing osteoporosis care in skilled nursing facilities: perceptions of medical directors and directors of nursing.

Journal Article J Am Med Dir Assoc · 2004 OBJECTIVES: The objectives of this study were to identify the barriers to osteoporosis clinical practice guideline use perceived by Medical Directors (MED DIR) and Directors of Nursing (DON) in skilled nursing facilities; and to describe differences in the ... Full text Link to item Cite

The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies.

Journal Article Osteoporos Int · November 2003 BACKGROUND: The contribution of hip fracture to the risk of subsequent fractures is unclear. METHODS: Data from the Baltimore Hip Studies and the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were used. Baltimore subjects enrolle ... Full text Link to item Cite

What is "resistance" in Paget's disease of bone?

Journal Article Arthritis Rheum · August 2003 Full text Link to item Cite

Risk factors for hip fracture in skilled nursing facilities: who should be evaluated?

Journal Article Osteoporos Int · July 2003 This paper aims to identify risk factors for hip fracture in Medicare skilled nursing facility (SNF) residents and to develop a predictive model based on routinely collected administrative data (the Minimum Data Set, MDS) to identify high-risk residents. P ... Full text Link to item Cite

Osteoporosis considerations in the frail elderly.

Journal Article Curr Opin Rheumatol · July 2003 Osteoporosis is a growing public health problem throughout the world, in part because of the increasing numbers of people living beyond the age of 65 years. Skeletal fractures are the clinical manifestation of the disease, with older patients the most seve ... Full text Link to item Cite

A controlled trial of inpatient and outpatient geriatric evaluation and management.

Journal Article N Engl J Med · March 21, 2002 BACKGROUND: Over the past 20 years, both inpatient units and outpatient clinics have developed programs for geriatric evaluation and management. However, the effects of these interventions on survival and functional status remain uncertain. METHODS: We con ... Full text Link to item Cite

Incidence and natural history of Paget's disease of bone in England and Wales.

Journal Article J Bone Miner Res · March 2002 This study used a large, primary care, record-linkage resource (the General Practice Research Database [GPRD]) to evaluate the incidence, clinical presentation, and natural history of Paget's disease of bone in England and Wales. Between 1988 and 1999, we ... Full text Link to item Cite

Guidelines for the diagnosis and therapy of the Paget's disease of the bone

Journal Article Revista Espanola de Enfermedades Metabolicas Oseas · January 1, 2001 Cite

Expert physician recommendations and current practice patterns for evaluating and treating men with osteoporotic hip fracture.

Journal Article J Am Geriatr Soc · October 2000 OBJECTIVES: To develop recommendations for the evaluation and the treatment of men with osteoporotic hip fracture from expert publications in the field of male osteoporosis, and to define the current practice patterns in a tertiary care VA Medical Center i ... Full text Link to item Cite

Ask the expert Question and Answer

Journal Article Annals of Long-Term Care · September 11, 2000 Cite

Heterogeneity in Paget disease of the bone.

Journal Article Am J Med Genet · June 19, 2000 Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget dis ... Full text Link to item Cite

Timed loaded standing: a measure of combined trunk and arm endurance suitable for people with vertebral osteoporosis.

Journal Article Osteoporos Int · 2000 Chronic back tiredness or fatigue is a common complaint of people who have a history of osteoporotic vertebral fracture. Trunk muscle endurance has not been studied in people with vertebral osteoporosis, partly due to the lack of assessment tools. We devel ... Full text Link to item Cite

Factors associated with self-rated health in patients with Paget's disease of bone.

Journal Article J Bone Miner Res · October 1999 Multiple studies show that poor self-rated health (SRH) increases the risk of mortality up to 5-fold when compared to excellent SRH. This powerful association remains even with objective health status and risk factors controlled. However, few studies have ... Full text Link to item Cite

Spinal deformity and mobility self-confidence among women with osteoporosis and vertebral fractures.

Journal Article Aging (Milano) · August 1999 This study evaluated the direct and indirect effects of spinal deformity on confidence in mobility among 185 older women with osteoporosis and vertebral fractures. We administered multidimensional tests of physical and psychosocial impairment and function ... Full text Link to item Cite

Caring for the patient with paget’s disease of the bone

Journal Article Nurse Practitioner · January 1, 1999 Approximately 1 to 3 million Americans suffer from Paget’s disease of thebone. This chronic disease often results In pa!ny deformity, and mobility impairments, and can dramatically impair a patient's quality of life. The primary care provider plays a pivot ... Full text Cite

Management of patients with vertebral compression fractures.

Journal Article Pharmacotherapy · January 1999 Osteoporosis is a disease of low bone mass that may not manifest until a patient has a fracture. Hip fracture is the most devastating, but vertebral fracture is the most common, occurring in 25% of women over 50 years of age and 40% of those age 80-85 year ... Full text Link to item Cite

Managing patients with complications of osteoporosis.

Journal Article Endocrinol Metab Clin North Am · June 1998 This article reviews the impact of osteoporosis on quality of life. It defines specific impairments and suggests how best to minimize the impact of osteoporosis on patients' daily lives. Specific issues such as a spinal deformity, limitations on activities ... Full text Link to item Cite

Dementia associated with hyperphosphatemic tumoral calcinosis.

Journal Article Clin Neurol Neurosurg · June 1998 Hyperphosphatemic tumoral calcinosis (HTC) is a rare inherited metabolic disorder manifested by pararticular calcification and hyperphosphatemia, caused by an elevated renal phosphate reabsorption threshold and elevated serum 1,25-dihydroxyvitamin D levels ... Full text Link to item Cite

Peyronie's disease is associated with Paget's disease of bone.

Journal Article J Bone Miner Res · June 1997 Peyronie's disease is an idiopathic disorder in which an inflammatory fibrosis occurs in the tunica albuginea of the corpora cavernosa which causes the erect penis to become deformed. Peyronie's disease has a prevalence of 1% in men over age 50 years. Page ... Full text Link to item Cite

Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone.

Journal Article Calcif Tissue Int · May 1997 Zoledronate (CGP 42446) is a third generation imidazole ring containing bisphosphonate that has been found in animal studies to be up to 850 times more potent than pamidronate. In this first study reporting the effects of this drug in humans, 16 patients w ... Full text Link to item Cite

Paget's disease of bone and quality of life.

Journal Article J Bone Miner Res · December 1996 Little is known about how Paget's disease of bone affects quality of life. To better understand the relative impact of factors on quality of life, we mailed a brief survey to 2000 people randomly selected from the Paget's Foundation mailing list. The sampl ... Full text Link to item Cite

Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone.

Journal Article J Clin Endocrinol Metab · March 1996 Alendronate, an aminobisphosphonate, is much more potent than etidronate, an older bisphosphonate, in inhibiting osteoclast-mediated bone resorption, and unlike etidronate, therapeutic doses of alendronate are not associated with abnormal mineralization. I ... Full text Link to item Cite

The duke approach to faculty development in geriatric medicine

Journal Article Educational Gerontology · January 1, 1996 A number of studies have documented that there is an inadequate number of physicians trained in geriatrics in the United States. Over the last 15 years, we have developed a Geriatric Physician Fellowship Program directed at developing academic geriatric ph ... Full text Cite

Functional and mobility impairments associated with Paget's disease of bone.

Journal Article J Am Geriatr Soc · May 1995 OBJECTIVE: To determine if patients with Paget's disease of bone involving the tibia, femur, and/or acetabular portion of the ilium had more impairments in function and mobility than age- and sex-matched control subjects. PATIENTS AND METHODS: A case contr ... Full text Link to item Cite

Drug-induced bone disease.

Journal Article Clin Geriatr Med · November 1994 Drugs can cause accelerated bone loss as well as disturbances in serum calcium levels. This article focuses on chemically induced bone diseases that commonly affect the elderly and result in either osteoporosis, osteomalacia, hypercalcemia or hypocalcemia. ... Link to item Cite

Association of osteoporotic vertebral compression fractures with impaired functional status.

Journal Article Am J Med · June 1993 PURPOSE: To determine if vertebral compression fractures in elderly women were associated with impairments in physical, functional, and psychosocial performance. SUBJECTS AND METHODS: Ten white women with confirmed vertebral compression fractures were age- ... Full text Link to item Cite

Salmon calcitonin reduces vertebral bone loss in glucocorticoid-treated beagles.

Journal Article Am J Physiol · June 1993 Glucocorticoids induce bone loss by increasing bone resorption and decreasing bone formation. In this study we have investigated the potential of salmon calcitonin to attenuate glucocorticoid-induced bone loss in a dog model. Male beagles were divided into ... Full text Link to item Cite

Psychosocial functioning and osteoporosis in late life: Results of a multidisciplinary intervention

Journal Article Journal of Women's Health · January 1, 1993 Objective: To determine whether older women and men with osteoporosis who participated in a medica. evaluation program showed improvement in psychosocial functioning when compared to a age-, gender-, and disease severity-matched group of osteoporotic patie ... Full text Cite

Uremic tumoral calcinosis: preliminary observations suggesting an association with aberrant vitamin D homeostasis.

Journal Article Am J Kidney Dis · December 1991 Periarticular tumoral calcification is a unique form of soft tissue calcification that occurs infrequently in patients with end-stage renal disease. The mechanism underlying such massive periarticular calcifications is unknown. The radiographic similarity ... Full text Link to item Cite

Effects of short-term administration of glucocorticoids on bone metabolism in healthy elderly men.

Journal Article J Am Geriatr Soc · December 1991 OBJECTIVE: To determine the effects of short-term glucocorticoid administration in healthy elderly men on bone GLA protein (BGP) levels, as well as levels of calcium, phosphorus, immunoreactive parathyroid hormone (PTH), and alkaline phosphatase. DESIGN: S ... Full text Link to item Cite

Osteoporosis in late life: does health locus of control affect psychosocial adaptation?

Journal Article J Am Geriatr Soc · July 1991 Osteoporosis, a metabolic bone disease most prevalent in older adults, is a major public health problem. Although management of osteoporosis through diet, exercise, and medication has improved, little is known about the psychosocial consequences of this di ... Full text Link to item Cite

Dental lesions in tumoral calcinosis.

Journal Article J Oral Pathol Med · May 1991 Tumoral calcinosis (TC) is a rare inherited autosomal dominant metabolic disease manifested by elevated serum phosphorus and 1,25 dihydroxyvitamin D levels and periarticular cystic and solid tumorous calcifications. The dental findings in a large family ha ... Full text Link to item Cite

The metabolic effects of calcium supplementation in the elderly.

Journal Article J Am Geriatr Soc · February 1991 Because the value of calcium supplementation in age-related bone loss is controversial, we conducted a study to examine the effects of six months of calcium supplementation on parathyroid hormone (PTH) and other indices of bone metabolism. Calcium carbonat ... Full text Link to item Cite

Calcium supplementation lowers serum parathyroid hormone levels in elderly subjects.

Journal Article J Gerontol · September 1990 To determine the effect of calcium supplementation on parathyroid hormone levels (PTH) in a group of elderly subjects at risk for developing Type II (senile) osteoporosis, 40 healthy volunteers participated in a randomized double-blind crossover study. Cal ... Full text Link to item Cite

Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention.

Journal Article J Gerontol · September 1990 Osteoporosis is a common complication of chronic glucocorticoid therapy, especially in older patients who already are at risk of having a reduced bone mass. Glucocorticoids cause bone loss by altering the bone remodeling sequence: bone resorption by osteoc ... Full text Link to item Cite

Imaging of tumoral calcinosis: new observations.

Journal Article Radiology · January 1990 Five patients with tumoral calcinosis were evaluated with radiography, bone scintigraphy, computed tomography (CT), and magnetic resonance (MR) imaging. The arthropathy of calcium pyrophosphate dihydrate deposition disease was seen in two of the patients a ... Full text Link to item Cite

Geriatrics.

Journal Article JAMA · May 19, 1989 Link to item Cite

Treatment of osteoporosis. The psychological impact of a medical education program on older patients.

Journal Article J Am Geriatr Soc · May 1989 Participants in a therapeutic program for osteoporosis were studied to determine if program participation improved psychological outcomes. The 4-day program included intensive education about the disease and its prognosis, physical therapy education, nutri ... Full text Link to item Cite

Geriatrics: Reply

Journal Article Journal of the American Medical Association · 1989 Full text Cite

Correlations of serum concentrations of 1,25-dihydroxyvitamin D, phosphorus, and parathyroid hormone in tumoral calcinosis.

Journal Article J Clin Endocrinol Metab · July 1988 The inherited metabolic disorder tumoral calcinosis is characterized by elevated serum phosphorus and 1,25-dihydroxyvitamin D [1,25-(OH)2D] levels and paraarticular calcific tumors. The pathogenesis of this disease is obscure, but an elevated renal phospha ... Full text Link to item Cite

What is the clinical significance of bone loss in primary hyperparathyroidism?

Journal Article Arch Intern Med · November 1987 To help determine the clinical significance of the bone loss associated with primary hyperparathyroidism, we studied the prevalence of vertebral fractures in a group of patients with this disorder. From a registry of parathyroidectomies, 206 cases were rev ... Link to item Cite

Skeletal disorders in malignant disease.

Journal Article Clin Geriatr Med · August 1987 When the elderly are afflicted by malignancy, chances are good that at some point in the course of their illness the skeleton will be involved. Bone metastases, hypercalcemia, and other paraneoplastic syndromes are commonly encountered and require definiti ... Link to item Cite

Calcification of entheses associated with X-linked hypophosphatemic osteomalacia.

Journal Article N Engl J Med · July 4, 1985 We undertook a retrospective analysis of 26 patients with X-linked hypophosphatemic osteomalacia (or rickets), whose ages ranged from 1 to 62 years and who were from 11 different kindreds, to determine the prevalence and clinical characteristics of a uniqu ... Full text Link to item Cite

Healing of bone disease in X-linked hypophosphatemic rickets/osteomalacia. Induction and maintenance with phosphorus and calcitriol.

Journal Article J Clin Invest · June 1985 Although conventional therapy (pharmacologic doses of vitamin D and phosphorus supplementation) is usually successful in healing the rachitic bone lesion in patients with X-linked hypophosphatemic rickets, it does not heal the coexistent osteomalacia. Beca ... Full text Link to item Cite

Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity.

Journal Article J Clin Endocrinol Metab · June 1985 Tumoral calcinosis is a rare inherited metabolic disorder characterized by hyperphosphatemia, elevated serum 1,25-dihydroxyvitamin D levels and periarticular cystic and solid calcifications. Based on previous investigations, the inheritance of this disorde ... Full text Link to item Cite

The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets.

Journal Article J Clin Endocrinol Metab · April 1985 Controversy exists over the role that PTH and extracellular fluid calcium concentration may play in modulation of the renal phosphate transport defect in X-linked hypophosphatemic rickets. In previous studies, administration of PTH to affected subjects res ... Full text Link to item Cite

Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse

Journal Article The Prostate · January 1, 1985 There are few established human prostatic adenocarcinoma cell lines in existence. Most established lines are nonfunctional and hormonally insensitive. A human prostate adenocarcinoma (9479) has been serially transplanted for more than 4 years in athymic nu ... Full text Cite

Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia.

Journal Article Calcif Tissue Int · March 1982 In order to determine whether a defect in vitamin D metabolism might play a role in the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia (XLH), we compared the serum 1,25-dihydroxyvitamin D [1,25(OH)2D] level in 52 normal subjects and 37 ... Full text Link to item Cite

Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity.

Journal Article J Clin Endocrinol Metab · March 1982 Patients with X-linked hypophosphatemic rickets (XLH) have normal or marginally low serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] levels despite manifesting hypophosphatemia and phosphate depletion, which increase 1,25-(OH)2D production in many animal specie ... Full text Link to item Cite

An overview of calcium homeostasis in humans.

Journal Article Urol Clin North Am · June 1981 Link to item Cite

Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia.

Journal Article J Clin Invest · November 1980 Although a defect in renal transport of phosphate seems well established as the primary abnormality underlying the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia, several observations indicate that renal phosphate wasting and hypophosph ... Full text Link to item Cite

Hypophosphatemic osteomalacia: association with prostatic carcinoma.

Journal Article Ann Intern Med · August 1980 Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniqu ... Full text Link to item Cite