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Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.

Publication ,  Journal Article
Itty, S; Day, S; Lyles, KW; Stinnett, SS; Vajzovic, LM; Mruthyunjaya, P
Published in: Retina
September 2014

PURPOSE: To compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients. METHODS: Medical records of all patients diagnosed with age-related macular degeneration and tested for serum 25OHD level at a single medical center were reviewed. Control patients were selected from patients diagnosed with pseudophakia but without age-related macular degeneration. The lowest 25OHD level available for each patient was recorded. RESULTS: Two hundred sixteen patients with nonneovascular age-related macular degeneration, 146 with NVAMD, and 100 non-age-related macular degeneration control patients were included. The levels of 25OHD (mean ± SD) were significantly lower in NVAMD patients (26.1 ± 14.4 ng/mL) versus nonneovascular age-related macular degeneration (31.5 ± 18.2 ng/mL, P = 0.003) and control (29.4 ± 10.1 ng/mL, P = 0.049) patients. The prevalence of vitamin D insufficiency (<30 ng/mL 25OHD), deficiency (<20 ng/mL), and severe deficiency (<10 ng/mL) were highest in the NVAMD group. The highest quintile of 25OHD was associated with a 0.35 (95% confidence interval, 0.18-0.68) odds ratio for NVAMD. CONCLUSION: This is the largest study to compare 25OHD levels in patients with the different clinical forms of age-related macular degeneration. Mean 25OHD levels were lower and vitamin D deficiency was more prevalent in NVAMD patients. These associations suggest that further research is necessary regarding vitamin D deficiency as a potentially modifiable risk factor for the development of NVAMD.

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Published In

Retina

DOI

EISSN

1539-2864

Publication Date

September 2014

Volume

34

Issue

9

Start / End Page

1779 / 1786

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Vitamin D Deficiency
  • Vitamin D
  • Tandem Mass Spectrometry
  • Pseudophakia
  • Ophthalmology & Optometry
  • Male
  • Humans
  • Geographic Atrophy
  • Female
 

Citation

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Itty, S., Day, S., Lyles, K. W., Stinnett, S. S., Vajzovic, L. M., & Mruthyunjaya, P. (2014). Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration. Retina, 34(9), 1779–1786. https://doi.org/10.1097/IAE.0000000000000178
Itty, Sujit, Shelley Day, Kenneth W. Lyles, Sandra S. Stinnett, Lejla M. Vajzovic, and Prithvi Mruthyunjaya. “Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.Retina 34, no. 9 (September 2014): 1779–86. https://doi.org/10.1097/IAE.0000000000000178.
Itty S, Day S, Lyles KW, Stinnett SS, Vajzovic LM, Mruthyunjaya P. Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration. Retina. 2014 Sep;34(9):1779–86.
Itty, Sujit, et al. “Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.Retina, vol. 34, no. 9, Sept. 2014, pp. 1779–86. Pubmed, doi:10.1097/IAE.0000000000000178.
Itty S, Day S, Lyles KW, Stinnett SS, Vajzovic LM, Mruthyunjaya P. Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration. Retina. 2014 Sep;34(9):1779–1786.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

September 2014

Volume

34

Issue

9

Start / End Page

1779 / 1786

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Vitamin D Deficiency
  • Vitamin D
  • Tandem Mass Spectrometry
  • Pseudophakia
  • Ophthalmology & Optometry
  • Male
  • Humans
  • Geographic Atrophy
  • Female