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Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention.

Publication ,  Journal Article
Mitchell, DR; Lyles, KW
Published in: J Gerontol
September 1990

Osteoporosis is a common complication of chronic glucocorticoid therapy, especially in older patients who already are at risk of having a reduced bone mass. Glucocorticoids cause bone loss by altering the bone remodeling sequence: bone resorption by osteoclasts is increased, and bone formation by osteoblasts is decreased. Serum levels of osteocalcin, a protein made by osteoblasts, are decreased with glucocorticoid therapy, further evidence of decreased osteoblast function. Glucocorticoids decrease calcium absorption by the gastrointestinal tract and increase renal calcium excretion. Several recent studies suggest that low-dose glucocorticoid therapy is not associated with bone loss. Calcium supplementation with vitamin D is recommended. Several short-term studies have shown prevention of glucocorticoid-induced bone loss with bisphosphonates, calcitonin, and progesterone. Long-term clinical trials should be undertaken to determine strategies to prevent this type of osteoporosis.

Duke Scholars

Published In

J Gerontol

DOI

ISSN

0022-1422

Publication Date

September 1990

Volume

45

Issue

5

Start / End Page

M153 / M158

Location

United States

Related Subject Headings

  • Osteoporosis
  • Humans
  • Glucocorticoids
  • Bone Resorption
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mitchell, D. R., & Lyles, K. W. (1990). Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention. J Gerontol, 45(5), M153–M158. https://doi.org/10.1093/geronj/45.5.m153
Mitchell, D. R., and K. W. Lyles. “Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention.J Gerontol 45, no. 5 (September 1990): M153–58. https://doi.org/10.1093/geronj/45.5.m153.
Mitchell, D. R., and K. W. Lyles. “Glucocorticoid-induced osteoporosis: mechanisms for bone loss; evaluation of strategies for prevention.J Gerontol, vol. 45, no. 5, Sept. 1990, pp. M153–58. Pubmed, doi:10.1093/geronj/45.5.m153.

Published In

J Gerontol

DOI

ISSN

0022-1422

Publication Date

September 1990

Volume

45

Issue

5

Start / End Page

M153 / M158

Location

United States

Related Subject Headings

  • Osteoporosis
  • Humans
  • Glucocorticoids
  • Bone Resorption
  • Aged