Skip to main content

Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial.

Publication ,  Journal Article
Gray, BA; Hagey, JM; Crabtree, D; Wynn, C; Weber, JM; Pieper, CF; Haddad, LB
Published in: Obstet Gynecol
September 2019

OBJECTIVE: To evaluate the effect of oral gabapentin in conjunction with usual oral pain management regimens of lorazepam, ibuprofen, oxycodone, and acetaminophen for surgical abortion on pain 5 minutes postprocedure. METHODS: This was a randomized, double-blind, placebo-controlled trial of patients from 6 0/7-14 6/7 weeks of gestation scheduled to undergo surgical abortion at the Duke Family Planning Clinic. Participants were administered 600 mg of oral gabapentin compared with placebo with usual oral pain management. Pain score was assessed using a 100-mm visual analog scale, with the primary outcome being pain score 5 minutes after the procedure. The effect of gabapentin was assessed using a linear regression model controlling for baseline pain. We also measured pain perception 24 hours after the procedure. Secondary outcome measures included anxiety, side effects, and usage of opiate pain medication in the 24-hour postoperative period. RESULTS: Out of 113 women screened for this study; 96 women were recruited, enrolled, and randomized to study treatment arm from August 2016 to June 2018. Pain at 5 minutes after the procedure was similar between the gabapentin and placebo groups ((Equation is included in full-text article.)=3.40; 95% CI -8.20 to 15.0; P=.56). Gabapentin and placebo were well tolerated, with no statistically significant difference in side effects or anxiety levels. Although prescription of opioids after the procedure was not standardized among patients, 73% of women received a short-term prescription for oxycodone. A lower percentage of women in the gabapentin group self-reported taking opioids in the 24 hours postprocedure (18% vs 47%; odds ratio 0.26; 95% CI 0.09-0.75). CONCLUSION: The addition of gabapentin to usual oral pain management regimens with paracervical block did not reduce postoperative pain for patients undergoing outpatient surgical abortion. Although the addition of gabapentin was well tolerated and reduced oral opiate use 24 hours postprocedure, it did not affect the experience of pain during and immediately after the procedure. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02725710.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2019

Volume

134

Issue

3

Start / End Page

611 / 619

Location

United States

Related Subject Headings

  • Uterus
  • Pregnancy
  • Pain, Postoperative
  • Pain Measurement
  • Pain Management
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gabapentin
  • Female
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gray, B. A., Hagey, J. M., Crabtree, D., Wynn, C., Weber, J. M., Pieper, C. F., & Haddad, L. B. (2019). Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial. Obstet Gynecol, 134(3), 611–619. https://doi.org/10.1097/AOG.0000000000003398
Gray, Beverly A., Jill M. Hagey, Donna Crabtree, Clara Wynn, Jeremy M. Weber, Carl F. Pieper, and Lisa B. Haddad. “Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial.Obstet Gynecol 134, no. 3 (September 2019): 611–19. https://doi.org/10.1097/AOG.0000000000003398.
Gray BA, Hagey JM, Crabtree D, Wynn C, Weber JM, Pieper CF, et al. Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial. Obstet Gynecol. 2019 Sep;134(3):611–9.
Gray, Beverly A., et al. “Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial.Obstet Gynecol, vol. 134, no. 3, Sept. 2019, pp. 611–19. Pubmed, doi:10.1097/AOG.0000000000003398.
Gray BA, Hagey JM, Crabtree D, Wynn C, Weber JM, Pieper CF, Haddad LB. Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial. Obstet Gynecol. 2019 Sep;134(3):611–619.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2019

Volume

134

Issue

3

Start / End Page

611 / 619

Location

United States

Related Subject Headings

  • Uterus
  • Pregnancy
  • Pain, Postoperative
  • Pain Measurement
  • Pain Management
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gabapentin
  • Female
  • Double-Blind Method