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Benzodiazepine receptor declines in hippocampal formation following limbic seizures.

Publication ,  Journal Article
Kraus, VM; Dasheiff, RM; Fanelli, RJ; McNamara, JO
Published in: Brain Res
October 31, 1983

Electrolytic lesions of entorhinal cortex have previously been shown to consistently produce limbic seizures. We report a bilateral and symmetrical decline in benzodiazepine receptor number in dentate gyrus of the hippocampal formation in unilateral entorhinal cortex-lesioned animals. We think this decline is caused by seizures since phenobarbital pretreatment prevented the appearance of limbic seizures and blocked the receptor decline. We postulate that these receptor declines may contribute to decreased endogenous recurrent inhibition (a presumed GABAergic synapse) of dentate granule cells which could lead to their repetitive firing. Thus these benzodiazepine receptor declines may be a consequence of limbic seizures yet increase the likelihood of subsequent seizures.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 31, 1983

Volume

277

Issue

2

Start / End Page

305 / 309

Location

Netherlands

Related Subject Headings

  • Seizures
  • Receptors, GABA-A
  • Receptors, Cell Surface
  • Rats, Inbred Strains
  • Rats
  • Phenobarbital
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Hippocampus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kraus, V. M., Dasheiff, R. M., Fanelli, R. J., & McNamara, J. O. (1983). Benzodiazepine receptor declines in hippocampal formation following limbic seizures. Brain Res, 277(2), 305–309. https://doi.org/10.1016/0006-8993(83)90938-1
Kraus, V. M., R. M. Dasheiff, R. J. Fanelli, and J. O. McNamara. “Benzodiazepine receptor declines in hippocampal formation following limbic seizures.Brain Res 277, no. 2 (October 31, 1983): 305–9. https://doi.org/10.1016/0006-8993(83)90938-1.
Kraus VM, Dasheiff RM, Fanelli RJ, McNamara JO. Benzodiazepine receptor declines in hippocampal formation following limbic seizures. Brain Res. 1983 Oct 31;277(2):305–9.
Kraus, V. M., et al. “Benzodiazepine receptor declines in hippocampal formation following limbic seizures.Brain Res, vol. 277, no. 2, Oct. 1983, pp. 305–09. Pubmed, doi:10.1016/0006-8993(83)90938-1.
Kraus VM, Dasheiff RM, Fanelli RJ, McNamara JO. Benzodiazepine receptor declines in hippocampal formation following limbic seizures. Brain Res. 1983 Oct 31;277(2):305–309.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

October 31, 1983

Volume

277

Issue

2

Start / End Page

305 / 309

Location

Netherlands

Related Subject Headings

  • Seizures
  • Receptors, GABA-A
  • Receptors, Cell Surface
  • Rats, Inbred Strains
  • Rats
  • Phenobarbital
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Hippocampus