James O'Connell McNamara Sr.
Duke School of Medicine Professor in Neuroscience
The goal of this laboratory is to elucidate the cellular and molecular mechanisms underlying epileptogenesis, the process by which a normal brain becomes epileptic. The epilepsies constitute a group of common, serious neurological disorders, among which temporal lobe epilepsy (TLE) is the most prevalent and devastating. Many patients with severe TLE experienced an episode of prolonged seizures (status epilepticus, SE) years prior to the onset of TLE. Because induction of SE alone is sufficient to induce TLE in diverse mammalian species, the occurrence of de novo SE is thought to contribute to development of TLE in humans. Elucidating the molecular mechanisms by which an episode of SE induces lifelong TLE in an animal model will provide targets for preventive and/or disease modifying therapies. Using a chemical-genetic method, we discovered a molecular mechanism required for induction of TLE by an episode of SE, namely, the excessive activation of the BDNF receptor tyrosine kinase, TrkB (Liu et al., 2013). We subsequently discovered that phospholipase Cg1 is the dominant signaling effector by which excessive activation of TrkB promotes epilepsy (Gu et al., 2015). We designed a novel peptide (pY816) that uncouples TrkB from phospholipase Cg1. Treatment with pY816 following status epilepticus inhibited TLE (Gu et al., 2015). This provides proof-of-concept evidence for a novel strategy targeting receptor tyrosine kinase signaling and identifies a therapeutic with promise for prevention of TLE caused by status epilepticus in humans.
There are two major objectives of our current work. 1. We are developing peptide and small molecule inhibitors of TrkB signaling for advancement to the clinic. 2. We seek to understand the cellular consequences of TrkB activation that transform the brain from normal to epileptic. We have identified the sites within hippocampus at which SE-induced activation of TrkB occurs (Helgager et al 2013). One is the spines of apical dendrites of CA1 pyramidal cells. We are utilizing an in vitro model in which we mimic the enhanced synaptic release of glutamate during SE. Using two photon uncaging microscopy, exquisitely localized high concentrations of glutamate are generated over a spine of an apical dendrite of a CA1 pyramidal cell in cultured hippocampus, resulting in long term potentiation. We have developed novel sensors to dynamically image activation of TrkB within a single spine. We have discovered that induction of long term potentiation requires activation of TrkB, mediated in part by uncaging induced release of BDNF from the same spine (Harward et al 2016). This provides a valuable model with which to elucidate the mechanisms mediating activation of TrkB and the downstream signaling pathways by which its activation promotes long term potentiation (Hedrick et al 2016).
Helgager J, Liu G, McNamara JO. The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. J Comp Neurol. 521(3):499-521. 2013. (PMCID: PMC3527653)
Liu, G., Gu, B, He, X., Joshi, R.B., Wackerle, H.D., Rodriguiz, R.M., Wetsel, W.C., and McNamara, J.O. Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy. Neuron 79:31-38, 2013. (PMCID: PMC3744583).*
Gu, B., Huang, Yang Zhong Huang, He, Xiao-Ping He, Joshi, R. B., Jang, Wonjo, & McNamara, J.O. A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. Neuron 88(3):484-491, 2015. PMID:26481038. PMCID: pending
Harward, S. C., Hedrick, N. G., Hall, C. E., Parra-bueno, P., Milner, T. A., Pan, E., … Yasuda, R., McNamara J.O. (2016). Autocrine BDNF-TrkB signalling within a single dendritic spine, 13–16. doi:10.1038/nature19766
Hedrick, N. G., Harward, S. C., Hall, C. E., Murakoshi, H., McNamara, J. O., & Yasuda, R. (2016). Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. Nature. doi:10.1038/nature19784
Our publications can be found at: http://www.ncbi.nlm.nih.gov/sites/myncbi/1rMG926fr2ikx/bibliography/48320844/public/?sort=date&direction=ascending
Current Appointments & Affiliations
- Duke School of Medicine Professor in Neuroscience, Neurobiology, Basic Science Departments 1993
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2002
- Professor of Neurology, Neurology, Epilepsy and Sleep, Neurology 2013
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1995
- Director, Center for Translational Neuroscience, Neurobiology, Basic Science Departments 2002
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
Contact Information
- Box3209, Durham, NC 27710
- Bryan Research Building, 311 Research Driveroom 401C, Durham, NC 27710
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jmc@neuro.duke.edu
(919) 684-0323
- Background
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Education, Training, & Certifications
- M.D., University of Michigan at Ann Arbor 1968
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Duke Appointment History
- Professor of Medicine, Neurology, Clinical Science Departments 2002 - 2013
- Chair, Department of Neurobiology, Neurobiology, Basic Science Departments 2002 - 2011
- Professor of Medicine, Medicine, Clinical Science Departments 1985 - 2002
- Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2002
- Associate Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1995
- Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1981 - 1986
- Associate Professor of Medicine, Medicine, Clinical Science Departments 1980 - 1985
- Assistant Professor of Medicine, Medicine, Clinical Science Departments 1976 - 1980
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1973 - 1976
- Recognition
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In the News
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SEP 28, 2016 -
JUN 21, 2013 News & Observer
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Awards & Honors
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Pan, E, Zhao, Z, and McNamara, JO. "LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling." Journal of Neurophysiology 121, no. 2 (February 2019): 609-619. Full Text
- Anderson, RJ, Cook, JJ, Delpratt, N, Nouls, JC, Gu, B, McNamara, JO, Avants, BB, Johnson, GA, and Badea, A. "Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework." Neuroinformatics (December 19, 2018). Full Text
- Dingledine, R, Coulter, DA, Fritsch, B, Gorter, JA, Lelutiu, N, McNamara, J, Nadler, JV, Pitkänen, A, Rogawski, MA, Skene, P, Sloviter, RS, Wang, Y, Wadman, WJ, Wasterlain, C, and Roopra, A. "Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models." Scientific data 4 (May 9, 2017): 170061-. Full Text
- Alexander, GM, Huang, YZ, Soderblom, EJ, He, X-P, Moseley, MA, and McNamara, JO. "Vagal nerve stimulation modifies neuronal activity and the proteome of excitatory synapses of amygdala/piriform cortex." Journal of Neurochemistry 140, no. 4 (February 3, 2017): 629-644. Full Text
- Anderson, RJ, Cook, JJ, Delpratt, NA, Nouls, JC, Gu, B, McNamara, JO, Avants, BB, Johnson, GA, and Badea, A. "An HPC Pipeline with Validation Framework for Small Animal Multivariate Brain Analysis (SAMBA)." CoRR abs/1709.10483 (2017).
- Rigbye, KA, van Hasselt, PM, Burgess, R, Damiano, JA, Mullen, SA, Petrovski, S, Puranam, RS, van Gassen, KLI, Gecz, J, Scheffer, IE, McNamara, JO, Berkovic, SF, and Hildebrand, MS. "Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus?." Epilepsy Research 128 (December 2016): 48-51. Full Text
- Harward, SC, Hedrick, NG, Hall, CE, Parra-Bueno, P, Milner, TA, Pan, E, Laviv, T, Hempstead, BL, Yasuda, R, and McNamara, JO. "Autocrine BDNF-TrkB signalling within a single dendritic spine." Nature 538, no. 7623 (October 2016): 99-103. Full Text
- Hedrick, NG, Harward, SC, Hall, CE, Murakoshi, H, McNamara, JO, and Yasuda, R. "Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity." Nature 538, no. 7623 (October 2016): 104-108. Full Text
- Gu, B, Huang, YZ, He, X-P, Joshi, RB, Jang, W, and McNamara, JO. "A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus." Neuron 88, no. 3 (November 2015): 484-491. Full Text Open Access Copy
- Puranam, RS, He, XP, Yao, L, Le, T, Jang, W, Rehder, CW, Lewis, DV, and McNamara, JO. "Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, no. 23 (June 2015): 8866-8881. Full Text
- Helgager, J, Huang, YZ, and McNamara, JO. "Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo." The Journal of Comparative Neurology 522, no. 17 (December 2014): 3885-3899. Full Text
- Helgager, J, Huang, YZ, and Mcnamara, JO. "Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo." Journal of Comparative Neurology 522, no. 17 (December 1, 2014): 3885-3899. Full Text
- Liu, G, Kotloski, RJ, and McNamara, JO. "Antiseizure effects of TrkB kinase inhibition." Epilepsia 55, no. 8 (August 2014): 1264-1273. Full Text
- He, XP, Wen, R, and McNamara, JO. "Impairment of kindling development in phospholipase Cγ1 heterozygous mice." Epilepsia 55, no. 3 (March 2014): 456-463. Full Text
- "Antiseizure effects of TrkB kinase inhibition." Epilepsia 55, no. 8 (January 1, 2014): 1264-1273. Full Text
- Harward, SC, and McNamara, JO. "Aligning animal models with clinical epilepsy: where to begin?." Advances in experimental medicine and biology 813 (January 2014): 243-251. (Review) Full Text
- Harward, SC, and McNamara, JO. "Aligning animal models with clinical epilepsy: Where to begin?." Advances in Experimental Medicine and Biology 813 (January 1, 2014): 243-251. Full Text
- Harward, SC, and McNamara, JO. "Aligning animal models with clinical epilepsy: Where to begin?." Advances in Experimental Medicine and Biology 813 (January 1, 2014): 243-251. Full Text
- Ruzzo, EK, Capo-Chichi, J-M, Ben-Zeev, B, Chitayat, D, Mao, H, Pappas, AL, Hitomi, Y, Lu, Y-F, Yao, X, Hamdan, FF, Pelak, K, Reznik-Wolf, H, Bar-Joseph, I, Oz-Levi, D, Lev, D, Lerman-Sagie, T, Leshinsky-Silver, E, Anikster, Y, Ben-Asher, E, Olender, T, Colleaux, L, Décarie, J-C, Blaser, S, Banwell, B, Joshi, RB, He, X-P, Patry, L, Silver, RJ, Dobrzeniecka, S, Islam, MS, Hasnat, A, Samuels, ME, Aryal, DK, Rodriguiz, RM, Jiang, Y-H, Wetsel, WC, McNamara, JO, Rouleau, GA, Silver, DL, Lancet, D, Pras, E, Mitchell, GA, Michaud, JL, and Goldstein, DB. "Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy." Neuron 80, no. 2 (October 2013): 429-441. Full Text
- Liu, G, Gu, B, He, X-P, Joshi, RB, Wackerle, HD, Rodriguiz, RM, Wetsel, WC, and McNamara, JO. "Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy." Neuron 79, no. 1 (July 10, 2013): 31-38. Full Text Open Access Copy Link to Item
- Choudhuri, S, Mandal, LK, Paine, SK, Sen, A, Dutta, D, Chowdhury, IH, Mukherjee, A, Saha, A, Bhadhuri, G, and Bhattacharya, B. "Reply: To PMID 22653543." Retina (Philadelphia, Pa.) 33, no. 7 (July 2013): 1481-. (Letter) Full Text
- Harward, SC, and McNamara, JO. "In search of the ever-elusive positive endozepine." Neuron 78, no. 6 (June 2013): 951-952. Full Text
- Wang, H-G, He, XP, Li, Q, Madison, RD, Moore, SD, McNamara, JO, and Pitt, GS. "The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability." The Journal of Biological Chemistry 288, no. 19 (May 2013): 13258-13268. Full Text
- Helgager, J, Liu, G, and McNamara, JO. "The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis." J Comp Neurol 521, no. 3 (February 15, 2013): 499-Spc1. Full Text Link to Item
- Liu, G, Gu, B, He, X-P, Joshi, R, Wackerle, H, Rodriguiz, R, Wetsel, W, and McNamara, J. "Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy." Neuron 79, no. 1 (2013): 31-38. Full Text
- Singh, SP, He, X, Mcnamara, JO, and Danzer, SC. "Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis." Hippocampus 23, no. 12 (2013): 1309-1320. Full Text
- Singh, SP, He, X, Mcnamara, JO, and Danzer, SC. "Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis." Hippocampus (2013). Full Text
- Alexander, GM, and McNamara, JO. "Vagus nerve stimulation elevates seizure threshold in the kindling model." Epilepsia 53, no. 11 (November 2012): 2043-2052. Full Text Link to Item
- Soren Leonard, A, Puranam, RS, Helgager, J, Liu, G, and McNamara, JO. "Conditional deletion of TrkC does not modify limbic epileptogenesis." Epilepsy Res 102, no. 1-2 (November 2012): 126-130. Full Text Link to Item
- Huang, YZ, and McNamara, JO. "Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 32, no. 44 (October 2012): 15521-15532. Full Text
- Heinzen, EL, Depondt, C, Cavalleri, GL, Ruzzo, EK, Walley, NM, Need, AC, Ge, D, He, M, Cirulli, ET, Zhao, Q, Cronin, KD, Gumbs, CE, Campbell, CR, Hong, LK, Maia, JM, Shianna, KV, McCormack, M, Radtke, RA, O'Conner, GD, Mikati, MA, Gallentine, WB, Husain, AM, Sinha, SR, Chinthapalli, K, Puranam, RS, McNamara, JO, Ottman, R, Sisodiya, SM, Delanty, N, and Goldstein, DB. "Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy." American Journal of Human Genetics 91, no. 2 (August 2, 2012): 293-302. Full Text
- Thiel, KW, Hernandez, LI, Dassie, JP, Thiel, WH, Liu, X, Stockdale, KR, Rothman, AM, Hernandez, FJ, McNamara, JO, and Giangrande, PH. "Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers." Nucleic Acids Research 40, no. 13 (July 2012): 6319-6337. Full Text
- Alexander, GM, and McNamara, JO. "Vagus nerve stimulation elevates seizure threshold in the kindling model." Epilepsia 53, no. 11 (2012): 2043-2052. Full Text
- Alexander, GM, and McNamara, JO. "Vagus nerve stimulation elevates seizure threshold in the kindling model." Epilepsia 53, no. 11 (January 1, 2012): 2243-2252. Full Text
- Heinzen, EL, Depondt, C, Cavalleri, GL, Ruzzo, EK, Walley, NM, Need, AC, Ge, D, He, M, Cirulli, ET, Zhao, Q, Cronin, KD, Gumbs, CE, Campbell, CR, Hong, LK, Maia, JM, Shianna, KV, McCormack, M, Radtke, RA, O'Conner, GD, Mikati, MA, Gallentine, WB, Husain, AM, Sinha, SR, Chinthapalli, K, Puranam, RS, McNamara, JO, Ottman, R, Sisodiya, SM, Delanty, N, and Goldstein, DB. "Exome Sequencing Followed by Large-Scale Genotyping Fails to Identify Single Rare Variants of Large Effect in Idiopathic Generalized Epilepsy." American Journal of Human Genetics (2012). Full Text
- Hernandez, FJ, Stockdale, KR, Huang, L, Horswill, AR, Behlke, MA, and McNamara, JO. "Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media." Nucleic Acid Therapeutics 22, no. 1 (2012): 58-68. Full Text
- Jones, DL, and McNamara, JO. "The Epilepsies." (2012): 705-718. Full Text
- Pan, E, Zhang, X-A, Huang, Z, Krezel, A, Zhao, M, Tinberg, CE, Lippard, SJ, and McNamara, JO. "Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse." Neuron 71, no. 6 (September 21, 2011): 1116-1126. Full Text
- McNamara, JO, and Scharfman, HE. "Temporal lobe epilepsy and the BDNF receptor, TrkB." Epilepsia 51, no. SUPPL. 5 (December 1, 2010): 46-null. Full Text
- Crooks, KR, Kleven, DT, Rodriguiz, RM, Wetsel, WC, and McNamara, JO. "TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine." Neuropharmacology 58, no. 7 (June 2010): 1067-1077. Full Text Link to Item
- Xing, Q, Zhao, F, Chen, S, McNamara, J, Decoster, MA, and Lvov, YM. "Porous biocompatible three-dimensional scaffolds of cellulose microfiber/gelatin composites for cell culture." Acta Biomaterialia 6, no. 6 (June 2010): 2132-2139. Full Text
- He, XP, Pan, E, Sciarretta, C, Minichiello, L, and McNamara, JO. "Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 18 (May 2010): 6188-6196. Full Text
- Huang, YZ, and McNamara, JO. "Mutual regulation of Src family kinases and the neurotrophin receptor TrkB." The Journal of Biological Chemistry 285, no. 11 (March 2010): 8207-8217. Full Text
- Danzer, SC, He, X, Loepke, AW, and McNamara, JO. "Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy." Hippocampus 20, no. 1 (2010): 113-124. Full Text
- Kotloski, R, and McNamara, JO. "Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model." Hippocampus 20, no. 6 (2010): 713-723. Full Text
- Dassie, JP, Liu, X-Y, Thomas, GS, Whitaker, RM, Thiel, KW, Stockdale, KR, Meyerholz, DK, McCaffrey, AP, McNamara, JO, and Giangrande, PH. "Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors." Nature Biotechnology 27, no. 9 (September 2009): 839-849. Full Text
- Alexander, GM, Rogan, SC, Abbas, AI, Armbruster, BN, Pei, Y, Allen, JA, Nonneman, RJ, Hartmann, J, Moy, SS, Nicolelis, MA, McNamara, JO, and Roth, BL. "Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors." Neuron 63, no. 1 (July 2009): 27-39. Full Text
- Ma, H, Tarr, J, Decoster, MA, McNamara, J, Caruntu, D, Chen, JF, O'Connor, CJ, and Zhou, WL. "Synthesis of magnetic porous hollow silica nanotubes for drug delivery." Journal of Applied Physics 105, no. 7 (April 27, 2009). Full Text
- Cerchia, L, Giangrande, PH, McNamara, JO, and Franciscis, VD. "Cell-specific aptamers for targeted therapies." Methods in Molecular Biology 535 (2009): 59-78. Full Text
- McNamara, JO, Huang, YZ, and Pan, E. "Plasticity of dentate granule cell mossy fiber synapses: A Putative mechanism of limbic epileptogenesis." (December 1, 2008): 715-729. (Chapter) Full Text
- Roeloffs, R, Wickenden, AD, Crean, C, Werness, S, McNaughton-Smith, G, Stables, J, McNamara, JO, Ghodadra, N, and Rigdon, GC. "In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models." The Journal of Pharmacology and Experimental Therapeutics 326, no. 3 (September 2008): 818-828. Full Text
- Huang, YZ, Pan, E, Xiong, Z-Q, and McNamara, JO. "Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse." Neuron 57, no. 4 (February 2008): 546-558. Full Text
- Danzer, SC, Kotloski, RJ, Walter, C, Hughes, M, and McNamara, JO. "Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB." Hippocampus 18, no. 7 (January 2008): 668-678. Full Text
- McNamara, JO, Kolonias, D, Pastor, F, Mittler, RS, Chen, L, Giangrande, PH, Sullenger, B, and Gilboa, E. "Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice." The Journal of Clinical Investigation 118, no. 1 (January 2008): 376-386. Full Text
- Tahirovic, YA, Geballe, M, Gruszecka-Kowalik, E, Myers, SJ, Lyuboslavsky, P, Le, P, French, A, Irier, H, Choi, W-B, Easterling, K, Yuan, H, Wilson, LJ, Kotloski, R, McNamara, JO, Dingledine, R, Liotta, DC, Traynelis, SF, and Snyder, JP. "Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists." Journal of Medicinal Chemistry 51, no. 18 (2008): 5506-5521. Full Text
- Cavalleri, GL, Weale, ME, Shianna, KV, Singh, R, Lynch, JM, Grinton, B, Szoeke, C, Murphy, K, Kinirons, P, O'Rourke, D, Ge, D, Depondt, C, Claeys, KG, Pandolfo, M, Gumbs, C, Walley, N, McNamara, J, Mulley, JC, Linney, KN, Sheffield, LJ, Radtke, RA, Tate, SK, Chissoe, SL, Gibson, RA, Hosford, D, Stanton, A, Graves, TD, Hanna, MG, Eriksson, K, Kantanen, A-M, Kalviainen, R, O'Brien, TJ, Sander, JW, Duncan, JS, Scheffer, IE, Berkovic, SF, Wood, NW, Doherty, CP, Delanty, N, and Sisodiya, SM et al. "Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study." Lancet Neurol 6, no. 11 (November 2007): 970-980. Full Text Link to Item
- Leonard, AS, and McNamara, JO. "Does epileptiform activity contribute to cognitive impairment in Alzheimer's disease?." Neuron 55, no. 5 (September 6, 2007): 677-678. Full Text Link to Item
- Huang, YZ, and McNamara, JO. "Inhibiting glycolysis to reduce seizures: how it might work." Nature Neuroscience 9, no. 11 (November 2006): 1351-1352. Full Text
- McNamara, JO, Huang, YZ, and Leonard, AS. "Molecular signaling mechanisms underlying epileptogenesis." Science'S Stke : Signal Transduction Knowledge Environment 2006, no. 356 (October 10, 2006): re12-null. (Review) Full Text
- Nemeroff, CB, Mayberg, HS, Krahl, SE, McNamara, J, Frazer, A, Henry, TR, George, MS, Charney, DS, and Brannan, SK. "Erratum: VNS therapy in treatment-resistant depression: Clinical evidence and putative neurobiological mechanisms (Neuropsychopharmacology (2006) 31 (1345-1355) DOI: 10.1038/sj.npp.1301082)." Neuropsychopharmacology 31, no. 10 (October 7, 2006): 2329-null. Full Text
- Loo, LS, and McNamara, JO. "Impaired volume regulation is the mechanism of excitotoxic sensitization to complement." J Neurosci 26, no. 40 (October 4, 2006): 10177-10187. Full Text Link to Item
- Bausch, SB, He, S, Petrova, Y, Wang, X-M, and McNamara, JO. "Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus." Journal of Neurophysiology 96, no. 4 (October 2006): 2151-2167. Full Text
- He, X-P, Butler, L, Liu, X, and McNamara, JO. "The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model." Neuroscience 141, no. 1 (August 2006): 515-520. Full Text
- McNamara, JO, Andrechek, ER, Wang, Y, Viles, KD, Rempel, RE, Gilboa, E, Sullenger, BA, and Giangrande, PH. "Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras." Nature Biotechnology 24, no. 8 (August 2006): 1005-1015. Full Text
- Nemeroff, CB, Mayberg, HS, Krahl, SE, McNamara, J, Frazer, A, Henry, TR, George, MS, Charney, DS, and Brannan, SK. "VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 31, no. 7 (July 2006): 1345-1355. (Review) Full Text
- MCNAMARA, JAMESO. "An Animal Model of Rasmussen's Encephalitis11This work was supported by a grant (NS 36808) from the National Institute of Neurological Disease and Stroke." (2006): 535-537. Full Text
- Mi, J, Zhang, X, Giangrande, PH, McNamara, JO, Nimjee, SM, Sarraf-Yazdi, S, Sullenger, BA, and Clary, BM. "Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival." Biochemical and Biophysical Research Communications 338, no. 2 (December 2005): 956-963. Full Text
- Puranam, RS, Jain, S, Kleindienst, AM, Saxena, S, Kim, M-K, Kelly Changizi, B, Padma, MV, Andrews, I, Elston, RC, Tiwari, HK, and McNamara, JO. "A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26." Annals of Neurology 58, no. 3 (September 2005): 449-458. Full Text
- Grigston, JC, VanDongen, HMA, McNamara, JO, and VanDongen, AMJ. "Translation of an integral membrane protein in distal dendrites of hippocampal neurons." Eur J Neurosci 21, no. 6 (March 2005): 1457-1468. Full Text Link to Item
- Bausch, SB, and McNamara, JO. "Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures." Journal of Neurophysiology 92, no. 6 (December 2004): 3582-3595. Full Text
- Danzer, SC, and McNamara, JO. "Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 24, no. 50 (December 2004): 11346-11355. Full Text
- Huang, Y, and McNamara, JO. "Ischemic stroke: "acidotoxicity" is a perpetrator." Cell 118, no. 6 (September 2004): 665-666. (Review) Full Text
- Persaud-Sawin, D-A, McNamara, JO, Rylova, S, Vandongen, A, and Boustany, R-MN. "A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes." Pediatr Res 56, no. 3 (September 2004): 449-463. Full Text Link to Item
- McNamara, JO, Grigston, JC, VanDongen, HMA, and VanDongen, AMJ. "Rapid dendritic transport of TGN38, a putative cargo receptor." Brain Res Mol Brain Res 127, no. 1-2 (August 23, 2004): 68-78. Full Text Link to Item
- He, X-P, Kotloski, R, Nef, S, Luikart, BW, Parada, LF, and McNamara, JO. "Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model." Neuron 43, no. 1 (July 2004): 31-42. Full Text
- Danzer, SC, He, X, and McNamara, JO. "Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus." Hippocampus 14, no. 3 (January 2004): 345-355. Full Text
- Danzer, SC, Pan, E, Nef, S, Parada, LF, and McNamara, JO. "Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation." Neuroscience 126, no. 4 (January 2004): 859-869. Full Text
- Xiong, Z-Q, Qian, W, Suzuki, K, and McNamara, JO. "Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 23, no. 3 (February 2003): 955-960. Full Text
- Barnes, G, Puranam, RS, Luo, Y, and McNamara, JO. "Temporal specific patterns of semaphorin gene expression in rat brain after kainic acid-induced status epilepticus." Hippocampus 13, no. 1 (January 2003): 1-20. Full Text
- Danzer, SC, Crooks, KRC, Lo, DC, and McNamara, JO. "Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22, no. 22 (November 2002): 9754-9763. Full Text
- Xiong, ZQ, and McNamara, JO. "Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack." Neuron 36, no. 3 (October 24, 2002): 363-374. Link to Item
- Xiong, Z-Q, and McNamara, JO. "Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?." Neuron 35, no. 6 (September 12, 2002): 1011-1013. (Review) Link to Item
- He, X-P, Minichiello, L, Klein, R, and McNamara, JO. "Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22, no. 17 (September 2002): 7502-7508. Full Text
- McNamara, JO. "B cells and epilepsy: The odd couple." Neurology 58, no. 5 (2002): 677-678.
- Andrews, PI, Dichter, MA, Berkovic, SF, Newton, MR, and McNamara, JO. "Plasmapheresis in rasmussen's encephalitis." Neurology 57, no. 11 SUPPL. 4 (December 11, 2001).
- Andrews, PI, Dichter, MA, Berkovic, SF, Newton, MR, and McNamara, JO. "Plasmapheresis in Rasmussen's encephalitis." NEUROLOGY 57, no. 11 (December 2001): S37-S41. Link to Item
- Puranam, RS, and McNamara, JO. "Epilepsy and all that jazz." Nat Med 7, no. 10 (October 2001): 1103-1105. Full Text Link to Item
- McKeown, MJ, and McNamara, JO. "When do epileptic seizures really begin?." Neuron 30, no. 1 (April 2001): 1-3. (Review) Link to Item
- Yang, R, Puranam, RS, Butler, LS, Qian, WH, He, XP, Moyer, MB, Blackburn, K, Andrews, PI, and McNamara, JO. "Autoimmunity to Munc-18 in Rasmussen's encephalitis (vol 28, pg 375, 2000)." NEURON 29, no. 2 (February 2001): U22-U22. Link to Item
- Yang, R, Puranam, RS, Butler, LS, Qian, WH, He, XP, Moyer, MB, Blackburn, K, Andrews, PI, and McNamara, JO. "Erratum: Autoimmunity to Munc-18 in Rasmussen's Encephalitis (Neuron (November 2000) 28 (375-383))." Neuron 29, no. 2 (January 1, 2001): 547-null. Full Text
- Bausch, SB, and McNamara, JO. "Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures." Journal of Neurophysiology 84, no. 6 (December 2000): 2918-2932. Full Text
- Yang, R, Puranam, RS, Butler, LS, Qian, WH, He, XP, Moyer, MB, Blackburn, K, Andrews, PI, and McNamara, JO. "Autoimmunity to munc-18 in Rasmussen's encephalitis." Neuron 28, no. 2 (November 2000): 375-383. Link to Item
- Whitney, KD, and McNamara, JO. "GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 20, no. 19 (October 2000): 7307-7316. Full Text
- Foldvary, N, Nashold, B, Mascha, E, Thompson, EA, Lee, N, McNamara, JO, Lewis, DV, Luther, JS, Friedman, AH, and Radtke, RA. "Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis." Neurology 54, no. 3 (February 2000): 630-634. Full Text
- Lees, GV, Jones, EG, and McNamara, J. "Epilepsy." Neurobiology of Disease 7, no. 5 (2000): 549-551. Full Text
- Whitney, KD, Andrews, PI, and McNamara, JO. "Immunoglobulin G and complement immunoreactivity in the cerebral cortex of patients with Rasmussen's encephalitis." Neurology 53, no. 4 (September 11, 1999): 699-708. Link to Item
- McNamara, JO. "Emerging insights into the genesis of epilepsy." Nature 399, no. SUPPL. (June 24, 1999). (Review) Full Text
- McNamara, JO. "Emerging insights into the genesis of epilepsy." NATURE 399, no. 6738 (June 24, 1999): A15-A22. Full Text Link to Item
- Binder, DK, Routbort, MJ, and McNamara, JO. "Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 19, no. 11 (June 1999): 4616-4626. Full Text
- McNamara, JO. "Emerging insights into the genesis of epilepsy." Nature 399, no. 6738 Suppl (June 1999): A15-A22. (Review) Full Text
- Puranam, RS, and McNamara, JO. "Seizure disorders in mutant mice: relevance to human epilepsies." Curr Opin Neurobiol 9, no. 3 (June 1999): 281-287. (Review) Link to Item
- Bausch, SB, and McNamara, JO. "Experimental partial epileptogenesis." Curr Opin Neurol 12, no. 2 (April 1999): 203-209. (Review) Link to Item
- Binder, DK, Routbort, MJ, Ryan, TE, Yancopoulos, GD, and McNamara, JO. "Selective inhibition of kindling development by intraventricular administration of TrkB receptor body." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 19, no. 4 (February 1999): 1424-1436. Full Text
- McNamara, JO, Whitney, KD, Andrews, PI, He, XP, Janumpalli, S, and Patel, MN. "Evidence for glutamate receptor autoimmunity in the pathogenesis of Rasmussen encephalitis." Adv Neurol 79 (1999): 543-550. (Review) Link to Item
- Routbort, MJ, Bausch, SB, and McNamara, JO. "Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures." Neuroscience 94, no. 3 (January 1999): 755-765. Full Text
- Whitney, KD, and McNamara, JO. "Autoimmunity and neurological disease: antibody modulation of synaptic transmission." Annu Rev Neurosci 22 (1999): 175-195. (Review) Full Text Link to Item
- Wilson, MH, Puranam, RS, Ottman, R, Gilliam, C, Limbird, LE, George, AL, and McNamara, JO. "Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy." Neurology 51, no. 6 (December 1998): 1730-1731. Link to Item
- Kraus, JE, and McNamara, JO. "Measurement of NMDA receptor protein subunits in discrete hippocampal regions of kindled animals." Brain Res Mol Brain Res 61, no. 1-2 (October 30, 1998): 114-120. Link to Item
- Puranam, RS, and McNamara, JO. "Stargazing nets new calcium channel subunit." Nature Genetics 19, no. 4 (August 1998): 313-314. Full Text
- Parent, JM, Janumpalli, S, McNamara, JO, and Lowenstein, DH. "Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat." Neuroscience Letters 247, no. 1 (May 1998): 9-12. Full Text
- Janumpalli, S, Butler, LS, MacMillan, LB, Limbird, LE, and McNamara, JO. "A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 18, no. 6 (March 1998): 2004-2008. Full Text
- Zheng, D, Butler, LS, and McNamara, JO. "Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes." Neuroscience 83, no. 1 (March 1998): 251-258. Full Text
- McNamara, JO, and Puranam, RS. "Epilepsy genetics: an abundance of riches for biologists." Curr Biol 8, no. 5 (February 26, 1998): R168-R170. (Review) Link to Item
- He, XP, Patel, M, Whitney, KD, Janumpalli, S, Tenner, A, and McNamara, JO. "Glutamate receptor GluR3 antibodies and death of cortical cells." Neuron 20, no. 1 (January 1998): 153-163. Link to Item
- Sprengel, R, Suchanek, B, Amico, C, Brusa, R, Burnashev, N, Rozov, A, Hvalby, O, Jensen, V, Paulsen, O, Andersen, P, Kim, JJ, Thompson, RF, Sun, W, Webster, LC, Grant, SG, Eilers, J, Konnerth, A, Li, J, McNamara, JO, and Seeburg, PH. "Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo." Cell 92, no. 2 (January 1998): 279-289. Full Text
- Andrews, PI, McNamara, JO, and Lewis, DV. "Clinical and electroencephalographic correlates in Rasmussen's encephalitis." Epilepsia 38, no. 2 (February 1997): 189-194. Link to Item
- Lerea, LS, Carlson, NG, Simonato, M, Morrow, JD, Roberts, JL, and McNamara, JO. "Prostaglandin F2alpha is required for NMDA receptor-mediated induction of c-fos mRNA in dentate gyrus neurons." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 17, no. 1 (January 1997): 117-124. Full Text
- McNamara, JO. "The battle against the Sacred disease heats up: Recent advances in the understanding and treatment of epilepsies." Current Opinion in Neurology 10, no. 2 (January 1, 1997): 85-87. (Review) Full Text
- Silva, AJ, Simpson, EM, Takahashi, JS, Lipp, H-P, Nakanishi, S, Wehner, JM, Giese, KP, Tully, T, Abel, T, Chapman, PF, Fox, K, Grant, S, Itohara, S, Lathe, R, Mayford, M, McNamara, JO, Morris, RJ, Picciotto, M, Roder, J, Shin, H-S, Slesinger, PA, Storm, DR, Stryker, MP, Tonegawa, S, Wang, Y, and Wolfer, DP. "Mutant mice and neuroscience: Recommendations concerning genetic background." Neuron 19, no. 4 (1997): 755-759. Full Text
- Jain, S, Dixit, SN, Andrews, PI, Radtke, R, Maheshwari, MC, and McNamara, JO. "Disease expression among probands with juvenile myoclonic epilepsy and their family members in two population groups." Journal of Epilepsy 9, no. 4 (December 1, 1996): 259-267. Full Text
- Sutula, T, Koch, J, Golarai, G, Watanabe, Y, and McNamara, JO. "NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 16, no. 22 (November 1996): 7398-7406. Full Text
- Andrews, PI, and McNamara, JO. "Rasmussen's encephalitis: an autoimmune disorder?." Curr Opin Neurobiol 6, no. 5 (October 1996): 673-678. (Review) Link to Item
- Kraus, JE, Nadler, JV, and McNamara, JO. "Regulation of alternative splicing of NMDAR1 in the kindling model." Brain Res Mol Brain Res 41, no. 1-2 (September 5, 1996): 97-104. Link to Item
- Mattson, RH, Cramer, JA, Collins, JF, Browne, TR, Crill, WE, Homan, RW, Carter, GS, Mayersdorf, A, Davenport, J, Lubozynski, MF, Williamson, PD, Ebersole, JS, Scheyer, RD, McCutchen, CB, Mamdani, MB, Ramsay, RE, Rowan, AJ, Salinsky, M, McNamara, JO, Shin, C, Smith, DB, Treiman, DM, DelgadoEscueta, AV, Rosenthal, NP, Warner, JJ, and Wilder, BJ. "Prognosis for total control of complex partial and secondarily generalized tonic clonic seizures." NEUROLOGY 47, no. 1 (July 1996): 68-76. Full Text Link to Item
- Watanabe, Y, Johnson, RS, Butler, LS, Binder, DK, Spiegelman, BM, Papaioannou, VE, and McNamara, JO. "Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 16, no. 12 (June 1996): 3827-3836. Full Text
- McNamara, JO, and Puranam, RS. "Protease inhibitor implicated." Nature 381, no. 6577 (May 2, 1996): 26-27. Full Text
- McNamara, JO, and Puranam, RS. "Epilepsy. Protease inhibitor implicated." Nature 381, no. 6577 (May 2, 1996): 26-27. Full Text Link to Item
- Andrews, PI, and McNamara, JO. "Rasmussen's encephalitis: an autoimmune disorder?." Curr Opin Neurol 9, no. 2 (April 1996): 141-145. Link to Item
- Patel, M, Day, BJ, Crapo, JD, Fridovich, I, and McNamara, JO. "Requirement for superoxide in excitotoxic cell death." Neuron 16, no. 2 (February 1996): 345-355. Full Text
- Andrews, PI, Dichter, MA, Berkovic, SF, Newton, MR, and McNamara, JO. "Plasmapheresis in Rasmussen's encephalitis." Neurology 46, no. 1 (January 1996): 242-246. Link to Item
- McNamara, JO, Patel, M, He, XP, Janumpalli, S, and Whitney, KD. "Glutamate receptor autoimmunity in Rasmussen's encephalitis." Cold Spring Harb Symp Quant Biol 61 (1996): 327-332. (Review) Link to Item
- Patel, MN, and McNamara, JO. "Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors." Neuroscience 69, no. 3 (December 1995): 763-770. Link to Item
- Li, L, Chin, LS, Shupliakov, O, Brodin, L, Sihra, TS, Hvalby, O, Jensen, V, Zheng, D, McNamara, JO, and Greengard, P. "Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice." Proceedings of the National Academy of Sciences of the United States of America 92, no. 20 (September 1995): 9235-9239. Full Text
- Butler, LS, Silva, AJ, Abeliovich, A, Watanabe, Y, Tonegawa, S, and McNamara, JO. "Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation." Proceedings of the National Academy of Sciences of the United States of America 92, no. 15 (July 1995): 6852-6855. Full Text
- Kraus, JE, and McNamara, JO. "Clinical relevance of defects in signalling pathways." Curr Opin Neurobiol 5, no. 3 (June 1995): 358-366. (Review) Link to Item
- Lerea, LS, Carlson, NG, and McNamara, JO. "N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways." Mol Pharmacol 47, no. 6 (June 1995): 1119-1125. Link to Item
- McNamara, JO. "Analyses of the molecular basis of kindling development." Psychiatry Clin Neurosci 49, no. 3 (June 1995): S175-S178. (Review) Link to Item
- Hosford, DA, Simonato, M, Cao, Z, Garcia-Cairasco, N, Silver, JM, Butler, L, Shin, C, and McNamara, JO. "Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development." J Neurosci 15, no. 3 Pt 2 (March 1995): 2513-2523. Link to Item
- Hosford, DA, Simonato, M, Cao, Z, Garcia-Cairasco, N, Silver, JM, Butler, L, Shin, C, and McNamara, JO. "Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development." The Journal of Neuroscience 15, no. 3 (March 1, 1995): 2513-2523. Full Text
- Hosford, DA, Simonato, M, Cao, Z, Garcia-Cairasco, N, Silver, JM, Butler, L, Shin, C, and McNamara, JO. "Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development." Journal of Neuroscience 15, no. 3 II (January 1, 1995): 2513-2523.
- McNamara, JO. "c-fos: An epiphenomenon or causal link in mossy fiber sprouting and kindling." Journal of the Japan Epilepsy Society 13, no. 1 (1995): 26--.
- NASHOLD, BS, FOLDVARY, N, WILSON, WP, LEE, N, THOMPSON, EA, LUTHER, JS, FRIEDMAN, AH, LEWIS, DV, MCNAMARA, JO, and RADTKE, RA. "LONG-TERM OUTCOME FOLLOWING TEMPORAL LOBECTOMY FOR TEMPORAL-LOBE EPILEPSY." EPILEPSIA 36 (1995): 374-374. Link to Item
- SHAFQAT, S, TAMARAPPOO, BK, KILBERG, MS, PURANAM, RS, MCNAMARA, JO, GUADANOFERRAZ, A, and FREMEAU, RT. "CLONING AND EXPRESSION OF A NOVEL NA+-DEPENDENT NEUTRAL AMINO-ACID TRANSPORTER STRUCTURALLY RELATED TO MAMMALIAN NA+/GLUTAMATE COTRANSPORTERS (VOL 268, PG 15351, 1993)." JOURNAL OF BIOLOGICAL CHEMISTRY 269, no. 31 (August 5, 1994): 20208-20208. Link to Item
- Kraus, JE, Yeh, GC, Bonhaus, DW, Nadler, JV, and McNamara, JO. "Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 14, no. 7 (July 1994): 4196-4205. Full Text
- Rogers, SW, Andrews, PI, Gahring, LC, Whisenand, T, Cauley, K, Crain, B, Hughes, TE, Heinemann, SF, and McNamara, JO. "Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis." Science (New York, N.Y.) 265, no. 5172 (July 1994): 648-651. Full Text
- McNamara, JO. "Cellular and molecular basis of epilepsy." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 14, no. 6 (June 1994): 3413-3425. (Review) Full Text
- Nadler, JV, Thompson, MA, and McNamara, JO. "Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists." Neuropharmacology 33, no. 2 (February 1994): 147-153. Link to Item
- Ambrose, HJ, Byrd, PJ, McConville, CM, Cooper, PR, Stankovic, T, Riley, JH, Shiloh, Y, McNamara, JO, Fukao, T, and Taylor, AMR. "A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia." Genomics 21, no. 3 (1994): 612-619. Full Text
- MACDONALD, RL, LEPPIK, IE, DICHTER, MA, LINDHOUT, D, CHADWICK, D, PELLOCK, JM, and MCNAMARA, JO. "ANTIEPILEPTIC DRUGS - OPTIMAL USE AND FUTURE-PROSPECTS." EPILEPSIA 35 (1994): S58-S60. Link to Item
- MCNAMARA, JO. "ANTIEPILEPTIC DRUGS - OPTIMAL USE AND FUTURE-PROSPECTS - INTRODUCTION AND SYMPOSIUM OVERVIEW." EPILEPSIA 35 (1994): S1-S2. Link to Item
- Macdonald, RL, Leppik, IE, Dichter, MA, Lindhout, D, Chadwick, D, Pellock, JM, and McNamara, JO. "Panel discussion." Epilepsia 35, no. SUPPL. 4 (January 1, 1994).
- McNamara, JO. "Identification of genetic defect of an epilepsy: strategies for therapeutic advances." Epilepsia 35 Suppl 1 (1994): S51-S57. (Review) Link to Item
- McNamara, JO. "Introduction and Symposium Overview." Epilepsia 35 (January 1, 1994): S1-S1. Full Text
- McNamara, JO. "Molecular genetics and epilepsy: Foundation for therapeutic advances. Introduction and symposium overview." Epilepsia 35, no. SUPPL. 1 (1994): S1-.
- Shafqat, S, Tamarappoo, BK, Kilberg, MS, Puranam, RS, McNamara, JO, Guadano-Ferraz, A, and Fremeau, RT. "Erratum: Cloning and expression of a novel Na+-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters (Journal of Biological Chemistry (1993) 268 (15351-15355))." Journal of Biological Chemistry 269, no. 31 (January 1, 1994): 20208-null.
- Shin, C, and McNamara, JO. "Mechanism of epilepsy." Annual Review of Medicine 45 (January 1994): 379-389. (Review) Full Text
- WALLACE, DC, MCNAMARA, JO, and LOWENSTEIN, DH. "MOLECULAR-GENETICS AND EPILEPSY - FOUNDATION FOR THERAPEUTIC ADVANCES - PANEL DISCUSSION." EPILEPSIA 35 (1994): S58-S62. Link to Item
- Wallace, DC, McNamara, JO, and Lowenstein, DH. "Panel discussion." Epilepsia 35, no. SUPPL. 1 (January 1, 1994).
- Puranam, RS, Eubanks, JH, Heinemann, SF, and McNamara, JO. "Chromosomal localization of gene for human glutamate receptor subunit-7." Somatic Cell and Molecular Genetics 19, no. 6 (November 1993): 581-588. Full Text
- McNamara, JO. "Excitatory amino acid receptors and epilepsy." Current Opinion in Neurology and Neurosurgery 6, no. 4 (August 1993): 583-587. (Review)
- Shafqat, S, Tamarappoo, BK, Kilberg, MS, Puranam, RS, McNamara, JO, Guadaño-Ferraz, A, and Fremeau, RT. "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters." J Biol Chem 268, no. 21 (July 25, 1993): 15351-15355. Link to Item
- McNamara, JO, and Fridovich, I. "Human genetics. Did radicals strike Lou Gehrig?." Nature 362, no. 6415 (March 1993): 20-21. Full Text
- Labiner, DM, Butler, LS, Cao, Z, Hosford, DA, Shin, C, and McNamara, JO. "Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 13, no. 2 (February 1993): 744-751. Full Text
- Couser, RJ, Ferrara, TB, Wheeler, W, McNamara, J, Falde, B, Johnson, K, and Hoekstra, RE. "Pulmonary follow-up 2.5 years after a randomized, controlled, multiple dose bovine surfactant study of preterm newborn infants." Pediatric pulmonology 15, no. 3 (1993): 163-167.
- Eubanks, JH, Puranam, RS, Kleckner, NW, Bettler, B, Heinemann, SF, and McNamara, JO. "The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis." Proceedings of the National Academy of Sciences of the United States of America 90, no. 1 (January 1993): 178-182. Full Text
- Lerea, LS, and McNamara, JO. "Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways." Neuron 10, no. 1 (January 1993): 31-41. Link to Item
- McNamara, JO. "The neurobiological basis of epilepsy." Trends Neurosci 15, no. 10 (October 1992): 357-359. Link to Item
- Lerea, LS, Butler, LS, and McNamara, JO. "NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 12, no. 8 (August 1992): 2973-2981. Full Text
- McNamara, JO, Eubanks, JH, McPherson, JD, Wasmuth, JJ, Evans, GA, and Heinemann, SF. "Chromosomal localization of human glutamate receptor genes." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 12, no. 7 (July 1992): 2555-2562. Full Text
- Martin, D, McNamara, JO, and Nadler, JV. "Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 12, no. 5 (May 1992): 1928-1935. Full Text
- Bonhaus, DW, and McNamara, JO. "Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel." Epilepsy Res Suppl 8 (1992): 181-188. Link to Item
- McNamara, JO, Morrisett, R, and Nadler, JV. "Recent advances in understanding mechanisms of the kindling model." Adv Neurol 57 (1992): 555-560. (Review) Link to Item
- Simonato, M, Hosford, DA, Labiner, DM, Shin, C, Mansbach, HH, and McNamara, JO. "Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy." Brain Res Mol Brain Res 11, no. 2 (September 1991): 115-124. Link to Item
- Bonhaus, DW, Russell, RD, and McNamara, JO. "Activation of substantia nigra pars reticulata neurons: role in the initiation and behavioral expression of kindled seizures." Brain Res 545, no. 1-2 (April 5, 1991): 41-48. Link to Item
- Silver, JM, Shin, C, and McNamara, JO. "Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy." Annals of Neurology 29, no. 4 (April 1991): 356-363. Full Text
- Hosford, DA, Crain, BJ, Cao, Z, Bonhaus, DW, Friedman, AH, Okazaki, MM, Nadler, JV, and McNamara, JO. "Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 11, no. 2 (February 1991): 428-434. Full Text
- Bonhaus, DW, Perry, WB, and McNamara, JO. "Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats." Brain Res 532, no. 1-2 (November 5, 1990): 82-86. Link to Item
- Shin, C, McNamara, JO, Morgan, JI, Curran, T, and Cohen, DR. "Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats." Journal of Neurochemistry 55, no. 3 (September 1990): 1050-1055. Full Text
- Dingledine, R, McBain, CJ, and McNamara, JO. "Excitatory amino acid receptors in epilepsy." Trends in Pharmacological Sciences 11, no. 8 (August 1990): 334-338. (Review) Full Text
- Yeh, GC, Bonhaus, DW, and McNamara, JO. "Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding." Mol Pharmacol 38, no. 1 (July 1990): 14-19. Link to Item
- Chen, LS, Weingart, JB, and McNamara, JO. "Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy." J Pharmacol Exp Ther 253, no. 3 (June 1990): 1272-1277. Link to Item
- Hosford, DA, Bonhaus, DW, and McNamara, JO. "A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain." Brain Research 516, no. 2 (May 1990): 192-200. Full Text
- Morrisett, RA, Chow, CC, Sakaguchi, T, Shin, C, and McNamara, JO. "Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation." J Neurochem 54, no. 5 (May 1990): 1517-1525. Link to Item
- WALCZAK, TS, RADTKE, RA, MCNAMARA, JO, LEWIS, DV, LUTHER, JS, THOMPSON, E, WILSON, WP, FRIEDMAN, AH, and NASHOLD, BS. "ANTERIOR TEMPORAL LOBECTOMY FOR COMPLEX PARTIAL SEIZURES - EVALUATION, RESULTS, AND LONG-TERM FOLLOW-UP IN 100 CASES." NEUROLOGY 40, no. 3 (March 1990): 413-418. Full Text Link to Item
- Walczak, TS, Radtke, RA, McNamara, JO, Lewis, DV, Luther, JS, Thompson, E, Wilson, WP, Friedman, AH, and Nashold, BS. "Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases." Neurology 40, no. 3 Pt 1 (March 1990): 413-418. Link to Item
- Hosford, DA, and McNamara, JO. "Basic mechanisms of the epilepsies." Current Opinion in Neurology and Neurosurgery 3, no. 2 (January 1, 1990): 262-265. (Review)
- McNamara, JO, Yeh, G, Bonhaus, DW, Okazaki, M, and Nadler, JV. "NMDA receptor plasticity in the kindling model." Adv Exp Med Biol 268 (1990): 451-459. (Review) Link to Item
- Nadler, JV, Martin, D, Bowe, MA, Morrisett, RA, and McNamara, JO. "Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA." Adv Exp Med Biol 268 (1990): 407-417. (Review) Link to Item
- Okazaki, MM, McNamara, JO, and Nadler, JV. "Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling." Neuroscience 37, no. 1 (January 1990): 135-142. Full Text
- Walczak, TS, Radtke, RA, McNamara, JO, Lewis, DV, Luther, JS, Thompson, E, Wilson, WP, Friedman, AH, and Nashold, BS. "Anterior temporal lobectomy for complex partial seizures: Evaluation, results, and long-term follow-up in 100 cases." Neurology 40, no. 3 (1990): 413-418.
- McNamara, JO, Rigsbee, LC, Butler, LS, and Shin, C. "Intravenous phenytoin is an effective anticonvulsant in the kindling model." Ann Neurol 26, no. 5 (November 1989): 675-678. Full Text Link to Item
- Yeh, GC, Bonhaus, DW, Nadler, JV, and McNamara, JO. "N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex." Proceedings of the National Academy of Sciences of the United States of America 86, no. 20 (October 1989): 8157-8160. Full Text
- Morrisett, RA, Chow, C, Nadler, JV, and McNamara, JO. "Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats." Brain Res 496, no. 1-2 (September 4, 1989): 25-28. Link to Item
- Bonhaus, DW, Yeh, GC, Skaryak, L, and McNamara, JO. "Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes." Molecular Pharmacology 36, no. 2 (August 1989): 273-279.
- Chen, LS, Millington, DS, Maltby, DA, and McNamara, JO. "Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures." Neuropharmacology 28, no. 8 (August 1989): 781-786. Full Text
- Okazaki, MM, McNamara, JO, and Nadler, JV. "N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling." Brain Res 482, no. 2 (March 20, 1989): 359-364. Link to Item
- Bonhaus, DW, and McNamara, JO. "TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling." Neurosci Biobehav Rev 13, no. 4 (1989): 261-267. (Review) Link to Item
- DICHTER, MA, MCNAMARA, JO, PORTER, RJ, LEVY, RH, LEPPIK, IE, LEBER, PD, KUPFERBERG, HJ, and HRUBY, VJ. "RESEARCH IN EPILEPTOGENESIS - THE SEARCH FOR TOMORROWS ANTIEPILEPTIC DRUGS - PANEL DISCUSSION." EPILEPSIA 30 (1989): S64-S68. Link to Item
- Mattson, RH, Cramer, JA, McCutchen, CB, Browne, TR, Collins, JF, Crill, WE, Delgrado-Escueta, AV, Homan, RW, Lubozynski, MF, Mayerdorf, A, McNamara, JO, Rosenthal, NP, Smith, DB, Treiman, DM, and Williamson, PD. "Barbiturate-related connective tissue disorders." Archives of Internal Medicine 149, no. 4 (1989): 911-914.
- McNamara, JO, Bonhaus, DW, and Nadler, JV. "Novel approach to studying N‐methyl‐D‐aspartate receptor function in the kindling model of epilepsy." Drug Development Research 17, no. 4 (January 1, 1989): 321-330. Full Text
- McNamara, JO. "Development of new pharmacological agents for epilepsy: lessons from the kindling model." Epilepsia 30 Suppl 1 (1989): S13-S18. Link to Item
- Mikati, MA, Browne, TR, Collins, JF, Cramer, J, Crill, WE, Delgado-Escueta, AV, Homan, RW, Lubozynski, MF, Mattson, RH, Mayersdorf, A, McCutchen, CB, McNamara, JO, Rosenthal, P, Smith, DB, Treiman, DM, and Williamson, PD. "Time course of carbamazepine autoinduction." Neurology 39, no. 4 (January 1, 1989): 592-594.
- Traynelis, SF, Dingledine, R, McNamara, JO, Butler, L, and Rigsbee, L. "Effect of kindling on potassium-induced electrographic seizures in vitro." Neuroscience Letters 105, no. 3 (1989): 326-332.
- Hosford, DA, and McNamara, JO. "Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats." Brain Research 462, no. 2 (October 1988): 205-210. Full Text
- Bonhaus, DW, and McNamara, JO. "N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis." Molecular Pharmacology 34, no. 3 (September 1988): 250-255.
- Hosford, DA, Bonhaus, DW, and McNamara, JO. "Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus." European Journal of Pharmacology 151, no. 3 (July 1988): 501-503. Full Text
- Bragdon, AC, Taylor, DM, McNamara, JO, and Wilson, WA. "Abnormal hyperexcitability of hippocampal slices from kindled rats is transient." Brain Res 453, no. 1-2 (June 21, 1988): 257-264. Link to Item
- McNamara, JO, Russell, RD, Rigsbee, L, and Bonhaus, DW. "Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models." Neuropharmacology 27, no. 6 (June 1988): 563-568. Full Text
- Bonhaus, DW, and McNamara, JO. "Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission." Brain Research 438, no. 1-2 (January 1988): 391-394. Full Text
- McNamara, JO. "Pursuit of the mechanisms of kindling." Trends in Neurosciences 11, no. 1 (January 1988): 33-36. (Review) Full Text
- King, PH, Shin, C, Mansbach, HH, Chen, LS, and McNamara, JO. "Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold." Brain Res 423, no. 1-2 (October 13, 1987): 261-268. Link to Item
- Bonhaus, DW, Burge, BC, and McNamara, JO. "Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel." European Journal of Pharmacology 142, no. 3 (October 1987): 489-490. Full Text
- Homan, RW, and Miller, B. "Causes of treatment failure with antiepileptic drugs vary over time." Neurology 37, no. 10 (October 1987): 1620-1623. Full Text
- Gellman, RL, Kallianos, JA, and McNamara, JO. "Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development." The Journal of Pharmacology and Experimental Therapeutics 241, no. 3 (June 1987): 891-898.
- Bonhaus, DW, Rigsbee, LC, and McNamara, JO. "Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism." Brain Research 405, no. 2 (1987): 358-363.
- Bonhaus, DW, and McNamara, JO. "Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge." Brain Research 407, no. 1 (1987): 102-109.
- Crain, BJ, Chang, K-J, and McNamara, JO. "An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats." Brain Research 412, no. 2 (1987): 343-351.
- Platt, K, Butler, LS, Bonhaus, DW, and McNamara, JO. "Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol." Journal of Pharmacology and Experimental Therapeutics 241, no. 3 (1987): 751-754.
- Shin, C, Scialabba, FA, and McNamara, JO. "Stimulation of substantia nigra pars reticulata enhances dentate granule cell excitability." Brain Research 411, no. 1 (1987): 21-27.
- Shin, C, Silver, JM, Bonhaus, DW, and McNamara, JO. "The role of substantia nigra in the development of kindling: pharmacologic and lesion studies." Brain Research 412, no. 2 (1987): 311-317.
- Bonhaus, DW, Walters, JR, and McNamara, JO. "Activation of substantia nigra neurons: role in the propagation of seizures in kindled rats." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 6, no. 10 (October 1986): 3024-3030. Full Text
- Frush, DP, Giacchino, JL, and McNamara, JO. "Evidence implicating dentate granule cells in development of entorhinal kindling." Exp Neurol 92, no. 1 (April 1986): 92-101. Link to Item
- Frush, DP, and McNamara, JO. "Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex." Exp Neurol 92, no. 1 (April 1986): 102-113. Link to Item
- Crain, BJ, Chang, K-J, and McNamara, JO. "Quantitative autoradiographic analysis of mu and delta opioid binding sites in the rat hippocampal formation." Journal of Comparative Neurology 246, no. 2 (1986): 170-180.
- Fanelli, RJ, and McNamara, JO. "Effects of age on kindling and kindled seizure-induced increase of benzodiazepine receptor binding." Brain Research 362, no. 1 (January 1986): 17-22. Full Text
- Iadarola, MJ, Shin, C, McNamara, JO, and Yang, H-YT. "Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling." Brain Research 365, no. 1 (1986): 185-191.
- McNamara, JO, Bonhaus, DW, and Shin, C. "Role of the substantia nigra in the kindling model of limbic epilepsy." Advances in Experimental Medicine and Biology 203 (1986): 139-146.
- McNamara, JO. "Kindling model of epilepsy." Advances in neurology 44 (1986): 303-318.
- Shin, C, Rigsbee, LC, and McNamara, JO. "Anti-seizure and anti-epileptogenic effect of γ-vinyl γ-aminobutyric acid in amygdaloid kindling." Brain Research 398, no. 2 (1986): 370-374.
- Silver, JM, Bonhaus, DW, and McNamara, JO. "Method of lesioning brainstem determines seizure probability." Journal of Neuroscience Methods 17, no. 4 (1986): 303-310.
- Somjen, GG, Aitken, PG, Giacchino, JL, and McNamara, JO. "Interstitial ion concentrations and paroxysmal discharges in hippocampal formation and spinal cord." Adv Neurol 44 (1986): 663-680. (Review) Link to Item
- Shin, C, Pedersen, HB, and McNamara, JO. "γ-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: A quantitative radiohistochemical study." Journal of Neuroscience 5, no. 10 (December 1, 1985): 2696-2701.
- King, GL, Dingledine, R, Giacchino, JL, and McNamara, JO. "Abnormal neuronal excitability in hippocampal slices from kindled rats." Journal of Neurophysiology 54, no. 5 (November 1985): 1295-1304. Full Text
- Shin, C, Pedersen, HB, and McNamara, JO. "gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 5, no. 10 (October 1985): 2696-2701. Full Text
- Mattson, RH, Cramer, JA, Collins, JF, Smith, DB, Delgado-Escueta, AV, Browne, TR, Williamson, PD, Treiman, DM, McNamara, JO, and McCutchen, CB. "Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures." The New England Journal of Medicine 313, no. 3 (July 1985): 145-151. Full Text
- Somjen, GG, Aitken, PG, Giacchino, JL, and McNamara, JO. "Sustained potential shifts and paroxysmal discharges in hippocampal formation." Journal of Neurophysiology 53, no. 4 (April 1985): 1079-1097. Full Text
- Savage, DD, Rigsbee, LC, and McNamara, JO. "Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 5, no. 2 (February 1985): 408-413. Full Text
- Crain, BJ, Valdes, F, Chang, K-J, and McNamara, JO. "Autoradiographic localization of benzomorphan binding sites in rat brain." European Journal of Pharmacology 113, no. 2 (1985): 179-186.
- Iadarola, MJ, Fanelli, RJ, McNamara, JO, and Wilson, WA. "Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding." The Journal of Pharmacology and Experimental Therapeutics 232, no. 1 (January 1985): 127-133.
- MCNAMARA, JO, PIERCE, L, and SLATER, D. "INTERMITTENT CLAUDICATION DUE TO CAUDA-EQUINA COMPRESSION." NORTH CAROLINA MEDICAL JOURNAL 46, no. 7 (1985): 398-398. Link to Item
- McNamara, JO, Bonhaus, DW, Shin, C, Crain, BJ, Gellman, RL, and Giacchino, JL. "The kindling model of epilepsy: a critical review." Crc Critical Reviews in Clinical Neurobiology 1, no. 4 (January 1985): 341-391. (Review)
- Giacchino, JL, Somjen, GG, Frush, DP, and McNamara, JO. "Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse." Exp Neurol 86, no. 3 (December 1984): 483-492. Link to Item
- Savage, DD, Nadler, JV, and McNamara, JO. "Reduced kainic acid binding in rat hippocampal formation after limbic kindling." Brain Research 323, no. 1 (December 1984): 128-131. Full Text
- McNamara, JO, Galloway, MT, Rigsbee, LC, and Shin, C. "Evidence implicating substantia nigra in regulation of kindled seizure threshold." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 4, no. 9 (September 1984): 2410-2417. Full Text
- McNamara, JO. "Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy." Federation Proceedings 43, no. 10 (July 1984): 2516-2520.
- Savage, DD, Werling, LL, Nadler, JV, and McNamara, JO. "Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling." Brain Research 307, no. 1-2 (July 1984): 332-335. Full Text
- McNamara, JO. "Kindling: an animal model of complex partial epilepsy." Annals of Neurology 16 Suppl (January 1984): S72-S76. Full Text
- Savage, DD, Dasheiff, RM, and McNamara, JO. "Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells." The Journal of Comparative Neurology 221, no. 1 (November 1983): 106-112. Full Text
- Fanelli, RJ, and McNamara, JO. "Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA)." The Journal of Pharmacology and Experimental Therapeutics 226, no. 1 (July 1983): 147-150.
- Crain, BJ, Chang, K, McNamara, JO, and Graham, DG. "83 OPIOID RECEPTORS IN HIPPOCAMPAL FORMATION IN THE KINDLING MODEL OF TEMPORAL LOBE EPILEPSY." Journal of Neuropathology and Experimental Neurology 42, no. 3 (May 1983): 332-332. Full Text
- CRAMER, JA, SMITH, DB, MATTSON, RH, ESCUETA, AVD, COLLINS, JF, BROWNE, TR, CRILL, WE, HOMAN, RW, MAYERSDORF, A, MCCUTCHEN, CB, MCNAMARA, JO, ROSENTHAL, NP, TREIMAN, DM, WILDER, BJ, and WILLIAMSON, PD. "A METHOD OF QUANTIFICATION FOR THE EVALUATION OF ANTI-EPILEPTIC DRUG-THERAPY." NEUROLOGY 33, no. 3 (1983): 26-37. Full Text Link to Item
- Cramer, JA, Smith, DB, Mattson, RH, Escueta, AVD, Collins, JF, Browne, TR, Crill, WE, Homan, RW, Mayersdorf, A, McCutchen, CB, McNamara, JO, Rosenthal, NP, Treiman, DM, Wilder, BJ, and Williamson, PD. "A method of quantification for the evaluation of antiepileptic drug therapy." Neurology 33, no. 3 (January 1, 1983): 26-37.
- Kraus, VMB, Dasheiff, RM, Fanelli, RJ, and McNamara, JO. "Benzodiazepine receptor declines in hippocampal formation following limbic seizures." Brain Research 277, no. 2 (1983): 305-309.
- MATTSON, RH, CRAMER, JA, ESCUETA, AVD, SMITH, DB, COLLINS, JF, BROWNE, TR, CRILL, WE, HOMAN, RW, MAYERSDORF, A, MCCUTCHEN, CB, MCNAMARA, JO, ROSENTHAL, NP, TREIMAN, DM, WILDER, BJ, WILLIAMSON, PD, and YOUNG, LM. "A DESIGN FOR THE PROSPECTIVE EVALUATION OF THE EFFICACY AND TOXICITY OF ANTI-EPILEPTIC DRUGS IN ADULTS." NEUROLOGY 33, no. 3 (1983): 14-25. Full Text Link to Item
- Mattson, RH, Cramer, JA, Escueta, AVD, Smith, DB, Collins, JF, Browne, TR, Crill, WE, Homan, RW, Mayersdorf, A, McCutchen, CB, McNamara, JO, Rosenthal, NP, Treiman, DM, Wilder, BJ, Williamson, PD, and Young, LM. "A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults." Neurology 33, no. 3 (January 1, 1983): 14-25.
- McNamara, JO, Rigsbee, LC, and Galloway, MT. "Evidence that Substantia Nigra is crucial to neural network of kindled seizures." European Journal of Pharmacology 86, no. 3-4 (January 1983): 485-486. Full Text
- Savage, DD, Werling, LL, Nadler, JV, and McNamara, JO. "Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling." European Journal of Pharmacology 85, no. 2 (November 1982): 255-256. Full Text
- Savage, DD, and McNamara, JO. "Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus." The Journal of Pharmacology and Experimental Therapeutics 222, no. 3 (September 1982): 670-673.
- Dasheiff, RM, Savage, DD, and McNamara, JO. "Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation." Brain Research 235, no. 2 (1982): 327-334. Full Text
- Dasheiff, RM, and McNamara, JO. "Electrolytic entorhinal lesions cause seizures." Brain Research 231, no. 2 (1982): 444-450. Full Text
- Dasheiff, RM, and McNamara, JO. "Intradentate colchicine retards the development of amygdala kindling." Annals of Neurology 11, no. 4 (1982): 347-352.
- Luther, JS, McNamara, JO, Carwile, S, Miller, P, and Hope, V. "Pseudoepileptic seizures: Methods and video analysis to aid diagnosis." Annals of Neurology 12, no. 5 (1982): 458-462. Full Text
- VALDES, F, DASHEIFF, RM, BIRMINGHAM, F, CRUTCHER, KA, and MCNAMARA, JO. "BENZODIAZEPINE RECEPTOR INCREASES AFTER REPEATED SEIZURES - EVIDENCE FOR LOCALIZATION TO DENTATE GRANULE CELLS." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79, no. 1 (1982): 193-197. Full Text Link to Item
- Valdes, F, Fanelli, RJ, and McNamara, JO. "Barbiturate and GABA receptors coupled to benzodiazepine receptors in rat hippocampal formation: a radiohistochemical study." Life Sciences 29, no. 18 (November 1981): 1895-1900. Full Text
- Dasheiff, RM, Byrne, MC, Patrone, V, and McNamara, JO. "Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures." Brain Research 206, no. 1 (1981): 233-238. Full Text
- Dasheiff, RM, and McNamara, JO. "Cellular localization of muscarinic cholinergic receptors in the dentate gyrus of hippocampal formation." Epilepsia 22, no. 2 (January 1, 1981): 225-226.
- McNamara, JO. "Epilepsy." Proceedings, the annual meeting of the Medical Section of the American Council of Life Insurance (1981): 141-151.
- PRITCHETT, ELC, MCNAMARA, JO, and GALLAGHER, JJ. "DETECTION AND MECHANISMS OF ARRHYTHMOGENIC EPILEPSY - REPLY." AMERICAN HEART JOURNAL 101, no. 6 (1981): 864-864. Full Text Link to Item
- Pritchett, ELC, McNamara, JO, and Gallagher, JJ. "Reply." American Heart Journal 101, no. 6 (January 1, 1981): 864-null. (Letter) Full Text
- Byrne, MC, Gottlieb, R, and McNamara, JO. "Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system." Experimental Neurology 69, no. 1 (1980): 85-98.
- Dasheiff, RM, and McNamara, JO. "Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling." Brain Research 195, no. 2 (1980): 345-353. Full Text
- Dasheiff, RM, and McNamara, JO. "Evidence for an agonist-independent decline of hippocampal muscarinic receptors in kindling." Neurology 30, no. 4 (1980): E-4.
- MCNAMARA, JO, PEPER, AM, and PATRONE, V. "REPEATED SEIZURES INDUCE LONG-TERM INCREASE IN HIPPOCAMPAL BENZODIAZEPINE RECEPTORS." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77, no. 5 (1980): 3029-3032. Full Text Link to Item
- McNamara, JO, Byrne, MC, Dasheiff, RM, and Fitz, JG. "The kindling model of epilepsy: A review." Progress in Neurobiology 15, no. 2 (1980): 139-159.
- McNamara, JO, Carwile, S, Hope, V, Luther, J, and Miller, P. "Effects of oral choline on human complex partial seizures." Neurology 30, no. 12 (1980): 1334-1336.
- McNamara, JO, Peper, A, and Patrone, V. "Repeated seizures induce increased numbers of hippocampal benzodiazepine receptors." Neurology 30, no. 4 (January 1, 1980).
- McNamara, JO, Peper, AM, and Patrone, V. "Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors." Proceedings of the National Academy of Sciences of the United States of America 77, no. 5 I (January 1, 1980): 3029-3032. Full Text
- McNamara, JO. "Complex neuronal systems: approach to development of new strategies in the treatment of epilepsy." Advances in neurology 27 (1980): 185-197.
- Pritchett, ELC, McNamara, JO, and Gallagher, JJ. "Arrhythmogenic epilepsy: An hypothesis." American Heart Journal 100, no. 5 (1980): 683-688.
- Fitz, JG, and McNamara, JO. "Muscarinic cholinergic regulation of epileptic spiking in kindling." Brain Research 178, no. 1 (December 1979): 117-127. Full Text
- Fitz, JG, and McNamara, JO. "Spontaneous interictal spiking in the awake kindled rat." Electroencephalography and Clinical Neurophysiology 47, no. 5 (1979): 592-596.
- McNamara, JO. "Human hypoxia and seizures: effects and interactions." Advances in neurology 26 (1979): 137-143.
- Mc Namara, JO. "Muscarinic cholinergic receptors participate in the kindling model of epilepsy." Neurology 28, no. 4 (January 1, 1978): 346-null.
- McNamara, JO. "Muscarinic cholinergic receptors participate in the kindling model of epilepsy." Brain Research 154, no. 2 (1978): 415-420. Full Text
- McNamara, JO. "Selective alterations of regional β-adrenergic receptor binding in the kindling model of epilepsy." Experimental Neurology 61, no. 3 (1978): 582-591.
- McNamara, JO, Heyman, A, Silver, D, and Mandel, ME. "The value of carotid endarterectomy in treating transient cerebral ischemia of the posterior circulation." Neurology 27, no. 7 (1977): 682-684.
- McNamara, JO, and Appel, SH. "Biochemical approaches to dementia." Contemporary neurology series 15 (1977): 155-168.
- McNamara, JO, and Appel, SH. "Myelin basic protein phosphatase activity in rat brain." Journal of Neurochemistry 29, no. 1 (1977): 27-35.
- McNamara, JO, and Toomim, C. "Receptor binding studies in kindling." Neurology 27, no. 4 (January 1, 1977): 374-null.
- Headington, JT, McNamara, JO, and Brownell, AK. "Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases." Archives of Pathology and Laboratory Medicine 99, no. 1 (1975): 16-24.
- McNamara, JO, Curran, JR, and Itabashi, HH. "Congenital ichthyosis with spastic paraplegia of adult onset." Archives of Neurology 32, no. 10 (1975): 699-701.
- Conomy, JP, and McNamara, JO. "Emergency management of the patient with seizures. 1. Generalized status epilepticus." Postgraduate medicine 55, no. 2 (February 1974): 71-74. Full Text
- Conomy, JP, and McNamara, JO. "Emergency management of the patient with seizures. 1. Classification and treatment system, common seizure disorders." Postgraduate medicine 55, no. 2 (February 1974): 59-66. Full Text
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Book Sections
- Kraus, JE, and McNamara, JO. "Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy." In The Cortical Neuron. March 22, 2012. Full Text
- Decoster, MA, McNamara, J, Cotton, K, Green, D, Jeyasankar, C, Idowu, R, Evans, K, Xing, Q, and Lvov, Y. "Bionanocomposites for multidimensional brain cell signaling." In Natural Polymers, Biopolymers, Biomaterials, and Their Composites, Blends, and IPNs, 91-98. January 1, 2012. Full Text
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Conference Papers
- Danzer, SC, He, XP, and McNamara, JO. "Dynamic regulation of hippocampal excitatory and feedforward inhibitory pathways during epileptogenesis." 2005. Link to Item
- McNamara, JO, He, X-P, and Kotloski, R. "Conditional deletion of TRKB prevents epileptogenesis in the kindling model." 2005. Link to Item
- Danzer, SC, Hughes, M, Kotloski, RJ, Nef, S, Parada, LF, and McNamara, JO. "Reducing TrkB levels protects hippocampal neurons from seizure-induced cell death." 2004. Link to Item
- McNamara, JO, Newton, SS, and Scharfmann, HE. "Neurotrophins and epileptogenesis." 2004. Link to Item
- Barnes, GN, Luo, Y, Ebens, A, and McNamara, JO. "Anatomical and temporal specific patterns of semaphorin gene expression in a rat model of limbic epileptogenesis." 1999. Link to Item
- Bausch, SB, and McNamara, JO. "CA1 pyramidal cells may form recurrent excitatory synapses in kainic acid-treated hippocampus." 1999. Link to Item
- Binder, DK, and McNamara, JO. "Kindling: A pathologic activity-driven structural and functional plasticity in mature brain." 1998. Link to Item
- ANDREWS, PI, LEWIS, DV, and MCNAMARA, JO. "CLINICAL AND ELECTROENCEPHALOGRAPHIC EVIDENCE FOR EPILEPTOGENIC AUTOANTIBODIES IN RASMUSSENS ENCEPHALITIS (RE)." 1995. Link to Item
- BUTLER, LS, SILVA, AJ, WATANABE, Y, TONEGAWA, S, and MCNAMARA, JO. "LIMBIC EPILEPSY IN ALPHA-CALCIUM-CALMODULIN KINASE-II MUTANT MICE." 1995. Link to Item
- JAIN, S, DIXIT, SN, ANDREWS, PI, RADTKE, R, MAHESHWARI, MC, and MCNAMARA, JO. "DISEASE EXPRESSION AMONG PROBANDS WITH JUVENILE MYOCLINIC EPILEPSY AND THEIR FAMILY MEMBERS IN 2 POPULATION GROUPS." 1995. Link to Item
- MCNAMARA, JO, and ANDREWS, PI. "AUTOIMMUNE EPILEPSY - ASPECTS OF THE PATHOGENESIS OF RASMUSSENS ENCEPHALITIS." 1995. Link to Item
- MCNAMARA, JO. "MOLECULAR-GENETIC ADVANCES - IMPLICATION FOR THERAPY OF EPILEPSY." 1995. Link to Item
- MCNAMARA, JO. "MECHANISMS OF THE KINDLING MODEL." 1988. Link to Item
- MORRISETT, RA, CHOW, CC, NADLER, JV, and MCNAMARA, JO. "BIOCHEMICAL-EVIDENCE OF INCREASED NMDA RECEPTOR FUNCTION IN THE HIPPOCAMPUS OF KINDLED ANIMALS." 1988. Link to Item
- RADTKE, RA, HEINZ, ER, CRAIN, BJ, LEWIS, DV, MCNAMARA, JO, and FRIEDMAN, AH. "MAGNETIC-RESONANCE IMAGING - PATHOLOGIC CORRELATION AFTER TEMPORAL LOBECTOMY." 1988. Link to Item
- WALCZAK, TS, RADTKE, R, LEWIS, D, MCNAMARA, JO, and FRIEDMAN, A. "EEG PREDICTORS OF SUCCESS IN TEMPORAL LOBECTOMY - ANALYSIS OF 100 CASES." 1988. Link to Item
- MCNAMARA, JO. "THE KINDLING MODEL OF EPILEPSY." 1987. Link to Item
- WALCZAK, TS, RADTKE, RA, LEWIS, DV, MCNAMARA, JO, THOMPSON, E, FRIEDMAN, AH, and NASHOLD, BS. "FACTORS PREDICTING SUCCESS IN TEMPORAL LOBECTOMY FOR COMPLEX PARTIAL SEIZURES." 1987. Link to Item
- MCNAMARA, JO. "ANTIEPILEPTIC DRUG ACTIONS IN EXPERIMENTAL-ANIMALS AND HUMANS." 1986. Link to Item
- PLATT, K, BONHAUS, D, BUTLER, L, and MCNAMARA, JO. "SUBSTANTIA-NIGRA CONTROL OF SEIZURE PROPAGATION - ROLE OF NORADRENERGIC NEURONS." 1986. Link to Item
- RADTKE, RA, MCNAMARA, JO, LEWIS, DV, and HEINZ, ER. "USEFULNESS OF MAGNETIC-RESONANCE-IMAGING IN PRESURGICAL EVALUATION OF INTRACTABLE COMPLEX PARTIAL SEIZURES." 1986. Link to Item
- BONHAUS, DW, WALTERS, JR, and MCNAMARA, JO. "EVIDENCE IMPLICATING THE SUBSTANTIA NIGRA IN PROPAGATION OF LIMBIC SEIZURES - LESSONS FROM THE KINDLING MODEL." 1985. Link to Item
- BONHAUS, DW, WALTERS, JR, and MCNAMARA, JO. "INVESTIGATION OF MECHANISM BY WHICH SUBSTANTIA NIGRA PROPAGATES LIMBIC SEIZURES." 1985. Link to Item
- BRAGDON, AC, TAYLOR, DM, RIGSBEE, LC, MCNAMARA, JO, and WILSON, WA. "UNILATERAL KINDLING INDUCES A BILATERAL INCREASE IN TEMPORAL, BUT NOT SEPTAL, HIPPOCAMPAL EXCITABILITY." 1985. Link to Item
- DASHEIFF, RM, and MCNAMARA, JO. "LIMBIC SEIZURES DOWN-REGULATE MUSCARINIC CHOLINERGIC RECEPTORS IN HIPPOCAMPAL-FORMATION." 1983. Link to Item
- VALDES, F, DASHEIFF, RM, BIRMINGHAM, F, CRUTCHER, K, and MCNAMARA, JO. "BENZODIAZEPINE RECEPTOR INCREASES FOLLOWING REPEATED SEIZURES - EVIDENCE FOR LOCALIZATION TO DENTATE GRANULE CELLS." 1983. Link to Item
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