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Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.

Publication ,  Journal Article
Goode, AP; Cleveland, RJ; Schwartz, TA; Nelson, AE; Kraus, VB; Hillstrom, HJ; Hannan, MT; Flowers, P; Renner, JB; Jordan, JM; Golightly, YM
Published in: BMC Musculoskelet Disord
April 9, 2019

BACKGROUND: Chronic low back pain (cLBP) affects millions of Americans and costs billions. Studies suggest a link between cLBP and joint hypermobility. METHODS: We conducted cross-sectional primary analyses of joint hypermobility and cLBP, lumbar spine osteoarthritis (OA), and lumbar facet joint OA (FOA) in 3 large studies-the Generalized Osteoarthritis Study, Genetics of Generalized Osteoarthritis Study, and Johnston County Osteoarthritis Project (total n = 5072). Associations of joint hypermobility and Beighton trunk flexion with cLBP and lumbar OA were estimated using separate adjusted logistic regression models. Adjusted pooled odds ratios (pORs) and 95% confidence intervals (CIs) were then summarized-using random effect univariate, multivariate crude, and adjusted models-and heterogeneity was determined (I2 statistic). RESULTS: In univariate models, hypermobility was associated with symptomatic FOA (pOR = 0.64 [95% CI 0.44, 0.93]) but this result was not found in the multivariate models. In multivariate adjusted models, hypermobility was not significantly associated with cLBP and lumbar OA, but trunk flexion was inversely associated with cLBP (pOR = 0.40 [95% 0.26, 0.62]), spine OA (pOR = 0.66 [95% CI 0.50, 0.87]), symptomatic spine OA (pOR = 0.39 [95% CI 0.28, 0.53]), and symptomatic FOA (pOR = 0.53 [95% CI 0.37, 0.77]). Generally, between-study heterogeneity was moderate-high. CONCLUSIONS: Hypermobility was not associated with cLBP or lumbar OA. The inverse association of trunk flexion with cLBP and lumbar OA may indicate a role for a flexible spine in avoiding or managing these conditions.

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Published In

BMC Musculoskelet Disord

DOI

EISSN

1471-2474

Publication Date

April 9, 2019

Volume

20

Issue

1

Start / End Page

158

Location

England

Related Subject Headings

  • Osteoarthritis, Spine
  • Orthopedics
  • Middle Aged
  • Male
  • Lumbar Vertebrae
  • Low Back Pain
  • Longitudinal Studies
  • Joint Instability
  • Humans
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Goode, A. P., Cleveland, R. J., Schwartz, T. A., Nelson, A. E., Kraus, V. B., Hillstrom, H. J., … Golightly, Y. M. (2019). Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis. BMC Musculoskelet Disord, 20(1), 158. https://doi.org/10.1186/s12891-019-2523-2
Goode, Adam P., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.BMC Musculoskelet Disord 20, no. 1 (April 9, 2019): 158. https://doi.org/10.1186/s12891-019-2523-2.
Goode AP, Cleveland RJ, Schwartz TA, Nelson AE, Kraus VB, Hillstrom HJ, et al. Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis. BMC Musculoskelet Disord. 2019 Apr 9;20(1):158.
Goode, Adam P., et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.BMC Musculoskelet Disord, vol. 20, no. 1, Apr. 2019, p. 158. Pubmed, doi:10.1186/s12891-019-2523-2.
Goode AP, Cleveland RJ, Schwartz TA, Nelson AE, Kraus VB, Hillstrom HJ, Hannan MT, Flowers P, Renner JB, Jordan JM, Golightly YM. Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis. BMC Musculoskelet Disord. 2019 Apr 9;20(1):158.
Journal cover image

Published In

BMC Musculoskelet Disord

DOI

EISSN

1471-2474

Publication Date

April 9, 2019

Volume

20

Issue

1

Start / End Page

158

Location

England

Related Subject Headings

  • Osteoarthritis, Spine
  • Orthopedics
  • Middle Aged
  • Male
  • Lumbar Vertebrae
  • Low Back Pain
  • Longitudinal Studies
  • Joint Instability
  • Humans
  • Female