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Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation.

Publication ,  Journal Article
Stabler, T; Piette, J-C; Chevalier, X; Marini-Portugal, A; Kraus, VB
Published in: Arthritis Rheum
November 2004

OBJECTIVE: There is evidence that autoimmunity plays a significant role in the pathogenesis of relapsing polychondritis (RP). This study was designed to investigate circulating levels of various cytokines in relation to the etiology of this rare disorder, and to compare the pattern of cytokine elevations in RP with that in another autoimmune disease, rheumatoid arthritis (RA). METHODS: Serum from 22 patients with active RP and an equal number of age- and sex-matched healthy controls and RA patients were available for analysis. The following cytokines were measured: interleukin-1beta (IL-1beta), IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-gamma (IFNgamma), tumor necrosis factor alpha, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1beta (MIP-1beta). Results were analyzed by nonparametric Mann-Whitney test with Holm stepdown adjustment for multiple testing. RESULTS: The levels of 3 of these cytokines showed significant differences between RP patients and controls. Compared with controls, mean serum levels of MCP-1, MIP-1beta, and IL-8 were all much higher in patients with active RP. In contrast, RA patients showed a more general increase in all cytokines measured, with much higher levels of IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-13, IFNgamma, G-CSF, GM-CSF, MCP-1, and MIP-1beta compared with controls. CONCLUSION: Levels of 3 serum cytokines were significantly higher in RP patients than in age- and sex-matched controls. One of these 3 cytokines, IL-8, was not significantly elevated in RA samples. Overall, in RP, a more discrete group of cytokines exhibited significantly increased levels than was found in RA. Each of the 3 cytokines that were elevated in RP is a proinflammatory chemokine, characteristic of activation of the monocyte and macrophage lineage, and in the case of IL-8, also of neutrophils. These data suggest a major role for a cell-mediated immune response in the pathophysiology of RP.

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 2004

Volume

50

Issue

11

Start / End Page

3663 / 3667

Location

United States

Related Subject Headings

  • Polychondritis, Relapsing
  • Monocytes
  • Middle Aged
  • Male
  • Macrophages
  • Macrophage Inflammatory Proteins
  • Interleukin-8
  • Humans
  • Female
  • Cytokines
 

Citation

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Stabler, T., Piette, J.-C., Chevalier, X., Marini-Portugal, A., & Kraus, V. B. (2004). Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum, 50(11), 3663–3667. https://doi.org/10.1002/art.20613
Stabler, Thomas, Jean-Charles Piette, Xavier Chevalier, Andre Marini-Portugal, and Virginia B. Kraus. “Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation.Arthritis Rheum 50, no. 11 (November 2004): 3663–67. https://doi.org/10.1002/art.20613.
Stabler T, Piette J-C, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 2004 Nov;50(11):3663–7.
Stabler, Thomas, et al. “Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation.Arthritis Rheum, vol. 50, no. 11, Nov. 2004, pp. 3663–67. Pubmed, doi:10.1002/art.20613.
Stabler T, Piette J-C, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 2004 Nov;50(11):3663–3667.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 2004

Volume

50

Issue

11

Start / End Page

3663 / 3667

Location

United States

Related Subject Headings

  • Polychondritis, Relapsing
  • Monocytes
  • Middle Aged
  • Male
  • Macrophages
  • Macrophage Inflammatory Proteins
  • Interleukin-8
  • Humans
  • Female
  • Cytokines