A Neural Circuit for Gut-Induced Reward.

Published

Journal Article

The gut is now recognized as a major regulator of motivational and emotional states. However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical activation of gut-innervating vagal sensory neurons recapitulates the hallmark effects of stimulating brain reward neurons. Specifically, right, but not left, vagal sensory ganglion activation sustained self-stimulation behavior, conditioned both flavor and place preferences, and induced dopamine release from Substantia nigra. Cell-specific transneuronal tracing revealed asymmetric ascending pathways of vagal origin throughout the CNS. In particular, transneuronal labeling identified the glutamatergic neurons of the dorsolateral parabrachial region as the obligatory relay linking the right vagal sensory ganglion to dopamine cells in Substantia nigra. Consistently, optical activation of parabrachio-nigral projections replicated the rewarding effects of right vagus excitation. Our findings establish the vagal gut-to-brain axis as an integral component of the neuronal reward pathway. They also suggest novel vagal stimulation approaches to affective disorders.

Full Text

Duke Authors

Cited Authors

  • Han, W; Tellez, LA; Perkins, MH; Perez, IO; Qu, T; Ferreira, J; Ferreira, TL; Quinn, D; Liu, Z-W; Gao, X-B; Kaelberer, MM; Bohórquez, DV; Shammah-Lagnado, SJ; de Lartigue, G; de Araujo, IE

Published Date

  • October 18, 2018

Published In

Volume / Issue

  • 175 / 3

Start / End Page

  • 665 - 678.e23

PubMed ID

  • 30245012

Pubmed Central ID

  • 30245012

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2018.08.049

Language

  • eng

Conference Location

  • United States