TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
Published
Journal Article
T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of these two distinct lineages during viral infection remain unclear. We found that viral-specific TFH and Th1 cells showed reciprocal expression of the transcriptions factors TCF1 and Blimp1 early after infection, even before the differential expression of the canonical TFH marker CXCR5. Furthermore, TCF1 was intrinsically required for the TFH cell response to viral infection; in the absence of TCF1, the TFH cell response was severely compromised, and the remaining TCF1-deficient TFH cells failed to maintain TFH-associated transcriptional and metabolic signatures, which were distinct from those in Th1 cells. Mechanistically, TCF1 functioned through forming negative feedback loops with IL-2 and Blimp1. Our findings demonstrate an essential role of TCF1 in TFH cell responses to viral infection.
Full Text
Duke Authors
Cited Authors
- Wu, T; Shin, HM; Moseman, EA; Ji, Y; Huang, B; Harly, C; Sen, JM; Berg, LJ; Gattinoni, L; McGavern, DB; Schwartzberg, PL
Published Date
- September 29, 2015
Published In
Volume / Issue
- 12 / 12
Start / End Page
- 2099 - 2110
PubMed ID
- 26365183
Pubmed Central ID
- 26365183
Electronic International Standard Serial Number (EISSN)
- 2211-1247
Digital Object Identifier (DOI)
- 10.1016/j.celrep.2015.08.049
Language
- eng
Conference Location
- United States