Skip to main content
Journal cover image

B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.

Publication ,  Journal Article
Moseman, EA; Iannacone, M; Bosurgi, L; Tonti, E; Chevrier, N; Tumanov, A; Fu, Y-X; Hacohen, N; von Andrian, UH
Published in: Immunity
March 23, 2012

Neutralizing antibodies have been thought to be required for protection against acutely cytopathic viruses, such as the neurotropic vesicular stomatitis virus (VSV). Utilizing mice that possess B cells but lack antibodies, we show here that survival upon subcutaneous (s.c.) VSV challenge was independent of neutralizing antibody production or cell-mediated adaptive immunity. However, B cells were absolutely required to provide lymphotoxin (LT) α1β2, which maintained a protective subcapsular sinus (SCS) macrophage phenotype within virus draining lymph nodes (LNs). Macrophages within the SCS of B cell-deficient LNs, or of mice that lack LTα1β2 selectively in B cells, displayed an aberrant phenotype, failed to replicate VSV, and therefore did not produce type I interferons, which were required to prevent fatal VSV invasion of intranodal nerves. Thus, although B cells are essential for survival during VSV infection, their contribution involves the provision of innate differentiation and maintenance signals to macrophages, rather than adaptive immune mechanisms.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

March 23, 2012

Volume

36

Issue

3

Start / End Page

415 / 426

Location

United States

Related Subject Headings

  • Vesiculovirus
  • Vesicular Stomatitis
  • Signal Transduction
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Macrophages
  • Lymphotoxin alpha1, beta2 Heterotrimer
  • Lymph Nodes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moseman, E. A., Iannacone, M., Bosurgi, L., Tonti, E., Chevrier, N., Tumanov, A., … von Andrian, U. H. (2012). B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity, 36(3), 415–426. https://doi.org/10.1016/j.immuni.2012.01.013
Moseman, E Ashley, Matteo Iannacone, Lidia Bosurgi, Elena Tonti, Nicolas Chevrier, Alexei Tumanov, Yang-Xin Fu, Nir Hacohen, and Ulrich H. von Andrian. “B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.Immunity 36, no. 3 (March 23, 2012): 415–26. https://doi.org/10.1016/j.immuni.2012.01.013.
Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, et al. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23;36(3):415–26.
Moseman, E. Ashley, et al. “B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.Immunity, vol. 36, no. 3, Mar. 2012, pp. 415–26. Pubmed, doi:10.1016/j.immuni.2012.01.013.
Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23;36(3):415–426.
Journal cover image

Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

March 23, 2012

Volume

36

Issue

3

Start / End Page

415 / 426

Location

United States

Related Subject Headings

  • Vesiculovirus
  • Vesicular Stomatitis
  • Signal Transduction
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Macrophages
  • Lymphotoxin alpha1, beta2 Heterotrimer
  • Lymph Nodes