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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.

Publication ,  Journal Article
Junt, T; Moseman, EA; Iannacone, M; Massberg, S; Lang, PA; Boes, M; Fink, K; Henrickson, SE; Shayakhmetov, DM; Di Paolo, NC; van Rooijen, N ...
Published in: Nature
November 1, 2007

Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers. They are also the staging ground of adaptive immune responses to pathogen-derived antigens. It is unclear how virus particles are cleared from afferent lymph and presented to cognate B cells to induce antibody responses. Here we identify a population of CD11b+CD169+MHCII+ macrophages on the floor of the subcapsular sinus (SCS) and in the medulla of lymph nodes that capture viral particles within minutes after subcutaneous injection. Macrophages in the SCS translocated surface-bound viral particles across the SCS floor and presented them to migrating B cells in the underlying follicles. Selective depletion of these macrophages compromised local viral retention, exacerbated viraemia of the host, and impaired local B-cell activation. These findings indicate that CD169+ macrophages have a dual physiological function. They act as innate 'flypaper' by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph-tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

November 1, 2007

Volume

450

Issue

7166

Start / End Page

110 / 114

Location

England

Related Subject Headings

  • Vesiculovirus
  • Sialic Acid Binding Ig-like Lectin 1
  • Receptors, Immunologic
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins
  • Macrophages
  • Lymph Nodes
  • Lymph
  • General Science & Technology
 

Citation

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Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., … von Andrian, U. H. (2007). Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 450(7166), 110–114. https://doi.org/10.1038/nature06287
Junt, Tobias, E Ashley Moseman, Matteo Iannacone, Steffen Massberg, Philipp A. Lang, Marianne Boes, Katja Fink, et al. “Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.Nature 450, no. 7166 (November 1, 2007): 110–14. https://doi.org/10.1038/nature06287.
Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1;450(7166):110–4.
Junt, Tobias, et al. “Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.Nature, vol. 450, no. 7166, Nov. 2007, pp. 110–14. Pubmed, doi:10.1038/nature06287.
Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1;450(7166):110–114.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

November 1, 2007

Volume

450

Issue

7166

Start / End Page

110 / 114

Location

England

Related Subject Headings

  • Vesiculovirus
  • Sialic Acid Binding Ig-like Lectin 1
  • Receptors, Immunologic
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins
  • Macrophages
  • Lymph Nodes
  • Lymph
  • General Science & Technology