Computing the ankle-brachial index with parallel computational fluid dynamics.

Published

Journal Article

The ankle-brachial index (ABI), a ratio of arterial blood pressure in the ankles and upper arms, is used to diagnose and monitor circulatory conditions such as coarctation of the aorta and peripheral artery disease. Computational simulations of the ABI can potentially determine the parameters that produce an ABI indicative of ischemia or other abnormalities in blood flow. However, 0- and 1-D computational methods are limited in describing a 3-D patient-derived geometry. Thus, we present a massively parallel framework for computational fluid dynamics (CFD) simulations in the full arterial system. Using the lattice Boltzmann method to solve the Navier-Stokes equations, we employ highly parallelized and scalable methods to generate the simulation domain and efficiently distribute the computational load among processors. For the first time, we compute an ABI with 3-D CFD. In this proof-of-concept study, we investigate the dependence of ABI on the presence of stenoses, or narrowed regions of the arteries, by directly modifying the arterial geometry. As a result, our framework enables the computation a hemodynamic factor characterizing flow at the scale of the full arterial system, in a manner that is extensible to patient-specific imaging data and holds potential for treatment planning.

Full Text

Duke Authors

Cited Authors

  • Gounley, J; Draeger, EW; Oppelstrup, T; Krauss, WD; Gunnels, JA; Chaudhury, R; Nair, P; Frakes, D; Leopold, JA; Randles, A

Published Date

  • January 2019

Published In

Volume / Issue

  • 82 /

Start / End Page

  • 28 - 37

PubMed ID

  • 30385003

Pubmed Central ID

  • 30385003

Electronic International Standard Serial Number (EISSN)

  • 1873-2380

International Standard Serial Number (ISSN)

  • 0021-9290

Digital Object Identifier (DOI)

  • 10.1016/j.jbiomech.2018.10.007

Language

  • eng