Amanda Randles
Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences
My research in biomedical simulation and high performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
Current Appointments & Affiliations
- Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences, Biomedical Engineering, Pratt School of Engineering 2018 - 2025
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2015
- Assistant Professor of Computer Science, Computer Science, Trinity College of Arts & Sciences 2016
- Assistant Professor of Mathematics, Mathematics, Trinity College of Arts & Sciences 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
Contact Information
- 301 Gross Hall, 140 Science Dr., Durham, NC 27708
- Box 90984, Durham, NC 27708
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amanda.randles@duke.edu
(919) 660-5425
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Google Scholar
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Randles Lab Site
- Background
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Education, Training, & Certifications
- Ph.D., Harvard University 2013
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Duke Appointment History
- Assistant Professor in the Department of Mechanical Engineering and Material Science, Mechanical Engineering and Materials Science, Pratt School of Engineering 2015 - 2018
- Recognition
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In the News
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JUL 6, 2018 Pratt School of Engineering -
NOV 1, 2017 -
SEP 21, 2017 -
MAR 17, 2016 BBC News -
MAR 16, 2016 -
NOV 19, 2015 -
SEP 14, 2015 China Daily -
AUG 31, 2015 -
JUN 5, 2015 Pratt School of Engineering
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Awards & Honors
- IEEE-CS Technical Consortium on High Performance Computing (TCHPC) Award for Excellence for Early Career Researchers in High Performance Computing. IEEE. November 2017
- MIT TR35 Visionary. MIT TR35. 2017
- Ralph E. Powe Junior Faculty Enhancement Award. Oak Ridge Associated Universities. May 2016
- Best Paper, IEEE International Conference on Computational Science (ICCS) 2015. IEEE. May 2015
- Gordon Bell Finalist. ACM. 2015
- Early Independence Award. NIH. September 2014
- Lawrence Fellowship. Lawrence Livermore National Laboratory. 2013
- U.S. Delegate . Heidelberg Laureate Forum. 2013
- Anita Borg Memorial Scholarship. Google. 2012
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2012
- U.S. Delegate . Lindau Nobel Laureates and Students Meeting Dedicated to Physics. 2012
- Computational Science Graduate Fellowship. Department of Energy. 2010
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2010
- Gordon Bell Finalist. ACM. 2010
- Graduate Research Fellowship. National Science Foundation. 2009
- Expertise
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Subject Headings
- Aortic Coarctation
- Atherosclerosis
- Biomechanical Phenomena
- Biophysics
- Cancer
- Cancer cells
- Cardiovascular Diseases
- Computational Biology
- Computational fluid dynamics
- Computer Simulation
- Fluid mechanics
- Hemodynamics
- High performance computing
- Lattice Boltzmann methods
- Metastasis
- Multiscale modeling
- Parallel algorithms
- Parallel computers
- Research
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Selected Grants
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- ORNL Joint Faculty Appointment for Amanda Randles awarded by UT-Battelle, LLC 2017 - 2019
- Toward coupled multiphysics models of hemodynamics on leadership systems awarded by National Institutes of Health 2014 - 2019
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2019
- Interactive virtual reality cardiovascular visualizations: User study for clinicians - Harvey Shi award awarded by Sigma Xi 2018 - 2019
- Student Support: IEEE Cluster 2018 Conference awarded by National Science Foundation 2018 - 2019
- Hartwell Fellowship awarded by Hartwell Foundation 2017 - 2018
- Using GPU-Accelerated Computational Fluid Dynamics to Study In-stent Restenosis awarded by Oak Ridge Associated Universities 2016 - 2017
- Publications & Artistic Works
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Selected Publications
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Conference Papers
- Herschlag, G, Lee, S, Vetter, JS, and Randles, A. "GPU data access on complex geometries for D3Q19 lattice boltzmann method." August 3, 2018. Full Text
- Gounley, J, Vardhan, M, and Randles, A. "A computational framework to assess the influence of changes in vascular geometry on blood flow." June 26, 2017. Full Text
- Gounley, J, Draeger, EW, and Randles, A. "Numerical simulation of a compound capsule in a constricted microchannel." January 2017. Full Text
- Laurence, TA, Ly, S, Fong, E, Shusteff, M, Randles, A, Gounley, J, and Draeger, E. "Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations." January 1, 2017. Full Text
- Gounley, J, Chaudhury, R, Vardhan, M, Driscoll, M, Pathangey, G, Winarta, K, Ryan, J, Frakes, D, and Randles, A. "Does the degree of coarctation of the aorta influence wall shear stress focal heterogeneity?." August 2016. Full Text Open Access Copy
- Randles, A, Draeger, EW, Oppelstrup, T, Krauss, L, and Gunnels, JA. "Massively parallel models of the human circulatory system." November 15, 2015. Full Text
- Kale, V, Randles, A, and Gropp, WD. "Locality-optimized mixed static/dynamic scheduling for improving load balancing on SMPs." September 9, 2014. Full Text
- You, Y, Song, SL, Fu, H, Marquez, A, Dehnavi, MM, Barker, K, Cameron, KW, Randles, AP, and Yang, G. "MIC-SVM: Designing a highly efficient support vector machine for advanced modern multi-core and many-core architectures." January 1, 2014. Full Text
- Randles, AP, Kale, V, Hammond, J, Gropp, W, and Kaxiras, E. "Performance analysis of the lattice Boltzmann model beyond Navier-Stokes." October 7, 2013. Full Text
- Randles, AP, Rand, DG, Lee, C, Morrisett, G, Sircar, J, Nowak, MA, and Pfister, H. "Massively parallel model of extended memory use in evolutionary game dynamics." October 7, 2013. Full Text
- Randles, A, and Zeger, L. "Efficient Resource Allocation for Broadcasting Multi-Slot Messages With Random Access with Capture." IEEE Military Communications Conference. November 7, 2011 - November 10, 2011. Baltimore, MD. IEEE, October 2011. Link to Item
- Randles, A, Melchionna, S, Kaxiras, E, Latt, J, Sircar, J, Bernaschi, M, Bisson, M, and Succi, S. "Multiscale simulation of cardiovascular flows on the IBM Bluegene/P: full heart-circulation system at red-blood cell resolution." ACM/IEEE International Conference for High Performance Computing, Networking, Storage, and Analysis. November 13, 2010 - November 19, 2010. New Orleans, LA. ACM IEEE, November 2010.
- Randles, A. "Parallel Genomic Sequence-Search on a Massively Parallel System." ACM International Conference on Computing Frontiers. May 7, 2007 - May 9, 2007. Ischia, Italy. ACM, May 2007.
- Randles, A, Draeger, EW, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology. September 7, 2014 - September 10, 2014. Cambridge, MA. Link to Item
- Randles, A, King, A, Budnik, T, McCarthy, P, Michaud, P, Mundy, M, Sexton, J, and Stewart, G. "Asynchronous task dispatch for high throughput computing for the eServer IBM Blue Gene Supercomputer." IEEE International Symposium on Parallel and Distributed Processing. April 14, 2008 - April 18, 2008. Miami, FL. Full Text Link to Item
- Randles, A, and Kaxiras, EK. "A Spatio-Temporal Coupling Method to Reduce the Time-to-Solution of Cardiovascular Simulations." International Parallel and Distributed Processing Symposium. May 19, 2014 - May 23, 2014. Full Text Link to Item
- Randles, A. "MIC-SVM: Designing A Highly Efficient Support Vector Machine for Advanced Modern Multi-Core and Many-Core Architectures." IEEE International Parallel and Distributed Processing Symposium. May 19, 2014 - May 23, 2014. Full Text
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Journal Articles
- Gounley, J, Draeger, EW, Oppelstrup, T, Krauss, WD, Gunnels, JA, Chaudhury, R, Nair, P, Frakes, D, Leopold, JA, and Randles, A. "Computing the ankle-brachial index with parallel computational fluid dynamics." Journal of Biomechanics (October 19, 2018). Full Text
- Hegele, LA, Scagliarini, A, Sbragaglia, M, Mattila, KK, Philippi, PC, Puleri, DF, Gounley, J, and Randles, A. "High-Reynolds-number turbulent cavity flow using the lattice Boltzmann method." Physical Review E 98.4 (October 4, 2018). Full Text
- Rafat, M, Stone, HA, Auguste, DT, Dabagh, M, Randles, A, Heller, M, and Rabinov, JD. "Impact of diversity of morphological characteristics and Reynolds number on local hemodynamics in basilar aneurysms." Aiche Journal 64.7 (July 2018): 2792-2802. Full Text
- Gounley, J, Vardhan, M, and Randles, A. "A framework for comparing vascular hemodynamics at different points in time." Computer Physics Communications (June 2018). Full Text
- Randles, A, Frakes, DH, and Leopold, JA. "Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease." Trends in Biotechnology 35.11 (November 2017): 1049-1061. (Review) Full Text
- Dabagh, M, Jalali, P, Butler, PJ, Randles, A, and Tarbell, JM. "Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow." Journal of the Royal Society, Interface 14.130 (May 2017). Full Text
- Randles, A, Draeger, EW, and Bailey, PE. "Massively parallel simulations of hemodynamics in the primary large arteries of the human vasculature." Journal of Computational Science 9 (July 2015): 70-75. Full Text
- Whitley, HD, Scullard, CR, Benedict, LX, Castor, JI, Randles, A, Glosli, JN, Richards, DF, Desjarlais, MP, and Graziani, FR. "Lenard-Balescu Calculations and Classical Molecular Dynamics Simulations of Electrical and Thermal Conductivities of Hydrogen Plasmas." Contributions to Plasma Physics 55.2-3 (February 2015): 192-202. Full Text
- You, Y, Fu, H, Song, SL, Randles, A, Kerbyson, D, Marquez, A, Yang, G, and Hoisie, A. "Scaling Support Vector Machines on modern HPC platforms." Journal of Parallel and Distributed Computing 76 (February 2015): 16-31. Full Text
- Randles, A, and Kaxiras, E. "Parallel in time approximation of the lattice Boltzmann method for laminar flows." Journal of Computational Physics 270 (August 2014): 577-586. Full Text
- Almendro, V, Cheng, Y-K, Randles, A, Itzkovitz, S, Marusyk, A, Ametller, E, Gonzalez-Farre, X, Muñoz, M, Russnes, HG, Helland, A, Rye, IH, Borresen-Dale, A-L, Maruyama, R, van Oudenaarden, A, Dowsett, M, Jones, RL, Reis-Filho, J, Gascon, P, Gönen, M, Michor, F, and Polyak, K. "Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity." Cell Reports 6.3 (February 2014): 514-527. Full Text
- Randles, A, Draeger, E, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology 41.January (January 1, 2014): 217-220.
- You, Y, Fu, H, Song, SL, Randles, A, Kerbyson, D, Marquez, A, Yang, G, and Hoisie, A. "Scaling Support Vector Machines on modern HPC platforms." Journal of Parallel and Distributed Computing (2014). Full Text
- Keyes, DE, McInnes, LC, Woodward, C, Gropp, W, Myra, E, Pernice, M, Bell, J, Brown, J, Clo, A, Connors, J, Constantinescu, E, Estep, D, Evans, K, Farhat, C, Hakim, A, Hammond, G, Hansen, G, Hill, J, Isaac, T, Jiao, X, Jordan, K, Kaushik, D, Kaxiras, E, Koniges, A, Lee, K, Lott, A, Lu, Q, Magerlein, J, Maxwell, R, McCourt, M, Mehl, M, Pawlowski, R, Randles, AP, Reynolds, D, Rivière, B, Rüde, U, Scheibe, T, Shadid, J, Sheehan, B, Shephard, M, Siegel, A, Smith, B, Tang, X, Wilson, C, and Wohlmuth, B. "Multiphysics simulations." The International Journal of High Performance Computing Applications 27.1 (February 2013): 4-83. Full Text
- Randles, A, Baecher, M, Pfister, H, and Kaxiras, E. "A Lattice Boltzmann Simulation of Hemodynamics in a Patient-Specific Aortic Coarctation Model." Ed. O Camara, T Manso, M Pop, K Rhode, M Sermesant, and A Young. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges: Third International Workshop, STACOM 2012, Held in Conjunction with MICCAI 2012, Nice, France, October 5, 2012, Revised Selected Papers (2013): 17-25. Full Text Link to Item
- Randles, AP. "Massively parallel model of evolutionary game dynamics." Proceedings - 2012 SC Companion: High Performance Computing, Networking Storage and Analysis, SCC 2012 (December 1, 2012): 1531-. Full Text
- Randles, A, Baecher, M, Pfister, H, and Kaxiras, EK. "A Lattice Boltzmann Simulation of Hemodynamics in a Patient-Speci c Aortic Coarctation Model." Ed. O Camara, M Pop, T Mansi, M Sermesant, and A Young. Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges: 7746 (October 5, 2012): 17-25. Full Text Link to Item
- Borkin, MA, Gajos, KZ, Peters, A, Mitsouras, D, Melchionna, S, Rybicki, FJ, Feldman, CL, and Pfister, H. "Evaluation of artery visualizations for heart disease diagnosis." IEEE transactions on visualization and computer graphics 17.12 (December 2011): 2479-2488. Full Text
- Robson, B, Li, J, Dettinger, R, Peters, A, and Boyer, SK. "Drug discovery using very large numbers of patents. General strategy with extensive use of match and edit operations." Journal of Computer-Aided Molecular Design 25.5 (May 2011): 427-441. Full Text
- Jiang, K, Thorsen, O, Peters, A, Smith, B, and Sosa, CP. "An Efficient Parallel Implementation of the Hidden Markov Methods for Genomic Sequence-Search on a Massively Parallel System." IEEE Transactions on Parallel and Distributed Systems 19.1 (January 2008): 15-23. Full Text
- Pang, Y-P, Mullins, TJ, Swartz, BA, McAllister, JS, Smith, BE, Archer, CJ, Musselman, RG, Peters, AE, Wallenfelt, BP, and Pinnow, KW. "EUDOC on the IBM Blue Gene/L system: Accelerating the transfer of drug discoveries from laboratory to patient." IBM Journal of Research and Development 52.1.2 (January 2008): 69-81. Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 493: Projects in Biomedical Engineering (GE) 2018
- BME 494: Projects in Biomedical Engineering (GE) 2018
- BME 590L: Special Topics with Lab 2018
- BME 307: Transport Phenomena in Biological Systems (AC or GE, BB) 2017
- BME 394: Projects in Biomedical Engineering (GE) 2017
- BME 590: Special Topics in Biomedical Engineering 2016
- CEE 307: Transport Phenomena in Biological Systems (AC or GE, BB) 2016
- COMPSCI 394: Research Independent Study 2016
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