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Amanda Randles

Associate Professor of Biomedical Engineering
Biomedical Engineering
Box 90281, Durham, NC 27708
Wilkinson Building, Room No. 325, 534 Research Drive, Durham, NC 27708

Overview


My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.

Current Appointments & Affiliations


Associate Professor of Biomedical Engineering · 2023 - Present Biomedical Engineering, Pratt School of Engineering
Assistant Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science · 2022 - Present Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering
Associate Professor of Computer Science · 2025 - Present Computer Science, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2015 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published April 10, 2025
New Center Brings Technological Advances to the Future of Health Care
Published March 12, 2025
Creating Digital Twins to Save Lives
Published December 19, 2024
Building Digital Twins for Individualized Health Care

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Recent Publications


3D pore shape is predictable in randomly packed particle systems.

Journal Article Matter · October 2025 Geometric classifications of 3D pores are useful for studying relationships between pore geometry and function in granular materials. Pores are typically characterized by size, but size alone cannot explain 3D phenomena like transport. Here, we implement a ... Full text Cite

Photon-Counting Computed Tomography for Evaluation of Coiled Intracranial Aneurysms.

Journal Article AJNR Am J Neuroradiol · September 23, 2025 BACKGROUND AND PURPOSE: Intracranial aneurysms treated with endovascular embolization often require surveillance imaging using digital subtraction angiography, an invasive, risky, and expensive procedure. Existing non-invasive imaging modalities (standard ... Full text Open Access Link to item Cite

Simulation-based machine learning for real-time assessment of side-branch hemodynamics in coronary bifurcation lesions

Journal Article International Journal of High Performance Computing Applications · September 1, 2025 Provisional stenting is the standard treatment for coronary bifurcation lesions, relying on real-time assessment of side-branch (SB) hemodynamics to guide intervention. Functional metrics such as fractional flow reserve (FFR) and instantaneous wave-free ra ... Full text Open Access Cite
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Recent Grants


iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030

FDT-BioTech: Scalable Digital Twins to Power Virtual Trials and Test Treatments

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2025 - 2028

Dynamic models of the cardiovascular system capturing years, rather than heartbeats

ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2022 - 2027

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Education, Training & Certifications


Harvard University · 2013 Ph.D.