Amanda Randles | Scholars@Duke

Amanda Randles
Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences

My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.

Current Research Interests

Biomedical simulation and high-performance computing

Current Appointments & Affiliations

Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences, Biomedical Engineering, Pratt School of Engineering 2018 - 2025
Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2015
Assistant Professor of Computer Science, Computer Science, Trinity College of Arts & Sciences 2016
Assistant Professor of Mathematics, Mathematics, Trinity College of Arts & Sciences 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

301 Gross Hall, 140 Science Dr., Durham, NC 27708
Box 90984, Durham, NC 27708
amanda.randles@duke.edu (919) 660-5425
Google Scholar
Randles Lab Site

Background
Education, Training, & Certifications
- Ph.D., Harvard University 2013
Duke Appointment History
- Assistant Professor in the Department of Mechanical Engineering and Material Science, Mechanical Engineering and Materials Science, Pratt School of Engineering 2015 - 2018
Recognition
In the News
- JUL 6, 2018 Pratt School of Engineering
  
  Randles Selected to Help Pilot First U.S. Exascale Computer
- NOV 1, 2017
  
  Duke University Models How and Where Blood flow Impacts Health
- SEP 21, 2017
  
  Plumbing Virtual Vessels
- MAR 17, 2016 BBC News
  
  Supercomputer copies whole-body blood flow
- MAR 16, 2016
  
  New Collaborative Seed Grant Program Gives Eight Awards
- NOV 19, 2015
  
  NIH Features Randles Research on Fighting Cancer With Supercomputers
- SEP 14, 2015 China Daily
  
  Experts put health issues firmly in the spotlight
- AUG 31, 2015
  
  Randles Named Finalist for Supercomputing’s Top Honor
- JUN 5, 2015 Pratt School of Engineering
  
  Amanda Randles: Computing Complex Biological Systems
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- 3D Bioprinted Aneurysm for Intervention Modeling Validation awarded by Lawrence Livermore National Laboratory 2019
- Toward coupled multiphysics models of hemodynamics on leadership systems awarded by National Institutes of Health 2014 - 2019
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2019
- Interactive virtual reality cardiovascular visualizations: User study for clinicians - Harvey Shi award awarded by Sigma Xi 2018 - 2019
- Student Support: IEEE Cluster 2018 Conference awarded by National Science Foundation 2018 - 2019
- ORNL Joint Faculty Appointment for Amanda Randles awarded by UT-Battelle, LLC 2017 - 2019
- Hartwell Fellowship awarded by Hartwell Foundation 2017 - 2018
- Using GPU-Accelerated Computational Fluid Dynamics to Study In-stent Restenosis awarded by Oak Ridge Associated Universities 2016 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gounley, J, Vardhan, M, and Randles, A. "A Framework for Comparing Vascular Hemodynamics at Different Points in Time." Computer Physics Communications 235 (February 2019): 1-8. Full Text
  - Dabagh, M, and Randles, A. "Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature." Plos One 14.2 (January 2019): e0211418-null. Full Text
  - Gounley, J, Draeger, EW, Oppelstrup, T, Krauss, WD, Gunnels, JA, Chaudhury, R, Nair, P, Frakes, D, Leopold, JA, and Randles, A. "Computing the ankle-brachial index with parallel computational fluid dynamics." Journal of Biomechanics 82 (January 2019): 28-37. Full Text
  - Hegele, LA, Scagliarini, A, Sbragaglia, M, Mattila, KK, Philippi, PC, Puleri, DF, Gounley, J, and Randles, A. "High-Reynolds-number turbulent cavity flow using the lattice Boltzmann method." Physical Review E 98.4 (October 4, 2018). Full Text
  - Rafat, M, Stone, HA, Auguste, DT, Dabagh, M, Randles, A, Heller, M, and Rabinov, JD. "Impact of diversity of morphological characteristics and Reynolds number on local hemodynamics in basilar aneurysms." Aiche Journal 64.7 (July 2018): 2792-2802. Full Text
  - Randles, A, Frakes, DH, and Leopold, JA. "Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease." Trends in Biotechnology 35.11 (November 2017): 1049-1061. (Review) Full Text
  - Dabagh, M, Jalali, P, Butler, PJ, Randles, A, and Tarbell, JM. "Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow." Journal of the Royal Society, Interface 14.130 (May 2017). Full Text
  - Randles, A, Draeger, EW, and Bailey, PE. "Massively parallel simulations of hemodynamics in the primary large arteries of the human vasculature." Journal of Computational Science 9 (July 1, 2015): 70-75. Full Text
  - Whitley, HD, Scullard, CR, Benedict, LX, Castor, JI, Randles, A, Glosli, JN, Richards, DF, Desjarlais, MP, and Graziani, FR. "Lenard-Balescu calculations and classical molecular dynamics simulations of electrical and thermal conductivities of hydrogen plasmas." Contributions to Plasma Physics 55.2-3 (January 1, 2015): 192-202. Full Text
  - You, Y, Fu, H, Song, SL, Randles, A, Kerbyson, D, Marquez, A, Yang, G, and Hoisie, A. "Scaling Support Vector Machines on modern HPC platforms." Journal of Parallel and Distributed Computing 76 (January 1, 2015): 16-31. Full Text
  - Randles, A, and Kaxiras, E. "Parallel in time approximation of the lattice Boltzmann method for laminar flows." Journal of Computational Physics 270 (August 1, 2014): 577-586. Full Text
  - Almendro, V, Cheng, Y-K, Randles, A, Itzkovitz, S, Marusyk, A, Ametller, E, Gonzalez-Farre, X, Muñoz, M, Russnes, HG, Helland, A, Rye, IH, Borresen-Dale, A-L, Maruyama, R, van Oudenaarden, A, Dowsett, M, Jones, RL, Reis-Filho, J, Gascon, P, Gönen, M, Michor, F, and Polyak, K. "Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity." Cell Reports 6.3 (February 2014): 514-527. Full Text
  - Randles, A, Draeger, E, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology 41.January (January 1, 2014): 217-220.
  - You, Y, Fu, H, Song, SL, Randles, A, Kerbyson, D, Marquez, A, Yang, G, and Hoisie, A. "Scaling Support Vector Machines on modern HPC platforms." Journal of Parallel and Distributed Computing (2014). Full Text
  - Peters Randles, A, Bächer, M, Pfister, H, and Kaxiras, E. "A lattice Boltzmann simulation of hemodynamics in a patient-specific aortic coarctation model." Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7746 LNCS (April 22, 2013): 17-25. Full Text
  - Keyes, DE, McInnes, LC, Woodward, C, Gropp, W, Myra, E, Pernice, M, Bell, J, Brown, J, Clo, A, Connors, J, Constantinescu, E, Estep, D, Evans, K, Farhat, C, Hakim, A, Hammond, G, Hansen, G, Hill, J, Isaac, T, Jiao, X, Jordan, K, Kaushik, D, Kaxiras, E, Koniges, A, Lee, K, Lott, A, Lu, Q, Magerlein, J, Maxwell, R, McCourt, M, Mehl, M, Pawlowski, R, Randles, AP, Reynolds, D, Rivière, B, Rüde, U, Scheibe, T, Shadid, J, Sheehan, B, Shephard, M, Siegel, A, Smith, B, Tang, X, Wilson, C, and Wohlmuth, B. "Multiphysics simulations: Challenges and opportunities." International Journal of High Performance Computing Applications 27.1 (February 1, 2013): 4-83. Full Text
  - Peters Randles, A, Bächer, M, Pfister, H, and Kaxiras, E. "A Lattice Boltzmann Simulation of Hemodynamics in a Patient-Specific Aortic Coarctation Model." (2013): 17-25. Full Text
  - Randles, AP. "Massively parallel model of evolutionary game dynamics." Proceedings 2012 Sc Companion: High Performance Computing, Networking Storage and Analysis, Scc 2012 (December 1, 2012): 1531-null. Full Text
  - Borkin, MA, Gajos, KZ, Peters, A, Mitsouras, D, Melchionna, S, Rybicki, FJ, Feldman, CL, and Pfister, H. "Evaluation of artery visualizations for heart disease diagnosis." IEEE transactions on visualization and computer graphics 17.12 (December 2011): 2479-2488. Full Text
  - Robson, B, Li, J, Dettinger, R, Peters, A, and Boyer, SK. "Drug discovery using very large numbers of patents. General strategy with extensive use of match and edit operations." Journal of Computer Aided Molecular Design 25.5 (May 2011): 427-441. Full Text
  - Jiang, K, Thorsen, O, Peters, A, Smith, B, and Sosa, CP. "An Efficient Parallel Implementation of the Hidden Markov Methods for Genomic Sequence-Search on a Massively Parallel System." Ieee Transactions on Parallel and Distributed Systems 19.1 (January 2008): 15-23. Full Text
  - Pang, Y-P, Mullins, TJ, Swartz, BA, McAllister, JS, Smith, BE, Archer, CJ, Musselman, RG, Peters, AE, Wallenfelt, BP, and Pinnow, KW. "EUDOC on the IBM Blue Gene/L system: Accelerating the transfer of drug discoveries from laboratory to patient." Ibm Journal of Research and Development 52.1.2 (January 2008): 69-81. Full Text
- Conference Papers
  - Herschlag, G, Lee, S, Vetter, JS, and Randles, A. "GPU data access on complex geometries for D3Q19 lattice boltzmann method." August 3, 2018. Full Text
  - Gounley, J, Vardhan, M, and Randles, A. "A computational framework to assess the influence of changes in vascular geometry on blood flow." June 26, 2017. Full Text
  - Gounley, J, Draeger, EW, and Randles, A. "Numerical simulation of a compound capsule in a constricted microchannel." January 2017. Full Text
  - Laurence, TA, Ly, S, Fong, E, Shusteff, M, Randles, A, Gounley, J, and Draeger, E. "Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations." January 1, 2017. Full Text
  - Gounley, J, Chaudhury, R, Vardhan, M, Driscoll, M, Pathangey, G, Winarta, K, Ryan, J, Frakes, D, and Randles, A. "Does the degree of coarctation of the aorta influence wall shear stress focal heterogeneity?." August 2016. Full Text Open Access Copy
  - Randles, A, Draeger, EW, Oppelstrup, T, Krauss, L, and Gunnels, JA. "Massively parallel models of the human circulatory system." November 15, 2015. Full Text
  - Kale, V, Randles, A, and Gropp, WD. "Locality-optimized mixed static/dynamic scheduling for improving load balancing on SMPs." September 9, 2014. Full Text
  - You, Y, Song, SL, Fu, H, Marquez, A, Dehnavi, MM, Barker, K, Cameron, KW, Randles, AP, and Yang, G. "MIC-SVM: Designing a Highly Efficient Support Vector Machine for Advanced Modern Multi-core and Many-Core Architectures." 2014 IEEE International Parallel & Distributed Processing Symposium (IPDPS). May 19, 2014 - May 23, 2014.: IEEE, May 2014. Full Text
  - You, Y, Song, SL, Fu, H, Marquez, A, Dehnavi, MM, Barker, K, Cameron, KW, Randles, AP, and Yang, G. "MIC-SVM: Designing a highly efficient support vector machine for advanced modern multi-core and many-core architectures." January 1, 2014. Full Text
  - Randles, AP, Kale, V, Hammond, J, Gropp, W, and Kaxiras, E. "Performance analysis of the lattice Boltzmann model beyond Navier-Stokes." October 7, 2013. Full Text
  - Randles, AP, Rand, DG, Lee, C, Morrisett, G, Sircar, J, Nowak, MA, and Pfister, H. "Massively parallel model of extended memory use in evolutionary game dynamics." October 7, 2013. Full Text
  - Randles, A, and Zeger, L. "Efficient Resource Allocation for Broadcasting Multi-Slot Messages With Random Access with Capture." IEEE Military Communications Conference. November 7, 2011 - November 10, 2011. Baltimore, MD. IEEE, October 2011. Link to Item
  - Randles, A, Melchionna, S, Kaxiras, E, Latt, J, Sircar, J, Bernaschi, M, Bisson, M, and Succi, S. "Multiscale simulation of cardiovascular flows on the IBM Bluegene/P: full heart-circulation system at red-blood cell resolution." ACM/IEEE International Conference for High Performance Computing, Networking, Storage, and Analysis. November 13, 2010 - November 19, 2010. New Orleans, LA. ACM IEEE, November 2010.
  - Peters, A, King, A, Budnik, T, McCarthy, P, Michaud, P, Mundy, M, Sexton, J, and Stewart, G. "Asynchronous task dispatch for high throughput computing for the eServer IBM Blue Gene® Supercomputer." Distributed Processing Symposium (IPDPS). April 14, 2008 - April 18, 2008.: IEEE, April 2008. Full Text
  - Randles, A. "Parallel Genomic Sequence-Search on a Massively Parallel System." ACM International Conference on Computing Frontiers. May 7, 2007 - May 9, 2007. Ischia, Italy. ACM, May 2007.
  - Randles, A, Draeger, EW, and Michor, F. "Analysis of pressure gradient across aortic stenosis with massively parallel computational simulations." Computing in Cardiology. September 7, 2014 - September 10, 2014. Cambridge, MA. Link to Item
  - Randles, A, and Kaxiras, EK. "A Spatio-Temporal Coupling Method to Reduce the Time-to-Solution of Cardiovascular Simulations." International Parallel and Distributed Processing Symposium. May 19, 2014 - May 23, 2014. Full Text Link to Item
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses