Sensing Mitochondrial Acetyl-CoA to Tune Respiration.

Published

Journal Article

Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.

Full Text

Duke Authors

Hirschey, Matthew

Cited Authors

Mills, CA; Trub, AG; Hirschey, MD

Published Date

January 2019

Published In

Trends in Endocrinology and Metabolism: Tem

Volume / Issue

30 / 1

Start / End Page

1 - 3

PubMed ID

30442533

Pubmed Central ID

30442533

Electronic International Standard Serial Number (EISSN)

1879-3061

International Standard Serial Number (ISSN)

1043-2760

Digital Object Identifier (DOI)

10.1016/j.tem.2018.10.003

Language

eng