Sensing Mitochondrial Acetyl-CoA to Tune Respiration.

Journal Article (Journal Article;Review)

Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.

Full Text

Duke Authors

Cited Authors

  • Mills, CA; Trub, AG; Hirschey, MD

Published Date

  • January 2019

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 1 - 3

PubMed ID

  • 30442533

Pubmed Central ID

  • PMC6380363

Electronic International Standard Serial Number (EISSN)

  • 1879-3061

Digital Object Identifier (DOI)

  • 10.1016/j.tem.2018.10.003


  • eng

Conference Location

  • United States