Sensing Mitochondrial Acetyl-CoA to Tune Respiration.
Published
Journal Article
Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567-580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.
Full Text
Duke Authors
Cited Authors
- Mills, CA; Trub, AG; Hirschey, MD
Published Date
- January 2019
Published In
Volume / Issue
- 30 / 1
Start / End Page
- 1 - 3
PubMed ID
- 30442533
Pubmed Central ID
- 30442533
Electronic International Standard Serial Number (EISSN)
- 1879-3061
International Standard Serial Number (ISSN)
- 1043-2760
Digital Object Identifier (DOI)
- 10.1016/j.tem.2018.10.003
Language
- eng