Overview
The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.
Current Appointments & Affiliations
Associate Professor of Medicine
·
2019 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Associate Professor in Pharmacology and Cancer Biology
·
2019 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2011 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Targeting androgen receptor signaling to enhance cancer immunotherapy.
Journal Article Trends Pharmacol Sci · December 3, 2025 Men experience higher cancer incidence and mortality than women, and accumulating evidence implicates androgen receptor (AR) signaling as a key biological driver of these sex-based disparities. AR signaling can suppress adaptive anticancer immunity. Precli ... Full text Link to item CiteCysteine S-acetylation is a widespread post-translational modification on metabolic proteins
Journal Article Npj Metabolic Health and Disease · December 1, 2025 Protein acetylation is a fundamental regulatory mechanism occurring primarily on lysine amino acids. Here we report systematic in vivo characterization of cysteine S-acetylation as a widespread post-translational modification in mammalian tissues. By devel ... Full text CitePathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.
Journal Article Nat Metab · December 2025 Understanding how cellular pathways interact is crucial for treating complex diseases like cancer. Individual gene-gene interaction studies have provided valuable insights, but may miss pathways working together. Here we develop a multi-gene approach to pa ... Full text Link to item CiteRecent Grants
Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Unified Program for Therapeutics in Children
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029View All Grants
Education, Training & Certifications
University of California, Santa Barbara ·
2006
Ph.D.