Matthew Hirschey | Scholars@Duke

Matthew Hirschey
Associate Professor of Medicine

The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2019
Associate Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2019
Member of Sarah W. Stedman Nutrition and Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

104775, Room 50-201, Durham, NC 27701
300 N. Duke Street, 50-201, Durham, NC 27701
matthew.hirschey@duke.edu (919) 479-2315
Hirschey Lab Website
Twitter

Background
Education, Training, & Certifications
- Ph.D., University of California - Santa Barbara 2006
Duke Appointment History
- Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011 - 2019
- Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2015 - 2019
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011 - 2015
- Instructor Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011
Recognition
In the News
- DEC 8, 2015 WNCN
  
  Is a diabetes drug the key to a longer life?
Awards & Honors
- New Scholar in Aging Award. Ellison Medical Foundation. 2013
Expertise
Subject Headings
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2019 - 2024
- Duke University Program in Environmental Health awarded by National Institutes of Health 2013 - 2024
- Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease awarded by National Institutes of Health 2019 - 2024
- In Vivo Modeling of Mitochondrial Complex I Deficiency in Retinal Ganglion Cells awarded by National Institutes of Health 2018 - 2023
- A Multi-Parametric low-cost pocket scope to Image and Quantify the Major Axes of Metabolism and the Associated Vasculature in Biological Tissue awarded by National Institutes of Health 2019 - 2022
- Duke Resident Physician-Scientist Program - NIAID awarded by National Institutes of Health 2018 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
- Determining the Sub-Cellular Organelles that Link Lipid Signaling and Epigenetics awarded by National Institutes of Health 2019 - 2021
- Glenn Award for Research in Biological Mechanisms of Aging awarded by Glenn Foundation for Medical Research 2018 - 2021
- The role of NRF2 in breast cancer dormancy and recurrence awarded by National Institutes of Health 2019 - 2020
- Statin-induced Increases in HMG-CoA lead to HMG-modified Fatty Acid Synthase awarded by National Institutes of Health 2017 - 2020
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Ethanol-induced Protein Acylation Regulates Metabolism awarded by National Institutes of Health 2013 - 2018
- The Role of SIRT5 in Regulating Cardiac Function and Metabolism awarded by National Institutes of Health 2015 - 2018
- SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease awarded by Ellison Medical Foundation 2013 - 2018
- Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2017
- Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging awarded by National Institutes of Health 2016 - 2017
- Protein Biomarkers in FRDA Cardiomyopathy to Monitor Disease Progression and Therapeutic Efficacy awarded by Friedreich's Ataxia Research Alliance 2016 - 2017
- The Role of Acetylation in Regulating Iron-Sulfur Cluster Biogenesis awarded by National Institutes of Health 2014 - 2017
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Gladstone 2010 - 2017
- Metabolic Sensing and Stress Response Deficit in Ataxia Telangiectasia awarded by A-T Children's Project 2014 - 2016
- The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism awarded by Canadian Diabetes Association 2015 - 2016
- The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism awarded by Canadian Diabetes Association 2013 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
External Relationships
- Duke-NUS
- GenFlow Biosciences
- Millipore Corporation (Merck)
- VL54, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hershberger, Kathleen A., John P. Rooney, Elena A. Turner, Lauren J. Donoghue, Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, et al. “Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans.” Redox Biol 43 (July 2021): 102000. https://doi.org/10.1016/j.redox.2021.102000.
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  - Keenan, E Keith, Derek K. Zachman, and Matthew D. Hirschey. “Discovering the landscape of protein modifications.” Molecular Cell 81, no. 9 (May 2021): 1868–78. https://doi.org/10.1016/j.molcel.2021.03.015.
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  - Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.” Mol Cell Biol 41, no. 2 (January 25, 2021). https://doi.org/10.1128/MCB.00269-20.
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  - Gonzalez-Hunt, Claudia P., Anthony L. Luz, Ian T. Ryde, Elena A. Turner, Olga R. Ilkayeva, Dhaval P. Bhatt, Matthew D. Hirschey, and Joel N. Meyer. “Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.” Toxicology 447 (January 15, 2021): 152630. https://doi.org/10.1016/j.tox.2020.152630.
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  - Madonna, Megan C., Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, et al. “In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.” Cancers (Basel) 13, no. 1 (January 5, 2021). https://doi.org/10.3390/cancers13010148.
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  - Enriquez-Hesles, Elisa, Daniel L. Smith, Nazif Maqani, Margaret B. Wierman, Matthew D. Sutcliffe, Ryan D. Fine, Agata Kalita, et al. “A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.” J Biol Chem 296 (January 2021): 100125. https://doi.org/10.1074/jbc.RA120.015402.
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  - Enriquez-Hesles, Elisa, Daniel L. Smith, Nazif Maqani, Margaret B. Wierman, Matthew D. Sutcliffe, Ryan D. Fine, Agata Kalita, et al. “A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.” J Biol Chem 296 (December 2, 2020): 100125. https://doi.org/10.1074/jbc.RA120.015402.
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  - Madonna, Megan, Joy Duer, Joyce Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, et al. “In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer,” November 2, 2020. https://doi.org/10.1101/2020.11.02.365288.
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  - Huynh, Frank K., Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M. S. Llaguno, Thi-Tina N. Nguyen, et al. “β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.” American Journal of Physiology. Endocrinology and Metabolism 319, no. 4 (October 2020): E805–13. https://doi.org/10.1152/ajpendo.00170.2020.
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  - Hirschey, Matthew. “Lab life - rebuild it better after coronavirus lockdowns ease.” Nature 582, no. 7811 (June 2020): 184. https://doi.org/10.1038/d41586-020-01708-8.
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  - Fox, Douglas B., Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, and James V. Alvarez. “NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.” Nat Metab 2, no. 4 (April 2020): 318–34. https://doi.org/10.1038/s42255-020-0191-z.
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  - Naiman, Shoshana, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, et al. “SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.” Cell Rep 29, no. 12 (December 17, 2019): 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067.
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  - Assiri, Mohammed A., Hadi R. Ali, John O. Marentette, Youngho Yun, Juan Liu, Matthew D. Hirschey, Laura M. Saba, Peter S. Harris, and Kristofer S. Fritz. “Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.” Hum Genomics 13, no. 1 (December 10, 2019): 65. https://doi.org/10.1186/s40246-019-0251-1.
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  - Ericksen, Russell E., Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J. White, Zhaobing Ding, et al. “Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.” Cell Metab 29, no. 5 (May 7, 2019): 1151-1165.e6. https://doi.org/10.1016/j.cmet.2018.12.020.
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  - Ali, Hadi R., Mohammed A. Assiri, Peter S. Harris, Cole R. Michel, Youngho Yun, John O. Marentette, Frank K. Huynh, et al. “Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.” J Proteome Res 18, no. 4 (April 5, 2019): 1513–31. https://doi.org/10.1021/acs.jproteome.8b00800.
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  - Nicholatos, Justin W., Timothy M. Robinette, Saurabh V. P. Tata, Jennifer D. Yordy, Adam B. Francisco, Michael Platov, Tiffany K. Yeh, et al. “Cellular energetics and mitochondrial uncoupling in canine aging.” Geroscience 41, no. 2 (April 2019): 229–42. https://doi.org/10.1007/s11357-019-00062-6.
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  - Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.
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  - Mills, Christine A., Alec G. Trub, and Matthew D. Hirschey. “Sensing Mitochondrial Acetyl-CoA to Tune Respiration.” Trends Endocrinol Metab 30, no. 1 (January 2019): 1–3. https://doi.org/10.1016/j.tem.2018.10.003.
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  - Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.
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  - Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.
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  - Trub, Alec G., and Matthew D. Hirschey. “Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.” Trends Biochem Sci 43, no. 5 (May 2018): 369–79. https://doi.org/10.1016/j.tibs.2018.02.002.
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  - Hu, Yue, Ivana Semova, Xiaowei Sun, Hong Kang, Satyapal Chahar, Anthony N. Hollenberg, David Masson, Matthew D. Hirschey, Ji Miao, and Sudha B. Biddinger. “Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.” J Biol Chem 293, no. 6 (February 9, 2018): 2006–14. https://doi.org/10.1074/jbc.M117.782557.
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  - Huynh, Frank K., Xiaoke Hu, Zhihong Lin, James D. Johnson, and Matthew D. Hirschey. “Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.” J Inherit Metab Dis 41, no. 1 (January 2018): 59–72. https://doi.org/10.1007/s10545-017-0069-8.
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  - Weir, Heather J., Pallas Yao, Frank K. Huynh, Caroline C. Escoubas, Renata L. Goncalves, Kristopher Burkewitz, Raymond Laboy, Matthew D. Hirschey, and William B. Mair. “Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.” Cell Metab 26, no. 6 (December 5, 2017): 884-896.e5. https://doi.org/10.1016/j.cmet.2017.09.024.
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  - Anderson, Kristin A., Andreas S. Madsen, Christian A. Olsen, and Matthew D. Hirschey. “Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.” Biochim Biophys Acta Bioenerg 1858, no. 12 (December 2017): 991–98. https://doi.org/10.1016/j.bbabio.2017.09.005.
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  - Hershberger, Kathleen A., Dennis M. Abraham, Angelical S. Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W. Locasale, and Matthew D. Hirschey. “Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.” J Biol Chem 292, no. 48 (December 1, 2017): 19767–81. https://doi.org/10.1074/jbc.M117.809897.
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  - Rajabi, Nima, Marina Auth, Kathrin R. Troelsen, Martin Pannek, Dhaval P. Bhatt, Martin Fontenas, Matthew D. Hirschey, Clemens Steegborn, Andreas S. Madsen, and Christian A. Olsen. “Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.” Angew Chem Int Ed Engl 56, no. 47 (November 20, 2017): 14836–41. https://doi.org/10.1002/anie.201709050.
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  - Hibshman, Jonathan D., Alexander E. Doan, Brad T. Moore, Rebecca Ew Kaplan, Anthony Hung, Amy K. Webster, Dhaval P. Bhatt, Rojin Chitrakar, Matthew D. Hirschey, and L Ryan Baugh. “daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.” Elife 6 (October 24, 2017). https://doi.org/10.7554/eLife.30057.
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  - Assiri, Mohammed A., Samantha R. Roy, Peter S. Harris, Hadi Ali, Yongliang Liang, Colin T. Shearn, David J. Orlicky, et al. “Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.” Alcohol Clin Exp Res 41, no. 10 (October 2017): 1705–14. https://doi.org/10.1111/acer.13473.
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  - Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.
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  - Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.
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  - Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.
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  - Hershberger, Kathleen A., Angelical S. Martin, and Matthew D. Hirschey. “Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases.” Nat Rev Nephrol 13, no. 4 (April 2017): 213–25. https://doi.org/10.1038/nrneph.2017.5.
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  - Wagner, Gregory R., and Matthew D. Hirschey. “A Prob(e)able Route to Lysine Acylation.” Cell Chemical Biology 24, no. 2 (February 2017): 126–28. https://doi.org/10.1016/j.chembiol.2017.01.011.
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  - Stram, Amanda R., Gregory R. Wagner, Brian D. Fogler, P Melanie Pride, Matthew D. Hirschey, and R Mark Payne. “Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.” Plos One 12, no. 5 (2017): e0178354. https://doi.org/10.1371/journal.pone.0178354.
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  - Luz, Anthony T., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.” Toxicol Sci 154, no. 1 (November 2016): 195. https://doi.org/10.1093/toxsci/kfw185.
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  - McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.
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  - Luz, Anthony L., Cristina Lagido, Matthew D. Hirschey, and Joel N. Meyer. “In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction.” Curr Protoc Toxicol 69 (August 1, 2016): 25.8.1-25.8.22. https://doi.org/10.1002/cptx.10.
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  - Luz, Anthony L., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.” Toxicol Sci 152, no. 2 (August 2016): 349–62. https://doi.org/10.1093/toxsci/kfw093.
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  - Quinones, Quintin J., Zhiquan Zhang, Qing Ma, Michael P. Smith, Erik Soderblom, M Arthur Moseley, James Bain, et al. “Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.” Anesthesiology 124, no. 6 (June 2016): 1296–1310. https://doi.org/10.1097/ALN.0000000000001113.
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  - Madsen, Andreas S., Christian Andersen, Mohammad Daoud, Kristin A. Anderson, Jonas S. Laursen, Saswati Chakladar, Frank K. Huynh, et al. “Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.” J Biol Chem 291, no. 13 (March 25, 2016): 7128–41. https://doi.org/10.1074/jbc.M115.668699.
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  - Block, Keith I., Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, ARM Ruhul Amin, Amr Amin, Katia Aquilano, et al. “Designing a broad-spectrum integrative approach for cancer prevention and treatment.” Semin Cancer Biol 35 Suppl (December 2015): S276–304. https://doi.org/10.1016/j.semcancer.2015.09.007.
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  - Hirschey, Matthew D., Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, et al. “Dysregulated metabolism contributes to oncogenesis.” Semin Cancer Biol 35 Suppl (December 2015): S129–50. https://doi.org/10.1016/j.semcancer.2015.10.002.
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  - Otsubo, Chikara, Sivakama Bharathi, Radha Uppala, Olga R. Ilkayeva, Dongning Wang, Kevin McHugh, Ye Zou, et al. “Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.” J Biol Chem 290, no. 39 (September 25, 2015): 23897–904. https://doi.org/10.1074/jbc.M115.655837.
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  - Hirschey, Matthew D., and Yingming Zhao. “Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.” Mol Cell Proteomics 14, no. 9 (September 2015): 2308–15. https://doi.org/10.1074/mcp.R114.046664.
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  - Huynh, Frank K., Deborah M. Muoio, and Matthew D. Hirschey. “SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.” Diabetes 64, no. 9 (September 2015): 3058–60. https://doi.org/10.2337/db15-0709.
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  - McDonnell, Eoin, Brett S. Peterson, Howard M. Bomze, and Matthew D. Hirschey. “SIRT3 regulates progression and development of diseases of aging.” Trends Endocrinol Metab 26, no. 9 (September 2015): 486–92. https://doi.org/10.1016/j.tem.2015.06.001.
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  - Liu, Xiaojing, Sushabhan Sadhukhan, Shengyi Sun, Gregory R. Wagner, Matthew D. Hirschey, Ling Qi, Hening Lin, and Jason W. Locasale. “High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.” Mol Cell Proteomics 14, no. 6 (June 2015): 1489–1500. https://doi.org/10.1074/mcp.M114.044859.
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  - Glass, O. K., B. A. Inman, G. Broadwater, K. S. Courneya, J. R. Mackey, S. Goruk, E. R. Nelson, et al. “Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.” Br J Cancer 112, no. 5 (March 3, 2015): 825–31. https://doi.org/10.1038/bjc.2014.662.
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  - Glass, O. K., B. A. Inman, G. Broadwater, K. S. Courneya, J. R. Mackey, S. Goruk, E. R. Nelson, et al. “Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study.” British Journal of Cancer 112, no. 5 (March 3, 2015): 825–31. https://doi.org/10.1038/bjc.2014.662.
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  - Burkewitz, Kristopher, Ianessa Morantte, Heather J. M. Weir, Robin Yeo, Yue Zhang, Frank K. Huynh, Olga R. Ilkayeva, Matthew D. Hirschey, Ana R. Grant, and William B. Mair. “Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.” Cell 160, no. 5 (February 26, 2015): 842–55. https://doi.org/10.1016/j.cell.2015.02.004.
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  - Moffat, Cynthia, Lavesh Bhatia, Teresa Nguyen, Peter Lynch, Miao Wang, Dongning Wang, Olga R. Ilkayeva, et al. “Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.” J Lipid Res 55, no. 12 (December 2014): 2458–70. https://doi.org/10.1194/jlr.M046961.
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  - Shaughnessy, Daniel T., Kimberly McAllister, Leroy Worth, Astrid C. Haugen, Joel N. Meyer, Frederick E. Domann, Bennett Van Houten, et al. “Mitochondria, energetics, epigenetics, and cellular responses to stress.” Environ Health Perspect 122, no. 12 (December 2014): 1271–78. https://doi.org/10.1289/ehp.1408418.
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  - Anderson, Kristin A., Michelle F. Green, Frank K. Huynh, Gregory R. Wagner, and Matthew D. Hirschey. “SnapShot: Mammalian Sirtuins.” Cell 159, no. 4 (November 6, 2014): 956-956.e1. https://doi.org/10.1016/j.cell.2014.10.045.
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  - Huynh, Frank K., and Matthew D. Hirschey. “Loss of Sirtuin 4 Leads to Insulin Resistance in Mice.” Endocrine Reviews 35, no. 3 (June 1, 2014).
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  - Wagner, Gregory R., and Matthew D. Hirschey. “Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.” Mol Cell 54, no. 1 (April 10, 2014): 5–16. https://doi.org/10.1016/j.molcel.2014.03.027.
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  - Tan, Minjia, Chao Peng, Kristin A. Anderson, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, et al. “Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.” Cell Metab 19, no. 4 (April 1, 2014): 605–17. https://doi.org/10.1016/j.cmet.2014.03.014.
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  - Huynh, Frank K., Michelle F. Green, Timothy R. Koves, and Matthew D. Hirschey. “Measurement of fatty acid oxidation rates in animal tissues and cell lines.” Methods Enzymol 542 (2014): 391–405. https://doi.org/10.1016/B978-0-12-416618-9.00020-0.
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  - Schechter, Matthew A., Michael K. H. Hsieh, Linda W. Njoroge, J Will Thompson, Erik J. Soderblom, Bryan J. Feger, Constantine D. Troupes, et al. “Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.” Plos One 9, no. 8 (2014): e104157. https://doi.org/10.1371/journal.pone.0104157.
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  - Bharathi, Sivakama S., Yuxun Zhang, Al-Walid Mohsen, Radha Uppala, Manimalha Balasubramani, Emanuel Schreiber, Guy Uechi, et al. “Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.” J Biol Chem 288, no. 47 (November 22, 2013): 33837–47. https://doi.org/10.1074/jbc.M113.510354.
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  - Hirschey, M. D. “Preface.” Methods in Molecular Biology 1077 (September 20, 2013).
  - Anderson, Kristin A., Dongning Wang, and Matthew D. Hirschey. “HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint?” Hepatology 57, no. 5 (May 2013): 1681–83. https://doi.org/10.1002/hep.26085.
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  - Huynh, Frank K., Kathleen A. Hershberger, and Matthew D. Hirschey. “Targeting sirtuins for the treatment of diabetes.” Diabetes Manag (Lond) 3, no. 3 (May 1, 2013): 245–57. https://doi.org/10.2217/dmt.13.6.
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  - Merksamer, Philip I., Yufei Liu, Wenjuan He, Matthew D. Hirschey, Danica Chen, and Eric Verdin. “The sirtuins, oxidative stress and aging: an emerging link.” Aging (Albany Ny) 5, no. 3 (March 2013): 144–50. https://doi.org/10.18632/aging.100544.
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  - Green, Michelle F., and Matthew D. Hirschey. “SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.” J Gerontol a Biol Sci Med Sci 68, no. 2 (February 2013): 105–7. https://doi.org/10.1093/gerona/gls132.
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  - Gut, Philipp, Bernat Baeza-Raja, Olov Andersson, Laura Hasenkamp, Joseph Hsiao, Daniel Hesselson, Katerina Akassoglou, Eric Verdin, Matthew D. Hirschey, and Didier Y. R. Stainier. “Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.” Nat Chem Biol 9, no. 2 (February 2013): 97–104. https://doi.org/10.1038/nchembio.1136.
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  - Shimazu, Tadahiro, Matthew D. Hirschey, John Newman, Wenjuan He, Kotaro Shirakawa, Natacha Le Moan, Carrie A. Grueter, et al. “Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.” Science 339, no. 6116 (January 11, 2013): 211–14. https://doi.org/10.1126/science.1227166.
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  - Fritz, Kristofer S., Michelle F. Green, Dennis R. Petersen, and Matthew D. Hirschey. “Ethanol metabolism modifies hepatic protein acylation in mice.” Plos One 8, no. 9 (2013): e75868. https://doi.org/10.1371/journal.pone.0075868.
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  - Gut, P., B. Baeza-Raja, O. Andersson, L. Hasenkamp, J. Hsiao, D. Hesselson, K. Akassoglou, E. Verdin, M. D. Hirschey, and D. Y. R. Stainier. “Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.” Nature Chemical Biology 9, no. 2 (2013): 97–104. https://doi.org/10.1038/nchembio.1136.
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  - Hershberger, Kathleen A., Jonathan Motley, Matthew D. Hirschey, and Kristin A. Anderson. “Generating mammalian sirtuin tools for protein-interaction analysis.” Methods Mol Biol 1077 (2013): 69–78. https://doi.org/10.1007/978-1-62703-637-5_5.
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  - Wang, Dongning, Michelle F. Green, Eoin McDonnell, and Matthew D. Hirschey. “Oxygen flux analysis to understand the biological function of sirtuins.” Methods Mol Biol 1077 (2013): 241–58. https://doi.org/10.1007/978-1-62703-637-5_16.
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  - Haas, Joel T., Ji Miao, Dipanjan Chanda, Yanning Wang, Enpeng Zhao, Mary E. Haas, Matthew Hirschey, et al. “Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.” Cell Metab 15, no. 6 (June 6, 2012): 873–84. https://doi.org/10.1016/j.cmet.2012.05.002.
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  - Fritz, Kristofer S., James J. Galligan, Matthew D. Hirschey, Eric Verdin, and Dennis R. Petersen. “Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.” Journal of Proteome Research 11, no. 3 (March 2012): 1633–43. https://doi.org/10.1021/pr2008384.
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  - Streeper, Ryan S., Carrie A. Grueter, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Mattew D. Hirschey, Eric Verdin, and Robert V. Farese. “Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.” Aging (Albany Ny) 4, no. 1 (January 2012): 13–27. https://doi.org/10.18632/aging.100424.
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  - Anderson, Kristin A., and Matthew D. Hirschey. “Mitochondrial protein acetylation regulates metabolism.” Essays Biochem 52 (2012): 23–35. https://doi.org/10.1042/bse0520023.
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  - Hirschey, Matthew D. “Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.” Cell Metab 14, no. 6 (December 7, 2011): 718–19. https://doi.org/10.1016/j.cmet.2011.10.006.
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  - Fritz, Kristofer S., James J. Galligan, Matthew D. Hirschey, Eric Verdin, and Dennis R. Petersen. “Mitochondrial Acetylomic Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice.” Free Radical Biology and Medicine 51 (November 2011): S19–20. https://doi.org/10.1016/j.freeradbiomed.2011.10.044.
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  - Hirschey, Matthew D., Tadahiro Shimazu, Enxuan Jing, Carrie A. Grueter, Amy M. Collins, Bradley Aouizerat, Alena Stančáková, et al. “SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.” Mol Cell 44, no. 2 (October 21, 2011): 177–90. https://doi.org/10.1016/j.molcel.2011.07.019.
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  - Jing, Enxuan, Brice Emanuelli, Matthew D. Hirschey, Jeremie Boucher, Kevin Y. Lee, David Lombard, Eric M. Verdin, and C Ronald Kahn. “Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.” Proc Natl Acad Sci U S A 108, no. 35 (August 30, 2011): 14608–13. https://doi.org/10.1073/pnas.1111308108.
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  - Hirschey, Matthew D., Tadahiro Shimazu, John A. Capra, Katherine S. Pollard, and Eric Verdin. “SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.” Aging (Albany Ny) 3, no. 6 (June 2011): 635–42. https://doi.org/10.18632/aging.100339.
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  - Hirschey, M. D., T. Shimazu, J. -. Y. Huang, B. Schwer, and E. Verdin. “SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.” Cold Spring Harb Symp Quant Biol 76 (2011): 267–77. https://doi.org/10.1101/sqb.2011.76.010850.
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  - Qiu, Xiaolei, Katharine Brown, Matthew D. Hirschey, Eric Verdin, and Danica Chen. “Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.” Cell Metab 12, no. 6 (December 1, 2010): 662–67. https://doi.org/10.1016/j.cmet.2010.11.015.
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  - Shimazu, Tadahiro, Matthew D. Hirschey, Lan Hua, Kristin E. Dittenhafer-Reed, Bjoern Schwer, David B. Lombard, Yu Li, et al. “SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.” Cell Metabolism 12, no. 6 (December 2010): 654–61. https://doi.org/10.1016/j.cmet.2010.11.003.
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  - Verdin, Eric, Matthew D. Hirschey, Lydia W. S. Finley, and Marcia C. Haigis. “Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.” Trends in Biochemical Sciences 35, no. 12 (December 2010): 669–75. https://doi.org/10.1016/j.tibs.2010.07.003.
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  - Huang, Jing-Yi, Matthew D. Hirschey, Tadahiro Shimazu, Linh Ho, and Eric Verdin. “Mitochondrial sirtuins.” Biochim Biophys Acta 1804, no. 8 (August 2010): 1645–51. https://doi.org/10.1016/j.bbapap.2009.12.021.
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  - Shimazu, Tadahiro, Matthew D. Hirschey, Jing-Yi Huang, Linh T. Y. Ho, and Eric Verdin. “Acetate metabolism and aging: An emerging connection.” Mech Ageing Dev 131, no. 7–8 (July 2010): 511–16. https://doi.org/10.1016/j.mad.2010.05.001.
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  - Hirschey, Matthew D., Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B. Lombard, Carrie A. Grueter, et al. “SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.” Nature 464, no. 7285 (March 4, 2010): 121–25. https://doi.org/10.1038/nature08778.
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  - Hirschey, Matthew D., Tadahiro Shimazu, Jing-Yi Huang, and Eric Verdin. “Acetylation of mitochondrial proteins.” Methods Enzymol 457 (2009): 137–47. https://doi.org/10.1016/S0076-6879(09)05008-3.
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  - Lombard, David B., Frederick W. Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S. Streeper, Raul Mostoslavsky, Jennifer Kim, et al. “Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.” Mol Cell Biol 27, no. 24 (December 2007): 8807–14. https://doi.org/10.1128/MCB.01636-07.
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  - Hirschey, Matthew D., Yong-Jin Han, Galen D. Stucky, and Alison Butler. “Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots.” J Biol Inorg Chem 11, no. 5 (July 2006): 663–69. https://doi.org/10.1007/s00775-006-0116-7.
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  - Saini, S., G. D. Rubin, and M. K. Kalra. “Preface.” Mdct: A Practical Approach, January 1, 2006. https://doi.org/10.1007/88-470-0413-6.
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  - Hirschey, Matthew D. “Making data-driven hypotheses for gene functions by integrating dependency, expression, and literature data,” n.d. https://doi.org/10.1101/2020.07.17.208751.
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  - Hirschey, Matthew D., and Eric Verdin. “Measuring fatty acid oxidation in tissue homogenates.” Protocol Exchange, n.d. https://doi.org/10.1038/nprot.2010.92.
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- Book Sections
  - Hershberger, K. A., and M. D. Hirschey. “Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins.” In Introductory Review on Sirtuins in Biology, Aging, and Disease, 83–93, 2018. https://doi.org/10.1016/B978-0-12-813499-3.00007-1.
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  - Huynh, F. K., E. Mcdonnell, K. A. Anderson, and M. D. Hirschey. “Sirtuins.” In Signaling Pathways in Liver Diseases: Third Edition, 374–84, 2015. https://doi.org/10.1002/9781118663387.ch27.
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- Conference Papers
  - Hirschey, Matthew. “Epigenetic Control of Gene Expression by Lipid Metabolism.” In Faseb Journal, Vol. 31. FEDERATION AMER SOC EXP BIOL, 2017.
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  - Zhang, Zhiquan, Qing Ma, Alina Nicoara, Quintin Quinones, Matthew Hirschey, and Mihai V. Podgoreanu. “Sex-Specific Cardioprotective Effects of Annexin A1 Peptide Mimetic Involve the Sirtuin 3 Signaling Pathway.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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  - Henriques, B. J., K. A. Anderson, M. D. Hirschey, and C. M. Gomes. “Regulation of mitochondria beta oxidation by non-enzymatic post-translational modifications.” In Febs Journal, 282:342–342. WILEY-BLACKWELL, 2015.
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  - Hirschey, Matthew. “Protein Acylation Regulates Metabolism.” In Biophysical Journal, 106:4a-4a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.053.
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