Overview
The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.
Current Appointments & Affiliations
Associate Professor of Medicine
·
2019 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Associate Professor in Pharmacology and Cancer Biology
·
2019 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2011 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
·
2012 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice.
Journal Article bioRxiv · May 13, 2025 Proper regulation of inflammatory responses is essential for organismal health. Dysregulation can lead to accelerated development of the diseases of aging and the aging process itself. Here, we identify a novel enzymatic activity of the mitochondrial sirtu ... Full text Link to item CiteFatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells.
Journal Article PLoS Pathog · May 2025 Epstein-Barr virus (EBV) is a gamma herpesvirus that infects up to 95% of the human population by adulthood, typically remaining latent in the host memory B cell pool. In immunocompromised individuals, EBV can drive the transformation and rapid proliferati ... Full text Link to item CitePathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia.
Journal Article bioRxiv · March 2, 2025 Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights 1,2 , but they miss ... Full text Link to item CiteRecent Grants
Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2029Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029View All Grants
Education, Training & Certifications
University of California, Santa Barbara ·
2006
Ph.D.