Matthew Hirschey | Scholars@Duke

Matthew Hirschey
Associate Professor in Medicine

The overall objective of the Hirschey Lab is to better understand metabolism and mitochondrial function, which is important for human health and several human diseases. Their research focuses on metabolism, with a particular interest in how cells use metabolites and chemical modifications to protein in order to regulate metabolism. The lab studies the regulation of this process by a family of enzymes called sirtuins, and how they maintain energy homeostasis. Their work has important implications for diabetes and obesity, cardiovascular disease, cancer, inborn errors, and the aging process itself.

Current Appointments & Affiliations

Associate Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2015
Assistant Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011
Member of Sarah W. Stedman Nutrition and Metabolism Center, Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

104775, Room 50-201, Durham, NC 27701
300 N. Duke Street, 50-201, Durham, NC 27701
matthew.hirschey@duke.edu (919) 479-2315
Hirschey Lab Website

Background
Education, Training, & Certifications
- Ph.D., University of California at Santa Barbara 2006
Duke Appointment History
- Assistant Professor in Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011 - 2015
- Instructor Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2011
Recognition
In the News
- DEC 8, 2015 WNCN
  
  Is a diabetes drug the key to a longer life?
Awards & Honors
- New Scholar in Aging Award. Ellison Medical Foundation. 2013
Expertise
Subject Headings
Research
Selected Grants
- In Vivo Modeling of Mitochondrial Complex I Deficiency in Retinal Ganglion Cells awarded by National Institutes of Health 2018 - 2023
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
- The role of ATM in Metabolic Stress Responses awarded by National Institutes of Health 2011 - 2021
- The Effects of a Novel Statin-Induced Protein Modification on Fatty Acid Synthase awarded by National Institutes of Health 2017 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Buck Institute for Research on Aging 2017 - 2019
- Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease awarded by National Institutes of Health 2014 - 2019
- Role of Protein Malonylation in Regulating Mitochondrial Function awarded by National Institutes of Health 2015 - 2018
- Ethanol-induced Protein Acylation Regulates Metabolism awarded by National Institutes of Health 2013 - 2018
- The Role of SIRT5 in Regulating Cardiac Function and Metabolism awarded by National Institutes of Health 2015 - 2018
- SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease awarded by Ellison Medical Foundation 2013 - 2018
- Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging awarded by National Institutes of Health 2016 - 2017
- Protein Biomarkers in FRDA Cardiomyopathy to Monitor Disease Progression and Therapeutic Efficacy awarded by Friedreich's Ataxia Research Alliance 2016 - 2017
- NRSA Predoctoral Fellowship awarded by National Institutes of Health 2014 - 2017
- Reversible Mitochondrial Protein Acetylation and Metabolic Regulation awarded by Gladstone 2010 - 2017
- Metabolic Sensing and Stress Response Deficit in Ataxia Telangiectasia awarded by A-T Children's Project 2014 - 2016
- The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism awarded by Canadian Diabetes Association 2015 - 2016
- The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism awarded by Canadian Diabetes Association 2013 - 2016
- Metabolic Regulators of Insulin Secretion and Insulin Resistance awarded by National Institutes of Health 2013 - 2015
Publications & Artistic Works
Selected Publications
- Book Sections
  - Huynh, FK, Mcdonnell, E, Anderson, KA, and Hirschey, MD. "Sirtuins." In Signaling Pathways in Liver Diseases: Third Edition, 374-384. September 28, 2015. Full Text
- Conference Papers
  - Hirschey, M. "Epigenetic Control of Gene Expression by Lipid Metabolism." April 2017. Link to Item
  - Zhang, Z, Ma, Q, Nicoara, A, Quinones, Q, Hirschey, M, and Podgoreanu, MV. "Sex-Specific Cardioprotective Effects of Annexin A1 Peptide Mimetic Involve the Sirtuin 3 Signaling Pathway." November 11, 2016. Link to Item
  - Henriques, BJ, Anderson, KA, Hirschey, MD, and Gomes, CM. "Regulation of mitochondria beta oxidation by non-enzymatic post-translational modifications." July 2015. Link to Item
  - Hirschey, M. "Protein Acylation Regulates Metabolism." January 2014. Full Text
- Journal Articles
  - Hershberger, KA, Abraham, DM, Liu, J, Locasale, JW, Grimsrud, PA, and Hirschey, MD. "Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload." The Journal of Biological Chemistry 293, no. 27 (July 2018): 10630-10645. Full Text
  - Peterson, BS, Campbell, JE, Ilkayeva, O, Grimsrud, PA, Hirschey, MD, and Newgard, CB. "Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition." Cell Reports 24, no. 1 (July 2018): 209-223.e6. Full Text
  - Trub, AG, and Hirschey, MD. "Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress." Trends in Biochemical Sciences 43, no. 5 (May 2018): 369-379. Full Text
  - Hu, Y, Semova, I, Sun, X, Kang, H, Chahar, S, Hollenberg, AN, Masson, D, Hirschey, MD, Miao, J, and Biddinger, SB. "Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways." The Journal of Biological Chemistry 293, no. 6 (February 2018): 2006-2014. Full Text
  - Huynh, FK, Hu, X, Lin, Z, Johnson, JD, and Hirschey, MD. "Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds." Journal of inherited metabolic disease 41, no. 1 (January 2018): 59-72. Full Text
  - Anderson, KA, Madsen, AS, Olsen, CA, and Hirschey, MD. "Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio." Biochimica Et Biophysica Acta. Bioenergetics 1858, no. 12 (December 2017): 991-998. (Review) Full Text
  - Hershberger, KA, Abraham, DM, Martin, AS, Mao, L, Liu, J, Gu, H, Locasale, JW, and Hirschey, MD. "Sirtuin 5 is required for mouse survival in response to cardiac pressure overload." The Journal of Biological Chemistry 292, no. 48 (December 2017): 19767-19781. Full Text
  - Weir, HJ, Yao, P, Huynh, FK, Escoubas, CC, Goncalves, RL, Burkewitz, K, Laboy, R, Hirschey, MD, and Mair, WB. "Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling." Cell Metabolism 26, no. 6 (December 2017): 884-896.e5. Full Text
  - Rajabi, N, Auth, M, Troelsen, KR, Pannek, M, Bhatt, DP, Fontenas, M, Hirschey, MD, Steegborn, C, Madsen, AS, and Olsen, CA. "Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight." Angewandte Chemie (International ed. in English) 56, no. 47 (November 2017): 14836-14841. Full Text
  - Hibshman, JD, Doan, AE, Moore, BT, Kaplan, RE, Hung, A, Webster, AK, Bhatt, DP, Chitrakar, R, Hirschey, MD, and Baugh, LR. "daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival." eLife 6 (October 24, 2017). Full Text
  - Assiri, MA, Roy, SR, Harris, PS, Ali, H, Liang, Y, Shearn, CT, Orlicky, DJ, Roede, JR, Hirschey, MD, Backos, DS, and Fritz, KS. "Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation." Alcoholism, Clinical and Experimental Research 41, no. 10 (October 2017): 1705-1714. Full Text
  - Martin, AS, Abraham, DM, Hershberger, KA, Bhatt, DP, Mao, L, Cui, H, Liu, J, Liu, X, Muehlbauer, MJ, Grimsrud, PA, Locasale, JW, Payne, RM, and Hirschey, MD. "Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model." Jci Insight 2, no. 14 (July 20, 2017). Full Text
  - Anderson, KA, Huynh, FK, Fisher-Wellman, K, Stuart, JD, Peterson, BS, Douros, JD, Wagner, GR, Thompson, JW, Madsen, AS, Green, MF, Sivley, RM, Ilkayeva, OR, Stevens, RD, Backos, DS, Capra, JA, Olsen, CA, Campbell, JE, Muoio, DM, Grimsrud, PA, and Hirschey, MD. "SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion." Cell Metabolism 25, no. 4 (April 2017): 838-855.e15. Full Text
  - Hershberger, KA, Martin, AS, and Hirschey, MD. "Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases." Nature Reviews. Nephrology 13, no. 4 (April 2017): 213-225. (Review) Full Text
  - Wagner, GR, Bhatt, DP, O'Connell, TM, Thompson, JW, Dubois, LG, Backos, DS, Yang, H, Mitchell, GA, Ilkayeva, OR, Stevens, RD, Grimsrud, PA, and Hirschey, MD. "A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation." Cell metabolism 25, no. 4 (April 2017): 823-837.e8. Full Text
  - Wagner, GR, and Hirschey, MD. "A Prob(e)able Route to Lysine Acylation." Cell chemical biology 24, no. 2 (February 2017): 126-128. Full Text
  - Stram, AR, Wagner, GR, Fogler, BD, Pride, PM, Hirschey, MD, and Payne, RM. "Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy." PloS one 12, no. 5 (January 2017): e0178354-. Full Text
  - Luz, AT, Godebo, TR, Bhatt, DP, Ilkayeva, OR, Maurer, LL, Hirschey, MD, and Meyer, JN. "Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans." Toxicological Sciences 154, no. 1 (November 2016): 195-null. Full Text
  - McDonnell, E, Crown, SB, Fox, DB, Kitir, B, Ilkayeva, OR, Olsen, CA, Grimsrud, PA, and Hirschey, MD. "Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation." Cell Reports 17, no. 6 (November 2016): 1463-1472. Full Text
  - Luz, AL, Godebo, TR, Bhatt, DP, Ilkayeva, OR, Maurer, LL, Hirschey, MD, and Meyer, JN. "From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans." Toxicological Sciences : an Official Journal of the Society of Toxicology 152, no. 2 (August 2016): 349-362. Full Text Open Access Copy
  - Luz, AL, Lagido, C, Hirschey, MD, and Meyer, JN. "In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction." Current Protocols in Toxicology 69 (August 2016): 25.8.1-25.8.22. Full Text
  - Quinones, QJ, Zhang, Z, Ma, Q, Smith, MP, Soderblom, E, Moseley, MA, Bain, J, Newgard, CB, Muehlbauer, MJ, Hirschey, M, Drew, KL, Barnes, BM, and Podgoreanu, MV. "Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats." Anesthesiology 124, no. 6 (June 2016): 1296-1310. Full Text
  - Madsen, AS, Andersen, C, Daoud, M, Anderson, KA, Laursen, JS, Chakladar, S, Huynh, FK, Colaço, AR, Backos, DS, Fristrup, P, Hirschey, MD, and Olsen, CA. "Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH." The Journal of Biological Chemistry 291, no. 13 (March 2016): 7128-7141. Full Text
  - Block, KI, Gyllenhaal, C, Lowe, L, Amedei, A, Amin, ARMR, Amin, A, Aquilano, K, Arbiser, J, Arreola, A, Arzumanyan, A, Ashraf, SS, Azmi, AS, Benencia, F, Bhakta, D, Bilsland, A, Bishayee, A, Blain, SW, Block, PB, Boosani, CS, Carey, TE, Carnero, A, Carotenuto, M, Casey, SC, Chakrabarti, M, Chaturvedi, R, Chen, GZ, Chen, H, Chen, S, Chen, YC, Choi, BK, Ciriolo, MR, Coley, HM, Collins, AR, Connell, M, Crawford, S, Curran, CS, Dabrosin, C, Damia, G, Dasgupta, S, DeBerardinis, RJ, Decker, WK, Dhawan, P, Diehl, AME, Dong, J-T, Dou, QP, Drew, JE, Elkord, E, El-Rayes, B, Feitelson, MA, Felsher, DW, Ferguson, LR, Fimognari, C, Firestone, GL, Frezza, C, Fujii, H, Fuster, MM, Generali, D, Georgakilas, AG, Gieseler, F, Gilbertson, M, Green, MF, Grue, B, Guha, G, Halicka, D, Helferich, WG, Heneberg, P, Hentosh, P, Hirschey, MD, Hofseth, LJ, Holcombe, RF, Honoki, K, Hsu, H-Y, Huang, GS, Jensen, LD, Jiang, WG, Jones, LW, Karpowicz, PA, Keith, WN, Kerkar, SP, Khan, GN, Khatami, M, Ko, YH, Kucuk, O, Kulathinal, RJ, Kumar, NB, Kwon, BS, Le, A, Lea, MA, Lee, H-Y, Lichtor, T, Lin, L-T, Locasale, JW, Lokeshwar, BL, Longo, VD, Lyssiotis, CA, MacKenzie, KL, Malhotra, M, Marino, M, Martinez-Chantar, ML, Matheu, A, Maxwell, C, McDonnell, E, Meeker, AK, Mehrmohamadi, M, Mehta, K, Michelotti, GA, Mohammad, RM, Mohammed, SI, Morre, DJ, Muralidhar, V, Muqbil, I, Murphy, MP, Nagaraju, GP, Nahta, R, Niccolai, E, Nowsheen, S, Panis, C, Pantano, F, Parslow, VR, Pawelec, G, Pedersen, PL, Poore, B, Poudyal, D, Prakash, S, Prince, M, Raffaghello, L, Rathmell, JC, Rathmell, WK, Ray, SK, Reichrath, J, Rezazadeh, S, Ribatti, D, Ricciardiello, L, Robey, RB, Rodier, F, Rupasinghe, HPV, Russo, GL, Ryan, EP, Samadi, AK, Sanchez-Garcia, I, Sanders, AJ, Santini, D, Sarkar, M, Sasada, T, Saxena, NK, Shackelford, RE, Shantha Kumara, HMC, Sharma, D, Shin, DM, Sidransky, D, Siegelin, MD, Signori, E, Singh, N, Sivanand, S, Sliva, D, Smythe, C, Spagnuolo, C, Stafforini, DM, Stagg, J, Subbarayan, PR, Sundin, T, Talib, WH, Thompson, SK, Tran, PT, Ungefroren, H, Vander Heiden, MG, Venkateswaran, V, Vinay, DS, Vlachostergios, PJ, Wang, Z, Wellen, KE, Whelan, RL, Yang, ES, Yang, H, Yang, X, Yaswen, P, Yedjou, C, Yin, X, Zhu, J, and Zollo, M. "Designing a broad-spectrum integrative approach for cancer prevention and treatment." Seminars in Cancer Biology 35 Suppl (December 2015): S276-S304. (Review) Full Text
  - Hirschey, MD, DeBerardinis, RJ, Diehl, AME, Drew, JE, Frezza, C, Green, MF, Jones, LW, Ko, YH, Le, A, Lea, MA, Locasale, JW, Longo, VD, Lyssiotis, CA, McDonnell, E, Mehrmohamadi, M, Michelotti, G, Muralidhar, V, Murphy, MP, Pedersen, PL, Poore, B, Raffaghello, L, Rathmell, JC, Sivanand, S, Vander Heiden, MG, Wellen, KE, and Target Validation Team, . "Dysregulated metabolism contributes to oncogenesis." Seminars in Cancer Biology 35 Suppl (December 2015): S129-S150. (Review) Full Text
  - Hirschey, MD, and Zhao, Y. "Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation." Molecular & Cellular Proteomics : Mcp 14, no. 9 (September 2015): 2308-2315. (Review) Full Text
  - Huynh, FK, Muoio, DM, and Hirschey, MD. "SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control." Diabetes 64, no. 9 (September 2015): 3058-3060. Full Text
  - McDonnell, E, Peterson, BS, Bomze, HM, and Hirschey, MD. "SIRT3 regulates progression and development of diseases of aging." Trends in Endocrinology and Metabolism: Tem 26, no. 9 (September 2015): 486-492. (Review) Full Text
  - Otsubo, C, Bharathi, S, Uppala, R, Ilkayeva, OR, Wang, D, McHugh, K, Zou, Y, Wang, J, Alcorn, JF, Zuo, YY, Hirschey, MD, and Goetzman, ES. "Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant." The Journal of Biological Chemistry 290, no. 39 (September 2015): 23897-23904. Full Text
  - Liu, X, Sadhukhan, S, Sun, S, Wagner, GR, Hirschey, MD, Qi, L, Lin, H, and Locasale, JW. "High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet." Molecular & Cellular Proteomics : Mcp 14, no. 6 (June 2015): 1489-1500. Full Text
  - Glass, OK, Inman, BA, Broadwater, G, Courneya, KS, Mackey, JR, Goruk, S, Nelson, ER, Jasper, J, Field, CJ, Bain, JR, Muehlbauer, M, Stevens, RD, Hirschey, MD, and Jones, LW. "Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study." British journal of cancer 112, no. 5 (March 2015): 825-831. Full Text
  - Burkewitz, K, Morantte, I, Weir, HJM, Yeo, R, Zhang, Y, Huynh, FK, Ilkayeva, OR, Hirschey, MD, Grant, AR, and Mair, WB. "Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal." Cell 160, no. 5 (February 2015): 842-855. Full Text
  - Glass, OK, Inman, BA, Broadwater, G, Courneya, KS, Mackey, JR, Goruk, S, Nelson, ER, Jasper, J, Field, CJ, Bain, JR, Muehlbauer, M, Stevens, RD, Hirschey, MD, and Jones, LW. "Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study." British Journal of Cancer 112, no. 5 (January 1, 2015): 825-831. Full Text
  - Moffat, C, Bhatia, L, Nguyen, T, Lynch, P, Wang, M, Wang, D, Ilkayeva, OR, Han, X, Hirschey, MD, Claypool, SM, and Seifert, EL. "Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver." Journal of Lipid Research 55, no. 12 (December 2014): 2458-2470. Full Text
  - Shaughnessy, DT, McAllister, K, Worth, L, Haugen, AC, Meyer, JN, Domann, FE, Van Houten, B, Mostoslavsky, R, Bultman, SJ, Baccarelli, AA, Begley, TJ, Sobol, RW, Hirschey, MD, Ideker, T, Santos, JH, Copeland, WC, Tice, RR, Balshaw, DM, and Tyson, FL. "Mitochondria, energetics, epigenetics, and cellular responses to stress." Environmental Health Perspectives 122, no. 12 (December 2014): 1271-1278. (Review) Full Text
  - Anderson, KA, Green, MF, Huynh, FK, Wagner, GR, and Hirschey, MD. "SnapShot: Mammalian Sirtuins." Cell 159, no. 4 (November 2014): 956-956.e1. Full Text
  - Huynh, FK, and Hirschey, MD. "Loss of Sirtuin 4 Leads to Insulin Resistance in Mice." ENDOCRINE REVIEWS 35, no. 3 (June 2014). Link to Item
  - Tan, M, Peng, C, Anderson, KA, Chhoy, P, Xie, Z, Dai, L, Park, J, Chen, Y, Huang, H, Zhang, Y, Ro, J, Wagner, GR, Green, MF, Madsen, AS, Schmiesing, J, Peterson, BS, Xu, G, Ilkayeva, OR, Muehlbauer, MJ, Braulke, T, Mühlhausen, C, Backos, DS, Olsen, CA, McGuire, PJ, Pletcher, SD, Lombard, DB, Hirschey, MD, and Zhao, Y. "Lysine glutarylation is a protein posttranslational modification regulated by SIRT5." Cell Metabolism 19, no. 4 (April 2014): 605-617. Full Text
  - Wagner, GR, and Hirschey, MD. "Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases." Molecular Cell 54, no. 1 (April 2014): 5-16. (Review) Full Text
  - Huynh, FK, Green, MF, Koves, TR, and Hirschey, MD. "Measurement of fatty acid oxidation rates in animal tissues and cell lines." Methods in Enzymology 542 (January 2014): 391-405. Full Text
  - Schechter, MA, Hsieh, MKH, Njoroge, LW, Thompson, JW, Soderblom, EJ, Feger, BJ, Troupes, CD, Hershberger, KA, Ilkayeva, OR, Nagel, WL, Landinez, GP, Shah, KM, Burns, VA, Santacruz, L, Hirschey, MD, Foster, MW, Milano, CA, Moseley, MA, Piacentino, V, and Bowles, DE. "Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure." PLoS ONE 9, no. 8 (January 2014): e104157-. Full Text Open Access Copy
  - Bharathi, SS, Zhang, Y, Mohsen, A-W, Uppala, R, Balasubramani, M, Schreiber, E, Uechi, G, Beck, ME, Rardin, MJ, Vockley, J, Verdin, E, Gibson, BW, Hirschey, MD, and Goetzman, ES. "Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site." The Journal of Biological Chemistry 288, no. 47 (November 2013): 33837-33847. Full Text
  - Anderson, KA, Wang, D, and Hirschey, MD. "HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint?." Hepatology 57, no. 5 (May 2013): 1681-1683. Full Text Link to Item
  - Huynh, FK, Hershberger, KA, and Hirschey, MD. "Targeting sirtuins for the treatment of diabetes." Diabetes management (London, England) 3, no. 3 (May 2013): 245-257. Full Text
  - Merksamer, PI, Liu, Y, He, W, Hirschey, MD, Chen, D, and Verdin, E. "The sirtuins, oxidative stress and aging: an emerging link." Aging 5, no. 3 (March 2013): 144-150. (Review) Full Text
  - Gut, P, Baeza-Raja, B, Andersson, O, Hasenkamp, L, Hsiao, J, Hesselson, D, Akassoglou, K, Verdin, E, Hirschey, MD, and Stainier, DYR. "Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism." Nature Chemical Biology 9, no. 2 (February 2013): 97-104. Full Text
  - Fritz, KS, Green, MF, Petersen, DR, and Hirschey, MD. "Ethanol metabolism modifies hepatic protein acylation in mice. (Published online)" PLoS One 8, no. 9 (2013): e75868-. Full Text Link to Item
  - Green, MF, and Hirschey, MD. "SIRT3 weighs heavily in the metabolic balance: A new role for SIRT3 in metabolic syndrome." Journals of Gerontology - Series A Biological Sciences and Medical Sciences 68, no. 2 (2013): 105-107. Full Text
  - Gut, P, Baeza-Raja, B, Andersson, O, Hasenkamp, L, Hsiao, J, Hesselson, D, Akassoglou, K, Verdin, E, Hirschey, MD, and Stainier, DYR. "Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism." Nature Chemical Biology 9, no. 2 (2013): 97-104. Full Text
  - Hershberger, KA, Motley, J, Hirschey, MD, and Anderson, KA. "Generating mammalian sirtuin tools for protein-interaction analysis." Methods Mol Biol 1077 (2013): 69-78. Full Text Link to Item
  - Shimazu, T, Hirschey, MD, Newman, J, He, W, Shirakawa, K, Le Moan, N, Grueter, CA, Lim, H, Saunders, LR, Stevens, RD, Newgard, CB, Farese, RV, de Cabo, R, Ulrich, S, Akassoglou, K, and Verdin, E. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science (New York, N.Y.) 339, no. 6116 (January 2013): 211-214. Full Text
  - Shimazu, T, Hirschey, MD, Newman, J, He, W, Shirakawa, K, Moan, NL, Grueter, CA, Lim, H, Saunders, LR, Stevens, RD, Newgard, CB, Jr, RVF, Cabo, RD, Ulrich, S, Akassoglou, K, and Verdin, E. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science 339, no. 6116 (2013): 211-214. Full Text
  - Wang, D, Green, MF, McDonnell, E, and Hirschey, MD. "Oxygen flux analysis to understand the biological function of sirtuins." Methods Mol Biol 1077 (2013): 241-258. Full Text Link to Item
  - Haas, JT, Miao, J, Chanda, D, Wang, Y, Zhao, E, Haas, ME, Hirschey, M, Vaitheesvaran, B, Farese, RV, Kurland, IJ, Graham, M, Crooke, R, Foufelle, F, and Biddinger, SB. "Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression." Cell Metabolism 15, no. 6 (June 2012): 873-884. Full Text
  - Fritz, KS, Galligan, JJ, Hirschey, MD, Verdin, E, and Petersen, DR. "Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice." Journal of Proteome Research 11, no. 3 (March 2012): 1633-1643. Full Text
  - Anderson, KA, and Hirschey, MD. "Mitochondrial protein acetylation regulates metabolism." Essays in Biochemistry 52 (January 2012): 23-35. (Review) Full Text
  - Streeper, RS, Grueter, CA, Salomonis, N, Cases, S, Levin, MC, Koliwad, SK, Zhou, P, Hirschey, MD, Verdin, E, and Farese, RV. "Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice." Aging 4, no. 1 (January 2012): 13-27. Full Text
  - Fritz, KS, Galligan, JJ, Hirschey, MD, Verdin, E, and Petersen, DR. "Mitochondrial Acetylomic Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice." Free Radical Biology and Medicine 51 (November 2011): S19-S20. Full Text
  - Hirschey, MD, Shimazu, T, Jing, E, Grueter, CA, Collins, AM, Aouizerat, B, Stančáková, A, Goetzman, E, Lam, MM, Schwer, B, Stevens, RD, Muehlbauer, MJ, Kakar, S, Bass, NM, Kuusisto, J, Laakso, M, Alt, FW, Newgard, CB, Farese, RV, Kahn, CR, and Verdin, E. "SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome." Molecular Cell 44, no. 2 (October 2011): 177-190. Full Text
  - Jing, E, Emanuelli, B, Hirschey, MD, Boucher, J, Lee, KY, Lombard, D, Verdin, EM, and Kahn, CR. "Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production." Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (August 22, 2011): 14608-14613. Full Text
  - Hirschey, MD, Shimazu, T, Capra, JA, Pollard, KS, and Verdin, E. "SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2." Aging 3, no. 6 (2011): 635-642.
  - Hirschey, MD, Shimazu, T, Huang, J-Y, Schwer, B, and Verdin, E. "SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism." Cold Spring Harbor Symposia on Quantitative Biology 76 (January 2011): 267-277. (Review) Full Text
  - Hirschey, MD. "Old enzymes, new tricks: Sirtuins are NAD ⁺-dependent De-acylases." Cell Metabolism 14, no. 6 (2011): 718-719. Full Text
  - Qiu, X, Brown, K, Hirschey, MD, Verdin, E, and Chen, D. "Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation." Cell Metabolism 12, no. 6 (December 2010): 662-667. Full Text
  - Shimazu, T, Hirschey, MD, Hua, L, Dittenhafer-Reed, KE, Schwer, B, Lombard, DB, Li, Y, Bunkenborg, J, Alt, FW, Denu, JM, Jacobson, MP, and Verdin, E. "SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production." Cell Metabolism 12, no. 6 (December 2010): 654-661. Full Text
  - Verdin, E, Hirschey, MD, Finley, LWS, and Haigis, MC. "Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling." Trends in Biochemical Sciences 35, no. 12 (December 2010): 669-675. (Review) Full Text
  - Huang, J-Y, Hirschey, MD, Shimazu, T, Ho, L, and Verdin, E. "Mitochondrial sirtuins." Biochimica Et Biophysica Acta 1804, no. 8 (August 2010): 1645-1651. (Review) Full Text
  - Shimazu, T, Hirschey, MD, Huang, J-Y, Ho, LTY, and Verdin, E. "Acetate metabolism and aging: An emerging connection." Mechanisms of Ageing and Development 131, no. 7-8 (July 2010): 511-516. Full Text
  - Hirschey, MD, and Verdin, E. "Measuring fatty acid oxidation in tissue homogenates." Protocol Exchange (April 15, 2010). Full Text
  - Hirschey, MD, Shimazu, T, Goetzman, E, Jing, E, Schwer, B, Lombard, DB, Grueter, CA, Harris, C, Biddinger, S, Ilkayeva, OR, Stevens, RD, Li, Y, Saha, AK, Ruderman, NB, Bain, JR, Newgard, CB, Farese, RV, Alt, FW, Kahn, CR, and Verdin, E. "SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation." Nature 464, no. 7285 (March 2010): 121-125. Full Text
  - Hirschey, MD, Shimazu, T, Huang, J-Y, and Verdin, E. "Acetylation of mitochondrial proteins." Methods Enzymol 457 (2009): 137-147. Full Text Link to Item
  - Lombard, DB, Alt, FW, Cheng, H-L, Bunkenborg, J, Streeper, RS, Mostoslavsky, R, Kim, J, Yancopoulos, G, Valenzuela, D, Murphy, A, Yang, Y, Chen, Y, Hirschey, MD, Bronson, RT, Haigis, M, Guarente, LP, Farese, RV, Weissman, S, Verdin, E, and Schwer, B. "Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation." Molecular and Cellular Biology 27, no. 24 (December 2007): 8807-8814. Full Text
  - Saini, S, Rubin, GD, and Kalra, MK. "Preface." MDCT: A Practical Approach (December 1, 2006). Full Text
  - Hirschey, MD, Han, Y-J, Stucky, GD, and Butler, A. "Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots." J Biol Inorg Chem 11, no. 5 (July 2006): 663-669. Full Text Link to Item
  - Burton, RM, Forsyth, JD, and Obel, B. "Preface." Technovation 8, no. 1-3 (1988): vii-.
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