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Matthew Hirschey

Associate Professor of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
104775, Room 50-201, Durham, NC 27701
300 N. Duke Street, 50-201, Durham, NC 27701

Selected Grants


Endocrinology and Metabolism Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Novel mitochondrial protective properties of annexin A1

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Endocrinology and Metabolism Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Novel mitochondrial protective properties of annexin A1

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Studies on the impact of acetyl-cysteine on metabolism

ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2022 - 2024

Duke University Program in Environmental Health

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2024

Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024

Duke Resident Physician-Scientist Program - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2023

Duke Training Grant in Nephrology

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023

In Vivo Modeling of Mitochondrial Complex I Deficiency in Retinal Ganglion Cells

ResearchAdvisor · Awarded by National Institutes of Health · 2018 - 2023

Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2022

Determining the Sub-Cellular Organelles that Link Lipid Signaling and Epigenetics

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

Glenn Award for Research in Biological Mechanisms of Aging

ResearchPrincipal Investigator · Awarded by Glenn Foundation for Medical Research · 2018 - 2021

The role of NRF2 in breast cancer dormancy and recurrence

FellowshipCollaborator · Awarded by National Institutes of Health · 2019 - 2020

Statin-induced Increases in HMG-CoA lead to HMG-modified Fatty Acid Synthase

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2020

Reversible Mitochondrial Protein Acetylation and Metabolic Regulation

ResearchCo Investigator · Awarded by Buck Institute for Research on Aging · 2017 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020

Pharmacology Industry Internships for Ph.D. Students

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2017 - 2019

Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer

EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019

Ethanol-induced Protein Acylation Regulates Metabolism

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018

The Role of SIRT5 in Regulating Cardiac Function and Metabolism

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018

SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease

ResearchPrincipal Investigator · Awarded by Ellison Medical Foundation · 2013 - 2018

Role of Protein Malonylation in Regulating Mitochondrial Function

FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2015 - 2017

Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2017

Protein Biomarkers in FRDA Cardiomyopathy to Monitor Disease Progression and Therapeutic Efficacy

ResearchPrincipal Investigator · Awarded by Friedreich's Ataxia Research Alliance · 2016 - 2017

The Role of Acetylation in Regulating Iron-Sulfur Cluster Biogenesis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2017

Reversible Mitochondrial Protein Acetylation and Metabolic Regulation

ResearchCo Investigator · Awarded by Gladstone · 2010 - 2017

Metabolic Sensing and Stress Response Deficit in Ataxia Telangiectasia

ResearchCollaborator · Awarded by A-T Children's Project · 2014 - 2016

The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism

FellowshipPrincipal Investigator · Awarded by Canadian Diabetes Association · 2015 - 2016

The Role of Adipose-Specific SIRT3 in Regulating Glucose and Lipid Metabolism

FellowshipPrincipal Investigator · Awarded by Canadian Diabetes Association · 2013 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Metabolic Regulators of Insulin Secretion and Insulin Resistance

ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2015

Fellowships, Gifts, and Supported Research


Seed Grant: Computational Biology Reading Group (CBRG) · 2022 PI · Duke Office for Faculty Advancement

External Relationships


  • Duke-NUS
  • GenFlow Biosciences
  • Heureka Labs
  • Millipore Corporation (Merck)

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.