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Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.

Publication ,  Journal Article
Stanland, LJ; Luftig, MA
Published in: Future Virol
November 2018

Epstein-Barr Virus (EBV) was the first discovered human tumor virus and is the etiological agent of B cell lymphomas and also epithelial cancers. Indeed, nearly 10% of gastric cancers worldwide are EBV-positive and display unique molecular, epigenetic, and clinicopathological features. EBV-positive gastric cancers display the highest rate of host genome methylation of all tumor types studied and harbor recurrent mutations activating PI3Kα, silencing ARID1A, and amplifying PD-L1. While EBV infection of B cells can be studied efficiently, de novo epithelial cell infection is much more difficult. We propose that new culture models including 3D-based gastric organoids and xenografts can bring new insight into EBV-induced gastric carcinogenesis and will lead to improved precision medicine-based therapies for patients with EBV-positive gastric cancer.

Duke Scholars

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Published In

Future Virol

DOI

ISSN

1746-0794

Publication Date

November 2018

Volume

13

Issue

11

Start / End Page

803 / 818

Location

England

Related Subject Headings

  • Virology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

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Chicago
ICMJE
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Stanland, L. J., & Luftig, M. A. (2018). Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer. Future Virol, 13(11), 803–818. https://doi.org/10.2217/fvl-2018-0071
Stanland, Lyla J., and Micah A. Luftig. “Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.Future Virol 13, no. 11 (November 2018): 803–18. https://doi.org/10.2217/fvl-2018-0071.
Stanland LJ, Luftig MA. Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer. Future Virol. 2018 Nov;13(11):803–18.
Stanland, Lyla J., and Micah A. Luftig. “Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.Future Virol, vol. 13, no. 11, Nov. 2018, pp. 803–18. Pubmed, doi:10.2217/fvl-2018-0071.
Stanland LJ, Luftig MA. Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer. Future Virol. 2018 Nov;13(11):803–818.
Journal cover image

Published In

Future Virol

DOI

ISSN

1746-0794

Publication Date

November 2018

Volume

13

Issue

11

Start / End Page

803 / 818

Location

England

Related Subject Headings

  • Virology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology