Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.
Journal Article (Journal Article)
Epstein-Barr Virus (EBV) was the first discovered human tumor virus and is the etiological agent of B cell lymphomas and also epithelial cancers. Indeed, nearly 10% of gastric cancers worldwide are EBV-positive and display unique molecular, epigenetic, and clinicopathological features. EBV-positive gastric cancers display the highest rate of host genome methylation of all tumor types studied and harbor recurrent mutations activating PI3Kα, silencing ARID1A, and amplifying PD-L1. While EBV infection of B cells can be studied efficiently, de novo epithelial cell infection is much more difficult. We propose that new culture models including 3D-based gastric organoids and xenografts can bring new insight into EBV-induced gastric carcinogenesis and will lead to improved precision medicine-based therapies for patients with EBV-positive gastric cancer.
- Stanland, LJ; Luftig, MA
- November 2018
Volume / Issue
- 13 / 11
Start / End Page
- 803 - 818
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)