Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer


Journal Article (Review)

© 2018 2018 Future Medicine Ltd. Epstein-Barr virus (EBV) was the first discovered human tumor virus and is the etiological agent of B-cell lymphomas and also epithelial cancers. Indeed, nearly 10% of gastric cancers worldwide are EBV-positive and display unique molecular, epigenetic and clinicopathological features. EBV-positive gastric cancers display the highest rate of host genome methylation of all tumor types studied and harbor recurrent mutations activating PI3Kα, silencing ARID1A and amplifying PD-L1. While EBV infection of B cells can be studied efficiently, de novo epithelial cell infection is much more difficult. We propose that new culture models including 3D-based gastric organoids and xenografts can bring new insight into EBV- induced gastric carcinogenesis and will lead to improved precision medicine-based therapies for patients with EBV-positive gastric cancer.

Full Text

Duke Authors

Cited Authors

  • Stanland, LJ; Luftig, MA

Published Date

  • November 1, 2018

Published In

Volume / Issue

  • 13 / 11

Start / End Page

  • 803 - 818

Electronic International Standard Serial Number (EISSN)

  • 1746-0808

International Standard Serial Number (ISSN)

  • 1746-0794

Digital Object Identifier (DOI)

  • 10.2217/fvl-2018-0071

Citation Source

  • Scopus