Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.

Journal Article (Journal Article)

Epstein-Barr Virus (EBV) was the first discovered human tumor virus and is the etiological agent of B cell lymphomas and also epithelial cancers. Indeed, nearly 10% of gastric cancers worldwide are EBV-positive and display unique molecular, epigenetic, and clinicopathological features. EBV-positive gastric cancers display the highest rate of host genome methylation of all tumor types studied and harbor recurrent mutations activating PI3Kα, silencing ARID1A, and amplifying PD-L1. While EBV infection of B cells can be studied efficiently, de novo epithelial cell infection is much more difficult. We propose that new culture models including 3D-based gastric organoids and xenografts can bring new insight into EBV-induced gastric carcinogenesis and will lead to improved precision medicine-based therapies for patients with EBV-positive gastric cancer.

Full Text

Duke Authors

Cited Authors

  • Stanland, LJ; Luftig, MA

Published Date

  • November 2018

Published In

Volume / Issue

  • 13 / 11

Start / End Page

  • 803 - 818

PubMed ID

  • 34367314

Pubmed Central ID

  • PMC8345226

International Standard Serial Number (ISSN)

  • 1746-0794

Digital Object Identifier (DOI)

  • 10.2217/fvl-2018-0071


  • eng

Conference Location

  • England