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Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.

Publication ,  Journal Article
Fixsen, E; Patel, J; Selim, MA; Kheterpal, M
Published in: Oncologist
March 2019

Checkpoint inhibitors such as pembrolizumab, an anti-PD-1 monoclonal antibody, are a promising new category of oncological therapeutics, associated with a higher risk of immune-related adverse events including dermatological, autoimmune and endocrine sequelae. Here, we present a case of a woman 76 years of age with stage IV lung adenocarcinoma who developed a severe and steroid-refractory lichenoid dermatitis associated with pruritus on pembrolizumab. This eruption resolved completely with a short course of oral cyclosporine. Cyclosporine is a promising and effective treatment option for checkpoint inhibitor-related severe cutaneous eruptions.

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Published In

Oncologist

DOI

EISSN

1549-490X

Publication Date

March 2019

Volume

24

Issue

3

Start / End Page

e103 / e105

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Lichenoid Eruptions
  • Humans
  • Female
  • Dermatologic Agents
  • Dermatitis
  • Cyclosporine
  • Antibodies, Monoclonal, Humanized
  • Aged
  • 3211 Oncology and carcinogenesis
 

Citation

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Fixsen, E., Patel, J., Selim, M. A., & Kheterpal, M. (2019). Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine. Oncologist, 24(3), e103–e105. https://doi.org/10.1634/theoncologist.2018-0531
Fixsen, Emma, Jigar Patel, Maria Angelica Selim, and Meenal Kheterpal. “Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.Oncologist 24, no. 3 (March 2019): e103–5. https://doi.org/10.1634/theoncologist.2018-0531.
Fixsen E, Patel J, Selim MA, Kheterpal M. Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine. Oncologist. 2019 Mar;24(3):e103–5.
Fixsen, Emma, et al. “Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.Oncologist, vol. 24, no. 3, Mar. 2019, pp. e103–05. Pubmed, doi:10.1634/theoncologist.2018-0531.
Fixsen E, Patel J, Selim MA, Kheterpal M. Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine. Oncologist. 2019 Mar;24(3):e103–e105.

Published In

Oncologist

DOI

EISSN

1549-490X

Publication Date

March 2019

Volume

24

Issue

3

Start / End Page

e103 / e105

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Lichenoid Eruptions
  • Humans
  • Female
  • Dermatologic Agents
  • Dermatitis
  • Cyclosporine
  • Antibodies, Monoclonal, Humanized
  • Aged
  • 3211 Oncology and carcinogenesis