The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin.

Journal Article (Journal Article)

BACKGROUND: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight. METHODS: Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined. RESULTS: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p=0.005), and median integrated leptin levels also increased (20%) significantly (p<0.001). BMI significantly increased (5 ± 2%; p=0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline. CONCLUSIONS: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.

Full Text

Duke Authors

Cited Authors

  • Francois, F; Roper, J; Joseph, N; Pei, Z; Chhada, A; Shak, JR; de Perez, AZO; Perez-Perez, GI; Blaser, MJ

Published Date

  • April 14, 2011

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 37 -

PubMed ID

  • 21489301

Pubmed Central ID

  • PMC3089783

Electronic International Standard Serial Number (EISSN)

  • 1471-230X

Digital Object Identifier (DOI)

  • 10.1186/1471-230X-11-37


  • eng

Conference Location

  • England