Jatin Roper
Assistant Professor of Medicine
My laboratory is interested in understanding the molecular mechanisms of stem cell function in the normal intestine and in colorectal cancer using innovative three-dimensional organoid and in vivo platforms. We demonstrated that high fat diet-induced obesity activates peroxisome proliferator-activated receptor delta (PPARd) signaling in intestinal stem cells and progenitor cells, which increases stem cell regeneration and tumor initiation in the colon. We also pioneered novel orthotopic transplantation and in situ CRISPR/Cas9 gene editing models of colorectal cancer that recapitulate the adenoma-carcinoma-metastasis sequence. Research in the laboratory is focused on three main areas: 1) Immune regulation of the intestinal epithelium and colorectal cancer; 2) The effects of diet-induced obesity on regeneration in the intestine; and 3) analysis of colorectal cancer heterogeneity with single-cell mRNA sequencing and genetically engineered mouse models. The overall goal of this research is to develop new treatment approaches for intestinal diseases such as inflammatory bowel disease and colorectal cancer. I am also a gastroenterologist at Duke University Hospital and the Durham VA Hospital. My clinical interests include colorectal cancer screening and gastrointestinal cancer genetics.
Current Research Interests
intestinal stem cell biology, inflammatory bowel disease, colorectal cancer
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2019
- Assistant Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2020
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
Contact Information
- 905 S. Lasalle Street, Gsrb-1, Room 1033, Durham, NC 27710
- DUMC 103862, Durham, NC 27710
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jatin.roper@duke.edu
(919) 660-2923
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Roper Lab website
- Background
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Education, Training, & Certifications
- Postdoctoral Fellow (mentor: Omer H. Yilmaz, M.D., PhD), Koch Institute for Integrative Cancer Research at MIT 2014 - 2018
- Postdoctoral Fellow in Gastroenterology and Hepatology, Tufts University School of Medicine 2011 - 2014
- Fellowship in Gastroenterology and Hepatology, Tufts University School of Medicine 2008 - 2012
- Residency in Internal Medicine, New York University School of Medicine 2006 - 2008
- Michael Saperstein Medical Scholar, New York University School of Medicine 2005 - 2006
- Internship in Internal Medicine, New York University School of Medicine 2004 - 2005
- M.D., Boston University School of Medicine 2004
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Medical Licensure
- 2018-02505. North Carolina. 2018
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Duke Appointment History
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Basic Science Departments 2019
- Recognition
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In the News
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DEC 8, 2020 Innovation and Entrepreneurship -
JUN 9, 2017 Nature Reviews Cancer -
MAY 2, 2017 Colon Cancer New Today -
MAY 1, 2017 MIT News -
APR 30, 2017 The Scientist -
MAY 5, 2016 Cell Stem Cell -
APR 19, 2016 Stem Cells Portal -
MAR 10, 2016 Obesity News Today -
MAR 8, 2016 Science Signaling -
MAR 5, 2016 Medical Daily -
MAR 2, 2016 Nature -
MAR 2, 2016 Ecancer News
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Awards & Honors
- Koch Institute for Integrative Cancer Research at MIT Image Award. Koch Institute for Integrative Cancer Research at MIT. 2018
- Vector Laboratories Photo Contest Winner. Vector Laboratories. 2017
- 1st Place, basic research, Massachusetts Medical Society Research Poster Symposium. Massachusetts Medical Society. 2016
- Digestive Disease Week Basic Science Travel Award. American Gastroenterological Association . 2016
- Koch Institute for Integrative Cancer Research at MIT Image Award. Koch Institute for Integrative Cancer Research at MIT. 2016
- V Scholar Award. V Foundation for Cancer Research. 2013
- ACG Travel Award for Outstanding Clinical Research Presentation. American College of Gastroenterology. 2011
- Investing in the Future: Clinical Research in IBD Award. American Gastroenterological Association . 2011
- 2nd place for Outstanding Poster. Tufts Medical Center Cancer Center . 2010
- Michael Saperstein Medical Scholar. NYU Langone Medical Center Department of Medicine. 2006
- Alumni Association Award. Boston University School of Medicine. May 2004
- Magna Cum laude. Boston University. May 2001
- David E. Rogers Fellowship. New York Academy of Medicine. 2001
- Research
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Selected Grants
- Ultra-bright fluorescent nanoparticles for colorectal adenoma detection awarded by National Institutes of Health 2021 - 2023
- Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy awarded by Department of Defense 2020 - 2023
- Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy awarded by National Institutes of Health 2021 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling awarded by Texas A&M University 2021 - 2022
- Evaluation of estrogen receptor as a therapeutic target in melanoma, lung and colorectal cancer models awarded by Zentalis Pharmaceuticals 2020 - 2022
- Gilead Sponsored Research Agreement awarded by Gilead Sciences, Inc. 2020 - 2022
- Immune surveillance in obesity-associated cancer awarded by Elsa U. Pardee Foundation 2020 - 2021
- Viral transduction of intestinal epithelium in the colon of mice mediated by sub-mucosal injection awarded by Fractyl Laboratories, Inc. 2020 - 2021
- The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function awarded by National Institutes of Health 2015 - 2020
- Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta awarded by Columbia University 2019 - 2020
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Fellowships, Supported Research, & Other Grants
- Pilot Award awarded by AGA Research Foundation 2019 - 2020
- K08CA198002 awarded by National Cancer Institute 2015 - 2020
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External Relationships
- Fractyl
- Global Guidepoint
- Karl Storz
- egenesis
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Patel, Pooja, and Jatin Roper. “Gut Microbiome Composition Is Associated with COVID-19 Disease Severity.” Gastroenterology 161, no. 2 (August 2021): 722–24. https://doi.org/10.1053/j.gastro.2021.05.006.Full Text Link to Item
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Joseph, Abel, and Jatin Roper. “Genetic Evidence That a Gut Commensal Bacterium Can Cause Colorectal Cancer.” Gastroenterology 160, no. 4 (March 2021): 1424–26. https://doi.org/10.1053/j.gastro.2020.12.014.Full Text Link to Item
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Sheahan, Breanna J., Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, and Christopher M. Dekaney. “Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells.” Cell Mol Gastroenterol Hepatol 12, no. 1 (2021): 119–40. https://doi.org/10.1016/j.jcmgh.2021.01.015.Full Text Link to Item
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Cheung, Priscilla, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, et al. “Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.” Cell Stem Cell 27, no. 4 (October 1, 2020): 590-604.e9. https://doi.org/10.1016/j.stem.2020.07.003.Full Text Link to Item
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Han, Huajun, Laurie A. Davidson, Yang-Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un-Ho Jin, Gus A. Wright, et al. “Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.” Embo J 39, no. 19 (October 1, 2020): e104319. https://doi.org/10.15252/embj.2019104319.Full Text Link to Item
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Dorsey, Y Claire, and Jatin Roper. “Utility of Surveillance and Screening Colonoscopy in Older Adults.” Gastroenterology 159, no. 2 (August 2020): 795–97. https://doi.org/10.1053/j.gastro.2020.06.036.Full Text Link to Item
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Cheltsov, Anton, Natsuko Nomura, Venkata M. Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov. “Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.” Sci Rep 10, no. 1 (May 15, 2020): 8096. https://doi.org/10.1038/s41598-020-60784-y.Full Text Link to Item
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Rickelt, Steffen, Charlene Condon, Miyeko Mana, Charlie Whittaker, Christina Pfirschke, Jatin Roper, Deepa T. Patil, et al. “Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.” Clin Cancer Res 26, no. 6 (March 15, 2020): 1277–87. https://doi.org/10.1158/1078-0432.CCR-19-2898.Full Text Link to Item
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Wegermann, Kara, and Jatin Roper. “An Insoluble Mystery: Fiber and Diverticulitis.” Gastroenterology 158, no. 4 (March 2020): 1167–68. https://doi.org/10.1053/j.gastro.2020.01.020.Full Text Link to Item
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Sullivan, Brian, and Jatin Roper. “Single Dose Aspirin before Fecal Immunochemical Testing Does Not Increase Sensitivity for Advanced Colorectal Neoplasia.” Gastroenterology 157, no. 4 (October 2019): 1158–59. https://doi.org/10.1053/j.gastro.2019.08.002.Full Text Link to Item
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Jackstadt, Rene, Sander R. van Hooff, Joshua D. Leach, Xabier Cortes-Lavaud, Jeroen O. Lohuis, Rachel A. Ridgway, Valérie M. Wouters, et al. “Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.” Cancer Cell 36, no. 3 (September 16, 2019): 319-336.e7. https://doi.org/10.1016/j.ccell.2019.08.003.Full Text Link to Item
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Almeqdadi, Mohammad, Miyeko D. Mana, Jatin Roper, and Ömer H. Yilmaz. “Gut organoids: mini-tissues in culture to study intestinal physiology and disease.” Am J Physiol Cell Physiol 317, no. 3 (September 1, 2019): C405–19. https://doi.org/10.1152/ajpcell.00300.2017.Full Text Link to Item
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Serebrennikova, Oksana B., Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce, and Philip N. Tsichlis. “The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.” Proc Natl Acad Sci U S A 116, no. 28 (July 9, 2019): 14039–48. https://doi.org/10.1073/pnas.1901465116.Full Text Link to Item
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Pentinmikko, Nalle, Sharif Iqbal, Miyeko Mana, Simon Andersson, Armand B. Cognetta, Radu M. Suciu, Jatin Roper, et al. “Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.” Nature 571, no. 7765 (July 2019): 398–402. https://doi.org/10.1038/s41586-019-1383-0.Full Text Link to Item
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Roper, Jatin, and Xiling Shen. “Novel Three-Dimensional Cultures of Patient-Derived Cancer and Tumor Immune Cells.” Gastroenterology 157, no. 1 (July 2019): 260–61. https://doi.org/10.1053/j.gastro.2019.05.036.Full Text Link to Item
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Roper, Jatin, and Ömer H. Yilmaz. “Breakthrough Moments: Genome Editing and Organoids.” Cell Stem Cell 24, no. 6 (June 6, 2019): 841–42. https://doi.org/10.1016/j.stem.2019.05.008.Full Text Link to Item
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Chan, Edmond M., Tsukasa Shibue, James M. McFarland, Benjamin Gaeta, Mahmoud Ghandi, Nancy Dumont, Alfredo Gonzalez, et al. “WRN helicase is a synthetic lethal target in microsatellite unstable cancers.” Nature 568, no. 7753 (April 2019): 551–56. https://doi.org/10.1038/s41586-019-1102-x.Full Text Link to Item
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Lannagan, Tamsin R. M., Young K. Lee, Tongtong Wang, Jatin Roper, Mark L. Bettington, Lochlan Fennell, Laura Vrbanac, et al. “Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.” Gut 68, no. 4 (April 2019): 684–92. https://doi.org/10.1136/gutjnl-2017-315920.Full Text Link to Item
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Goncalves, Marcus D., Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J. Murphy, Chantal Pauli, et al. “High-fructose corn syrup enhances intestinal tumor growth in mice.” Science 363, no. 6433 (March 22, 2019): 1345–49. https://doi.org/10.1126/science.aat8515.Full Text Link to Item
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Peng, B., M. Almeqdadi, F. Laroche, S. Palantavida, M. Dokukin, J. Roper, O. H. Yilmaz, H. Feng, and I. Sokolov. “Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Materials Today 23 (March 1, 2019): 16–25. https://doi.org/10.1016/j.mattod.2018.11.001.Full Text
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Peng, B., M. Almeqdadi, F. Laroche, S. Palantavida, M. Dokukin, J. Roper, O. H. Yilmaz, H. Feng, and I. Sokolov. “Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Data in Brief 22 (February 1, 2019): 383–91. https://doi.org/10.1016/j.dib.2018.12.030.Full Text
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Koh, Gar Yee, Anne Kane, Kyongbum Lee, Qiaobing Xu, Xian Wu, Jatin Roper, Joel B. Mason, and Jimmy W. Crott. “Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.” Int J Cancer 143, no. 7 (October 1, 2018): 1797–1805. https://doi.org/10.1002/ijc.31559.Full Text Link to Item
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Beyaz, Semir, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, et al. “Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.” Nature 560, no. 7717 (August 2018): E26. https://doi.org/10.1038/s41586-018-0187-y.Full Text Link to Item
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Dhingra, Rohit, Puja Rai, Jakob Sieker, and Jatin Roper. “Myxedema Ascites: An Unusual Presentation of Uncontrolled Hypothyroidism.” Cureus, May 14, 2018. https://doi.org/10.7759/cureus.2627.Full Text
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Roper, Jatin, Tuomas Tammela, Adam Akkad, Mohammad Almeqdadi, Sebastian B. Santos, Tyler Jacks, and Ömer H. Yilmaz. “Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.” Nat Protoc 13, no. 2 (February 2018): 217–34. https://doi.org/10.1038/nprot.2017.136.Full Text Link to Item
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Lau, Allison N., William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, et al. “PKM2 is not required for colon cancer initiated by APC loss.” Cancer & Metabolism 5, no. 1 (December 2017). https://doi.org/10.1186/s40170-017-0172-1.Full Text
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Roper, Jatin, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian, Steffen Rickelt, Mohammad Almeqdadi, et al. “In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.” Nat Biotechnol 35, no. 6 (June 2017): 569–76. https://doi.org/10.1038/nbt.3836.Full Text Link to Item
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Roper, Jatin, and Ömer H. Yilmaz. “Metabolic Teamwork in the Stem Cell Niche.” Cell Metab 25, no. 5 (May 2, 2017): 993–94. https://doi.org/10.1016/j.cmet.2017.04.019.Full Text Link to Item
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Kedrin, D., S. C. C. Gandhi, M. Wolf, J. Roper, O. Yilmaz, K. Corey, H. Khalili, F. C. Stanford, and M. Gala. “Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals.” Clinical and Translational Gastroenterology 8, no. 2 (February 9, 2017). https://doi.org/10.1038/ctg.2017.1.Full Text
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Beyaz, Semir, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, et al. “High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.” Nature 531, no. 7592 (March 3, 2016): 53–58. https://doi.org/10.1038/nature17173.Full Text Link to Item
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Yun, Jihye, Edouard Mullarky, Changyuan Lu, Kaitlyn N. Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, et al. “Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.” Science 350, no. 6266 (December 11, 2015): 1391–96. https://doi.org/10.1126/science.aaa5004.Full Text Link to Item
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Golovko, Daniel, Dmitriy Kedrin, Ömer H. Yilmaz, and Jatin Roper. “Colorectal cancer models for novel drug discovery.” Expert Opin Drug Discov 10, no. 11 (2015): 1217–29. https://doi.org/10.1517/17460441.2015.1079618.Full Text Link to Item
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Belmont, Peter J., Ping Jiang, Trevor D. McKee, Tao Xie, Jason Isaacson, Nicole E. Baryla, Jatin Roper, et al. “Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.” Sci Signal 7, no. 351 (November 11, 2014): ra107. https://doi.org/10.1126/scisignal.2005516.Full Text Link to Item
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Paul, Sonali, Golrokh Javid Sepehr, Barbara Weinstein, and Jatin Roper. “Co-occurrence of idiopathic granulomatous hepatitis and primary biliary cirrhosis.” Dig Dis Sci 59, no. 11 (November 2014): 2831–35. https://doi.org/10.1007/s10620-014-3216-1.Full Text Link to Item
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Roper, Jatin, Eric S. Martin, and Kenneth E. Hung. “Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.” Curr Protoc Pharmacol 65 (June 16, 2014): 14.29.1-14.2910. https://doi.org/10.1002/0471141755.ph1429s65.Full Text Link to Item
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Belmont, Peter J., Eva Budinska, Ping Jiang, Mark J. Sinnamon, Erin Coffee, Jatin Roper, Tao Xie, et al. “Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.” Dis Model Mech 7, no. 6 (June 2014): 613–23. https://doi.org/10.1242/dmm.013904.Full Text Link to Item
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Roper, Jatin, Mark J. Sinnamon, Erin M. Coffee, Peter Belmont, Lily Keung, Larissa Georgeon-Richard, Wei Vivian Wang, et al. “Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.” Cancer Lett 347, no. 2 (June 1, 2014): 204–11. https://doi.org/10.1016/j.canlet.2014.02.018.Full Text Link to Item
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Faber, Anthony C., Erin M. Coffee, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, et al. “mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.” Cancer Discov 4, no. 1 (January 2014): 42–52. https://doi.org/10.1158/2159-8290.CD-13-0315.Full Text Link to Item
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Coffee, E. M., A. C. Faber, J. Roper, M. J. Sinnamon, G. Goel, and L. Keung. “Erratum: Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAFV600E colorectal cancer (Clinical Cancer Research (2013) 19 (2688-98)).” Clinical Cancer Research 19, no. 14 (July 15, 2013): 4018. https://doi.org/10.1158/1078-0432.CCR-13-1433.Full Text
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Martin, Eric S., Peter J. Belmont, Mark J. Sinnamon, Larissa Georgeon Richard, Jing Yuan, Erin M. Coffee, Jatin Roper, et al. “Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.” Clin Cancer Res 19, no. 11 (June 1, 2013): 2929–40. https://doi.org/10.1158/1078-0432.CCR-12-2307.Full Text Link to Item
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Coffee, Erin M., Anthony C. Faber, Jatin Roper, Mark J. Sinnamon, Gautam Goel, Lily Keung, Wei Vivian Wang, et al. “Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.” Clin Cancer Res 19, no. 10 (May 15, 2013): 2688–98. https://doi.org/10.1158/1078-0432.CCR-12-2556.Full Text Link to Item
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Roper, Jatin, and Kenneth E. Hung. “Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development.” Trends Pharmacol Sci 33, no. 8 (August 2012): 449–55. https://doi.org/10.1016/j.tips.2012.05.001.Full Text Link to Item
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Francois, Fritz, Jatin Roper, Neal Joseph, Zhiheng Pei, Aditi Chhada, Joshua R. Shak, Asalia Z Olivares de Perez, Guillermo I. Perez-Perez, and Martin J. Blaser. “The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin.” Bmc Gastroenterol 11 (April 14, 2011): 37. https://doi.org/10.1186/1471-230X-11-37.Full Text Link to Item
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Roper, Jatin, Michael P. Richardson, Wei Vivian Wang, Larissa Georgeon Richard, Wei Chen, Erin M. Coffee, Mark J. Sinnamon, et al. “The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.” Plos One 6, no. 9 (2011): e25132. https://doi.org/10.1371/journal.pone.0025132.Full Text Link to Item
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Shak, J. R., J. Roper, G. I. Perez-Perez, C. H. Tseng, F. Francois, Z. Gamagaris, C. Patterson, et al. “The effect of laparoscopic gastric banding surgeryon plasma levels of appetite-control, insulinotropic, and digestive hormones (Obesity Surgery DOI: 10.1007/s11695-008-9454-6).” Obesity Surgery 18, no. 9 (September 1, 2008): 1097–98. https://doi.org/10.1007/s11695-008-9562-3.Full Text
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Shak, Joshua R., Jatin Roper, Guillermo I. Perez-Perez, Chi-hong Tseng, Fritz Francois, Zoi Gamagaris, Carlie Patterson, et al. “The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones.” Obes Surg 18, no. 9 (September 2008): 1089–96. https://doi.org/10.1007/s11695-008-9454-6.Full Text Link to Item
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Roper, Jatin, Fritz Francois, Peter L. Shue, Michelle S. Mourad, Zhiheng Pei, Asalia Z. Olivares de Perez, Guillermo I. Perez-Perez, Chi-Hong Tseng, and Martin J. Blaser. “Leptin and ghrelin in relation to Helicobacter pylori status in adult males.” J Clin Endocrinol Metab 93, no. 6 (June 2008): 2350–57. https://doi.org/10.1210/jc.2007-2057.Full Text Link to Item
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Francois, F., J. Roper, A. J. Goodman, Z. Pei, M. Ghumman, M. Mourad, AZ Olivares de Perez, G. I. Perez-Perez, C. -. H. Tseng, and M. J. Blaser. “The association of gastric leptin with oesophageal inflammation and metaplasia.” Gut 57, no. 1 (January 2008): 16–24. https://doi.org/10.1136/gut.2007.131672.Full Text Link to Item
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Pillinger, Michael H., Nada Marjanovic, Seok-Yong Kim, Yong-Chan Lee, Jose U. Scher, Jatin Roper, Aryeh M. Abeles, et al. “Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.” J Biol Chem 282, no. 26 (June 29, 2007): 18722–31. https://doi.org/10.1074/jbc.M703022200.Full Text Link to Item
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Book Sections
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Cetinbas, N. M., J. Roper, and Ö. H. Yilmaz. “The Cancer Stem Cell Niche.” In Biology and Engineering of Stem Cell Niches, 167–84, 2017. https://doi.org/10.1016/B978-0-12-802734-9.00011-1.Full Text
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Roper, J., and K. E. Hung. “Molecular mechanisms of colorectal carcinogenesis.” In Molecular Pathogenesis of Colorectal Cancer, 25–65, 2013. https://doi.org/10.1007/978-1-4614-8412-7_2.Full Text
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Conference Papers
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Dangi, A., J. Wang, A. Joseph, J. Roper, N. Surana, and X. Luo. “A Mouse Model of Paratopic Intestinal Transplantation to Delineate GVHD-Free Alloimmune Rejection Responses.” In American Journal of Transplantation, 20:636–636, 2020.Link to Item
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Jelly, E. T., W. Kendall, R. Schmitz, S. J. Knechtle, D. L. Sudan, A. Joseph, J. Roper, J. Kwun, and A. Wax. “Novel implementations of optical coherence tomography for clinical applications in the lower gastrointestinal tract.” In Optics Infobase Conference Papers, Vol. Part F180-OCT-2020, 2020.
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Coffee, Erin M., Anthony C. Faber, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, et al. “Abstract C263: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.” In Therapeutic Agents: Small Molecule Kinase Inhibitors. American Association for Cancer Research, 2013. https://doi.org/10.1158/1535-7163.targ-13-c263.Full Text
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Cancer Modeling with Three-Dimensional Organoids. 2018 Corning 3D Cell Culture Summit. October 17, 2018 2018
- Dietary regulation of intestinal stem cells and cancer. Beth Israel Deaconess Medical Center Division of Gastroenterology Clinical Seminar Series. June 20, 2018 2018
- Obesity, metabolism, and stem cell function. invited podium presentation. Digestive Disease Week. June 4, 2018 2018
- Colorectal cancer modeling with CRISPR-Cas9 genome editing and organoid transplantation. Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women's Hospital. March 24, 2018 2018
- Colorectal cancer modeling with CRISPR-Cas9 genome editing and organoid transplantation. 27th Annual CSIBD Summer Course: Current Techniques in Molecular Genetics, Massachusetts General Hospital. July 19, 2017 2017
- Dietary control of stem cells in obesity and cancer. Graduate Program in Nutrition Fall 2016 Seminar Series at Texas A&M University. September 26, 2016 2016
- Get with the Colorectal Cancer Syndromes Guideline. QuantiaMD. July 25, 2016 2016
- Epithelial genome editing and organoid transplantation models of colorectal cancer. Mayo Clinic Center for Cell Signaling in Gastroenterology. July 18, 2016 2016
- Sequential genome editing in CRISPR/Cas9-based colorectal cancer mouse models. Lecture Presentation, Gastrointestinal Oncology Section. Digestive Disease Week. May 21, 2016 2016
- Epithelial genome editing and orthotopic transplantation models of sequential mutagenesis in colorectal cancer. Broad Institute Cell Circuits and Epigenomics Program Seminar Series. May 16, 2016 2016
- Sequential genome editing in CRISPR/Cas9-based colorectal cancer mouse models. Oral Plenary Presentation. Keystone Symposia: Stem Cells and Cancer. March 8, 2016 2016
- CRISPR/Cas9-based colorectal cancer models in diverse physiological states. Boston University Medical Center Department of Pathology Seminar. November 20, 2015 2015
- CRISPR/Cas9-based colorectal cancer models in diverse physiological states. Koch Institute for Integrative Cancer Research at MIT Fall Retreat. November 2, 2015 2015
- The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model for sporadic colorectal cancer. Gastrointestinal Oncology Distinguished Abstracts Plenary. Digestive Disease Week. May 2011 2011
- Gastric and circulating leptin levels are related to degree of Helicobacter pylori-associated gastritis. Podium Presentation, North American Conference of GI Fellows. American College of Gastroenterology. January 2008 2008
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Service to the Profession
- American Gastroenterology Association (AGA) Future Leader’s Program . 2015 - 2016 2015 - 2016
- Member, American Gastroenterology Association (AGA) Research Awards Panel . 2015 - 2018 2015 - 2018
- Member, American Gastroenterology Association (AGA) Academy of Educators . 2013 - 2019 2013 - 2019
- Council Reviewer, Gastrointestinal Oncology Section of the American Gastroenterology Association (AGA) Institute Council . 2012 - 2019 2012 - 2019
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Clinical Activities
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Assistant Professor of Medicine, Division of Gastroenterology, Duke University
Gastrointestinal endoscopy, Duke University Hospital
Hereditary Cancer Clinic, Duke Cancer Center
Attending Physician, Durham VA Medical Center Department of Medicine, Division of Gastroenterology
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Assistant Professor of Medicine, Division of Gastroenterology, Duke University
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