Jatin Roper | Scholars@Duke

Jatin Roper
Assistant Professor of Medicine

My laboratory is interested in understanding the molecular mechanisms of stem cell function in the normal intestine and in colorectal cancer using innovative three-dimensional organoid and in vivo platforms. We demonstrated that high fat diet-induced obesity activates peroxisome proliferator-activated receptor delta (PPARd) signaling in intestinal stem cells and progenitor cells, which increases stem cell regeneration and tumor initiation in the colon. We also pioneered novel orthotopic transplantation and in situ CRISPR/Cas9 gene editing models of colorectal cancer that recapitulate the adenoma-carcinoma-metastasis sequence. Research in the laboratory is focused on three main areas: 1) Immune regulation of the intestinal epithelium and colorectal cancer; 2) The effects of diet-induced obesity on regeneration in the intestine; and 3) analysis of colorectal cancer heterogeneity with single-cell mRNA sequencing and genetically engineered mouse models. The overall goal of this research is to develop new treatment approaches for intestinal diseases such as inflammatory bowel disease and colorectal cancer. I am also a gastroenterologist at Duke University Hospital and the Durham VA Hospital. My clinical interests include colorectal cancer screening and gastrointestinal cancer genetics.

Current Research Interests

intestinal stem cell biology, inflammatory bowel disease, colorectal cancer

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2019
Assistant Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

905 S. Lasalle Street, Gsrb-1, Room 1033, Durham, NC 27710
DUMC 103862, Durham, NC 27710
jatin.roper@duke.edu (919) 660-2923
Roper Lab website

Background
Education, Training, & Certifications
- Postdoctoral Fellow (mentor: Omer H. Yilmaz, M.D., PhD), Koch Institute for Integrative Cancer Research at MIT 2014 - 2018
- Postdoctoral Fellow in Gastroenterology and Hepatology, Tufts University School of Medicine 2011 - 2014
- Fellowship in Gastroenterology and Hepatology, Tufts University School of Medicine 2008 - 2012
- Residency in Internal Medicine, New York University School of Medicine 2006 - 2008
- Michael Saperstein Medical Scholar, New York University School of Medicine 2005 - 2006
- Internship in Internal Medicine, New York University School of Medicine 2004 - 2005
- M.D., Boston University School of Medicine 2004
Medical Licensure
- 2018-02505. North Carolina. 2018
Previous Appointments & Affiliations
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Basic Science Departments 2019
Recognition
In the News
- DEC 8, 2020 Innovation and Entrepreneurship
  
  Three I&E Incubation Awards Fund Novel Ideas to Solar Energy, IBD & Medical Laser Research
- JUN 9, 2017 Nature Reviews Cancer
  
  Tailored Mouse Models
- MAY 2, 2017 Colon Cancer New Today
  
  New MIT Mouse Model Using CRISPR Technology Could Speed Up Colon Cancer Research
- MAY 1, 2017 MIT News
  
  New model could speed up colon cancer research
- APR 30, 2017 The Scientist
  
  Gut Organoid Transplants Produce Colorectal Cancer in Mice
- MAY 5, 2016 Cell Stem Cell
  
  You are what you eat: linking high-fat diet to stem cell dysfunction and tumorigenesis
- APR 19, 2016 Stem Cells Portal
  
  Deregulated Intestinal Stem and Progenitor Cells - Linking Obesity to Cancer
- MAR 10, 2016 Obesity News Today
  
  High-fat Diets Direct Certain Intestinal Cells Toward Tumor Formation in Mice
- MAR 8, 2016 Science Signaling
  
  Fatty diet alters stem cells
- MAR 5, 2016 Medical Daily
  
  Colon Cancer Risk Linked To High-Fat Diet: How Eating More Fat Can Increase Intestinal Tumors
- MAR 2, 2016 Nature
  
  Dietary fat promotes intestinal dysregulation
- MAR 2, 2016 Ecancer News
  
  High-fat diets enhance the tumour-generating capacity of intestinal progenitor cell
Awards & Honors
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Wnt signaling in obesity-associated colorectal cancer awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models. awarded by American Gastroenterological Association 2022 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Ultra-bright fluorescent nanoparticles for colorectal adenoma detection awarded by National Institutes of Health 2021 - 2023
- Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy awarded by Department of Defense 2020 - 2023
- Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy awarded by National Institutes of Health 2021 - 2022
- Low cost OCT probe for GI applications awarded by Lumedica 2021 - 2022
- Adipose tissue-colorectal tumor cross-talk: new targets for breaking the obesity-cancer link awarded by University of Utah 2021 - 2022
- Role of immune regulation in colorectal cancer chemotherapeutic response awarded by Yale University 2021 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling awarded by Texas A&M University 2021 - 2022
- Evaluation of estrogen receptor as a therapeutic target in melanoma, lung and colorectal cancer models awarded by Zentalis Pharmaceuticals 2020 - 2022
- Gilead Sponsored Research Agreement awarded by Gilead Sciences, Inc. 2020 - 2022
- Immune surveillance in obesity-associated cancer awarded by Elsa U. Pardee Foundation 2020 - 2021
- Viral transduction of intestinal epithelium in the colon of mice mediated by sub-mucosal injection awarded by Fractyl Laboratories, Inc. 2020 - 2021
- The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function awarded by National Institutes of Health 2015 - 2020
- Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta awarded by Columbia University 2019 - 2020
Fellowships, Supported Research, & Other Grants
- Pilot Award awarded by AGA Research Foundation 2019 - 2020
- K08CA198002 awarded by National Cancer Institute 2015 - 2020
External Relationships
- Friedman Schuman
- Global Guidepoint
- Mudabala
- egenesis
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bowers, Laura W., Elaine M. Glenny, Arunima Punjala, Nadia A. Lanman, Audrey Goldbaum, Caroline Himbert, Stephanie A. Montgomery, et al. “Weight loss and/or sulindac mitigate obesity-associated transcriptome, microbiome, and protumor effects in a murine model of colon cancer.” Cancer Prev Res (Phila), June 2, 2022. https://doi.org/10.1158/1940-6207.CAPR-21-0531.
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  - Lee, Tzu-Hao, Jatin Roper, and Lindsay King. “Mirror, Mirror, on the Wall, Who Is the Fittest of Them All? A Novel Prediction Model for Postoperative Hepatic Decompensation in Patients With Cirrhosis.” Gastroenterology 162, no. 4 (April 2022): 1352–53. https://doi.org/10.1053/j.gastro.2021.10.024.
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  - Sullivan, Brian A., Michael Noujaim, and Jatin Roper. “Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.” Gastrointest Endosc Clin N Am 32, no. 2 (April 2022): 177–94. https://doi.org/10.1016/j.giec.2021.12.001.
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  - Wu, Xian, Per M. Ueland, Jatin Roper, Gar Yee Koh, Xu Liang, Jimmy W. Crott, Ömer H. Yilmaz, Roderick T. Bronson, and Joel B. Mason. “Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice.” J Nutr 151, no. 12 (December 3, 2021): 3678–88. https://doi.org/10.1093/jn/nxab320.
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  - Beyaz, Semir, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, et al. “Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.” Cell Stem Cell 28, no. 11 (November 4, 2021): 1922-1935.e5. https://doi.org/10.1016/j.stem.2021.08.007.
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  - Patel, Pooja, and Jatin Roper. “Gut Microbiome Composition Is Associated with COVID-19 Disease Severity.” Gastroenterology 161, no. 2 (August 2021): 722–24. https://doi.org/10.1053/j.gastro.2021.05.006.
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  - Joseph, Abel, and Jatin Roper. “Genetic Evidence That a Gut Commensal Bacterium Can Cause Colorectal Cancer.” Gastroenterology 160, no. 4 (March 2021): 1424–26. https://doi.org/10.1053/j.gastro.2020.12.014.
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  - Sheahan, Breanna J., Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, and Christopher M. Dekaney. “Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells.” Cell Mol Gastroenterol Hepatol 12, no. 1 (2021): 119–40. https://doi.org/10.1016/j.jcmgh.2021.01.015.
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  - Cheung, Priscilla, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, et al. “Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.” Cell Stem Cell 27, no. 4 (October 1, 2020): 590-604.e9. https://doi.org/10.1016/j.stem.2020.07.003.
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  - Han, Huajun, Laurie A. Davidson, Yang-Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un-Ho Jin, Gus A. Wright, et al. “Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.” The Embo Journal 39, no. 19 (October 2020): e104319. https://doi.org/10.15252/embj.2019104319.
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  - Dorsey, Y Claire, and Jatin Roper. “Utility of Surveillance and Screening Colonoscopy in Older Adults.” Gastroenterology 159, no. 2 (August 2020): 795–97. https://doi.org/10.1053/j.gastro.2020.06.036.
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  - Cheltsov, Anton, Natsuko Nomura, Venkata M. Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov. “Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer.” Sci Rep 10, no. 1 (May 15, 2020): 8096. https://doi.org/10.1038/s41598-020-60784-y.
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  - Rickelt, Steffen, Charlene Condon, Miyeko Mana, Charlie Whittaker, Christina Pfirschke, Jatin Roper, Deepa T. Patil, et al. “Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.” Clin Cancer Res 26, no. 6 (March 15, 2020): 1277–87. https://doi.org/10.1158/1078-0432.CCR-19-2898.
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  - Wegermann, Kara, and Jatin Roper. “An Insoluble Mystery: Fiber and Diverticulitis.” Gastroenterology 158, no. 4 (March 2020): 1167–68. https://doi.org/10.1053/j.gastro.2020.01.020.
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  - Sullivan, Brian, and Jatin Roper. “Single Dose Aspirin before Fecal Immunochemical Testing Does Not Increase Sensitivity for Advanced Colorectal Neoplasia.” Gastroenterology 157, no. 4 (October 2019): 1158–59. https://doi.org/10.1053/j.gastro.2019.08.002.
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  - Jackstadt, Rene, Sander R. van Hooff, Joshua D. Leach, Xabier Cortes-Lavaud, Jeroen O. Lohuis, Rachel A. Ridgway, Valérie M. Wouters, et al. “Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.” Cancer Cell 36, no. 3 (September 16, 2019): 319-336.e7. https://doi.org/10.1016/j.ccell.2019.08.003.
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  - Almeqdadi, Mohammad, Miyeko D. Mana, Jatin Roper, and Ömer H. Yilmaz. “Gut organoids: mini-tissues in culture to study intestinal physiology and disease.” Am J Physiol Cell Physiol 317, no. 3 (September 1, 2019): C405–19. https://doi.org/10.1152/ajpcell.00300.2017.
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  - Serebrennikova, Oksana B., Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce, and Philip N. Tsichlis. “The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.” Proc Natl Acad Sci U S A 116, no. 28 (July 9, 2019): 14039–48. https://doi.org/10.1073/pnas.1901465116.
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  - Pentinmikko, Nalle, Sharif Iqbal, Miyeko Mana, Simon Andersson, Armand B. Cognetta, Radu M. Suciu, Jatin Roper, et al. “Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.” Nature 571, no. 7765 (July 2019): 398–402. https://doi.org/10.1038/s41586-019-1383-0.
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  - Roper, Jatin, and Xiling Shen. “Novel Three-Dimensional Cultures of Patient-Derived Cancer and Tumor Immune Cells.” Gastroenterology 157, no. 1 (July 2019): 260–61. https://doi.org/10.1053/j.gastro.2019.05.036.
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  - Roper, Jatin, and Ömer H. Yilmaz. “Breakthrough Moments: Genome Editing and Organoids.” Cell Stem Cell 24, no. 6 (June 6, 2019): 841–42. https://doi.org/10.1016/j.stem.2019.05.008.
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  - Chan, Edmond M., Tsukasa Shibue, James M. McFarland, Benjamin Gaeta, Mahmoud Ghandi, Nancy Dumont, Alfredo Gonzalez, et al. “WRN helicase is a synthetic lethal target in microsatellite unstable cancers.” Nature 568, no. 7753 (April 2019): 551–56. https://doi.org/10.1038/s41586-019-1102-x.
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  - Lannagan, Tamsin R. M., Young K. Lee, Tongtong Wang, Jatin Roper, Mark L. Bettington, Lochlan Fennell, Laura Vrbanac, et al. “Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.” Gut 68, no. 4 (April 2019): 684–92. https://doi.org/10.1136/gutjnl-2017-315920.
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  - Goncalves, Marcus D., Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J. Murphy, Chantal Pauli, et al. “High-fructose corn syrup enhances intestinal tumor growth in mice.” Science 363, no. 6433 (March 22, 2019): 1345–49. https://doi.org/10.1126/science.aat8515.
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  - Peng, B., M. Almeqdadi, F. Laroche, S. Palantavida, M. Dokukin, J. Roper, O. H. Yilmaz, H. Feng, and I. Sokolov. “Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Materials Today 23 (March 1, 2019): 16–25. https://doi.org/10.1016/j.mattod.2018.11.001.
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  - Peng, B., M. Almeqdadi, F. Laroche, S. Palantavida, M. Dokukin, J. Roper, O. H. Yilmaz, H. Feng, and I. Sokolov. “Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Data in Brief 22 (February 1, 2019): 383–91. https://doi.org/10.1016/j.dib.2018.12.030.
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  - Koh, Gar Yee, Anne Kane, Kyongbum Lee, Qiaobing Xu, Xian Wu, Jatin Roper, Joel B. Mason, and Jimmy W. Crott. “Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.” Int J Cancer 143, no. 7 (October 1, 2018): 1797–1805. https://doi.org/10.1002/ijc.31559.
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  - Beyaz, Semir, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, et al. “Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.” Nature 560, no. 7717 (August 2018): E26. https://doi.org/10.1038/s41586-018-0187-y.
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  - Dhingra, Rohit, Puja Rai, Jakob Sieker, and Jatin Roper. “Myxedema Ascites: An Unusual Presentation of Uncontrolled Hypothyroidism.” Cureus, May 14, 2018. https://doi.org/10.7759/cureus.2627.
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  - Roper, Jatin, Tuomas Tammela, Adam Akkad, Mohammad Almeqdadi, Sebastian B. Santos, Tyler Jacks, and Ömer H. Yilmaz. “Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.” Nat Protoc 13, no. 2 (February 2018): 217–34. https://doi.org/10.1038/nprot.2017.136.
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  - Lau, Allison N., William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, et al. “PKM2 is not required for colon cancer initiated by APC loss.” Cancer &Amp; Metabolism 5, no. 1 (December 2017). https://doi.org/10.1186/s40170-017-0172-1.
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  - Roper, Jatin, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian, Steffen Rickelt, Mohammad Almeqdadi, et al. “In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.” Nat Biotechnol 35, no. 6 (June 2017): 569–76. https://doi.org/10.1038/nbt.3836.
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  - Roper, Jatin, and Ömer H. Yilmaz. “Metabolic Teamwork in the Stem Cell Niche.” Cell Metab 25, no. 5 (May 2, 2017): 993–94. https://doi.org/10.1016/j.cmet.2017.04.019.
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  - Kedrin, D., S. C. C. Gandhi, M. Wolf, J. Roper, O. Yilmaz, K. Corey, H. Khalili, F. C. Stanford, and M. Gala. “Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals.” Clinical and Translational Gastroenterology 8, no. 2 (February 9, 2017). https://doi.org/10.1038/ctg.2017.1.
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  - Beyaz, Semir, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, et al. “High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.” Nature 531, no. 7592 (March 3, 2016): 53–58. https://doi.org/10.1038/nature17173.
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  - Yun, Jihye, Edouard Mullarky, Changyuan Lu, Kaitlyn N. Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, et al. “Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.” Science 350, no. 6266 (December 11, 2015): 1391–96. https://doi.org/10.1126/science.aaa5004.
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  - Golovko, Daniel, Dmitriy Kedrin, Ömer H. Yilmaz, and Jatin Roper. “Colorectal cancer models for novel drug discovery.” Expert Opin Drug Discov 10, no. 11 (2015): 1217–29. https://doi.org/10.1517/17460441.2015.1079618.
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  - Belmont, Peter J., Ping Jiang, Trevor D. McKee, Tao Xie, Jason Isaacson, Nicole E. Baryla, Jatin Roper, et al. “Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.” Sci Signal 7, no. 351 (November 11, 2014): ra107. https://doi.org/10.1126/scisignal.2005516.
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  - Paul, Sonali, Golrokh Javid Sepehr, Barbara Weinstein, and Jatin Roper. “Co-occurrence of idiopathic granulomatous hepatitis and primary biliary cirrhosis.” Dig Dis Sci 59, no. 11 (November 2014): 2831–35. https://doi.org/10.1007/s10620-014-3216-1.
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  - Roper, Jatin, Eric S. Martin, and Kenneth E. Hung. “Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.” Curr Protoc Pharmacol 65 (June 16, 2014): 14.29.1-14.2910. https://doi.org/10.1002/0471141755.ph1429s65.
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  - Belmont, Peter J., Eva Budinska, Ping Jiang, Mark J. Sinnamon, Erin Coffee, Jatin Roper, Tao Xie, et al. “Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.” Dis Model Mech 7, no. 6 (June 2014): 613–23. https://doi.org/10.1242/dmm.013904.
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  - Roper, Jatin, Mark J. Sinnamon, Erin M. Coffee, Peter Belmont, Lily Keung, Larissa Georgeon-Richard, Wei Vivian Wang, et al. “Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.” Cancer Lett 347, no. 2 (June 1, 2014): 204–11. https://doi.org/10.1016/j.canlet.2014.02.018.
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  - Faber, Anthony C., Erin M. Coffee, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, et al. “mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.” Cancer Discov 4, no. 1 (January 2014): 42–52. https://doi.org/10.1158/2159-8290.CD-13-0315.
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  - Coffee, E. M., A. C. Faber, J. Roper, M. J. Sinnamon, G. Goel, and L. Keung. “Erratum: Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF^V600E colorectal cancer (Clinical Cancer Research (2013) 19 (2688-98)).” Clinical Cancer Research 19, no. 14 (July 15, 2013): 4018. https://doi.org/10.1158/1078-0432.CCR-13-1433.
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  - Martin, Eric S., Peter J. Belmont, Mark J. Sinnamon, Larissa Georgeon Richard, Jing Yuan, Erin M. Coffee, Jatin Roper, et al. “Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.” Clin Cancer Res 19, no. 11 (June 1, 2013): 2929–40. https://doi.org/10.1158/1078-0432.CCR-12-2307.
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  - Coffee, Erin M., Anthony C. Faber, Jatin Roper, Mark J. Sinnamon, Gautam Goel, Lily Keung, Wei Vivian Wang, et al. “Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.” Clin Cancer Res 19, no. 10 (May 15, 2013): 2688–98. https://doi.org/10.1158/1078-0432.CCR-12-2556.
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  - Roper, Jatin, and Kenneth E. Hung. “Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development.” Trends Pharmacol Sci 33, no. 8 (August 2012): 449–55. https://doi.org/10.1016/j.tips.2012.05.001.
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  - Francois, Fritz, Jatin Roper, Neal Joseph, Zhiheng Pei, Aditi Chhada, Joshua R. Shak, Asalia Z Olivares de Perez, Guillermo I. Perez-Perez, and Martin J. Blaser. “The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin.” Bmc Gastroenterol 11 (April 14, 2011): 37. https://doi.org/10.1186/1471-230X-11-37.
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  - Roper, Jatin, Michael P. Richardson, Wei Vivian Wang, Larissa Georgeon Richard, Wei Chen, Erin M. Coffee, Mark J. Sinnamon, et al. “The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.” Plos One 6, no. 9 (2011): e25132. https://doi.org/10.1371/journal.pone.0025132.
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  - Shak, J. R., J. Roper, G. I. Perez-Perez, C. H. Tseng, F. Francois, Z. Gamagaris, C. Patterson, et al. “The effect of laparoscopic gastric banding surgeryon plasma levels of appetite-control, insulinotropic, and digestive hormones (Obesity Surgery DOI: 10.1007/s11695-008-9454-6).” Obesity Surgery 18, no. 9 (September 1, 2008): 1097–98. https://doi.org/10.1007/s11695-008-9562-3.
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  - Shak, Joshua R., Jatin Roper, Guillermo I. Perez-Perez, Chi-hong Tseng, Fritz Francois, Zoi Gamagaris, Carlie Patterson, et al. “The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones.” Obes Surg 18, no. 9 (September 2008): 1089–96. https://doi.org/10.1007/s11695-008-9454-6.
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  - Roper, Jatin, Fritz Francois, Peter L. Shue, Michelle S. Mourad, Zhiheng Pei, Asalia Z. Olivares de Perez, Guillermo I. Perez-Perez, Chi-Hong Tseng, and Martin J. Blaser. “Leptin and ghrelin in relation to Helicobacter pylori status in adult males.” J Clin Endocrinol Metab 93, no. 6 (June 2008): 2350–57. https://doi.org/10.1210/jc.2007-2057.
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  - Francois, F., J. Roper, A. J. Goodman, Z. Pei, M. Ghumman, M. Mourad, AZ Olivares de Perez, G. I. Perez-Perez, C. -. H. Tseng, and M. J. Blaser. “The association of gastric leptin with oesophageal inflammation and metaplasia.” Gut 57, no. 1 (January 2008): 16–24. https://doi.org/10.1136/gut.2007.131672.
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  - Pillinger, Michael H., Nada Marjanovic, Seok-Yong Kim, Yong-Chan Lee, Jose U. Scher, Jatin Roper, Aryeh M. Abeles, et al. “Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.” J Biol Chem 282, no. 26 (June 29, 2007): 18722–31. https://doi.org/10.1074/jbc.M703022200.
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- Book Sections
  - Cetinbas, N. M., J. Roper, and Ö. H. Yilmaz. “The Cancer Stem Cell Niche.” In Biology and Engineering of Stem Cell Niches, 167–84, 2017. https://doi.org/10.1016/B978-0-12-802734-9.00011-1.
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  - Roper, J., and K. E. Hung. “Molecular mechanisms of colorectal carcinogenesis.” In Molecular Pathogenesis of Colorectal Cancer, 25–65, 2013. https://doi.org/10.1007/978-1-4614-8412-7_2.
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- Conference Papers
  - Glenny, Elaine M., Laura W. Bowers, Diana Li, Jatin Roper, and Stephen D. Hursting. “Links between obesity and secreted frizzled-related protein 4 (Sfrp4) in a murine model of colon cancer.” In Cancer Research, Vol. 81, 2021.
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  - Kendall, Wesley Y., Julianna Bordas, Evan T. Jelly, Babak Mirminachi, Abel Joseph, Jatin Roper, and Adam Wax. “Spectroscopic optical coherence tomography for early detection of colorectal cancer in a mouse model.” In Bio Optics: Design and Application, DF1A-4, 2021.
  - Dangi, A., J. Wang, A. Joseph, J. Roper, N. Surana, and X. Luo. “A Mouse Model of Paratopic Intestinal Transplantation to Delineate GVHD-Free Alloimmune Rejection Responses.” In American Journal of Transplantation, 20:636–636, 2020.
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  - Jelly, Evan T., Wesley Kendall, Robin Schmitz, Stuart J. Knechtle, Debra L. Sudan, Abel Joseph, Jatin Roper, Jean Kwun, and Adam Wax. “Novel Implementations of Optical Coherence Tomography for Clinical Applications in the Lower Gastrointestinal Tract.” In Optical Coherence Tomography, OTu4E-4, 2020.
  - Coffee, Erin M., Anthony C. Faber, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, et al. “Abstract C263: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.” In Molecular Cancer Therapeutics, 12:C263–C263. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1535-7163.targ-13-c263.
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Teaching & Mentoring
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- Assistant Professor of Medicine, Division of Gastroenterology, Duke University
  Gastrointestinal endoscopy, Duke University Hospital
  Hereditary Cancer Clinic, Duke Cancer Center
  Attending Physician, Durham VA Medical Center Department of Medicine, Division of Gastroenterology

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