Research Interests
intestinal stem cell biology, inflammatory bowel disease, colorectal cancer
Selected Grants
Role and regulation of asparagine in colorectal cancer
ResearchPrincipal Investigator · Awarded by Yale University · 2025 - 2029Mitigation of gastrointestinal acute radiation syndrome by promoting clusterin-mediated intestinal regeneration
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2029Tissue-Specific Regulation and Effects of CYP24A1
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2027Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2027Training Program in Developmental and Stem Cell Biology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027Wnt signaling in obesity-associated colorectal cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027Adipose tissue-colorectal tumor cross-talk: new targets for breaking the obesity-cancer link
ResearchPrincipal Investigator · Awarded by University of Utah · 2021 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Role of immune regulation in colorectal cancer chemotherapeutic response
ResearchPrincipal Investigator · Awarded by Yale University · 2021 - 2025Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models.
ResearchCollaborator · Awarded by American Gastroenterological Association · 2022 - 2025Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Ultra-bright fluorescent nanoparticles for colorectal adenoma detection
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy
ResearchPrincipal Investigator · Awarded by Department of Defense · 2020 - 2023Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2022Low cost OCT probe for GI applications
ResearchPrincipal Investigator · Awarded by Lumedica · 2021 - 2022Evaluation of estrogen receptor as a therapeutic target in melanoma, lung and colorectal cancer models
ResearchCo Investigator · Awarded by Zentalis Pharmaceuticals · 2020 - 2022Image-Guided Radiation Therapy System for Small Animals
EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022Gilead Sponsored Research Agreement
ResearchPrincipal Investigator · Awarded by Gilead Sciences, Inc. · 2020 - 2022Immune surveillance in obesity-associated cancer
ResearchPrincipal Investigator · Awarded by Elsa U. Pardee Foundation · 2020 - 2021Viral transduction of intestinal epithelium in the colon of mice mediated by sub-mucosal injection
ResearchPrincipal Investigator · Awarded by Fractyl Laboratories, Inc. · 2020 - 2021The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2020Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta
ResearchCo-Principal Investigator · Awarded by Columbia University · 2019 - 2020Fellowships, Gifts, and Supported Research
Pilot Award ·
April 2019
- April 2020
Awarded by: AGA Research Foundation
K08CA198002 ·
September 2015
- September 2020
Awarded by: National Cancer Institute