https://orcid.org/0000-0002-8851-1352
Research Interests
intestinal stem cell biology, inflammatory bowel disease, colorectal cancer
Selected Grants
Role and regulation of asparagine in colorectal cancer
ResearchPrincipal Investigator · Awarded by Yale University · 2025 - 2029Mitigation of gastrointestinal acute radiation syndrome by promoting clusterin-mediated intestinal regeneration
ResearchCo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Tissue-Specific Regulation and Effects of CYP24A1
ResearchCo Investigator · Awarded by Weill Cornell Medicine · 2024 - 2027Tissue-Specific Regulation and Effects of CYP24A1
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2027Chemoprevention of duodenal and rectal polyposis in familial adenomatous polyposis (FAP) with fish oil
ResearchPrincipal Investigator · Awarded by Collaborative Group of the Americas on Inherited Gastrointestinal Cancer · 2025 - 2027Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1994 - 2027Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 1988 - 2027Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027Training Program in Developmental and Stem Cell Biology
Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2001 - 2027Treatment of the W1282X CFTR mutation by delivery of size-optimized base editors in adeno-associated virus with cross-species tropism
FellowshipPrincipal Investigator · Awarded by Cystic Fibrosis Foundation · 2026 - 2027Wnt signaling in obesity-associated colorectal cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027Adipose tissue-colorectal tumor cross-talk: new targets for breaking the obesity-cancer link
ResearchPrincipal Investigator · Awarded by University of Utah · 2021 - 2026Role of immune regulation in colorectal cancer chemotherapeutic response
ResearchPrincipal Investigator · Awarded by Yale University · 2021 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models.
ResearchCollaborator · Awarded by American Gastroenterological Association · 2022 - 2025Ultra-bright fluorescent nanoparticles for colorectal adenoma detection
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy
ResearchPrincipal Investigator · Awarded by Department of Defense · 2020 - 2023Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2022Low cost OCT probe for GI applications
ResearchPrincipal Investigator · Awarded by Lumedica · 2021 - 2022Evaluation of estrogen receptor as a therapeutic target in melanoma, lung and colorectal cancer models
ResearchCo Investigator · Awarded by Zentalis Pharmaceuticals · 2020 - 2022Image-Guided Radiation Therapy System for Small Animals
EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022Gilead Sponsored Research Agreement
ResearchPrincipal Investigator · Awarded by Gilead Sciences, Inc. · 2020 - 2022Immune surveillance in obesity-associated cancer
ResearchPrincipal Investigator · Awarded by Elsa U. Pardee Foundation · 2020 - 2021Viral transduction of intestinal epithelium in the colon of mice mediated by sub-mucosal injection
ResearchPrincipal Investigator · Awarded by Fractyl Laboratories, Inc. · 2020 - 2021The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2020Treatment of gastrointestinal acute radiation syndrome with activation of peroxisome proliferator-activated receptor delta
ResearchCo-Principal Investigator · Awarded by Columbia University · 2019 - 2020Fellowships, Gifts, and Supported Research
Pilot Award ·
April 2019
- April 2020
Awarded by: AGA Research Foundation
K08CA198002 ·
September 2015
- September 2020
Awarded by: National Cancer Institute
External Relationships
- Friedman Schuman Layser
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.