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Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry.

Publication ,  Journal Article
Ziaeian, B; Hernandez, AF; DeVore, AD; Wu, J; Xu, H; Heidenreich, PA; Matsouaka, RA; Bhatt, DL; Yancy, CW; Fonarow, GC
Published in: Am Heart J
May 2019

BACKGROUND: Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. METHODS: Using the Get With The Guidelines (GWTG)-HF Registry linked to Centers for Medicare & Medicaid Services claims data, we evaluated differences between HF patients with and without diabetes. Adjusted Cox proportional-hazard models controlling for patient and hospital characteristics were used to evaluate mortality and readmission outcomes. RESULTS: A cohort of 86,659 HF patients aged ≥65 years was followed for 3 years from discharge. Unadjusted all-cause mortality was between 4.4% and 5.5% and all-cause hospitalization was between 19.4% and 22.6% for all groups at 30 days. For all-cause mortality at 3 years from hospital discharge, diabetes was associated with an adjusted hazard ratio of 1.27 (95% CI 1.07-1.49, P = .0051) for HFrEF, 0.95 (95% CI 0.55-1.65, P = .8536) for HFbEF, 1.02 (95% CI 0.87-1.19, P = .8551) for HFpEF. For all-cause readmission, diabetes was associated with an adjusted hazard ratio of 1.06 (95% CI 0.87-1.29, P = .5585) for HFrEF, 1.48 (95% CI 1.15-1.90, P = .0023) for HFbEF, and 1.06 (95% CI 0.91-1.22, P = .4747) for HFpEF. CONCLUSIONS: HFrEF and HFbEF patients with diabetes are at increased risk for mortality and rehospitalization after hospitalization for HF, independent of other patient and hospital characteristics. Among HFpEF patients, diabetes does not appear to be independently associated with significant additional risks.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2019

Volume

211

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • United States
  • Stroke Volume
  • Registries
  • Proportional Hazards Models
  • Practice Guidelines as Topic
  • Patient Readmission
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
 

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Ziaeian, B., Hernandez, A. F., DeVore, A. D., Wu, J., Xu, H., Heidenreich, P. A., … Fonarow, G. C. (2019). Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry. Am Heart J, 211, 1–10. https://doi.org/10.1016/j.ahj.2019.01.006
Ziaeian, Boback, Adrian F. Hernandez, Adam D. DeVore, Jingjing Wu, Haolin Xu, Paul A. Heidenreich, Roland A. Matsouaka, Deepak L. Bhatt, Clyde W. Yancy, and Gregg C. Fonarow. “Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry.Am Heart J 211 (May 2019): 1–10. https://doi.org/10.1016/j.ahj.2019.01.006.
Ziaeian B, Hernandez AF, DeVore AD, Wu J, Xu H, Heidenreich PA, et al. Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry. Am Heart J. 2019 May;211:1–10.
Ziaeian, Boback, et al. “Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry.Am Heart J, vol. 211, May 2019, pp. 1–10. Pubmed, doi:10.1016/j.ahj.2019.01.006.
Ziaeian B, Hernandez AF, DeVore AD, Wu J, Xu H, Heidenreich PA, Matsouaka RA, Bhatt DL, Yancy CW, Fonarow GC. Long-term outcomes for heart failure patients with and without diabetes: From the Get With The Guidelines-Heart Failure Registry. Am Heart J. 2019 May;211:1–10.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2019

Volume

211

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • United States
  • Stroke Volume
  • Registries
  • Proportional Hazards Models
  • Practice Guidelines as Topic
  • Patient Readmission
  • Male
  • Humans
  • Hospitalization
  • Heart Failure