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Establishing a generalized polyepigenetic biomarker for tobacco smoking.

Publication ,  Journal Article
Sugden, K; Hannon, EJ; Arseneault, L; Belsky, DW; Broadbent, JM; Corcoran, DL; Hancox, RJ; Houts, RM; Moffitt, TE; Poulton, R; Prinz, JA ...
Published in: Translational psychiatry
February 2019

Large-scale epigenome-wide association meta-analyses have identified multiple 'signatures'' of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Longitudinal data show that changes in DNA methylation accumulate with increased exposure to tobacco smoking and attenuate with quitting. Data from twins discordant for smoking behavior show that smoking influences DNA methylation independently of genetic and environmental risk factors. Physiological data show that changes in DNA methylation track smoking-related changes in lung function and gum health over time. Moreover, DNA methylation changes predict corresponding changes in gene expression in pathways related to inflammation, immune response, and cellular trafficking. Finally, we present prospective data about the link between adverse childhood experiences (ACEs) and epigenetic modifications; these findings document the importance of controlling for smoking-related DNA methylation changes when studying biological embedding of stress in life-course research. We introduce the polyepigenetic DNA methylation score as a tool both for discovery and theory-guided research in epigenetic epidemiology.

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Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

February 2019

Volume

9

Issue

1

Start / End Page

92

Related Subject Headings

  • Young Adult
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Tobacco Smoking
  • New Zealand
  • Male
  • Longitudinal Studies
  • Humans
  • Genome-Wide Association Study
  • Female
 

Citation

APA
Chicago
ICMJE
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Sugden, K., Hannon, E. J., Arseneault, L., Belsky, D. W., Broadbent, J. M., Corcoran, D. L., … Caspi, A. (2019). Establishing a generalized polyepigenetic biomarker for tobacco smoking. Translational Psychiatry, 9(1), 92. https://doi.org/10.1038/s41398-019-0430-9
Sugden, Karen, Eilis J. Hannon, Louise Arseneault, Daniel W. Belsky, Jonathan M. Broadbent, David L. Corcoran, Robert J. Hancox, et al. “Establishing a generalized polyepigenetic biomarker for tobacco smoking.Translational Psychiatry 9, no. 1 (February 2019): 92. https://doi.org/10.1038/s41398-019-0430-9.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, et al. Establishing a generalized polyepigenetic biomarker for tobacco smoking. Translational psychiatry. 2019 Feb;9(1):92.
Sugden, Karen, et al. “Establishing a generalized polyepigenetic biomarker for tobacco smoking.Translational Psychiatry, vol. 9, no. 1, Feb. 2019, p. 92. Epmc, doi:10.1038/s41398-019-0430-9.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, Prinz JA, Thomson WM, Williams BS, Wong CCY, Mill J, Caspi A. Establishing a generalized polyepigenetic biomarker for tobacco smoking. Translational psychiatry. 2019 Feb;9(1):92.

Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

February 2019

Volume

9

Issue

1

Start / End Page

92

Related Subject Headings

  • Young Adult
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Tobacco Smoking
  • New Zealand
  • Male
  • Longitudinal Studies
  • Humans
  • Genome-Wide Association Study
  • Female