Neuroinflammation and Perioperative Neurocognitive Disorders.

Journal Article (Journal Article;Review)

Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting postoperative cognitive dysfunction. Dysregulated inflammation and neuronal injury are emerging from clinical studies as key features of perioperative neurocognitive disorders. These findings are paralleled by a growing body of preclinical investigations aimed at better understanding how surgery and anesthesia affect the central nervous system and possibly contribute to cognitive decline. Herein, we review the role of postoperative neuroinflammation and underlying mechanisms in immune-to-brain signaling after peripheral surgery.

Full Text

Duke Authors

Cited Authors

  • Subramaniyan, S; Terrando, N

Published Date

  • April 2019

Published In

Volume / Issue

  • 128 / 4

Start / End Page

  • 781 - 788

PubMed ID

  • 30883423

Pubmed Central ID

  • PMC6437083

Electronic International Standard Serial Number (EISSN)

  • 1526-7598

Digital Object Identifier (DOI)

  • 10.1213/ANE.0000000000004053


  • eng

Conference Location

  • United States