Current Appointments & Affiliations
Professor of Anesthesiology
·
2024 - Present
Anesthesiology,
Clinical Science Departments
Professor in Cell Biology
·
2024 - Present
Cell Biology,
Basic Science Departments
Professor in Integrative Immunobiology
·
2024 - Present
Integrative Immunobiology,
Basic Science Departments
Faculty Network Member of the Duke Institute for Brain Sciences
·
2017 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
In the News
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Recent Publications
Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.
Journal Article BJA Open · December 2024 BACKGROUND: We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity. METHODS: ... Full text Link to item CiteVagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.
Conference Pain · August 1, 2024 Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the ... Full text Link to item CiteInfectious Diseases.
Journal Article Adv Neurobiol · 2024 Microglia, brain-resident innate immune cells, have been extensively studied in neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 (COVID-19) pandemic highlighted how peripheral infection and inflammation can be detrimental t ... Full text Link to item CiteRecent Grants
IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers Disease
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2024 - 2029The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Translational Center for Barrier Microphysiological Systems
ResearchCo Investigator · Awarded by University of Rochester · 2024 - 2028View All Grants
Education, Training & Certifications
Imperial College London (United Kingdom) ·
2007
Ph.D.