Current Appointments & Affiliations
Professor of Anesthesiology
·
2024 - Present
Anesthesiology,
Clinical Science Departments
Professor in Cell Biology
·
2024 - Present
Cell Biology,
Basic Science Departments
Professor in Integrative Immunobiology
·
2024 - Present
Integrative Immunobiology,
Basic Science Departments
Faculty Network Member of the Duke Institute for Brain Sciences
·
2017 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
In the News
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Recent Publications
Pericytes repair engineered defects in the basement membrane to restore barrier integrity in an in vitro model of the blood-brain barrier.
Journal Article Mater Today Bio · December 2025 Pericytes play a key role in the brain where they support brain microvascular endothelial cells (BMECs) in forming the tightly regulated blood-brain barrier (BBB). The loss of pericytes, and corresponding weakening of the BBB, has been reported in response ... Full text Link to item CiteBasic Science and Pathogenesis.
Journal Article Alzheimers Dement · December 2025 BACKGROUND: Postoperative delirium is a significant problem in older adults, especially in subjects with underlying neurodegeneration. Peripheral surgical trauma has been described as a trigger for microglial activation and cognitive deficits, with the blo ... Full text Link to item CiteShear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB-on-a-Chip Model of Systemic Inflammation Leading to Astrogliosis.
Journal Article Adv Sci (Weinh) · November 2025 The blood-brain barrier (BBB) maintains cerebral homeostasis and protects the central nervous system (CNS) during systemic inflammation. Advanced in vitro models integrating circulation, a functional BBB, and reactive glial cells are essential for studying ... Full text Link to item CiteRecent Grants
Impact of hypertension and aging on postoperative delirium
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers Disease
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2024 - 2029The role of cerebrospinal fluid complement activation in delirium and post-intensive care unit long-term cognitive impairment
ResearchAdvisor · Awarded by National Institute on Aging · 2024 - 2029View All Grants
Education, Training & Certifications
Imperial College London (United Kingdom) ·
2007
Ph.D.