Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Imperial College London (United Kingdom) 2007
• 

  Duke Appointment History

  • Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2018 - 2021
  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2015 - 2018
• Recognition
• 

  In the News

  • OCT 11, 2018

    Duke Health News

    Nerve Stimulation in Mice Suggests New Way to Reduce Delirium After Surgery

  • JUL 12, 2016

    Duke Translational Medicine Institute / DukeCTSA

    Supplemental Grant Aids Search for Answers to Post-Anesthesia Memory Problems
• 

  Awards & Honors

  • New Investigator Award . International Society to Advance Alzheimer's Research and Treatment (ISTAART). 2019
  • Active Member (by election). Association of University Anesthesiologists. May 2018
  • Junior Faculty Award. Association of University Anesthesiologists. 2014
  • New Investigator Award. International Society for the Study of Fatty Acids and Lipids. 2014
  • Young Investigator Award in Inflammation. Eicosanoid Research Foundation. 2013
  • Young Investigator Scholarship. Alzheimer’s Drug Discovery Foundation. 2011
  • Prize for Contribution Neuroscience Course. Keele University, U.K.. 2007
• Expertise
• 

  Subject Headings

  • Anesthesia
  • Behavior, Animal
  • Blood-Brain Barrier
  • Brain
  • Cognition
  • Cytokines
  • Immunity
  • Inflammation
  • Macrophages
  • Memory Disorders
  • Metabolic Diseases
  • Microglia
  • Postoperative Complications
  • Tibial Fractures
• 

  Global Scholarship

  • Teaching

    • China (Country) 
• Research
• 

  Selected Grants

  • Protective role of Clec7a/dectin-1 in CNS autoimmunity awarded by National Institutes of Health 2020 - 2025
  • Bioelectronic regulation of CNS lymphatic drainage in delirium and AD. awarded by Alzheimer's Association 2019 - 2022
  • Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
  • Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health 2019 - 2022
  • Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
  • TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc 2020 - 2021
  • A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation 2018 - 2021
  • Profiling postoperative neuroinflammation in a mouse model of delirium superimposed on Parkinson's disease. awarded by  Harvard University 2020 - 2021
  • Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health 2018 - 2021
  • Ulinastatin and Postoperative Cognitive Dysfunction awarded by Takeda Pharmaceutical Company Limited 2019 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Role of TLR4 in surgery-induced cognitive decline awarded by Takeda Pharmaceutical Company Limited 2016 - 2018
  • NEUROPROTECTIVE EFFECTS OF URMC-099 IN POSTOPERATIVE COGNITIVE DYSFUNCTION awarded by University of Rochester Medical Center 2016 - 2017
• 

  External Relationships

  • Cambridge University Press
  • XuanWu Hospital, Beijing, China
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • VanDusen KW, Li Y-J, Cai V, Hall A, Hiles S, Will Thompson J, et al. Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction. J Alzheimers Dis. 2021 Feb 26;
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    • Terrando N, Park JJ, Devinney M, Chan C, Cooter M, Avasarala P, et al. Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults. Sci Rep. 2021 Feb 4;11(1):3047.
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    • Miller-Rhodes P, Gelbard HA, Terrando N. This Is Your Brain on (Low) Glucose. Trends Neurosci. 2020 Dec;43(12):933–5.
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    • Yang T, Velagapudi R, Terrando N. Neuroinflammation after surgery: from mechanisms to therapeutic targets. Nat Immunol. 2020 Nov;21(11):1319–26.
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    • Wang D-S, Terrando N, Orser BA. Targeting microglia to mitigate perioperative neurocognitive disorders. Br J Anaesth. 2020 Sep;125(3):229–32.
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    • Bassi GS, Kanashiro A, Coimbra NC, Terrando N, Maixner W, Ulloa L. Anatomical and clinical implications of vagal modulation of the spleen. Neurosci Biobehav Rev. 2020 May;112:363–73.
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    • Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, et al. Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia. Alzheimers Dement. 2020 May;16(5):734–49.
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    • Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, et al. Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020 Jan;132(1):55–68.
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    • VanDusen KW, Eleswarpu S, Moretti EW, Devinney MJ, Crabtree DM, Laskowitz DT, et al. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. J Alzheimers Dis. 2020;75(4):1319–28.
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    • Miller-Rhodes P, Kong C, Baht GS, Saminathan P, Rodriguiz RM, Wetsel WC, et al. The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders. J Neuroinflammation. 2019 Oct 28;16(1):193.
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    • Terrando N, Warner DS. Xenon for traumatic brain injury: a noble step forward and a wet blanket. Br J Anaesth. 2019 Jul;123(1):9–11.
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    • Klinger RY, Cooter M, Bisanar T, Terrando N, Berger M, Podgoreanu MV, et al. Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial. Anesthesiology. 2019 Jun;130(6):958–70.
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    • Berger M, Oyeyemi D, Olurinde MO, Whitson HE, Weinhold KJ, Woldorff MG, et al. The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction. J Am Geriatr Soc. 2019 Apr;67(4):794–8.
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    • Subramaniyan S, Terrando N. Neuroinflammation and Perioperative Neurocognitive Disorders. Anesth Analg. 2019 Apr;128(4):781–8.
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    • Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, et al. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. Br J Anaesth. 2019 Mar;122(3):350–60.
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    • Miller-Rhodes P, Kong C, Baht G, Rodriguiz R, Wetsel W, Gelbard H, et al. The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders. 2019 Feb;
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    • Huffman WJ, Subramaniyan S, Rodriguiz RM, Wetsel WC, Grill WM, Terrando N. Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice. Brain Stimul. 2019 Jan;12(1):19–29.
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    • Ma Q, Zhang Z, Shim J-K, Venkatraman TN, Lascola CD, Quinones QJ, et al. Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation. Front Neurosci. 2019;13:608.
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    • Velagapudi R, Subramaniyan S, Xiong C, Porkka F, Rodriguiz RM, Wetsel WC, et al. Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model. Front Immunol. 2019;10:2675.
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    • Yang T, Terrando N. The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders. Adv Exp Med Biol. 2019;1161:27–35.
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    • Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, et al. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 Dec;127(6):1406–13.
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    • Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Br J Anaesth. 2018 Nov;121(5):1005–12.
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    • Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Acta Anaesthesiol Scand. 2018 Nov;62(10):1473–80.
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    • Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al. Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018. Anesth Analg. 2018 Nov;127(5):1189–95.
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    • Berger M, Terrando N, Smith SK, Browndyke JN, Newman MF, Mathew JP. Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology. 2018 Oct;129(4):829–51.
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    • Xiong C, Liu J, Lin D, Zhang J, Terrando N, Wu A. Complement activation contributes to perioperative neurocognitive disorders in mice. J Neuroinflammation. 2018 Sep 4;15(1):254.
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    • Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018 Aug;129(2):343–66.
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    • Luo X, Fitzsimmons B, Mohan A, Zhang L, Terrando N, Kordasiewicz H, et al. Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. Brain Behav Immun. 2018 Aug;72:34–44.
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    • Klinger RY, James OG, Borges-Neto S, Bisanar T, Li Y-J, Qi W, et al. 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 Apr;128(4):728–44.
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    • Terrando N, Eckenhoff RG. One to rule them all? Br J Anaesth. 2018 Mar;120(3):428–30.
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    • Xiong C, Zhang Z, Baht GS, Terrando N. A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. J Vis Exp. 2018 Feb 27;(132).
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    • Femenía T, Giménez-Cassina A, Codeluppi S, Fernández-Zafra T, Katsu-Jiménez Y, Terrando N, et al. Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. J Neurosci. 2018 Jan 10;38(2):452–64.
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    • Terrando N, Pavlov VA. Editorial: Neuro-Immune Interactions in Inflammation and Autoimmunity. Front Immunol. 2018;9:772.
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    • Zhang L, Terrando N, Xu Z-Z, Bang S, Jordt S-E, Maixner W, et al. Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. Front Pharmacol. 2018;9:412.
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    • Yang T, Zhang X-M, Tarnawski L, Peleli M, Zhuge Z, Terrando N, et al. Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. Redox Biol. 2017 Oct;13:320–30.
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    • Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, et al. The immune response of the human brain to abdominal surgery. Ann Neurol. 2017 Apr;81(4):572–82.
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    • Whittington RA, Planel E, Terrando N. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Front Immunol. 2017;8:1464.
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    • Zhang Z, Ma Q, Shah B, Mackensen GB, Lo DC, Mathew JP, et al. Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats. Front Immunol. 2017;8:1050.
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    • Zhang M-D, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, et al. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6686–95.
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    • Li Y, Pan K, Chen L, Ning J-L, Li X, Yang T, et al. Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. J Neuroinflammation. 2016 Oct 12;13(1):268.
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    • Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, et al. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. J Neuroinflammation. 2016 Aug 30;13(1):211.
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    • Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang X-M, Terrando N, et al. Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. J Am Heart Assoc. 2016 Jul 18;5(7).
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    • Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology. 2016 May;124(5):1174–89.
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    • Zhao H-L, Ma D-Q, Terrando N. Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats. Journal of Anesthesia and Perioperative Medicine. 2016 Mar;3(2):57–62.
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    • Disma N, Mondardini MC, Terrando N, Absalom AR, Bilotta F. A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. Paediatr Anaesth. 2016 Jan;26(1):6–36.
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    • Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. J Alzheimers Dis. 2016;49(4):1191.
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    • Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, et al. Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Front Aging Neurosci. 2016;8:175.
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    • Qiu L, Zhu C, Bodogan T, Gómez-Galán M, Zhang Y, Zhou K, et al. Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. Toxicol Sci. 2016 Jan;149(1):121–33.
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    • Terrando N, Yang T, Wang X, Fang J, Cao M, Andersson U, et al. Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. Front Immunol. 2016;7:441.
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    • Berger M, Nadler JW, Browndyke J, Terrando N, Ponnusamy V, Cohen HJ, et al. Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly. Anesthesiol Clin. 2015 Sep;33(3):517–50.
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    • Yang T, Peleli M, Zollbrecht C, Giulietti A, Terrando N, Lundberg JO, et al. Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. Free Radic Biol Med. 2015 Jun;83:159–66.
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    • Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, et al. Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17;20:667–75.
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    • Terrando N, Eriksson LI, Eckenhoff RG. Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop. Anesth Analg. 2015 Mar;120(3):649–52.
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    • Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. J Alzheimers Dis. 2015;48(2):293–301.
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    • Liu X-C, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, et al. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain Behav Immun. 2014 Feb;36:80–9.
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    • Fu HQ, Yang T, Xiao W, Fan L, Wu Y, Terrando N, et al. Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. Plos One. 2014;9(8):e106331.
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    • Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. Faseb J. 2013 Sep;27(9):3564–71.
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    • Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, et al. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May;118(5):1098–105.
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    • Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, et al. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 8;18:1481–90.
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    • He H-J, Wang Y, Le Y, Duan K-M, Yan X-B, Liao Q, et al. Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats. Cns Neurosci Ther. 2012 Dec;18(12):994–1002.
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    • Hauck JN, Terrando N, Kukreja J, Brzezinski M. Does general anesthesia promote Alzheimer's disease? Journal of Anesthesia and Clinical Research. 2012 Feb 1;3(2).
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    • Terrando N, Maze M. In reply. Mayo Clinic Proceedings. 2012 Jan 1;87(2):210.
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    • Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, et al. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. Plos One. 2012;7(5):e37020.
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    • Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, et al. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec;70(6):986–95.
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    • Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, et al. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep;86(9):885–93.
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    • Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, et al. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care. 2011 Jun 24;15(3):R153.
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    • Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, et al. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain Res. 2011 Apr 6;1383:317–23.
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    • Monaco C, Terrando N, Midwood KS. Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011 Apr;63(4):500–11.
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    • Terrando N, Monaco C, Ma D, Foxwell BMJ, Feldmann M, Maze M. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20518–22.
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    • Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, et al. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010 Sep;68(3):360–8.
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    • Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, et al. The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care. 2010;14(3):R88.
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    • Zhang Z, Ma Q, Velagapudi R, Barclay WE, Rodriguiz RM, Wetsel WC, et al. Annexin-A1 tripeptide attenuates surgery-induced neuroinflammation and memory deficits through regulation of the NLRP3 inflammasome.
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  • Conference Papers

    • Devinney M, Maddipati KR, Chan C, Mathew JP, Cooter M, Terrando N, et al. METABOLIPIDOMIC ANALYSIS OF CEREBROSPINAL FLUID REVEALS INCREASED ARACHIDONIC ACID-DERIVED LIPIDS AND SPECIALIZED PRO-RESOLVING MEDIATORS 24 HRS AND 6-WEEKS FOLLOWING SURGERY AND ANESTHESIA. In: Anesthesia and Analgesia. 2019. p. 485–6.
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