Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Imperial College London (Uk) 2007
• 

  Duke Appointment History

  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2015 - 2018
• Recognition
• 

  In the News

  • OCT 11, 2018

    Duke Health News

    Nerve Stimulation in Mice Suggests New Way to Reduce Delirium After Surgery

  • JUL 12, 2016

    Duke Translational Medicine Institute / DukeCTSA

    Supplemental Grant Aids Search for Answers to Post-Anesthesia Memory Problems
• 

  Awards & Honors

  • Active Member (by election). Association of University Anesthesiologists. May 2018
  • Junior Faculty Award. Association of University Anesthesiologists. 2014
  • New Investigator Award. International Society for the Study of Fatty Acids and Lipids. 2014
  • Young Investigator Award in Inflammation. Eicosanoid Research Foundation. 2013
  • Young Investigator Scholarship. Alzheimer’s Drug Discovery Foundation. 2011
  • Prize for Contribution Neuroscience Course. Keele University, U.K.. 2007
• Expertise
• 

  Subject Headings

  • Anesthesia
  • Behavior, Animal
  • Blood-Brain Barrier
  • Brain
  • Cognition
  • Cytokines
  • Immunity
  • Inflammation
  • Macrophages
  • Memory Disorders
  • Metabolic Diseases
  • Microglia
  • Postoperative Complications
  • Tibial Fractures
• 

  Global Scholarship

  • Teaching

    • China (Country) 
• Research
• 

  Selected Grants

  • Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
  • Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
  • A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation 2018 - 2021
  • Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health 2018 - 2020
  • Role of TLR4 in surgery-induced cognitive decline awarded by Takeda Pharmaceutical Company Limited 2016 - 2018
  • NEUROPROTECTIVE EFFECTS OF URMC-099 IN POSTOPERATIVE COGNITIVE DYSFUNCTION awarded by University of Rochester Medical Center 2016 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Huffman WJ, Subramaniyan S, Rodriguiz RM, Wetsel WC, Grill WM, Terrando N. Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice. Brain Stimulation. 2019 Jan;12(1):19-29. PubMed Central PMCID: 30337243.  Full Text
    • Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang D-S, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group . Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesthesia and Analgesia. 2018 Dec;127(6):1406-1413. PubMed Central PMCID: 30303868.  Full Text
    • Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang X-M, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. British Journal of Anaesthesia. 2018 Dec.  Full Text
    • Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG, Nomenclature Consensus Working Group . Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. British Journal of Anaesthesia. 2018 Nov;121(5):1005-1012. PubMed Central PMCID: 30336844. (Review)  Full Text
    • Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG, Nomenclature Consensus Working Group . Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Acta Anaesthesiologica Scandinavica. 2018 Nov;62(10):1473-1480. PubMed Central PMCID: 30325016.  Full Text
    • Berger M, Terrando N, Smith SK, Browndyke JN, Newman MF, Mathew JP. Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology. 2018 Oct;129(4):829-851. PubMed Central PMCID: 29621031.  Full Text
    • Xiong C, Liu J, Lin D, Zhang J, Terrando N, Wu A. Complement activation contributes to perioperative neurocognitive disorders in mice. Journal of Neuroinflammation. 2018 Sep 4;15(1):254-null. PubMed Central PMCID: 30180861.  Full Text
    • Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018 Aug;129(2):343-366. PubMed Central PMCID: 29462012. (Review)  Full Text
    • Luo X, Fitzsimmons B, Mohan A, Zhang L, Terrando N, Kordasiewicz H, Ji R-R. Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. Brain, Behavior, and Immunity. 2018 Aug;72:34-44. PubMed Central PMCID: 29128611.  Full Text
    • Klinger RY, James OG, Borges-Neto S, Bisanar T, Li Y-J, Qi W, Berger M, Terrando N, Newman MF, Doraiswamy PM, Mathew JP, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group , Neurologic Outcomes Research Group (NORG) . 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 Apr;128(4):728-744. PubMed Central PMCID: 29389750.  Full Text
    • Terrando N, Eckenhoff RG. One to rule them all?. British Journal of Anaesthesia. 2018 Mar;120(3):428-430. PubMed Central PMCID: 29452796.  Full Text
    • Xiong C, Zhang Z, Baht GS, Terrando N. A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. Journal of Visualized Experiments : Jove. 2018 Feb 27;(132). PubMed Central PMCID: 29553500.  Full Text
    • Femenía T, Giménez-Cassina A, Codeluppi S, Fernández-Zafra T, Katsu-Jiménez Y, Terrando N, Eriksson LI, Gómez-Galán M. Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 2018 Jan;38(2):452-464. PubMed Central PMCID: 29175959.  Full Text
    • Terrando N, Pavlov VA. Editorial: Neuro-Immune Interactions in Inflammation and Autoimmunity. Frontiers in Immunology. 2018 Jan;9:772-null. PubMed Central PMCID: 29713326.  Full Text
    • Zhang L, Terrando N, Xu Z-Z, Bang S, Jordt S-E, Maixner W, Serhan CN, Ji R-R. Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. Frontiers in Pharmacology. 2018 Jan;9:412-null. PubMed Central PMCID: 29765320.  Full Text
    • Yang T, Zhang X-M, Tarnawski L, Peleli M, Zhuge Z, Terrando N, Harris RA, Olofsson PS, Larsson E, Persson AEG, Lundberg JO, Weitzberg E, Carlstrom M. Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. Redox Biology. 2017 Oct;13:320-330. PubMed Central PMCID: 28623824.  Full Text
    • Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. The immune response of the human brain to abdominal surgery. Annals of Neurology. 2017 Apr 11;81(4):572-582. PubMed Central PMCID: 28253549.  Full Text
    • Whittington RA, Planel E, Terrando N. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Frontiers in Immunology. 2017 Jan;8:1464-null. PubMed Central PMCID: 29163531. (Review)  Full Text
    • Zhang Z, Ma Q, Shah B, Mackensen GB, Lo DC, Mathew JP, Podgoreanu MV, Terrando N. Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats. Frontiers in Immunology. 2017 Jan;8:1050-null. PubMed Central PMCID: 28912778.  Full Text
    • Li Y, Pan K, Chen L, Ning J-L, Li X, Yang T, Terrando N, Gu J, Tao G. Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. Journal of Neuroinflammation. 2016 Oct 12;13(1):268-null. PubMed Central PMCID: 27733186.  Full Text  Open Access Copy
    • Zhang M-D, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, Andreska T, Akassoglou K, Harkany T, Hökfelt TGM, Terrando N. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 10;113(43):E6686-E6695. PubMed Central PMCID: 27791037.  Full Text
    • Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. Journal of Neuroinflammation. 2016 Aug 30;13(1):211-null. PubMed Central PMCID: 27577265.  Full Text  Open Access Copy
    • Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang X-M, Terrando N, Checa A, Sällström J, Wheelock CE, Winqvist O, Harris RA, Larsson E, Persson AEG, Fredholm BB, Carlström M. Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. Journal of the American Heart Association. 2016 Jul 18;5(7). PubMed Central PMCID: 27431647.  Full Text  Open Access Copy
    • Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology. 2016 May;124(5):1174-1189. PubMed Central PMCID: 26982508. (Review)  Full Text
    • Zhao H-L, Ma D-Q, Terrando N. Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats. Journal of Anesthesia and Perioperative Medicine. 2016 Mar;3(2):57-62.  Full Text
    • Disma N, Mondardini MC, Terrando N, Absalom AR, Bilotta F. A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. Paediatric Anaesthesia. 2016 Jan;26(1):6-36. PubMed Central PMCID: 26530523. (Review)  Full Text
    • Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Journal of Alzheimer'S Disease : Jad. 2016 Jan;49(4):1191-null. PubMed Central PMCID: 26756328.  Full Text
    • Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang T-L. Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Frontiers in Aging Neuroscience. 2016 Jan;8:175-null. PubMed Central PMCID: 27493629.  Full Text  Open Access Copy
    • Qiu L, Zhu C, Bodogan T, Gómez-Galán M, Zhang Y, Zhou K, Li T, Xu G, Blomgren K, Eriksson LI, Vutskits L, Terrando N. Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. Toxicological Sciences : an Official Journal of the Society of Toxicology. 2016 Jan;149(1):121-133. PubMed Central PMCID: 26424773.  Full Text
    • Terrando N, Yang T, Wang X, Fang J, Cao M, Andersson U, Erlandsson HH, Ouyang W, Tong J. Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. Frontiers in Immunology. 2016 Jan;7:441-null. PubMed Central PMCID: 27822212.  Full Text
    • Berger M, Nadler JW, Browndyke J, Terrando N, Ponnusamy V, Cohen HJ, Whitson HE, Mathew JP. Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly. Anesthesiology Clinics. 2015 Sep;33(3):517-550. PubMed Central PMCID: 26315636. (Review)  Full Text
    • Yang T, Peleli M, Zollbrecht C, Giulietti A, Terrando N, Lundberg JO, Weitzberg E, Carlström M. Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. Free Radical Biology & Medicine. 2015 Jun;83:159-166. PubMed Central PMCID: 25724690.  Full Text
    • Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Molecular Medicine (Cambridge, Mass.). 2015 Mar 17;20:667-675. PubMed Central PMCID: 25365546.  Full Text
    • Terrando N, Eriksson LI, Eckenhoff RG. Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop. Anesthesia and Analgesia. 2015 Mar;120(3):649-652. PubMed Central PMCID: 25695580.  Full Text
    • Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Journal of Alzheimer'S Disease : Jad. 2015 Jan;48(2):293-301. PubMed Central PMCID: 26401996. (Review)  Full Text
    • Liu X-C, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, Olsson SK, Orhan F, Kegel M, Asp L, Goiny M, Schwieler L, Engberg G, Karlsson H, Erhardt S. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain, Behavior, and Immunity. 2014 Feb;36:80-89. PubMed Central PMCID: 24140727.  Full Text
    • Fu HQ, Yang T, Xiao W, Fan L, Wu Y, Terrando N, Wang TL. Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. Plos One. 2014 Jan;9(8):e106331-null. PubMed Central PMCID: 25170959.  Full Text
    • Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, Lindskog M, Eriksson LI. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology. 2013 Sep;27(9):3564-3571. PubMed Central PMCID: 23709617.  Full Text
    • Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May;118(5):1098-1105. PubMed Central PMCID: 23353794.  Full Text
    • Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Molecular Medicine (Cambridge, Mass.). 2013 Feb 8;18:1481-1490. PubMed Central PMCID: 23296426.  Full Text
    • He H-J, Wang Y, Le Y, Duan K-M, Yan X-B, Liao Q, Liao Y, Tong J-B, Terrando N, Ouyang W. Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats. Cns Neuroscience & Therapeutics. 2012 Dec;18(12):994-1002. PubMed Central PMCID: 23078219.  Full Text
    • Hauck JN, Terrando N, Kukreja J, Brzezinski M. Does general anesthesia promote Alzheimer's disease?. Journal of Anesthesia and Clinical Research. 2012 Feb 1;3(2). (Review)  Full Text
    • Terrando N, Maze M. In reply. Mayo Clinic Proceedings. 2012 Jan 1;87(2):210-null. (Letter)  Full Text
    • Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. Plos One. 2012 Jan;7(5):e37020-null. PubMed Central PMCID: 22615878.  Full Text  Open Access Copy
    • Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. Resolving postoperative neuroinflammation and cognitive decline. Annals of Neurology. 2011 Dec;70(6):986-995. PubMed Central PMCID: 22190370.  Full Text
    • Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. Perioperative cognitive decline in the aging population. Mayo Clinic Proceedings. 2011 Sep;86(9):885-893. PubMed Central PMCID: 21878601.  Full Text
    • Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Critical Care (London, England). 2011 Jun 24;15(3):R153-null. PubMed Central PMCID: 21702944.  Full Text
    • Monaco C, Terrando N, Midwood KS. Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis. Arthritis Care & Research. 2011 Apr;63(4):500-511. PubMed Central PMCID: 21452263. (Review)  Full Text
    • Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain Research. 2011 Apr;1383:317-323. PubMed Central PMCID: 21281606.  Full Text
    • Terrando N, Monaco C, Ma D, Foxwell BMJ, Feldmann M, Maze M. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov;107(47):20518-20522. PubMed Central PMCID: 21041647.  Full Text
    • Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. Role of interleukin-1beta in postoperative cognitive dysfunction. Annals of Neurology. 2010 Sep;68(3):360-368. PubMed Central PMCID: 20818791.  Full Text
    • Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M. The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Critical Care (London, England). 2010 Jan;14(3):R88-null. PubMed Central PMCID: 20470406.  Full Text

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