Niccolò Terrando | Scholars@Duke

Niccolò Terrando
Assistant Professor in Anesthesiology

Current Appointments & Affiliations

Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2015
Assistant Research Professor in Cell Biology, Cell Biology, Basic Science Departments 2018
Faculty Network Member of Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2017

Contact Information

905 South Lasalle St., GSRB1 (Snyderman Building) Room 1002A, Durham, NC 27710
niccolo.terrando@duke.edu (919) 684-6121
Lab webpage

Background
Education, Training, & Certifications
- Ph.D., Imperial College London (Uk) 2007
Recognition
In the News
- JUL 12, 2016 Duke Translational Medicine Institute / DukeCTSA
  
  Supplemental Grant Aids Search for Answers to Post-Anesthesia Memory Problems
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Teaching
  - China (Country)
Research
Selected Grants
- Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2022
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- Role of TLR4 in surgery-induced cognitive decline awarded by Takeda Pharmaceutical Company Limited 2016 - 2018
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Berger M, Terrando N, Smith SK, Browndyke JN, Newman MF, Mathew JP. Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology. 2018 Apr 5. PubMed PMID: 29621031. Full Text
  - Klinger RY, James OG, Borges-Neto S, Bisanar T, Li Y-J, Qi W, Berger M, Terrando N, Newman MF, Doraiswamy PM, Mathew JP, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group , Neurologic Outcomes Research Group (NORG) . 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 Apr;128(4):728-744. PubMed PMID: 29389750. Full Text
  - Terrando N, Eckenhoff RG. One to rule them all?. British journal of anaesthesia. 2018 Mar;120(3):428-430. PubMed PMID: 29452796. Full Text
  - Xiong C, Zhang Z, Baht GS, Terrando N. A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. Journal of visualized experiments : JoVE. 2018 Feb 27;(132). PubMed PMID: 29553500. Full Text
  - Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Anesthesiology. 2018 Feb 19. PubMed PMID: 29462012. Full Text
  - Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG, Evered L, Eckenhoff RG, Ames D, Bekker A, Berger M, Blacker D, Browndyke J, Crosby G, Deiner SG, van Dijk D, DeKosky ST, Eckenhoff MF, Eriksson L, Galasko D, Hogan K, Inouye S, Knopman D, Lyketsos C, Marcantonio E, Maruff P, Maze M, Oh E, Orser BA, Ottens T, Price C, Rasmussen LS, Sachdev P, Schenning K, Scott DA, Seiber FE, Silbert B et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018 (Accepted). British Journal of Anaesthesia. 2018 Jan 1. Full Text
  - Femenía T, Giménez-Cassina A, Codeluppi S, Fernández-Zafra T, Katsu-Jiménez Y, Terrando N, Eriksson LI, Gómez-Galán M. Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 Jan;38(2):452-464. PubMed PMID: 29175959. Full Text
  - Terrando N, Pavlov VA. Editorial: Neuro-Immune Interactions in Inflammation and Autoimmunity. Frontiers in immunology. 2018 Jan;9:772-. PubMed PMID: 29713326. Full Text
  - Luo X, Fitzsimmons B, Mohan A, Zhang L, Terrando N, Kordasiewicz H, Ji R-R. Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. Brain, behavior, and immunity. 2017 Nov 8. PubMed PMID: 29128611. Full Text
  - Yang T, Zhang X-M, Tarnawski L, Peleli M, Zhuge Z, Terrando N, Harris RA, Olofsson PS, Larsson E, Persson AEG, Lundberg JO, Weitzberg E, Carlstrom M. Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. Redox biology. 2017 Oct;13:320-330. PubMed PMID: 28623824. Full Text
  - Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. The immune response of the human brain to abdominal surgery. Annals of neurology. 2017 Apr 11;81(4):572-582. PubMed PMID: 28253549. Full Text
  - Whittington RA, Planel E, Terrando N. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Frontiers in immunology. 2017 Jan;8:1464-. PubMed PMID: 29163531. (Review) Full Text
  - Zhang Z, Ma Q, Shah B, Mackensen GB, Lo DC, Mathew JP, Podgoreanu MV, Terrando N. Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats. Frontiers in immunology. 2017 Jan;8:1050-. PubMed PMID: 28912778. Full Text
  - Li Y, Pan K, Chen L, Ning J-L, Li X, Yang T, Terrando N, Gu J, Tao G. Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. Journal of neuroinflammation. 2016 Oct 12;13(1):268-. PubMed PMID: 27733186. Full Text Open Access Copy
  - Zhang M-D, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, Andreska T, Akassoglou K, Harkany T, Hökfelt TGM, Terrando N. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 10;113(43):E6686-E6695. PubMed PMID: 27791037. Full Text
  - Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM. Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. Journal of neuroinflammation. 2016 Aug 30;13(1):211-. PubMed PMID: 27577265. Full Text Open Access Copy
  - Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang X-M, Terrando N, Checa A, Sällström J, Wheelock CE, Winqvist O, Harris RA, Larsson E, Persson AEG, Fredholm BB, Carlström M. Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. Journal of the American Heart Association. 2016 Jul 18;5(7). PubMed PMID: 27431647. Full Text Open Access Copy
  - Steinberg BE, Sundman E, Terrando N, Eriksson LI, Olofsson PS. Neural Control of Inflammation: Implications for Perioperative and Critical Care. Anesthesiology. 2016 May;124(5):1174-1189. PubMed PMID: 26982508. (Review) Full Text
  - Zhao H-L, Ma D-Q, Terrando N. Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats. Journal of Anesthesia and Perioperative Medicine. 2016 Mar;3(2):57-62. Full Text
  - Disma N, Mondardini MC, Terrando N, Absalom AR, Bilotta F. A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. Paediatric anaesthesia. 2016 Jan;26(1):6-36. PubMed PMID: 26530523. (Review) Full Text
  - Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2016 Jan;49(4):1191-. PubMed PMID: 26756328. Full Text
  - Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang T-L. Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Frontiers in aging neuroscience. 2016 Jan;8:175-. PubMed PMID: 27493629. Full Text Open Access Copy
  - Qiu L, Zhu C, Bodogan T, Gómez-Galán M, Zhang Y, Zhou K, Li T, Xu G, Blomgren K, Eriksson LI, Vutskits L, Terrando N. Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2016 Jan;149(1):121-133. PubMed PMID: 26424773. Full Text
  - Terrando N, Yang T, Wang X, Fang J, Cao M, Andersson U, Erlandsson HH, Ouyang W, Tong J. Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats. Frontiers in immunology. 2016 Jan;7:441-. PubMed PMID: 27822212. Full Text
  - Berger M, Nadler JW, Browndyke J, Terrando N, Ponnusamy V, Cohen HJ, Whitson HE, Mathew JP. Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly. Anesthesiology clinics. 2015 Sep;33(3):517-550. PubMed PMID: 26315636. (Review) Full Text
  - Yang T, Peleli M, Zollbrecht C, Giulietti A, Terrando N, Lundberg JO, Weitzberg E, Carlström M. Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. Free radical biology & medicine. 2015 Jun;83:159-166. PubMed PMID: 25724690. Full Text
  - Terrando N, Eriksson LI, Eckenhoff RG. Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop. Anesthesia and analgesia. 2015 Mar;120(3):649-652. PubMed PMID: 25695580. Full Text
  - Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Molecular medicine (Cambridge, Mass.). 2015 Mar;20:667-675. PubMed PMID: 25365546. Full Text
  - Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2015 Jan;48(2):293-301. PubMed PMID: 26401996. (Review) Full Text
  - Liu X-C, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, Olsson SK, Orhan F, Kegel M, Asp L, Goiny M, Schwieler L, Engberg G, Karlsson H, Erhardt S. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain, behavior, and immunity. 2014 Feb;36:80-89. PubMed PMID: 24140727. Full Text
  - Fu HQ, Yang T, Xiao W, Fan L, Wu Y, Terrando N, Wang TL. Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. PloS one. 2014 Jan;9(8):e106331-. PubMed PMID: 25170959. Full Text
  - Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, Lindskog M, Eriksson LI. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Sep;27(9):3564-3571. PubMed PMID: 23709617. Full Text
  - Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M. Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May;118(5):1098-1105. PubMed PMID: 23353794. Full Text
  - Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Molecular medicine (Cambridge, Mass.). 2013 Feb;18:1481-1490. PubMed PMID: 23296426. Full Text
  - He H-J, Wang Y, Le Y, Duan K-M, Yan X-B, Liao Q, Liao Y, Tong J-B, Terrando N, Ouyang W. Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats. CNS neuroscience & therapeutics. 2012 Dec;18(12):994-1002. PubMed PMID: 23078219. Full Text
  - Terrando N, Maze M. In reply. Mayo Clinic Proceedings. 2012 Feb;87(2):210-210. Full Text
  - Nowak Hauck J. Does General Anesthesia Promote Alzheimer’s disease?. Journal of Anesthesia & Clinical Research. 2012;03(02). Full Text
  - Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. PloS one. 2012 Jan;7(5):e37020-. PubMed PMID: 22615878. Full Text Open Access Copy
  - Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. Resolving postoperative neuroinflammation and cognitive decline. Annals of neurology. 2011 Dec;70(6):986-995. PubMed PMID: 22190370. Full Text
  - Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. Perioperative cognitive decline in the aging population. Mayo Clinic proceedings. 2011 Sep;86(9):885-893. PubMed PMID: 21878601. Full Text
  - Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Critical care (London, England). 2011 Jun 24;15(3):R153-. PubMed PMID: 21702944. Full Text
  - Monaco C, Terrando N, Midwood KS. Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis. Arthritis care & research. 2011 Apr;63(4):500-511. PubMed PMID: 21452263. (Review) Full Text
  - Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain research. 2011 Apr;1383:317-323. PubMed PMID: 21281606. Full Text
  - Terrando N, Monaco C, Ma D, Foxwell BMJ, Feldmann M, Maze M. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov;107(47):20518-20522. PubMed PMID: 21041647. Full Text
  - Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. Role of interleukin-1beta in postoperative cognitive dysfunction. Annals of neurology. 2010 Sep;68(3):360-368. PubMed PMID: 20818791. Full Text
  - Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M. The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Critical care (London, England). 2010 Jan;14(3):R88-. PubMed PMID: 20470406. Full Text

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Education, Training, & Certifications

In the News

Awards & Honors

Subject Headings

Global Scholarship

Teaching

Selected Grants

Selected Publications

Journal Articles