Histone demethylases in neuronal differentiation, plasticity, and disease.

Journal Article (Journal Article;Review)

For more than 40 years after its discovery, histone methylation was thought to be largely irreversible. However, the first histone demethylase (HDM) was identified in 2004, challenging this notion. Since that time, more than 20 HDMs have been identified and characterized, and many have been shown to have critical roles in organismal development, cell fate, and disease. Here, we highlight some of the recent advances in our understanding of the function of HDMs in the context of neuronal development, plasticity, and disease. We focus, in particular, on molecular genetic studies of LSD1, Kdm6b, and Kdm5c that have elucidated both enzymatic and non-enzymatic gene regulatory functions of these HDMs in neurons.

Full Text

Duke Authors

Cited Authors

  • Swahari, V; West, AE

Published Date

  • December 2019

Published In

Volume / Issue

  • 59 /

Start / End Page

  • 9 - 15

PubMed ID

  • 30878844

Pubmed Central ID

  • PMC6745013

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2019.02.009

Language

  • eng

Conference Location

  • England