Blood Substitutes and Oxygen Therapeutics: A Review.

Journal Article (Journal Article;Review)

Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers have succeeded in providing a reasonable alternative to allogeneic blood transfusion. However, there remain scenarios in which blood transfusion is not an option, due to patient's religious beliefs, inability to find adequately cross-matched erythrocytes, or in remote locations. In these situations, artificial oxygen carriers may provide a mortality benefit for patients with severe, life-threatening anemia. This article provides an up-to-date review of the history and development, clinical trials, new technology, and current standing of artificial oxygen carriers as an alternative to transfusion when blood is not an option.

Full Text

Duke Authors

Cited Authors

  • Jahr, JS; Guinn, NR; Lowery, DR; Shore-Lesserson, L; Shander, A

Published Date

  • January 2021

Published In

Volume / Issue

  • 132 / 1

Start / End Page

  • 119 - 129

PubMed ID

  • 30925560

Electronic International Standard Serial Number (EISSN)

  • 1526-7598

Digital Object Identifier (DOI)

  • 10.1213/ANE.0000000000003957


  • eng

Conference Location

  • United States