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Insights into pediatric rhabdomyosarcoma research: Challenges and goals.

Publication ,  Journal Article
Yohe, ME; Heske, CM; Stewart, E; Adamson, PC; Ahmed, N; Antonescu, CR; Chen, E; Collins, N; Ehrlich, A; Galindo, RL; Gryder, BE; Hahn, H ...
Published in: Pediatr Blood Cancer
October 2019

Overall survival rates for pediatric patients with high-risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan.

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Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

October 2019

Volume

66

Issue

10

Start / End Page

e27869

Location

United States

Related Subject Headings

  • Rhabdomyosarcoma
  • Research Design
  • Oncology & Carcinogenesis
  • Humans
  • Drug Discovery
  • Drug Development
  • Child
  • Antineoplastic Combined Chemotherapy Protocols
  • 3213 Paediatrics
  • 3211 Oncology and carcinogenesis
 

Citation

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Yohe, M. E., Heske, C. M., Stewart, E., Adamson, P. C., Ahmed, N., Antonescu, C. R., … Langenau, D. M. (2019). Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer, 66(10), e27869. https://doi.org/10.1002/pbc.27869
Yohe, Marielle E., Christine M. Heske, Elizabeth Stewart, Peter C. Adamson, Nabil Ahmed, Cristina R. Antonescu, Eleanor Chen, et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.Pediatr Blood Cancer 66, no. 10 (October 2019): e27869. https://doi.org/10.1002/pbc.27869.
Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, et al. Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer. 2019 Oct;66(10):e27869.
Yohe, Marielle E., et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.Pediatr Blood Cancer, vol. 66, no. 10, Oct. 2019, p. e27869. Pubmed, doi:10.1002/pbc.27869.
Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM. Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer. 2019 Oct;66(10):e27869.
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

October 2019

Volume

66

Issue

10

Start / End Page

e27869

Location

United States

Related Subject Headings

  • Rhabdomyosarcoma
  • Research Design
  • Oncology & Carcinogenesis
  • Humans
  • Drug Discovery
  • Drug Development
  • Child
  • Antineoplastic Combined Chemotherapy Protocols
  • 3213 Paediatrics
  • 3211 Oncology and carcinogenesis