Insights into pediatric rhabdomyosarcoma research: Challenges and goals.
Publication
, Journal Article
Yohe, ME; Heske, CM; Stewart, E; Adamson, PC; Ahmed, N; Antonescu, CR; Chen, E; Collins, N; Ehrlich, A; Galindo, RL; Gryder, BE; Hahn, H ...
Published in: Pediatr Blood Cancer
October 2019
Overall survival rates for pediatric patients with high-risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan.
Duke Scholars
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Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
October 2019
Volume
66
Issue
10
Start / End Page
e27869
Location
United States
Related Subject Headings
- Rhabdomyosarcoma
- Research Design
- Oncology & Carcinogenesis
- Humans
- Drug Discovery
- Drug Development
- Child
- Antineoplastic Combined Chemotherapy Protocols
- 3213 Paediatrics
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Yohe, M. E., Heske, C. M., Stewart, E., Adamson, P. C., Ahmed, N., Antonescu, C. R., … Langenau, D. M. (2019). Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer, 66(10), e27869. https://doi.org/10.1002/pbc.27869
Yohe, Marielle E., Christine M. Heske, Elizabeth Stewart, Peter C. Adamson, Nabil Ahmed, Cristina R. Antonescu, Eleanor Chen, et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.” Pediatr Blood Cancer 66, no. 10 (October 2019): e27869. https://doi.org/10.1002/pbc.27869.
Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, et al. Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer. 2019 Oct;66(10):e27869.
Yohe, Marielle E., et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.” Pediatr Blood Cancer, vol. 66, no. 10, Oct. 2019, p. e27869. Pubmed, doi:10.1002/pbc.27869.
Yohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM. Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer. 2019 Oct;66(10):e27869.
Published In
Pediatr Blood Cancer
DOI
EISSN
1545-5017
Publication Date
October 2019
Volume
66
Issue
10
Start / End Page
e27869
Location
United States
Related Subject Headings
- Rhabdomyosarcoma
- Research Design
- Oncology & Carcinogenesis
- Humans
- Drug Discovery
- Drug Development
- Child
- Antineoplastic Combined Chemotherapy Protocols
- 3213 Paediatrics
- 3211 Oncology and carcinogenesis