Corinne Mary Linardic | Scholars@Duke

Corinne Mary Linardic
Associate Professor of Pediatrics

Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models and genetically engineered murine models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Using these models, we can study the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic RAS) in rhabdomyosarcoma formation and treatment resistance. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic RAS, and identification of new therapeutic targets for treatment of this childhood cancer.

Current Research Interests

Basic cancer biology of rhabdomyosarcoma

Roles of oncogenes and tumor suppressors
Identification of novel therapeutic targets
Developmental pathways (Hippo, Notch, Wnt)
Plasticity of rhabdomyosarcoma stem cells

Translational research in rhabdomyosarcoma

Children's Oncology Group
International INSTRuCT Soft Tissue Sarcoma Consortium

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2012
Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1999

Contact Information

Box 102382, DUMC, Durham, NC 27710
LSRC Bldg Rm B361f, Research Drive, Durham, NC 27710
linar001@mc.duke.edu (919) 684-3401
Duke Pediatric Hematology-Oncology
Linardic lab
Rhabdomyosarcoma NCI U54 Moonshot

Background
Education, Training, & Certifications
- Board Certification Hematology and Oncology, American Board of Pediatrics 2002
- Fellow, Pediatric Hematology-Oncology, Pediatrics, Duke University 1999 - 2001
- Fellow, Pediatric Hematology-Oncology, Pediatrics, Children's Hospital of Philadelphia 1998 - 1999
- Residency, Pediatrics, Children's Hospital of Philadelphia 1995 - 1998
- M.D., Duke University 1995
- Ph.D., Duke University 1993
Previous Appointments & Affiliations
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2009 - 2012
- Associate Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
- Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2001 - 2010
Recognition
Awards & Honors
- Annual Gordon G. Hammes Faculty Teaching Award. Graduate students in Basic Biomedical Sciences and the Duke University School of Medicine. May 8, 2019
Expertise
Subject Headings
Research
Selected Grants
- Vulnerabilities in the transcriptional program of fusion-positive rhabdomyosarcoma awarded by Department of Defense 2023 - 2026
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Institutional Summer Undergraduate Research Fellowship (SURF) awarded by American Society for Pharmacology and Experimental Therapeutics 2018 - 2025
- Development of RNAi-based therapeutics to target oncogenic lncRNAs in rhabdomyosarcoma awarded by Alex's Lemonade Stand 2022 - 2025
- Defining and targeting the molecular vulnerabilities of the PAX3-FOXO1 protein in rhabdomyosarcoma awarded by National Institutes of Health 2019 - 2024
- Pre-clinical studies of CDK8 human fusion-positive rhabdomyosarcoma awarded by Ryvu Therapeutics 2022 - 2024
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- Role of the macro lncRNA KCNQ1OT1 in embryonal rhabdomyosarcoma tumorigenesis awarded by Kate Amato Foundation Inc. 2019 - 2023
- Targeting CDK8 in fusion-positive rhabdomyosarcoma awarded by Rally! Foundation 2021 - 2023
- Role of the macro lncRNA KCNQ1OT1 in embryonal rhabdomyosarcoma tumorigenesis awarded by Alex's Lemonade Stand 2019 - 2023
- COG NCTN Year 9 BIQSFP Supplement & Progress Report awarded by Public Health Institute 2022 - 2023
- Committee Leadership: COG NCTN Network Group Operations Center awarded by Public Health Institute 2022 - 2023
- Generating a mouse model of CIC-rearranged Ewings-like sarcoma awarded by Alex's Lemonade Stand 2022 - 2023
- Targeting p53 in childhood rhabdomyosarcoma awarded by Massachusetts General Hospital 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- Therapeutic potential and use of novel CRISPR technology for lncRNA knockdown in rhabdomyosarcoma awarded by Alex's Lemonade Stand 2022
- Committee Leadership: COG NCTN Network Group Operations Center awarded by Public Health Institute 2021 - 2022
- Study Chair: COG NCTN Network Group Operations Center awarded by Public Health Institute 2021 - 2022
- Faces of Research 2020 awarded by Alex's Lemonade Stand 2021 - 2022
- Investigating co-activator TAZ as a regulator of PAX3-FOXO1, cancer cell stemness, and chemoresistance in fusion-positive rhabdomyosarcoma awarded by V Foundation for Cancer Research 2018 - 2021
- Novel regulators of checkpoint adaptation in fusion-positive rhabdomyosarcoma awarded by Alex's Lemonade Stand 2021
- Role of MST/Hippo kinase inactivation in driving fusion-positive rhabdomyosarcoma awarded by National Institutes of Health 2020 - 2021
- COMMITTEE LEADERSHIP: NIH National Clinical Trials Network (NCTN) Grant awarded by Children's Hospital of Philadelphia 2017 - 2021
- STUDY CHAIR: NIH National Clinical Trials Network (NCTN) Grant awarded by Children's Hospital of Philadelphia 2014 - 2021
- Identification and validation of the PAX3-FOXO1 protein interactome awarded by St. Baldrick's Foundation 2018 - 2020
- Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma awarded by V Foundation for Cancer Research 2016 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- 2018 ALSF Million Mile Grant awarded by Alex's Lemonade Stand 2018 - 2019
- Investigating the role of Hippo/MST kinases in alveolar rhabdomyosarcoma cancer cell stemness awarded by St. Baldrick's Foundation 2018
- A Novel Hippo-Notch axis controlling embryonal rhabdomyosarcoma tumorigenesis awarded by V Foundation for Cancer Research 2016 - 2018
- St. Baldrick's Summer Fellow Grant awarded by St. Baldrick's Foundation 2017 - 2018
- The role of MST1 in non-canonical Hippo signaling in rhabdomyosarcoma awarded by Alex's Lemonade Stand 2015 - 2018
- The role of MEST (mesoderm specific transcript) in rhabdomyosarcoma awarded by St. Baldrick's Foundation 2015 - 2016
- Validating a mouse model of rhabdomyosarcoma awarded by Alex's Lemonade Stand 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- The secreted protein SFRP3 as a therapeutic target in rhabdomyosarcoma awarded by V Foundation for Cancer Research 2015 - 2016
- Feasibility of a Couple-based Intervention for Parents of Children with Cancer awarded by National Institutes of Health 2012 - 2014
- Molecular Modeling of Pediatric Skeletal Muscle Tumors awarded by National Institutes of Health 2009 - 2013
External Relationships
- Bamboo Therapeutics/Pfizer
- Grid Therapeutics, LLC
- LabCorp (Laboratory Corp of America)
- Ryvu Therapeutics
- Thermo Fisher Scientific, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Milewski, David, Hyun Jung, G Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, et al. “Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group.” Clin Cancer Res 29, no. 2 (January 17, 2023): 364–78. https://doi.org/10.1158/1078-0432.CCR-22-1663.
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  - Kovach, Alexander R., Kristianne M. Oristian, David G. Kirsch, Rex C. Bentley, Changde Cheng, Xiang Chen, Po-Han Chen, Jen-Tsan Ashley Chi, and Corinne M. Linardic. “Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.” Mol Oncol 16, no. 20 (October 2022): 3587–3605. https://doi.org/10.1002/1878-0261.13304.
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  - Hettmer, Simone, Corinne M. Linardic, Anna Kelsey, Erin R. Rudzinski, Christian Vokuhl, Joanna Selfe, Olivia Ruhen, et al. “Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe.” Eur J Cancer 172 (September 2022): 367–86. https://doi.org/10.1016/j.ejca.2022.05.036.
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  - Crane, Jacquelyn N., Wei Xue, Amira Qumseya, Zhengya Gao, Carola A. S. Arndt, Sarah S. Donaldson, Douglas J. Harrison, et al. “Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group.” Pediatr Blood Cancer 69, no. 6 (June 2022): e29644. https://doi.org/10.1002/pbc.29644.
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  - Shern, Jack F., Joanna Selfe, Elisa Izquierdo, Rajesh Patidar, Hsien-Chao Chou, Young K. Song, Marielle E. Yohe, et al. “Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.” J Clin Oncol 39, no. 26 (September 10, 2021): 2859–71. https://doi.org/10.1200/JCO.20.03060.
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  - Li, Jenny J., Alexander R. Kovach, Margaret DeMonia, Katherine K. Slemmons, Kristianne M. Oristian, Candy Chen, and Corinne M. Linardic. “Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence.” Sci Rep 11, no. 1 (August 13, 2021): 16505. https://doi.org/10.1038/s41598-021-95355-2.
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  - Shields, Cara E., Sindhu Potlapalli, Selma M. Cuya-Smith, Sarah K. Chappell, Dongdong Chen, Daniel Martinez, Jennifer Pogoriler, et al. “Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target.” Mol Oncol 15, no. 8 (August 2021): 2156–71. https://doi.org/10.1002/1878-0261.12914.
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  - Pacenta, Holly L., Wendy Allen-Rhoades, David Langenau, Peter J. Houghton, Charles Keller, Christine M. Heske, Michael D. Deel, et al. “Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children's Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force.” J Clin Med 10, no. 7 (April 1, 2021). https://doi.org/10.3390/jcm10071416.
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  - Rudzinski, Erin R., Anna Kelsey, Christian Vokuhl, Corinne M. Linardic, Janet Shipley, Simone Hettmer, Ewa Koscielniak, Douglas S. Hawkins, and Gianni Bisogno. “Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe.” Pediatr Blood Cancer 68, no. 3 (March 2021): e28798. https://doi.org/10.1002/pbc.28798.
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  - Slemmons, Katherine K., Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, and Corinne M. Linardic. “A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.” Biol Open 10, no. 2 (February 9, 2021). https://doi.org/10.1242/bio.050211.
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  - Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Response to Zhang et al.” Genet Med 22, no. 3 (March 2020): 662. https://doi.org/10.1038/s41436-019-0690-z.
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  - Hart, Sarah J., Kanecia Zimmerman, Corinne M. Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, et al. “Detection of iron deficiency in children with Down syndrome.” Genet Med 22, no. 2 (February 2020): 317–25. https://doi.org/10.1038/s41436-019-0637-4.
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  - Lin, Yi-Tzu, Michael D. Deel, and Corinne M. Linardic. “RASSF4 is required for skeletal muscle differentiation.” Cell Biol Int 44, no. 2 (February 2020): 381–90. https://doi.org/10.1002/cbin.11238.
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  - Slemmons, Katherine K., Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, and Corinne M. Linardic. “A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling.” Biol Open, January 1, 2020. https://doi.org/10.1242/bio.050211.
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  - Yohe, Marielle E., Christine M. Heske, Elizabeth Stewart, Peter C. Adamson, Nabil Ahmed, Cristina R. Antonescu, Eleanor Chen, et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.” Pediatr Blood Cancer 66, no. 10 (October 2019): e27869. https://doi.org/10.1002/pbc.27869.
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  - Sun, Wenyue, Bishwanath Chatterjee, Jack F. Shern, Rajesh Patidar, Young Song, Yonghong Wang, Robert L. Walker, et al. “Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.” Int J Cancer 144, no. 11 (June 1, 2019): 2707–17. https://doi.org/10.1002/ijc.32006.
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  - Porter, Laura S., Donald H. Baucom, Melanie Bonner, Corinne Linardic, and Anne E. Kazak. “Parenting a child with cancer: a couple-based approach.” Transl Behav Med 9, no. 3 (May 16, 2019): 504–13. https://doi.org/10.1093/tbm/ibz016.
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  - Rauen, Katherine A., Lisa Schoyer, Lisa Schill, Beth Stronach, John Albeck, Brage S. Andresen, Hélène Cavé, et al. “Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.” Am J Med Genet A 176, no. 12 (December 2018): 2924–29. https://doi.org/10.1002/ajmg.a.40632.
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  - Oristian, Kristianne M., Lisa E. S. Crose, Nina Kuprasertkul, Rex C. Bentley, Yi-Tzu Lin, Nerissa Williams, David G. Kirsch, and Corinne M. Linardic. “Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.” Cancer Res 78, no. 19 (October 1, 2018): 5513–20. https://doi.org/10.1158/0008-5472.CAN-17-3912.
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  - Deel, Michael D., Katherine K. Slemmons, Ashley R. Hinson, Katia C. Genadry, Breanne A. Burgess, Lisa E. S. Crose, Nina Kuprasertkul, Kristianne M. Oristian, Rex C. Bentley, and Corinne M. Linardic. “The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis.” Clin Cancer Res 24, no. 11 (June 1, 2018): 2616–30. https://doi.org/10.1158/1078-0432.CCR-17-1207.
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  - Genadry, Katia C., Silvia Pietrobono, Rossella Rota, and Corinne M. Linardic. “Soft Tissue Sarcoma Cancer Stem Cells: An Overview.” Front Oncol 8 (2018): 475. https://doi.org/10.3389/fonc.2018.00475.
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  - Slemmons, Katherine K., Lisa E. S. Crose, Stefan Riedel, Manuela Sushnitha, Brian Belyea, and Corinne M. Linardic. “A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.” Molecular Cancer Research : Mcr 15, no. 12 (December 2017): 1777–91. https://doi.org/10.1158/1541-7786.mcr-17-0004.
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  - Ignatius, Myron S., Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, et al. “The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma.” Cell Rep 19, no. 11 (June 13, 2017): 2304–18. https://doi.org/10.1016/j.celrep.2017.05.061.
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  - Conti, Beatrice, Katherine K. Slemmons, Rossella Rota, and Corinne M. Linardic. “Recent Insights into Notch Signaling in Embryonal Rhabdomyosarcoma.” Curr Drug Targets 17, no. 11 (2016): 1235–44. https://doi.org/10.2174/1389450116666150907105756.
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  - Kephart, Julie J. G., Rosanne G. J. Tiller, Lisa E. S. Crose, Katherine K. Slemmons, Po-Han Chen, Ashley R. Hinson, Rex C. Bentley, Jen-Tsan Ashley Chi, and Corinne M. Linardic. “Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.” Clin Cancer Res 21, no. 21 (November 1, 2015): 4868–80. https://doi.org/10.1158/1078-0432.CCR-14-1797.
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  - Hedrick, Erik, Lisa Crose, Corinne M. Linardic, and Stephen Safe. “Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors.” Mol Cancer Ther 14, no. 9 (September 2015): 2143–53. https://doi.org/10.1158/1535-7163.MCT-15-0148.
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  - Korf, Bruce, Reza Ahmadian, Judith Allanson, Yoko Aoki, Annette Bakker, Emma Burkitt Wright, Brian Denger, et al. “The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach.” Am J Med Genet A 167A, no. 8 (August 2015): 1741–46. https://doi.org/10.1002/ajmg.a.37089.
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  - Deel, Michael D., Jenny J. Li, Lisa E. S. Crose, and Corinne M. Linardic. “A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas.” Front Oncol 5 (2015): 190. https://doi.org/10.3389/fonc.2015.00190.
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  - Slemmons, Katherine K., Lisa E. S. Crose, Erin Rudzinski, Rex C. Bentley, and Corinne M. Linardic. “Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.” Plos One 10, no. 10 (2015): e0140781. https://doi.org/10.1371/journal.pone.0140781.
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  - Hettmer, Simone, Zhizhong Li, Andrew N. Billin, Frederic G. Barr, D. D. W. Cornelison, Alan R. Ehrlich, Denis C. Guttridge, et al. “Rhabdomyosarcoma: current challenges and their implications for developing therapies.” Cold Spring Harb Perspect Med 4, no. 11 (November 3, 2014): a025650. https://doi.org/10.1101/cshperspect.a025650.
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  - Hinson, Ashley, Dorothee Newbern, and Corinne M. Linardic. “Asparaginase-Induced Hypertriglyceridemia Presenting as Pseudohyponatremia during Leukemia Treatment.” Case Rep Pediatr 2014 (2014): 635740. https://doi.org/10.1155/2014/635740.
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  - Crose, Lisa E. S., Kathleen A. Galindo, Julie Grondin Kephart, Candy Chen, Julien Fitamant, Nabeel Bardeesy, Rex C. Bentley, Rene L. Galindo, Jen-Tsan Ashley Chi, and Corinne M. Linardic. “Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.” J Clin Invest 124, no. 1 (January 2014): 285–96. https://doi.org/10.1172/JCI67087.
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  - Zhang, Minsi, Corinne M. Linardic, and David G. Kirsch. “RAS and ROS in rhabdomyosarcoma.” Cancer Cell 24, no. 6 (December 9, 2013): 689–91. https://doi.org/10.1016/j.ccr.2013.11.015.
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  - Blum, Jordan M., Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, Mohit Sachdeva, Irina Lagutina, et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.” Cell Rep 5, no. 4 (November 27, 2013): 933–40. https://doi.org/10.1016/j.celrep.2013.10.020.
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  - Chadalapaka, Gayathri, Indira Jutooru, Sandeep Sreevalsan, Satya Pathi, Kyounghyun Kim, Candy Chen, Lisa Crose, Corinne Linardic, and Stephen Safe. “Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.” Int J Cancer 132, no. 4 (February 15, 2013): 795–806. https://doi.org/10.1002/ijc.27730.
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  - Hinson, Ashley R. P., Rosanne Jones, Lisa E. S. Crose, Brian C. Belyea, Frederic G. Barr, and Corinne M. Linardic. “Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.” Front Oncol 3 (2013): 183. https://doi.org/10.3389/fonc.2013.00183.
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  - Crose, Lisa E. S., Katherine T. Etheridge, Candy Chen, Brian Belyea, Lindsay J. Talbot, Rex C. Bentley, and Corinne M. Linardic. “FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.” Clin Cancer Res 18, no. 14 (July 15, 2012): 3780–90. https://doi.org/10.1158/1078-0432.CCR-10-3063.
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  - Andersen, Nicholas D., Louis R. DiBernardo, Corinne M. Linardic, Michael G. W. Camitta, and Andrew J. Lodge. “Recurrent inflammatory myofibroblastic tumor of the heart.” Circulation 125, no. 19 (May 15, 2012): 2379–81. https://doi.org/10.1161/CIRCULATIONAHA.111.066191.
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  - Ignatius, Myron S., Eleanor Chen, Natalie M. Elpek, Adam Z. Fuller, Inês M. Tenente, Ryan Clagg, Sali Liu, et al. “In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.” Cancer Cell 21, no. 5 (May 15, 2012): 680–93. https://doi.org/10.1016/j.ccr.2012.03.043.
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  - Belyea, Brian, Julie Grondin Kephart, Jordan Blum, David G. Kirsch, and Corinne M. Linardic. “Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.” Sarcoma 2012 (2012): 406239. https://doi.org/10.1155/2012/406239.
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  - Belyea, Brian C., Sarasija Naini, Rex C. Bentley, and Corinne M. Linardic. “Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.” Clin Cancer Res 17, no. 23 (December 1, 2011): 7324–36. https://doi.org/10.1158/1078-0432.CCR-11-1004.
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  - La, Trang H., Suzanne L. Wolden, Zheng Su, Corinne Linardic, R Lor Randall, Douglas S. Hawkins, and Sarah S. Donaldson. “Local therapy for rhabdomyosarcoma of the hands and feet: is amputation necessary? A report from the Children's Oncology Group.” Int J Radiat Oncol Biol Phys 80, no. 1 (May 1, 2011): 206–12. https://doi.org/10.1016/j.ijrobp.2010.01.053.
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  - Crose, Lisa E. S., and Corinne M. Linardic. “Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma.” Sarcoma 2011 (2011): 756982. https://doi.org/10.1155/2011/756982.
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  - Naini, Sarasija, Katherine T. Etheridge, Stacey J. Adam, Stephen J. Qualman, Rex C. Bentley, Christopher M. Counter, and Corinne M. Linardic. “Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.” Cancer Res 68, no. 23 (December 1, 2008): 9583–88. https://doi.org/10.1158/0008-5472.CAN-07-6178.
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  - Linardic, Corinne M. “PAX3-FOXO1 fusion gene in rhabdomyosarcoma.” Cancer Lett 270, no. 1 (October 18, 2008): 10–18. https://doi.org/10.1016/j.canlet.2008.03.035.
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  - Linardic, Corinne M., and Christopher M. Counter. “Genetic modeling of Ras-induced human rhabdomyosarcoma.” Methods Enzymol 438 (2008): 419–27. https://doi.org/10.1016/S0076-6879(07)38028-2.
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  - Linardic, Corinne M., Sarasija Naini, James E. Herndon, Chimen Kesserwan, Stephen J. Qualman, and Christopher M. Counter. “The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.” Cancer Res 67, no. 14 (July 15, 2007): 6691–99. https://doi.org/10.1158/0008-5472.CAN-06-3210.
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  - Linardic, Corinne M., Sarasija Naini, Stacey J. Adam, Rex Bentley, and Christopher M. Counter. “Genetic modeling of alveolar rhabdomyosarcoma.” Pediatric Blood & Cancer 48, no. 6 (June 1, 2007): 624–624.
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  - Kendall, S DiSean, Corinne M. Linardic, Stacey J. Adam, and Christopher M. Counter. “A network of genetic events sufficient to convert normal human cells to a tumorigenic state.” Cancer Res 65, no. 21 (November 1, 2005): 9824–28. https://doi.org/10.1158/0008-5472.CAN-05-1543.
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  - Linardic, Corinne M., Diane L. Downie, Stephen Qualman, Rex C. Bentley, and Christopher M. Counter. “Genetic modeling of human rhabdomyosarcoma.” Cancer Res 65, no. 11 (June 1, 2005): 4490–95. https://doi.org/10.1158/0008-5472.CAN-04-3194.
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  - Armbruster, Blaine N., Corinne M. Linardic, Tim Veldman, Niharika P. Bansal, Diane L. Downie, and Christopher M. Counter. “Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.” Mol Cell Biol 24, no. 8 (April 2004): 3552–61. https://doi.org/10.1128/MCB.24.8.3552-3561.2004.
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  - Edinger, Aimee L., Corinne M. Linardic, Gary G. Chiang, Craig B. Thompson, and Robert T. Abraham. “Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.” Cancer Res 63, no. 23 (December 1, 2003): 8451–60.
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  - Fang, Yanan, Corinne M. Linardic, D Ashley Richardson, Wen Cai, Mohammad Behforouz, and Robert T. Abraham. “Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin.” Mol Cancer Ther 2, no. 6 (June 2003): 517–26.
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  - Linardic, Corinne M., Jerald Z. Gong, and Philip M. Rosoff. “Myelodysplasia as masquerader: A woman with hypereosinophilic syndrome and twelve years of "chronic ITP".” Med Pediatr Oncol 39, no. 2 (August 2002): 137–38. https://doi.org/10.1002/mpo.10085.
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  - Linardic, C. M., C. C. Hudson, and R. T. Abraham. “A pharmacologic and genetic model for investigating the role of the mammalian target of rapamycin in the control of cell growth and proliferation.” Pediatric Research 51, no. 4 (April 1, 2002): 254A-254A.
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  - Williams, S., C. Linardic, O. Wilson, P. Comp, and H. R. Gralnick. “Acquired hypoprothrombinemia: effects of danazol treatment.” Am J Hematol 53, no. 4 (December 1996): 272–76. https://doi.org/10.1002/(SICI)1096-8652(199612)53:4<272::AID-AJH14>3.0.CO;2-E.
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  - Linardic, C. M., S. Jayadev, and Y. A. Hannun. “Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.” Cell Growth Differ 7, no. 6 (June 1996): 765–74.
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  - Linardic, C. M., and Y. A. Hannun. “Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.” J Biol Chem 269, no. 38 (September 23, 1994): 23530–37.
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  - Jayadev, S., C. M. Linardic, and Y. A. Hannun. “Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.” J Biol Chem 269, no. 8 (February 25, 1994): 5757–63.
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  - Hannun, Y. A., and C. M. Linardic. “Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids.” Biochim Biophys Acta 1154, no. 3–4 (December 21, 1993): 223–36. https://doi.org/10.1016/0304-4157(93)90001-5.
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  - JAYADEV, S., C. M. LINARDIC, and Y. A. HANNUN. “ARACHIDONIC-ACID MAY MEDIATE TUMOR-NECROSIS-FACTOR ALPHA-STIMULATED SPHINGOMYELIN HYDROLYSIS.” Faseb Journal 7, no. 7 (April 20, 1993): A1257–A1257.
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  - LINARDIC, C. M., and Y. A. HANNUN. “LOCALIZATION OF TNF-ALPHA-INDUCED SPHINGOMYELIN HYDROLYSIS TO THE PLASMA-MEMBRANE.” Clinical Research 41, no. 2 (April 1, 1993): A240–A240.
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  - OBEID, L. M., C. M. LINARDIC, L. KAROLAK, and Y. A. HANNUN. “PROGRAMMED CELL-DEATH IS MEDIATED BY CERAMIDE.” Clinical Research 41, no. 2 (April 1, 1993): A240–A240.
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  - Obeid, L. M., C. M. Linardic, L. A. Karolak, and Y. A. Hannun. “Programmed cell death induced by ceramide.” Science 259, no. 5102 (March 19, 1993): 1769–71. https://doi.org/10.1126/science.8456305.
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  - Bielawska, A., C. M. Linardic, and Y. A. Hannun. “Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.” J Biol Chem 267, no. 26 (September 15, 1992): 18493–97.
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  - Bielawska, A., C. M. Linardic, and Y. A. Hannun. “Modulation of cell growth and differentiation by ceramide.” Febs Lett 307, no. 2 (July 28, 1992): 211–14. https://doi.org/10.1016/0014-5793(92)80769-d.
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  - Linardic, C. M., S. Jayadev, and Y. A. Hannun. “Brefeldin A promotes hydrolysis of sphingomyelin.” J Biol Chem 267, no. 21 (July 25, 1992): 14909–11.
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  - LINARDIC, C. M., S. JAYADEV, and Y. A. HANNUN. “BREFELDIN-A CAUSES DECREASES IN CELLULAR SPHINGOMYELIN LEVELS AND INDUCES DIFFERENTIATION OF HL-60 LEUKEMIA-CELLS.” Clinical Research 40, no. 2 (April 1, 1992): A169–A169.
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  - Kim, M. Y., C. Linardic, L. Obeid, and Y. Hannun. “Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.” J Biol Chem 266, no. 1 (January 5, 1991): 484–89.
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  - LINARDIC, C. M., and C. S. GREENBERG. “Inhibition of the Anticoagulant Properties of Antithrombin III and Heparin by Fibrin.” Annals of the New York Academy of Sciences 556, no. 1 (January 1, 1989): 459–61. https://doi.org/10.1111/j.1749-6632.1989.tb22536.x.
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  - LINARDIC, C. M., and C. S. GREENBERG. “INHIBITION OF THE ANTICOAGULANT PROPERTIES OF ANTITHROMBIN-III AND HEPARIN BY FIBRIN.” Annals of the New York Academy of Sciences 556 (1989): 459–61.
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- Book Sections
  - Gatz, S. A., J. Shipley, C. Keller, and C. M. Linardic. “Experimental models.” In Pediatric Oncology, 129–47, 2021. https://doi.org/10.1007/978-3-030-51160-9_10.
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- Conference Papers
  - Pecoraro, Adam F., Tooba Rashid, Breanne A. Burgess, Corinne M. Linardic, and Michael D. Deel. “Targeting transcriptional co-activators YAP1/TAZ in fusion-positive rhabdomyosarcoma demonstrates a novel strategy in ablating fusion-driven sarcoma transcriptional programing.” In Cancer Research, Vol. 82, 2022.
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  - Linardic, Corinne M. “Abstract IA06: Dysregulated Hippo signaling in childhood rhabdomyosarcoma.” In Molecular Cancer Research, 18:IA06–IA06. American Association for Cancer Research (AACR), 2020. https://doi.org/10.1158/1557-3125.hippo19-ia06.
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  - Kovach, Alexander R., and Corinne M. Linardic. “Genetic and pharmacologic inhibition of HES1 reduces YAP1 expression, impairing rhabdomyosarcoma cell growth.” In Molecular Cancer Research, 18:26–26, 2020.
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  - Linardic, Corinne M. “Dysregulated Hippo signaling in childhood rhabdomyosarcoma.” In Molecular Cancer Research, 18:13–14, 2020.
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  - Oristian, Kristianne M., Lisa E. S. Crose, Napasorn Kuprasertkul, Rex C. Bentley, Yi-Tzu Lin, Nerissa Williams, David G. Kirsch, and Corinne M. Linardic. “Loss of noncanonical Hippo signaling in fusion-positive alveolar rhabdomyosarcoma increases invasiveness and a dedifferentiated phenotype associated with metastasis.” In Molecular Cancer Research, 18:27–28, 2020.
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  - Burgess, Breanne A., Katherine K. Slemmons, Corinne M. Linardic, and Michael D. Deel. “Abstract 3670: Transcriptional co-activators TAZ/YAP are novel regulators of PAX3-FOXO1 transcriptional programing and fusion-positive rhabdomyosarcoma cancer cell stemness.” In Cancer Research, 79:3670–3670. American Association for Cancer Research (AACR), 2019. https://doi.org/10.1158/1538-7445.am2019-3670.
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  - Shern, John Frederick, Rajesh Patidar, Young Song, Ashley Walton, Jun S. Wei, Xinyu Wen, Erin R. Rudzinski, et al. “Targeted resequencing of pediatric rhabdomyosarcoma: report from the Children’s Oncology Group, the Children’s Cancer and Leukaemia Group, The Institute of Cancer Research UK, and the National Cancer Institute.” In Journal of Clinical Oncology, 36:10515–10515. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.10515.
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  - Slemmons, Katherine K., Lisa E. S. Crose, Stefan Riedel, Manuela Sushnitha, Brian Belyea, and Corinne M. Linardic. “Abstract 5830: A novel Notch-YAP circuit drives stemness and tumorigenesis in embryonal rhabdomyosarcoma.” In Cancer Research, 77:5830–5830. American Association for Cancer Research (AACR), 2017. https://doi.org/10.1158/1538-7445.am2017-5830.
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  - Mascarenhas, Leo, William H. Meyer, Elizabeth Lyden, David A. Rodeberg, Daniel Joseph Indelicato, Corrine M. Linardic, James Robert Anderson, and Douglas S. Hawkins. “Randomized phase II trial of bevacizumab and temsirolimus in combination with vinorelbine (V) and cyclophosphamide (C) for first relapse/disease progression of rhabdomyosarcoma (RMS): A report from the Children’s Oncology Group (COG).” In Journal of Clinical Oncology, 32:10003–10003. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.10003.
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  - Keskinyan, Vahakn, Tooba Rashid, Adam Pecoraro, Breanne Burgess, corinne Linardic, and Michael Deel. “YAP1 IS A KEY REGULATOR OF G2/M TRANSIT IN FUSION-POSITIVE RHABDOMYOSARCOMA,” n.d.
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