Corinne Mary Linardic
Associate Professor of Pediatrics

Pediatric Sarcomas: Sarcomas are among the most difficult-to-treat cancers in pediatric oncology, with metastatic forms having the highest mortality. We have established genetically defined human cell-based models for the pediatric skeletal muscle cancer known as rhabdomyosarcoma. Current therapies are based on xenograft models in immunocompromised mice, using established patient-derived patient cell lines, but because of the genetic variability of these cell lines, a true understanding of the causative role of certain genetic changes (e.g. chromosomal translocations and oncogenic Ras) in rhabdomyosarcoma formation is not understood. Specific goals of this research program include the identification of signaling pathways corrupted in rhabdomyosarcoma, with focus on the PAX3-FOXO1 mutation and its downstream effectors and oncogenic Ras, and identification of new therapeutic targets for treatment of this childhood cancer.

Current Appointments & Affiliations

Contact Information

  • Box 102382, DUMC, Durham, NC 27710
  • LSRC Bldg Rm B361F, Research Drive, Durham, NC 27710

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