Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens.

Journal Article (Journal Article)

OBJECTIVE: To compare the incidence of liver toxicity and clinical response between 2 initial dosing regimens of methotrexate (MTX) for treatment of juvenile idiopathic arthritis (JIA). METHODS: Clinical and laboratory data were abstracted from the medical records of 220 children newly prescribed MTX from the same geographic region. One cohort received initial doses of MTX > 0.5 mg/kg/week ("high-dose") and one cohort received initial doses of MTX

Full Text

Duke Authors

Cited Authors

  • Becker, ML; Rosé, CD; Cron, RQ; Sherry, DD; Bilker, WB; Lautenbach, E

Published Date

  • April 2010

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 870 - 875

PubMed ID

  • 20194449

Pubmed Central ID

  • PMC2893572

International Standard Serial Number (ISSN)

  • 0315-162X

Digital Object Identifier (DOI)

  • 10.3899/jrheum.090826


  • eng

Conference Location

  • Canada