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Mara Becker

Professor of Pediatrics
Pediatrics, Rheumatology
DUMC 3611, Durham, NC 27710
117B Davison Building, Dean's Suite, Durham, NC 27710

Overview


Dr. Becker is currently a Professor of Pediatrics and the Vice Dean for Faculty at Duke University School of Medicine. Prior to arriving at Duke in 2019, she spent 13 years at Children’s Mercy, Kansas City where she completed additional fellowship training in pediatric clinical pharmacology and served as Division Director of Rheumatology and Associate Chair for the Department of Pediatrics. At Duke, Dr. Becker served as the Vice Chair for Faculty in Pediatrics, until she assumed the role of Vice Dean for Faculty in July, 2022.

Dr. Becker’s translational research interest is to identify factors that enhance response and minimize toxicity to drugs used for the treatment of diseases in children, focusing on an individualized therapeutic strategy.  Her work focuses on methotrexate and its effect upon the folate pathway, utilizing cellular biomarkers and genetic differences to predict drug efficacy in patients with JIA. Her research has been funded by the Kansas City Area Life Sciences Institute, the PhRMA Foundation, the Rheumatology Research Foundation, and the National Institutes of Health. She has also served as a faculty leader at the Duke Clinical Research Institute where her work expanded to developing and supporting novel networks to carry out research and clinical trials, focusing on children with rare rheumatic and genetic conditions including the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry.

In her new role as Vice Dean, she has focused on fortifying and reimagining the Office for Faculty and the multiple programs and offices that support faculty in the School of Medicine.  New efforts in this role will focus on identifying opportunities to create standardized and transparent processes within the office, prioritizing leadership development for current leaders in the School of Medicine, and developing a training and mentorship program in Restorative Justice to strengthen community and support a healthy and productive work climate. In addition to her administrative work at Duke, Dr. Becker has held multiple leadership roles in national committees and organizations in her field.

Current Appointments & Affiliations


Professor of Pediatrics · 2021 - Present Pediatrics, Rheumatology, Pediatrics
Vice Dean for Faculty · 2022 - Present School of Medicine
Member in the Duke Clinical Research Institute · 2019 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Racial Disparities and Achievement of the Low Lupus Disease Activity State: A CARRA Registry Study.

Journal Article Arthritis Care Res (Hoboken) · January 2025 OBJECTIVE: Differential disease control may contribute to racial disparities in outcomes of childhood-onset systemic lupus erythematosus (cSLE). We evaluated associations of race and individual- or neighborhood-level social determinants of health (SDoH) wi ... Full text Link to item Cite

Identification of Plasma Metabolomic Biomarkers of Juvenile Idiopathic Arthritis

Conference Metabolites · September 1, 2024 Identification of disease and therapeutic biomarkers remains a significant challenge in the early diagnosis and effective treatment of juvenile idiopathic arthritis (JIA). In this study, plasma metabolomic profiling was conducted to identify disease-relate ... Full text Cite

Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.

Journal Article J Exp Med · August 5, 2024 Nucleic acid-sensing Toll-like receptors (TLR) 3, 7/8, and 9 are key innate immune sensors whose activities must be tightly regulated to prevent systemic autoimmune or autoinflammatory disease or virus-associated immunopathology. Here, we report a systemat ... Full text Link to item Cite
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Recent Grants


Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2021 - 2026

Optimal Dosing for Biologic Agents in Obese Patients with Rheumatoid and Juvenile Arthritis

ResearchAdvisor · Awarded by National Institutes of Health · 2020 - 2025

PTN 2.0 TO 6 Down Syndrome Extension

Clinical TrialPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2019 - 2025

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Education, Training & Certifications


University of Pennsylvania, School of Medicine · 2007 M.S.
Thomas Jefferson University, Sidney Kimmel Medical College · 1999 M.D.