Mara Becker | Scholars@Duke

Mara Becker
Professor of Pediatrics

My long-term research goal is to identify factors that enhance response and minimize toxicity to drugs used for the treatment of diseases in children, focusing on an individualized therapeutic strategy. My current translational research focuses on methotrexate and its effect upon the folate pathway, utilizing cellular biomarkers and genetic differences to predict drug efficacy and minimize toxicity in JIA. My work has expanded through key collaborations, to include a mouse model for experimental validation of the work, novel cytokine biomarkers including Nicotinamide Phosphoribosyltransferase (NAMPT), biologic therapeutic drug monitoring in JIA and IBD, and exploration of the folate pathway in patients with Down syndrome.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2021
Vice-Chair for Faculty, Pediatrics, Clinical Science Departments 2019
Vice Dean for Faculty, School of Medicine, Duke University 2022
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2019

Contact Information

117B Davison Building, Dean's Suite, Durham, NC 27710
DUMC 3611, Durham, NC 27710
mara.becker@duke.edu

Background
Education, Training, & Certifications
- M.S., University of Pennsylvania, School of Medicine 2007
- Rheumatology Fellow, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 2003 - 2004
- Chief Resident, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 2002 - 2003
- Residency, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 1999 - 2002
- M.D., Thomas Jefferson University, Sidney Kimmel Medical College 1999
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2020 - 2021
- Instructor in the Department of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2019 - 2020
- Adjunct Associate Professor in the Department of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2019
Leadership & Clinical Positions at Duke
- Vice Dean for Faculty, Duke University School of Medicine
Academic Positions Outside Duke
- Rheumatology Subboard, American Board of Pediatrics. 2020 - 2022
- Member-at Large, Board of Directors, Rheuamtology Research Foundation. 2019 - 2022
- Chair, JIA Committee, CARRA. 2019 - 2022
- Arthritis Advisory Committee, Food and Drug Administration. 2015 - 2021
Expertise
Subject Headings
Research
Selected Grants
- Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program awarded by National Institutes of Health 2021 - 2026
- Optimal Dosing for Biologic Agents in Obese Patients with Rheumatoid and Juvenile Arthritis awarded by National Institutes of Health 2020 - 2025
- Clinical Pharmacokinetics and Safety Trials in Down Syndrome awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN 2.0 TO 6 Down Syndrome Extension awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN 2.0 TO 6 Down Syndrome Extension awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN 2.0- TO 3 - Option 3 - BPCA Concept Development and Clinical Trial Readiness Support awarded by National Institute for Child Health & Human Develo 2021 - 2022
- Identifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIA awarded by Cincinnati Children's Hospital Medical Center 2017 - 2022
- HCQ Pharmacokinetics in Pediatric Lupus awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. 2019 - 2020
External Relationships
- American Board of Pediatrics
- American College of Rheumatology
- Canadian Arthritis Society
- Childhood Arthritis and Rheumatology Research Alliance
- Food and Drug Administration
- Patient Centered Outcomes Research Institute
- Rheumatology Research Foundation
Publications & Artistic Works
Selected Publications
- Books
  - Becker, M. L. Rash and Joint Pain in a Child, 2011. https://doi.org/10.1002/9781444397994.ch40.
    Full Text
  - Becker, M. L. Skin Target Lesion, 2011. https://doi.org/10.1002/9781444397994.ch76.
    Full Text
- Academic Articles
  - Boutzoukas, Angelique E., Rachel Olson, Mary Ann Sellers, Gwenyth Fischer, Chi D. Hornik, Omar Alibrahim, Kelechi Iheagwara, et al. “Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience.” Contemp Clin Trials 125 (December 25, 2022): 107067. https://doi.org/10.1016/j.cct.2022.107067.
    Full Text Link to Item
  - Hahn, Timothy, Carrie Daymont, Timothy Beukelman, Brandt Groh, Kimberly Hays, Catherine April Bingham, Lisabeth Scalzi, and Lisabeth CARRA Registry investigators. “Intraarticular steroids as DMARD-sparing agents for juvenile idiopathic arthritis flares: Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry.” Pediatr Rheumatol Online J 20, no. 1 (November 25, 2022): 107. https://doi.org/10.1186/s12969-022-00770-y.
    Full Text Link to Item
  - Ringold, Sarah, Anne C. Dennos, Yukiko Kimura, Timothy Beukelman, Peter Shrader, Thomas A. Phillips, Melanie Kohlheim, et al. “Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry.” Arthritis Care Res (Hoboken), August 3, 2022. https://doi.org/10.1002/acr.24994.
    Full Text Link to Item
  - Neely, Jessica, Kaveh Ardalan, Adam Huber, Susan Kim, and Susan Childhood Arthritis and Rheumatology Research Alliance Investigators. “Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry.” Pediatr Rheumatol Online J 20, no. 1 (July 19, 2022): 50. https://doi.org/10.1186/s12969-022-00709-3.
    Full Text Link to Item
  - Cannon, Laura, David Van Mater, Heather Van Mater, and Mara Becker. “Eye Swelling and Weight Loss in an 18-year-old Adolescent.” Pediatr Rev 43, no. 6 (June 1, 2022): 350–52. https://doi.org/10.1542/pir.2020-004891.
    Full Text Link to Item
  - Zimmerman, Kanecia O., Brian Perry, Emily Hanlen-Rosado, Adora Nsonwu, Morgan D. Lane, Daniel K. Benjamin, Mara Becker, Amy Corneli, and Amy Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. “Developing lay summaries and thank you notes in paediatric pragmatic clinical trials.” Health Expect 25, no. 3 (June 2022): 1029–37. https://doi.org/10.1111/hex.13448.
    Full Text Link to Item
  - Onel, Karen B., Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, et al. “2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.” Arthritis Care Res (Hoboken) 74, no. 4 (April 2022): 505–20. https://doi.org/10.1002/acr.24839.
    Full Text Link to Item
  - Onel, Karen B., Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, et al. “2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.” Arthritis Rheumatol 74, no. 4 (April 2022): 553–69. https://doi.org/10.1002/art.42037.
    Full Text Link to Item
  - Onel, Karen B., Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, et al. “2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis.” Arthritis Care Res (Hoboken) 74, no. 4 (April 2022): 521–37. https://doi.org/10.1002/acr.24853.
    Full Text Link to Item
  - Onel, Karen B., Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, et al. “2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.” Arthritis Rheumatol 74, no. 4 (April 2022): 570–85. https://doi.org/10.1002/art.42036.
    Full Text Link to Item
  - Baumer, Nicole T., Mara L. Becker, George T. Capone, Kathleen Egan, Juan Fortea, Benjamin L. Handen, Elizabeth Head, et al. “Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group.” J Neurodev Disord 14, no. 1 (March 23, 2022): 22. https://doi.org/10.1186/s11689-022-09435-z.
    Full Text Link to Item
  - Soulsby, William Daniel, Nayimisha Balmuri, Victoria Cooley, Linda M. Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta, and Bella CARRA Registry Investigators. “Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.” Pediatr Rheumatol Online J 20, no. 1 (March 7, 2022): 18. https://doi.org/10.1186/s12969-022-00676-9.
    Full Text Link to Item
  - Pinal-Fernandez, Iago, Katherine Pak, Albert Gil-Vila, Andres Baucells, Benjamin Plotz, Maria Casal-Dominguez, Assia Derfoul, et al. “Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis.” Arthritis Rheumatol 74, no. 2 (February 2022): 358–64. https://doi.org/10.1002/art.41931.
    Full Text Link to Item
  - Chang, Hsuan Ping, Valentina Shakhnovich, Adam Frymoyer, Ryan Sol Funk, Mara L. Becker, K. T. Park, and Dhaval K. Shah. “A population physiologically-based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab.” Br J Clin Pharmacol 88, no. 1 (January 2022): 290–302. https://doi.org/10.1111/bcp.14963.
    Full Text Link to Item
  - Ruperto, N., D. J. Lovell, A. Berman, F. Ávila-Zapata, G. Horneff, M. Alessio, M. L. Becker, et al. “Patient-Reported Outcomes Among Patients Aged 2–17 Years With Polyarticular-Course Juvenile Idiopathic Arthritis Treated With Subcutaneous Abatacept: 2-Year Results From an International Phase III Study.” Arthritis Care and Research, January 1, 2022. https://doi.org/10.1002/acr.24989.
    Full Text
  - Smitherman, E. A., R. A. Chahine, T. Beukelman, L. B. Lewandowski, A. F. Rahman, S. E. Wenderfer, J. R. Curtis, et al. “Childhood-onset lupus nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-term kidney status and variation in care.” Arthritis Care and Research, January 1, 2022. https://doi.org/10.1002/acr.25002.
    Full Text
  - Dave, Ishaan, Brandon Estroff, Talia Gergely, Christina A. Rostad, Lori A. Ponder, Courtney McCracken, Sampath Prahalad, and Sampath CARRA Registry Investigators. “Impact of the Season of Birth on the Development of Juvenile Idiopathic Arthritis in the United States: A Nationwide Registry-based Study.” J Rheumatol 48, no. 12 (December 2021): 1856–62. https://doi.org/10.3899/jrheum.201238.
    Full Text Link to Item
  - Kimura, Yukiko, Laura E. Schanberg, George A. Tomlinson, Mary Ellen Riordan, Anne C. Dennos, Vincent Del Gaizo, Katherine L. Murphy, et al. “Optimizing the Start Time of Biologics in Polyarticular Juvenile Idiopathic Arthritis: A Comparative Effectiveness Study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans.” Arthritis Rheumatol 73, no. 10 (October 2021): 1898–1909. https://doi.org/10.1002/art.41888.
    Full Text Link to Item
  - Ong, Mei Sing, Sarah Ringold, Yukiko Kimura, Laura E. Schanberg, George A. Tomlinson, Marc D. Natter, and Marc D. CARRA Registry Investigators. “Improved Disease Course Associated With Early Initiation of Biologics in Polyarticular Juvenile Idiopathic Arthritis: Trajectory Analysis of a Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans Study.” Arthritis Rheumatol 73, no. 10 (October 2021): 1910–20. https://doi.org/10.1002/art.41892.
    Full Text Link to Item
  - Randell, Rachel L., and Mara L. Becker. “Safety updates in novel therapeutics for pediatric rheumatic disease.” Curr Opin Rheumatol 33, no. 5 (September 1, 2021): 403–8. https://doi.org/10.1097/BOR.0000000000000811.
    Full Text Link to Item
  - Beukelman, Timothy, Aimee Lougee, Roland A. Matsouaka, David Collier, Dax G. Rumsey, Jennifer Schenfeld, Scott Stryker, Marinka Twilt, Yukiko Kimura, and Yukiko CARRA Registry Investigators. “Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry.” Pediatr Rheumatol Online J 19, no. 1 (August 21, 2021): 131. https://doi.org/10.1186/s12969-021-00625-y.
    Full Text Link to Item
  - Balmuri, Nayimisha, William Daniel Soulsby, Victoria Cooley, Linda Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta, and Bella CARRA Registry Investigators,. “Community poverty level influences time to first pediatric rheumatology appointment in Polyarticular Juvenile Idiopathic Arthritis.” Pediatr Rheumatol Online J 19, no. 1 (August 14, 2021): 122. https://doi.org/10.1186/s12969-021-00610-5.
    Full Text Link to Item
  - Mannion, Melissa L., Fenglong Xie, Daniel B. Horton, Sarah Ringold, Colleen K. Correll, Anne Dennos, Timothy Beukelman, and Timothy CARRA Registry Investigators. “Biologic Switching Among Nonsystemic Juvenile Idiopathic Arthritis Patients: A Cohort Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.” J Rheumatol 48, no. 8 (August 2021): 1322–29. https://doi.org/10.3899/jrheum.200437.
    Full Text Link to Item
  - Becker, Mara L., and Walter K. Kraft. “Seeking Similarities Rather Than Differences With Adults to Aid in Therapeutic Advancement for Children.” Clin Pharmacol Ther 110, no. 1 (July 2021): 11–14. https://doi.org/10.1002/cpt.2285.
    Full Text Link to Item
  - Rumsey, Dax G., Aimee Lougee, Roland Matsouaka, David H. Collier, Laura E. Schanberg, Jennifer Schenfeld, Natalie J. Shiff, et al. “Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA-B27, and Equal Sex Representation in Sacroiliitis.” Arthritis Care Res (Hoboken) 73, no. 7 (July 2021): 940–46. https://doi.org/10.1002/acr.24537.
    Full Text Link to Item
  - Morrow, Ryan, Ryan Funk, Mara Becker, Ashley Sherman, Leon Van Haandel, Taina Hudson, Rebecca Casini, and Valentina Shakhnovich. “Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease.” Pharmaceuticals (Basel) 14, no. 5 (May 14, 2021). https://doi.org/10.3390/ph14050463.
    Full Text Link to Item
  - Funk, Ryan S., Valentina Shakhnovich, Yu Kyoung Cho, Kishore Polireddy, Taina Jausurawong, Kyle Gress, and Mara L. Becker. “Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study.” Pediatr Rheumatol Online J 19, no. 1 (May 1, 2021): 62. https://doi.org/10.1186/s12969-021-00548-8.
    Full Text Link to Item
  - Maller, Justine, Emily Fox, K. T. Park, Sarah Sertial Paul, Kevin Baszis, Charlotte Borocco, Sampath Prahalad, et al. “Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis.” J Rheumatol 48, no. 4 (April 2021): 567–74. https://doi.org/10.3899/jrheum.200230.
    Full Text Link to Item
  - Kaufman, Katherine P., and Mara L. Becker. “Distinguishing Blau Syndrome from Systemic Sarcoidosis.” Curr Allergy Asthma Rep 21, no. 2 (February 9, 2021): 10. https://doi.org/10.1007/s11882-021-00991-3.
    Full Text Link to Item
  - Balevic, S. J., M. L. Becker, D. Gonzalez, and R. S. Funk. “Low etanercept concentrations in children with obesity and juvenile idiopathic arthritis.” Journal of Pediatric Pharmacology and Therapeutics 26, no. 8 (January 1, 2021): 809–14. https://doi.org/10.5863/1551-6776-26.8.809.
    Full Text
  - Funk, Ryan Sol, and Mara L. Becker. “Metabolomic Profiling Identifies Exogenous and Microbiota-Derived Metabolites as Markers of Methotrexate Efficacy in Juvenile Idiopathic Arthritis.” Front Pharmacol 12 (2021): 768599. https://doi.org/10.3389/fphar.2021.768599.
    Full Text Link to Item
  - Cannon, Laura, Endi Wang, and Mara Becker. “Diagnosis of Kikuchi-Fujimoto disease in an 11-year-old girl with fever and sickle cell disease.” Bmj Case Rep 13, no. 8 (August 24, 2020). https://doi.org/10.1136/bcr-2020-234302.
    Full Text Link to Item
  - Li, Suzanne C., Kathryn S. Torok, C Egla Rabinovich, Fatma Dedeoglu, Mara L. Becker, Polly J. Ferguson, Sandy D. Hong, et al. “Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma.” J Rheumatol 47, no. 8 (August 1, 2020): 1242–52. https://doi.org/10.3899/jrheum.190311.
    Full Text Link to Item
  - Nicek, Anna, Nasreen Talib, Daniel Lovell, Chelsey Smith, Mara L. Becker, and Jordan T. Jones. “Assessment and treatment of Down syndrome-associated arthritis: a survey of pediatric rheumatologists.” Pediatr Rheumatol Online J 18, no. 1 (July 13, 2020): 57. https://doi.org/10.1186/s12969-020-00445-6.
    Full Text Link to Item
  - Funk, Ryan S., Nasreen J. Talib, Kanecia O. Zimmerman, Leon van Haandel, and Mara L. Becker. “Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.” J Pediatr 221 (June 2020): 235–39. https://doi.org/10.1016/j.jpeds.2020.01.032.
    Full Text Link to Item
  - Tory, Heather, David Zurakowski, Susan Kim, and Susan CARRA Juvenile Dermatomyositis Quality Measures Workgroup for the CARRA Registry Investigators. “Patient and physician discordance of global disease assessment in juvenile dermatomyositis: findings from the Childhood Arthritis & Rheumatology Research Alliance Legacy Registry.” Pediatr Rheumatol Online J 18, no. 1 (January 15, 2020): 5. https://doi.org/10.1186/s12969-020-0402-x.
    Full Text Link to Item
  - Funk, Ryan S., Rakesh K. Singh, and Mara L. Becker. “Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro.” Clin Transl Sci 13, no. 1 (January 2020): 137–46. https://doi.org/10.1111/cts.12694.
    Full Text Link to Item
  - Pasnoor, Mamatha, Andrew J. Heim, Laura Herbelin, Jeffrey Statland, Mazen M. Dimachkie, Mara Becker, Richard J. Barohn, and Richard J. Methotrexate in MG Investigators of the Muscle Group Study. “Methotrexate Polyglutamation in a Myasthenia Gravis Clinical Trial.” Kans J Med 13, no. Suppl 2 (2020): 10–13.
    Open Access Copy Link to Item
  - Neely, Jessica, Craig S. Long, Hugh Sturrock, Susan Kim, and Susan Childhood Arthritis and Rheumatology Research Alliance Registry Investigators. “Association of Short-Term Ultraviolet Radiation Exposure and Disease Severity in Juvenile Dermatomyositis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.” Arthritis Care Res (Hoboken) 71, no. 12 (December 2019): 1600–1605. https://doi.org/10.1002/acr.23840.
    Full Text Link to Item
  - Connelly, Mark, Jennifer E. Weiss, and Jennifer E. for the CARRA Registry Investigators. “Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases.” Pediatr Rheumatol Online J 17, no. 1 (November 6, 2019): 72. https://doi.org/10.1186/s12969-019-0375-9.
    Full Text Link to Item
  - Li, Suzanne C., Robert C. Fuhlbrigge, Ronald M. Laxer, Elena Pope, Maria F. Ibarra, Katie Stewart, Thomas Mason, et al. “Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study.” Pediatr Rheumatol Online J 17, no. 1 (July 15, 2019): 43. https://doi.org/10.1186/s12969-019-0350-5.
    Full Text Link to Item
  - Lund, Robin M., Mara L. Becker, Steven Shapiro, Tyler Allison, and Julia G. Harris. “Scurvy presenting with limp and weakness: a case report.” Bmc Pediatr 19, no. 1 (July 6, 2019): 228. https://doi.org/10.1186/s12887-019-1605-5.
    Full Text Link to Item
  - Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing.” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.
    Full Text Link to Item
  - Singh, Rakesh K., Leon van Haandel, Paul Kiptoo, Mara L. Becker, Teruna J. Siahaan, and Ryan S. Funk. “Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model.” Eur J Pharmacol 853 (June 15, 2019): 264–74. https://doi.org/10.1016/j.ejphar.2019.03.052.
    Full Text Link to Item
  - Angeles-Han, Sheila T., Sarah Ringold, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.” Arthritis Rheumatol 71, no. 6 (June 2019): 864–77. https://doi.org/10.1002/art.40885.
    Full Text Link to Item
  - Angeles-Han, Sheila T., Sarah Ringold, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis.” Arthritis Care Res (Hoboken) 71, no. 6 (June 2019): 703–16. https://doi.org/10.1002/acr.23871.
    Full Text Link to Item
  - Ringold, Sarah, Sheila T. Angeles-Han, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.” Arthritis Rheumatol 71, no. 6 (June 2019): 846–63. https://doi.org/10.1002/art.40884.
    Full Text Link to Item
  - Ringold, Sarah, Sheila T. Angeles-Han, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis.” Arthritis Care Res (Hoboken) 71, no. 6 (June 2019): 717–34. https://doi.org/10.1002/acr.23870.
    Full Text Link to Item
  - Cooper, Ashley M., Mara Horwitz, and Mara L. Becker. “Improving the Safety of Teratogen Prescribing Practices in a Pediatric Rheumatology Clinic.” Pediatrics 143, no. 4 (April 2019). https://doi.org/10.1542/peds.2018-0803.
    Full Text Link to Item
  - Wu, Eveline Y., Suzanne C. Li, Kathryn S. Torok, Yamini V. Virkud, Robert C. Fuhlbrigge, C Egla Rabinovich, and C Egla Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry Investigators. “Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.” Acr Open Rheumatol 1, no. 2 (April 2019): 119–24. https://doi.org/10.1002/acr2.1019.
    Full Text Link to Item
  - Ramsey, L. B., H. Moncrieffe, C. N. Smith, M. Sudman, M. C. Marion, C. Langefeld, M. L. Becker, and S. D. Thompson. “Association of SLCO1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients.” Acr Open Rheumatology 1, no. 1 (March 1, 2019): 58–62. https://doi.org/10.1002/acr2.1008.
    Full Text
  - Jones, Jordan T., Nasreen Talib, Daniel Lovell, and Mara L. Becker. “Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals.” Paediatr Drugs 21, no. 1 (February 2019): 33–39. https://doi.org/10.1007/s40272-018-0322-0.
    Full Text Link to Item
  - Brunner, Hermine I., Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Alberto Berman, Inmaculada Calvo Penadés, Jordi Antón, et al. “Subcutaneous Abatacept in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis: Results From a Phase III Open-Label Study.” Arthritis Rheumatol 70, no. 7 (July 2018): 1144–54. https://doi.org/10.1002/art.40466.
    Full Text Link to Item
  - Hinks, Anne, Miranda C. Marion, Joanna Cobb, Mary E. Comeau, Marc Sudman, Hannah C. Ainsworth, John Bowes, et al. “Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.” Arthritis Rheumatol 70, no. 6 (June 2018): 957–62. https://doi.org/10.1002/art.40443.
    Full Text Open Access Copy Link to Item
  - Singh, Rakesh K., Leon van Haandel, Daniel P. Heruth, Shui Q. Ye, J Steven Leeder, Mara L. Becker, and Ryan S. Funk. “Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.” J Pharmacol Exp Ther 365, no. 1 (April 2018): 96–106. https://doi.org/10.1124/jpet.117.246199.
    Full Text Link to Item
  - Becker, Mara L., and Ryan S. Funk. “Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources.” Clin Transl Sci 11, no. 2 (March 2018): 106–8. https://doi.org/10.1111/cts.12513.
    Full Text Link to Item
  - McIntosh, Laura A., Miranda C. Marion, Marc Sudman, Mary E. Comeau, Mara L. Becker, John F. Bohnsack, Tasha E. Fingerlin, et al. “Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.” Arthritis Rheumatol 69, no. 11 (November 2017): 2222–32. https://doi.org/10.1002/art.40216.
    Full Text Open Access Copy Link to Item
  - Balevic, Stephen J., Mara L. Becker, Michael Cohen-Wolkowiez, and Laura E. Schanberg. “Clinical Trial Design in Juvenile Idiopathic Arthritis.” Paediatr Drugs 19, no. 5 (October 2017): 379–89. https://doi.org/10.1007/s40272-017-0244-2.
    Full Text Link to Item
  - Moncrieffe, Halima, Mark F. Bennett, Monica Tsoras, Lorie K. Luyrink, Anne L. Johnson, Huan Xu, Jason Dare, et al. “Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate.” Rheumatology (Oxford) 56, no. 9 (September 1, 2017): 1542–51. https://doi.org/10.1093/rheumatology/kex206.
    Full Text Link to Item
  - Kishi, Takayuki, Lisa G. Rider, Katherine Pak, Lilliana Barillas-Arias, Michael Henrickson, Paul L. McCarthy, Bracha Shaham, et al. “Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients.” Arthritis Care Res (Hoboken) 69, no. 7 (July 2017): 1088–94. https://doi.org/10.1002/acr.23113.
    Full Text Link to Item
  - Funk, Ryan S., Marcia A. Chan, and Mara L. Becker. “Cytokine Biomarkers of Disease Activity and Therapeutic Response after Initiating Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis.” Pharmacotherapy 37, no. 6 (June 2017): 700–711. https://doi.org/10.1002/phar.1938.
    Full Text Link to Item
  - Rider, Lisa G., Rohit Aggarwal, Angela Pistorio, Nastaran Bayat, Brian Erman, Brian M. Feldman, Adam M. Huber, et al. “2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.” Arthritis Rheumatol 69, no. 5 (May 2017): 911–23. https://doi.org/10.1002/art.40060.
    Full Text Link to Item
  - Hinks, A., J. Bowes, J. Cobb, H. C. Ainsworth, M. C. Marion, M. E. Comeau, M. Sudman, et al. “Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.” Ann Rheum Dis 76, no. 4 (April 2017): 765–72. https://doi.org/10.1136/annrheumdis-2016-210025.
    Full Text Link to Item
  - Kessler, Elizabeth A., Ashley K. Sherman, and Mara L. Becker. “Decreasing patient cost and travel time through pediatric rheumatology telemedicine visits.” Pediatr Rheumatol Online J 14, no. 1 (September 20, 2016): 54. https://doi.org/10.1186/s12969-016-0116-2.
    Full Text Link to Item
  - Pasnoor, Mamatha, Jianghua He, Laura Herbelin, Ted M. Burns, Sharon Nations, Vera Bril, Annabel K. Wang, et al. “A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis.” Neurology 87, no. 1 (July 5, 2016): 57–64. https://doi.org/10.1212/WNL.0000000000002795.
    Full Text Link to Item
  - Funk, R. S., R. Singh, L. Pramann, N. Gigliotti, S. Islam, D. P. Heruth, S. Q. Ye, M. A. Chan, J. S. Leeder, and M. L. Becker. “Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro.” Clin Transl Sci 9, no. 3 (June 2016): 149–57. https://doi.org/10.1111/cts.12399.
    Full Text Link to Item
  - Finkel, Terri H., Jin Li, Zhi Wei, Wei Wang, Haitao Zhang, Edward M. Behrens, Emma L. Reuschel, et al. “Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.” Bmc Med Genet 17 (March 22, 2016): 24. https://doi.org/10.1186/s12881-016-0285-3.
    Full Text Link to Item
  - Prahalad, Sampath, Courtney E. McCracken, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster Stevens, Larry B. Vogler, Carl D. Langefeld, Susan D. Thompson, and Susan D. Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Investigators. “Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry.” Pediatr Rheumatol Online J 14, no. 1 (March 10, 2016): 14. https://doi.org/10.1186/s12969-016-0075-7.
    Full Text Link to Item
  - Funk, R. S., and M. L. Becker. “Disease modifying anti-rheumatic drugs in juvenile idiopathic arthritis: striving for individualized therapy.” Expert Review of Precision Medicine and Drug Development 1, no. 1 (January 2, 2016): 53–68. https://doi.org/10.1080/23808993.2016.1133234.
    Full Text
  - Becker, M. L. “Using Methotrexate Metabolites to Make Clinical Decisions in JIA.” Current Treatment Options in Rheumatology 1, no. 4 (December 1, 2015): 381–95. https://doi.org/10.1007/s40674-015-0028-1.
    Full Text
  - Li, Yun R., Sihai D. Zhao, Jin Li, Jonathan P. Bradfield, Maede Mohebnasab, Laura Steel, Julie Kobie, et al. “Genetic sharing and heritability of paediatric age of onset autoimmune diseases.” Nat Commun 6 (October 9, 2015): 8442. https://doi.org/10.1038/ncomms9442.
    Full Text Open Access Copy Link to Item
  - Li, Yun R., Sihai D. Zhao, Jin Li, Jonathan P. Bradfield, Maede Mohebnasab, Laura Steel, Julie Kobie, et al. “Genetic sharing and heritability of paediatric age of onset autoimmune diseases.” Nat Commun 6 (October 9, 2015): 8442. https://doi.org/10.1038/ncomms9442.
    Full Text Open Access Copy Link to Item
  - Chiaroni-Clarke, R. C., Y. R. Li, J. E. Munro, R. A. Chavez, K. J. Scurrah, A. Pezic, J. D. Akikusa, et al. “The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.” Genes Immun 16, no. 7 (October 2015): 495–98. https://doi.org/10.1038/gene.2015.32.
    Full Text Link to Item
  - Li, Yun R., Jin Li, Sihai D. Zhao, Jonathan P. Bradfield, Frank D. Mentch, S Melkorka Maggadottir, Cuiping Hou, et al. “Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.” Nat Med 21, no. 9 (September 2015): 1018–27. https://doi.org/10.1038/nm.3933.
    Full Text Open Access Copy Link to Item
  - Li, Yun R., Jin Li, Sihai D. Zhao, Jonathan P. Bradfield, Frank D. Mentch, S Melkorka Maggadottir, Cuiping Hou, et al. “Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.” Nat Med 21, no. 9 (September 2015): 1018–27. https://doi.org/10.1038/nm.3933.
    Full Text Open Access Copy Link to Item
  - Ellis, Justine A., Katrina J. Scurrah, Yun R. Li, Anne-Louise Ponsonby, Raul A. Chavez, Angela Pezic, Terence Dwyer, et al. “Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.” J Steroid Biochem Mol Biol 145 (January 2015): 113–20. https://doi.org/10.1016/j.jsbmb.2014.10.012.
    Full Text Link to Item
  - Funk, Ryan S., Leon van Haandel, J Steven Leeder, and Mara L. Becker. “Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.” Arthritis Rheumatol 66, no. 12 (December 2014): 3476–85. https://doi.org/10.1002/art.38865.
    Full Text Link to Item
  - Rouster-Stevens, Kelly A., Stacy P. Ardoin, Ashley M. Cooper, Mara L. Becker, Leonard L. Dragone, Anna Huttenlocher, Karla B. Jones, et al. “Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology.” Arthritis Care Res (Hoboken) 66, no. 5 (May 2014): 649–57. https://doi.org/10.1002/acr.22238.
    Full Text Link to Item
  - Kessler, Elizabeth A., and Mara L. Becker. “Therapeutic advancements in juvenile idiopathic arthritis.” Best Pract Res Clin Rheumatol 28, no. 2 (April 2014): 293–313. https://doi.org/10.1016/j.berh.2014.03.005.
    Full Text Link to Item
  - Robinson, Angela Byun, Mark F. Hoeltzel, Dawn M. Wahezi, Mara L. Becker, Elizabeth A. Kessler, Heinrike Schmeling, Ruy Carrasco, et al. “Clinical characteristics of children with juvenile dermatomyositis: the Childhood Arthritis and Rheumatology Research Alliance Registry.” Arthritis Care Res (Hoboken) 66, no. 3 (March 2014): 404–10. https://doi.org/10.1002/acr.22142.
    Full Text Link to Item
  - Hashkes, Philip J., Mara L. Becker, David A. Cabral, Ronald M. Laxer, Amy S. Paller, C Egla Rabinovich, Dan Turner, and Francesco Zulian. “Methotrexate: new uses for an old drug.” J Pediatr 164, no. 2 (February 2014): 231–36. https://doi.org/10.1016/j.jpeds.2013.10.029.
    Full Text Link to Item
  - Grigoryev, D. N., J. Dalal, M. L. Becker, and S. Q. Ye. “Combined meta-analysis of systemic effects of allogeneic stem cell transplantation and systemic sclerosis.” Bmc Hematology 14, no. 1 (January 1, 2014): 7. https://doi.org/10.1186/2052-1839-14-7.
    Full Text
  - Polk, Brooke I., and Mara L. Becker. “Pharmacogenomics in childhood rheumatic disorders: a foundation for future individualized therapy.” Discov Med 16, no. 90 (December 2013): 267–75.
    Link to Item
  - Dai, Hongying, Richard J. Charnigo, Mara L. Becker, J Steven Leeder, and Alison A. Motsinger-Reif. “Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.” Biodata Mining 6, no. 1 (December 2013). https://doi.org/10.1186/1756-0381-6-1.
    Full Text
  - Funk, Ryan S., Leon van Haandel, Mara L. Becker, and J Steven Leeder. “Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.” J Pharmacol Exp Ther 347, no. 1 (October 2013): 154–63. https://doi.org/10.1124/jpet.113.206672.
    Full Text Link to Item
  - Fox, Emily J., J Steven Leeder, Shui Q. Ye, and Mara L. Becker. “Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.” J Rheumatol 40, no. 5 (May 2013): 741–42. https://doi.org/10.3899/jrheum.120639.
    Full Text Link to Item
  - Becker, M. L. “Role of methotrexate in juvenile idiopathic arthritis: Where we have been and where we are going.” International Journal of Clinical Rheumatology 8, no. 1 (February 1, 2013): 123–35. https://doi.org/10.2217/ijr.12.81.
    Full Text
  - Patel, Devika, Nathan Cook, Brandon Newell, and Mara Becker. “Fever, irritability, and ulcerations in an infant.” Pediatr Dermatol 30, no. 6 (2013): e287–88. https://doi.org/10.1111/j.1525-1470.2012.01778.x.
    Full Text Link to Item
  - Becker, Mara L. “Pharmacogenomics in pediatric rheumatology.” Curr Opin Rheumatol 24, no. 5 (September 2012): 541–47. https://doi.org/10.1097/BOR.0b013e3283556d13.
    Full Text Link to Item
  - Li, Suzanne C., Kathryn S. Torok, Elena Pope, Fatma Dedeoglu, Sandy Hong, Heidi T. Jacobe, C Egla Rabinovich, et al. “Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma.” Arthritis Care Res (Hoboken) 64, no. 8 (August 2012): 1175–85. https://doi.org/10.1002/acr.21687.
    Full Text Link to Item
  - Haandel, Leon van, Mara L. Becker, Todd D. Williams, John F. Stobaugh, and J Steven Leeder. “Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.” Rapid Commun Mass Spectrom 26, no. 14 (July 30, 2012): 1617–30. https://doi.org/10.1002/rcm.6268.
    Full Text Link to Item
  - Hinks, Anne, Joanna Cobb, Marc Sudman, Stephen Eyre, Paul Martin, Edward Flynn, Jonathon Packham, et al. “Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.” Ann Rheum Dis 71, no. 7 (July 2012): 1117–21. https://doi.org/10.1136/annrheumdis-2011-200814.
    Full Text Link to Item
  - Dai, H., M. Bhandary, M. Becker, J. S. Leeder, R. Gaedigk, and A. A. Motsinger-Reif. “Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.” Biodata Mining 5, no. 1 (May 23, 2012). https://doi.org/10.1186/1756-0381-5-3.
    Full Text
  - Becker, M. L. “Optimization of pediatric rheumatology therapeutics.” Clin Pharmacol Ther 91, no. 4 (April 2012): 597–606. https://doi.org/10.1038/clpt.2011.293.
    Full Text Link to Item
  - Becker, Mara L., Leon van Haandel, Roger Gaedigk, Bradley Thomas, Mark F. Hoeltzel, Andrew Lasky, Hongying Dai, John Stobaugh, and James S. Leeder. “Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.” Pharmacogenet Genomics 22, no. 4 (April 2012): 236–46. https://doi.org/10.1097/FPC.0b013e3283500202.
    Full Text Link to Item
  - Goldman, Jennifer, Mara L. Becker, Bridgette Jones, Mark Clements, and J Steven Leeder. “Development of biomarkers to optimize pediatric patient management: what makes children different?” Biomark Med 5, no. 6 (December 2011): 781–94. https://doi.org/10.2217/bmm.11.96.
    Full Text Link to Item
  - Haandel, Leon van, Mara L. Becker, T. D. Williams, J Steven Leeder, and John F. Stobaugh. “Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.” Bioanalysis 3, no. 24 (December 2011): 2783–96. https://doi.org/10.4155/bio.11.288.
    Full Text Link to Item
  - Mikkelsen, Torben S., Caroline F. Thorn, Jun J. Yang, Cornelia M. Ulrich, Deborah French, Gianluigi Zaza, Henry M. Dunnenberger, et al. “PharmGKB summary: methotrexate pathway.” Pharmacogenet Genomics 21, no. 10 (October 2011): 679–86. https://doi.org/10.1097/FPC.0b013e328343dd93.
    Full Text Link to Item
  - Neville, Kathleen A., Mara L. Becker, Jennifer L. Goldman, and Gregory L. Kearns. “Developmental pharmacogenomics.” Paediatr Anaesth 21, no. 3 (March 2011): 255–65. https://doi.org/10.1111/j.1460-9592.2011.03533.x.
    Full Text Link to Item
  - Becker, Mara L., Roger Gaedigk, Leon van Haandel, Bradley Thomas, Andrew Lasky, Mark Hoeltzel, Hongying Dai, John Stobaugh, and J Steven Leeder. “The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.” Arthritis Rheum 63, no. 1 (January 2011): 276–85. https://doi.org/10.1002/art.30080.
    Full Text Link to Item
  - Hinks, A., P. Martin, E. Flynn, S. Eyre, J. Packham, A. Barton, E. Baildam, et al. “Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.” Annals of the Rheumatic Diseases 69, no. 12 (December 1, 2010): 2169–72. https://doi.org/10.1136/ard.2009.126938.
    Full Text
  - Becker, Mara L., and J Steven Leeder. “Identifying genomic and developmental causes of adverse drug reactions in children.” Pharmacogenomics 11, no. 11 (November 2010): 1591–1602. https://doi.org/10.2217/pgs.10.146.
    Full Text Link to Item
  - Hinks, A., P. Martin, E. Flynn, S. Eyre, J. Packham, J. Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group, A. Barton, J. Worthington, and W. Thomson. “Association of the CCR5 gene with juvenile idiopathic arthritis.” Genes Immun 11, no. 7 (October 2010): 584–89. https://doi.org/10.1038/gene.2010.25.
    Full Text Link to Item
  - Becker, M. L., and J. S. Leeder. “Developmental pharmacogenetics in pediatric rheumatology: Utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.” Human Genomics and Proteomics, August 13, 2010. https://doi.org/10.4061/2010/257120.
    Full Text
  - Haandel, L. V., A. A. M. Heemskerk, M. L. Becker, J. S. Leeder, and J. F. Stobaugh. “Expedient methodology for total methotrexate polyglutamation pool determination in human erythrocytes.” Analytical Methods 2, no. 7 (July 1, 2010): 831–36. https://doi.org/10.1039/c0ay00164c.
    Full Text
  - Becker, Mara L., Leon van Haandel, Roger Gaedigk, Andrew Lasky, Mark Hoeltzel, John Stobaugh, and J Steven Leeder. “Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.” Arthritis Rheum 62, no. 6 (June 2010): 1803–12. https://doi.org/10.1002/art.27434.
    Full Text Link to Item
  - Becker, Mara L., Carlos D. Rosé, Randy Q. Cron, David D. Sherry, Warren B. Bilker, and Ebbing Lautenbach. “Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens.” J Rheumatol 37, no. 4 (April 2010): 870–75. https://doi.org/10.3899/jrheum.090826.
    Full Text Link to Item
  - Haandel, Leon van, Mara L. Becker, J Steven Leeder, Todd D. Williams, and John F. Stobaugh. “A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.” Rapid Commun Mass Spectrom 23, no. 23 (December 2009): 3693–3702. https://doi.org/10.1002/rcm.4300.
    Full Text Link to Item
  - Hinks, Anne, Anne Barton, Neil Shephard, Steve Eyre, John Bowes, Michele Cargill, Eric Wang, et al. “Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.” Arthritis Rheum 60, no. 1 (January 2009): 258–63. https://doi.org/10.1002/art.24179.
    Full Text Link to Item
  - Hinks, Anne, Xiayi Ke, Anne Barton, Steve Eyre, John Bowes, Jane Worthington, Susan D. Thompson, et al. “Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.” Arthritis Rheum 60, no. 1 (January 2009): 251–57. https://doi.org/10.1002/art.24187.
    Full Text Link to Item
  - Becker, Mara L., Tammy M. Martin, Trudy M. Doyle, and Carlos D. Rosé. “Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15.” Arthritis Rheum 56, no. 4 (April 2007): 1292–94. https://doi.org/10.1002/art.22509.
    Full Text Link to Item
  - Lamb, Rebecca, Wendy Thomson, Wendy British Society of Paediatric and Adolescent Rheumatology, Emma M. Ogilvie, and Rachelle Donn. “Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.” Arthritis Rheum 56, no. 4 (April 2007): 1286–91. https://doi.org/10.1002/art.22444.
    Full Text Link to Item
  - Becker, Mara L., and Carlos D. Rose. “Blau syndrome and related genetic disorders causing childhood arthritis.” Curr Rheumatol Rep 7, no. 6 (December 2005): 427–33. https://doi.org/10.1007/s11926-005-0046-3.
    Full Text Link to Item
  - Becker, Mara, Carlos D. Rosé, and Gail McIlvain-Simpson. “Niacin-like reaction to infliximab infusion in systemic juvenile rheumatoid arthritis.” J Rheumatol 31, no. 12 (December 2004): 2529–30.
    Link to Item
  - Zeggini, E., A. M. Reginato, A. Prais, W. Thomson, W. McLean, R. Donn, and R. BPRG Study Group. “Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis.” Rheumatology (Oxford) 43, no. 9 (September 2004): 1138–41. https://doi.org/10.1093/rheumatology/keh261.
    Full Text Link to Item
  - Donn, Rachelle, Zaynab Alourfi, Eleftheria Zeggini, Rebecca Lamb, Francine Jury, Mark Lunt, Christina Meazza, et al. “A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis.” Arthritis Rheum 50, no. 5 (May 2004): 1604–10. https://doi.org/10.1002/art.20178.
    Full Text Link to Item
  - De Benedetti, Fabrizio, Cristina Meazza, Marina Vivarelli, Federica Rossi, Angela Pistorio, Rebecca Lamb, Mark Lunt, et al. “Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.” Arthritis Rheum 48, no. 5 (May 2003): 1398–1407. https://doi.org/10.1002/art.10882.
    Full Text Link to Item
  - Zeggini, Eleftheria, Wendy Thomson, Dominic Kwiatkowski, Anna Richardson, William Ollier, Rachelle Donn, and Rachelle British Paediatric Rheumatology Study Group. “Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis.” Arthritis Rheum 46, no. 12 (December 2002): 3304–11. https://doi.org/10.1002/art.10698.
    Full Text Link to Item
  - Zeggini, Eleftheria, Rachelle P. Donn, William E. R. Ollier, Wendy Thomson, and Wendy British Paediatric Rheumatology Study Group. “Evidence for linkage of HLA loci in juvenile idiopathic oligoarthritis: independent effects of HLA-A and HLA-DRB1.” Arthritis Rheum 46, no. 10 (October 2002): 2716–20. https://doi.org/10.1002/art.10551.
    Full Text Link to Item
  - Donn, Rachelle, Zaynab Alourfi, Fabrizio De Benedetti, Cristina Meazza, Eleftheria Zeggini, Mark Lunt, Adam Stevens, et al. “Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.” Arthritis Rheum 46, no. 9 (September 2002): 2402–9. https://doi.org/10.1002/art.10492.
    Full Text Link to Item
  - Donn, R. P., A. Farhan, A. Stevans, A. Ramanan, W. E. R. Ollier, W. Thomson, and W. British Paediatric Rheumatology Study Group. “Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.” Rheumatology (Oxford) 41, no. 8 (August 2002): 930–36. https://doi.org/10.1093/rheumatology/41.8.930.
    Full Text Link to Item
  - Zeggini, E., W. Thomson, A. Alansari, W. Ollier, R. Donn, and R. British Paediatric Rheumatology Study Group. “Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis.” Rheumatology (Oxford) 41, no. 4 (April 2002): 462–65. https://doi.org/10.1093/rheumatology/41.4.462.
    Full Text Link to Item
  - Donn, Rachelle, Eleftheria Zeggini, Emma Shelley, William Ollier, Wendy Thomson, and Wendy British Paediatric Rheumatology Study Group. “Lack of association between juvenile idiopathic arthritis and fas gene polymorphism.” J Rheumatol 29, no. 1 (January 2002): 166–68.
    Link to Item
  - Becker, Mara. “Pharmacogenetics of oral antidiabetic drugs.,” n.d. https://doi.org/10.1155/2013/686315.
    Full Text Open Access Copy Link to Item
  - Becker, Mara. “May Thurner Syndrome.” Consultant for Pediatricians 8, no. 6 (n.d.): 236–37.
- Conference Papers
  - Jones, Jordan T., Chelsey Smith, Mara L. Becker, Daniel Lovell, and Daniel CARRA Registry Investigators. “Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.” In Arthritis Care Res (Hoboken), 73:1739–45, 2021. https://doi.org/10.1002/acr.24418.
    Full Text Link to Item
  - Li, Suzanne, Aaron Thammavongxay, Maria Ibarra, Kathryn Torok, Polly Ferguson, C Egla Rabinovich, Robert Fuhlbrigge, et al. “Long-Term Follow-up of Juvenile Localized Scleroderma Patients Treated with Methotrexate-Based Standardized Regimens (Consensus Treatment Plans).” In Arthritis & Rheumatology, 73:1598–1601, 2021.
    Link to Item
  - Bi, C., M. Becker, and S. Leeder. “Derivation of minimum best sample size from microarray data sets: A Monte Carlo approach.” In Ieee Ssci 2011 Symposium Series on Computational Intelligence Cibcb 2011: 2011 Ieee Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 129–34, 2011. https://doi.org/10.1109/CIBCB.2011.5948461.
    Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

Subject Headings

Selected Grants

External Relationships

Selected Publications

Books

Academic Articles

Conference Papers