Mara Becker | Scholars@Duke

Mara Becker
Instructor in the Department of Pediatrics

My long-term research goal is to identify factors that enhance response and minimize toxicity to drugs used for the treatment of diseases in children, focusing on an individualized therapeutic strategy. My current translational research focuses on methotrexate and its effect upon the folate pathway, utilizing cellular biomarkers and genetic differences to predict drug efficacy and minimize toxicity in JIA. My work has expanded through key collaborations, to include a mouse model for experimental validation of the work, novel cytokine biomarkers including Nicotinamide Phosphoribosyltransferase (NAMPT), biologic therapeutic drug monitoring in JIA and IBD, and exploration of the folate pathway in patients with Down syndrome.

Current Appointments & Affiliations

Instructor in the Department of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2019
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2019

Contact Information

mara.becker@duke.edu

Background
Education, Training, & Certifications
- Rheumatology Fellow, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 2003 - 2004
- Chief Resident, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 2002 - 2003
- Residency, Pediatrics/Dupont Hospital For Children, Thomas Jefferson University 1999 - 2002
- M.D., Jefferson Medical College of Thomas Jefferson University 1999
Duke Appointment History
- Adjunct Associate Professor in the Department of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2019
Leadership & Clinical Positions at Duke
- Vice Chair for Faculty, Department of Pediatrics
Academic Positions Outside Duke
- Arthritis Advisory Committee, Food and Drug Administration. 2015 - 2021
Research
Selected Grants
- Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT) awarded by National Institutes of Health 2016 - 2023
- Clinical Pharmacokinetics and Safety Trials in Down Syndrome 2019 - 2022
Industry Relationships
- American Board of Pediatrics
- American College of Rheumatology
- Childhood Arthritis and Rheumatology Research Alliance
- Food and Drug Administration
Publications & Artistic Works
Selected Publications
- Books
  - Becker, M. L. Rash and Joint Pain in a Child, 2011. https://doi.org/10.1002/9781444397994.ch40.
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  - Becker, M. L. Skin Target Lesion, 2011. https://doi.org/10.1002/9781444397994.ch76.
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- Academic Articles
  - Funk, Ryan S., Rakesh K. Singh, and Mara L. Becker. “Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro..” Clin Transl Sci, October 25, 2019. https://doi.org/10.1111/cts.12694.
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  - Li, Suzanne C., Kathryn S. Torok, C Egla Rabinovich, Fatma Dedeoglu, Mara L. Becker, Polly J. Ferguson, Sandy D. Hong, et al. “Initial Results from a Pilot Comparative Effectiveness Study of Three Methotrexate-Based Consensus Treatment Plans for Juvenile Localized Scleroderma..” J Rheumatol, October 15, 2019. https://doi.org/10.3899/jrheum.190311.
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  - Li, Suzanne C., Robert C. Fuhlbrigge, Ronald M. Laxer, Elena Pope, Maria F. Ibarra, Katie Stewart, Thomas Mason, et al. “Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study..” Pediatr Rheumatol Online J 17, no. 1 (July 15, 2019). https://doi.org/10.1186/s12969-019-0350-5.
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  - Lund, Robin M., Mara L. Becker, Steven Shapiro, Tyler Allison, and Julia G. Harris. “Scurvy presenting with limp and weakness: a case report..” Bmc Pediatr 19, no. 1 (July 6, 2019). https://doi.org/10.1186/s12887-019-1605-5.
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  - Zimmerman, Kanecia O., Daniel K. Benjamin, and Mara L. Becker. “Neonatal Therapeutics: Considerations for Dosing..” Am J Perinatol 36, no. S 02 (July 2019): S18–21. https://doi.org/10.1055/s-0039-1691772.
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  - Angeles-Han, Sheila T., Sarah Ringold, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis..” Arthritis Rheumatol 71, no. 6 (June 2019): 864–77. https://doi.org/10.1002/art.40885.
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  - Angeles-Han, Sheila T., Sarah Ringold, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis..” Arthritis Care Res (Hoboken) 71, no. 6 (June 2019): 703–16. https://doi.org/10.1002/acr.23871.
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  - Ringold, Sarah, Sheila T. Angeles-Han, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis..” Arthritis Rheumatol 71, no. 6 (June 2019): 846–63. https://doi.org/10.1002/art.40884.
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  - Ringold, Sarah, Sheila T. Angeles-Han, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis..” Arthritis Care Res (Hoboken) 71, no. 6 (June 2019): 717–34. https://doi.org/10.1002/acr.23870.
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  - Singh, Rakesh K., Leon van Haandel, Paul Kiptoo, Mara L. Becker, Teruna J. Siahaan, and Ryan S. Funk. “Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model.” European Journal of Pharmacology 853 (June 2019): 264–74. https://doi.org/10.1016/j.ejphar.2019.03.052.
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  - Cooper, Ashley M., Mara Horwitz, and Mara L. Becker. “Improving the Safety of Teratogen Prescribing Practices in a Pediatric Rheumatology Clinic..” Pediatrics 143, no. 4 (April 2019). https://doi.org/10.1542/peds.2018-0803.
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  - Ramsey, Laura B., Halima Moncrieffe, Chelsey N. Smith, Marc Sudman, Miranda C. Marion, Carl D. Langefeld, Mara L. Becker, and Susan D. Thompson. “Association of SLCO 1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients.” Acr Open Rheumatology 1, no. 1 (March 2019): 58–62. https://doi.org/10.1002/acr2.1008.
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  - Jones, Jordan T., Nasreen Talib, Daniel Lovell, and Mara L. Becker. “Clinical Features and Treatment of Down Syndrome Arthropathy: Experience from Two US Tertiary Hospitals..” Paediatr Drugs 21, no. 1 (February 2019): 33–39. https://doi.org/10.1007/s40272-018-0322-0.
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  - Brunner, Hermine I., Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Alberto Berman, Inmaculada Calvo Penadés, Jordi Antón, et al. “Subcutaneous Abatacept in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis: Results From a Phase III Open-Label Study..” Arthritis Rheumatol 70, no. 7 (July 2018): 1144–54. https://doi.org/10.1002/art.40466.
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  - Hinks, Anne, Miranda C. Marion, Joanna Cobb, Mary E. Comeau, Marc Sudman, Hannah C. Ainsworth, John Bowes, et al. “Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis..” Arthritis Rheumatol 70, no. 6 (June 2018): 957–62. https://doi.org/10.1002/art.40443.
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  - Singh, Rakesh K., Leon van Haandel, Daniel P. Heruth, Shui Q. Ye, J Steven Leeder, Mara L. Becker, and Ryan S. Funk. “Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.” Journal of Pharmacology and Experimental Therapeutics 365, no. 1 (April 2018): 96–106. https://doi.org/10.1124/jpet.117.246199.
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  - Becker, Mara L., and Ryan S. Funk. “Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources.” Clinical and Translational Science 11, no. 2 (March 2018): 106–8. https://doi.org/10.1111/cts.12513.
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  - McIntosh, Laura A., Miranda C. Marion, Marc Sudman, Mary E. Comeau, Mara L. Becker, John F. Bohnsack, Tasha E. Fingerlin, et al. “Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.” Arthritis & Rheumatology 69, no. 11 (November 2017): 2222–32. https://doi.org/10.1002/art.40216.
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  - Balevic, Stephen J., Mara L. Becker, Michael Cohen-Wolkowiez, and Laura E. Schanberg. “Clinical Trial Design in Juvenile Idiopathic Arthritis..” Paediatr Drugs 19, no. 5 (October 2017): 379–89. https://doi.org/10.1007/s40272-017-0244-2.
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  - Moncrieffe, Halima, Mark F. Bennett, Monica Tsoras, Lorie K. Luyrink, Anne L. Johnson, Huan Xu, Jason Dare, et al. “Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate.” Rheumatology 56, no. 9 (September 1, 2017): 1542–51. https://doi.org/10.1093/rheumatology/kex206.
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  - Kishi, Takayuki, Lisa G. Rider, Katherine Pak, Lilliana Barillas-Arias, Michael Henrickson, Paul L. McCarthy, Bracha Shaham, et al. “Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients..” Arthritis Care Res (Hoboken) 69, no. 7 (July 2017): 1088–94. https://doi.org/10.1002/acr.23113.
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  - Funk, Ryan S., Marcia A. Chan, and Mara L. Becker. “Cytokine Biomarkers of Disease Activity and Therapeutic Response after Initiating Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 37, no. 6 (June 2017): 700–711. https://doi.org/10.1002/phar.1938.
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  - Rider, Lisa G., Rohit Aggarwal, Angela Pistorio, Nastaran Bayat, Brian Erman, Brian M. Feldman, Adam M. Huber, et al. “2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative..” Arthritis Rheumatol 69, no. 5 (May 2017): 911–23. https://doi.org/10.1002/art.40060.
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  - Hinks, A., J. Bowes, J. Cobb, H. C. Ainsworth, M. C. Marion, M. E. Comeau, M. Sudman, et al. “Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.” Annals of the Rheumatic Diseases 76, no. 4 (April 2017): 765–72. https://doi.org/10.1136/annrheumdis-2016-210025.
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  - Finkel, Terri H., Jin Li, Zhi Wei, Wei Wang, Haitao Zhang, Edward M. Behrens, Emma L. Reuschel, et al. “Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.” Bmc Medical Genetics 17, no. 1 (December 2016). https://doi.org/10.1186/s12881-016-0285-3.
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  - Kessler, Elizabeth A., Ashley K. Sherman, and Mara L. Becker. “Decreasing patient cost and travel time through pediatric rheumatology telemedicine visits.” Pediatric Rheumatology 14, no. 1 (December 2016). https://doi.org/10.1186/s12969-016-0116-2.
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  - Pasnoor, Mamatha, Jianghua He, Laura Herbelin, Ted M. Burns, Sharon Nations, Vera Bril, Annabel K. Wang, et al. “A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis..” Neurology 87, no. 1 (July 5, 2016): 57–64. https://doi.org/10.1212/WNL.0000000000002795.
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  - Funk, R. S., R. Singh, L. Pramann, N. Gigliotti, S. Islam, D. P. Heruth, S. Q. Ye, M. A. Chan, J. S. Leeder, and M. L. Becker. “Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis andIn Vitro.” Clinical and Translational Science 9, no. 3 (June 2016): 149–57. https://doi.org/10.1111/cts.12399.
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  - Funk, Ryan S., and Mara L. Becker. “Disease modifying anti-rheumatic drugs in juvenile idiopathic arthritis: striving for individualized therapy.” Expert Review of Precision Medicine and Drug Development 1, no. 1 (January 2, 2016): 53–68. https://doi.org/10.1080/23808993.2016.1133234.
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  - Becker, Mara L. “Using Methotrexate Metabolites to Make Clinical Decisions in JIA.” Current Treatment Options in Rheumatology 1, no. 4 (December 2015): 381–95. https://doi.org/10.1007/s40674-015-0028-1.
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  - Li, Yun R., Sihai D. Zhao, Jin Li, Jonathan P. Bradfield, Maede Mohebnasab, Laura Steel, Julie Kobie, et al. “Genetic sharing and heritability of paediatric age of onset autoimmune diseases.” Nature Communications 6, no. 1 (December 2015). https://doi.org/10.1038/ncomms9442.
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  - Li, Yun R., Sihai D. Zhao, Jin Li, Jonathan P. Bradfield, Maede Mohebnasab, Laura Steel, Julie Kobie, et al. “Genetic sharing and heritability of paediatric age of onset autoimmune diseases.” Nature Communications 6, no. 1 (December 2015). https://doi.org/10.1038/ncomms9442.
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  - Chiaroni-Clarke, R. C., Y. R. Li, J. E. Munro, R. A. Chavez, K. J. Scurrah, A. Pezic, J. D. Akikusa, et al. “The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.” Genes & Immunity 16, no. 7 (October 2015): 495–98. https://doi.org/10.1038/gene.2015.32.
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  - Li, Yun R., Jin Li, Sihai D. Zhao, Jonathan P. Bradfield, Frank D. Mentch, S Melkorka Maggadottir, Cuiping Hou, et al. “Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.” Nature Medicine 21, no. 9 (September 2015): 1018–27. https://doi.org/10.1038/nm.3933.
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  - Li, Yun R., Jin Li, Sihai D. Zhao, Jonathan P. Bradfield, Frank D. Mentch, S Melkorka Maggadottir, Cuiping Hou, et al. “Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.” Nature Medicine 21, no. 9 (September 2015): 1018–27. https://doi.org/10.1038/nm.3933.
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  - Ellis, Justine A., Katrina J. Scurrah, Yun R. Li, Anne-Louise Ponsonby, Raul A. Chavez, Angela Pezic, Terence Dwyer, et al. “Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.” The Journal of Steroid Biochemistry and Molecular Biology 145 (January 2015): 113–20. https://doi.org/10.1016/j.jsbmb.2014.10.012.
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  - Funk, Ryan S., Leon van Haandel, J Steven Leeder, and Mara L. Becker. “Folate Depletion and Increased Glutamation in Juvenile Idiopathic Arthritis Patients Treated With Methotrexate.” Arthritis & Rheumatology 66, no. 12 (December 2014): 3476–85. https://doi.org/10.1002/art.38865.
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  - Rouster-Stevens, Kelly A., Stacy P. Ardoin, Ashley M. Cooper, Mara L. Becker, Leonard L. Dragone, Anna Huttenlocher, Karla B. Jones, et al. “Choosing Wisely: the American College of Rheumatology's Top 5 for pediatric rheumatology..” Arthritis Care Res (Hoboken) 66, no. 5 (May 2014): 649–57. https://doi.org/10.1002/acr.22238.
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  - Robinson, Angela Byun, Mark F. Hoeltzel, Dawn M. Wahezi, Mara L. Becker, Elizabeth A. Kessler, Heinrike Schmeling, Ruy Carrasco, et al. “Clinical characteristics of children with juvenile dermatomyositis: the Childhood Arthritis and Rheumatology Research Alliance Registry..” Arthritis Care Res (Hoboken) 66, no. 3 (March 2014): 404–10. https://doi.org/10.1002/acr.22142.
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  - Hashkes, Philip J., Mara L. Becker, David A. Cabral, Ronald M. Laxer, Amy S. Paller, C Egla Rabinovich, Dan Turner, and Francesco Zulian. “Methotrexate: new uses for an old drug..” J Pediatr 164, no. 2 (February 2014): 231–36. https://doi.org/10.1016/j.jpeds.2013.10.029.
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  - Grigoryev, D. N., J. Dalal, M. L. Becker, and S. Q. Ye. “Combined meta-analysis of systemic effects of allogeneic stem cell transplantation and systemic sclerosis.” Bmc Hematology 14, no. 1 (January 1, 2014). https://doi.org/10.1186/2052-1839-14-7.
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  - Dai, Hongying, Richard J. Charnigo, Mara L. Becker, J Steven Leeder, and Alison A. Motsinger-Reif. “Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.” Biodata Mining 6, no. 1 (December 2013). https://doi.org/10.1186/1756-0381-6-1.
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  - Patel, Devika, Nathan Cook, Brandon Newell, and Mara Becker. “Fever, irritability, and ulcerations in an infant..” Pediatr Dermatol 30, no. 6 (November 2013): e287–88. https://doi.org/10.1111/j.1525-1470.2012.01778.x.
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  - Funk, Ryan S., Leon van Haandel, Mara L. Becker, and J Steven Leeder. “Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line..” J Pharmacol Exp Ther 347, no. 1 (October 2013): 154–63. https://doi.org/10.1124/jpet.113.206672.
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  - FOX, E. M. I. L. Y. J., J. S. T. E. V. E. N. LEEDER, S. H. U. I. Q. YE, and M. A. R. A. L. BECKER. “Decreased Expression of Nicotinamide Phosphoribosyltransferase in Patients with Juvenile Idiopathic Arthritis Receiving Methotrexate.” The Journal of Rheumatology 40, no. 5 (May 2013): 741–42. https://doi.org/10.3899/jrheum.120639.
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  - Becker, Mara L. “Role of methotrexate in juvenile idiopathic arthritis: where we have been and where we are going.” International Journal of Clinical Rheumatology 8, no. 1 (February 2013): 123–35. https://doi.org/10.2217/ijr.12.81.
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  - Becker, Matthijs L., Ewan R. Pearson, and Ivan Tkáč. “Pharmacogenetics of Oral Antidiabetic Drugs.” International Journal of Endocrinology 2013 (2013): 1–10. https://doi.org/10.1155/2013/686315.
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  - Dai, Hongying, Madhusudan Bhandary, Mara Becker, J Steven Leeder, Roger Gaedigk, and Alison A. Motsinger-Reif. “Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.” Biodata Mining 5, no. 1 (December 2012). https://doi.org/10.1186/1756-0381-5-3.
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  - Becker, Mara L. “Pharmacogenomics in pediatric rheumatology.” Current Opinion in Rheumatology 24, no. 5 (September 2012): 541–47. https://doi.org/10.1097/bor.0b013e3283556d13.
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  - Li, Suzanne C., Kathryn S. Torok, Elena Pope, Fatma Dedeoglu, Sandy Hong, Heidi T. Jacobe, C Egla Rabinovich, et al. “Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma..” Arthritis Care Res (Hoboken) 64, no. 8 (August 2012): 1175–85. https://doi.org/10.1002/acr.21687.
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  - Becker, M. L. “Optimization of Pediatric Rheumatology Therapeutics.” Clinical Pharmacology & Therapeutics 91, no. 4 (April 2012): 597–606. https://doi.org/10.1038/clpt.2011.293.
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  - Becker, Mara L., Leon van Haandel, Roger Gaedigk, Bradley Thomas, Mark F. Hoeltzel, Andrew Lasky, Hongying Dai, John Stobaugh, and James S. Leeder. “Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis.” Pharmacogenetics and Genomics 22, no. 4 (April 2012): 236–46. https://doi.org/10.1097/fpc.0b013e3283500202.
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  - Goldman, Jennifer, Mara L. Becker, Bridgette Jones, Mark Clements, and J Steven Leeder. “Development of biomarkers to optimize pediatric patient management: what makes children different?.” Biomark Med 5, no. 6 (December 2011): 781–94. https://doi.org/10.2217/bmm.11.96.
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  - Haandel, Leon van, Mara L. Becker, T. D. Williams, J Steven Leeder, and John F. Stobaugh. “Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC–MS/MS.” Bioanalysis 3, no. 24 (December 2011): 2783–96. https://doi.org/10.4155/bio.11.288.
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  - Mikkelsen, Torben S., Caroline F. Thorn, Jun J. Yang, Cornelia M. Ulrich, Deborah French, Gianluigi Zaza, Henry M. Dunnenberger, et al. “PharmGKB summary: methotrexate pathway..” Pharmacogenet Genomics 21, no. 10 (October 2011): 679–86. https://doi.org/10.1097/FPC.0b013e328343dd93.
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  - Neville, Kathleen A., Mara L. Becker, Jennifer L. Goldman, and Gregory L. Kearns. “Developmental pharmacogenomics..” Paediatr Anaesth 21, no. 3 (March 2011): 255–65. https://doi.org/10.1111/j.1460-9592.2011.03533.x.
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  - Becker, Mara L., Roger Gaedigk, Leon van Haandel, Bradley Thomas, Andrew Lasky, Mark Hoeltzel, Hongying Dai, John Stobaugh, and J Steven Leeder. “The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.” Arthritis & Rheumatism 63, no. 1 (January 2011): 276–85. https://doi.org/10.1002/art.30080.
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  - Becker, Mara L., and J Steven Leeder. “Identifying genomic and developmental causes of adverse drug reactions in children..” Pharmacogenomics 11, no. 11 (November 2010): 1591–1602. https://doi.org/10.2217/pgs.10.146.
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  - BECKER, M. A. R. A. L., C. A. R. L. O. S. D. ROSÉ, R. A. N. D. Y. Q. CRON, D. A. V. I. D. D. SHERRY, W. A. R. R. E. N. B. BILKER, and E. B. B. I. N. G. LAUTENBACH. “Effectiveness and Toxicity of Methotrexate in Juvenile Idiopathic Arthritis: Comparison of 2 Initial Dosing Regimens.” The Journal of Rheumatology 37, no. 4 (April 2010): 870–75. https://doi.org/10.3899/jrheum.090826.
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  - Becker, Mara L., and J Steven Leeder. “Developmental Pharmacogenetics in Pediatric Rheumatology: Utilizing a New Paradigm to Effectively Treat Patients with Juvenile Idiopathic Arthritis with Methotrexate.” Human Genomics and Proteomics 2, no. 1 (January 2010). https://doi.org/10.4061/2010/257120.
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  - Haandel, Leon van, Anthonius A. M. Heemskerk, Mara L. Becker, J Steven Leeder, and John F. Stobaugh. “Expedient methodology for total methotrexate polyglutamation pool determination in human erythrocytes.” Analytical Methods 2, no. 7 (2010): 831–831. https://doi.org/10.1039/c0ay00164c.
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  - Haandel, Leon van, Mara L. Becker, J Steven Leeder, Todd D. Williams, and John F. Stobaugh. “A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.” Rapid Communications in Mass Spectrometry 23, no. 23 (December 15, 2009): 3693–3702. https://doi.org/10.1002/rcm.4300.
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  - Becker, Mara L., Tammy M. Martin, Trudy M. Doyle, and Carlos D. Rosé. “Interstitial pneumonitis in Blau syndrome with documented mutation inCARD15.” Arthritis & Rheumatism 56, no. 4 (April 2007): 1292–94. https://doi.org/10.1002/art.22509.
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  - Becker, Mara L., and Carlos D. Rose. “Blau syndrome and related genetic disorders causing childhood arthritis..” Curr Rheumatol Rep 7, no. 6 (December 2005): 427–33. https://doi.org/10.1007/s11926-005-0046-3.
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  - Becker, Mara, Carlos D. Rosé, and Gail McIlvain-Simpson. “Niacin-like reaction to infliximab infusion in systemic juvenile rheumatoid arthritis..” J Rheumatol 31, no. 12 (December 2004): 2529–30.
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  - Becker, Mara L., Leon van Haandel, Roger Gaedigk, Andrew Lasky, Mark Hoeltzel, John Stobaugh, and J Steven Leeder. “Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: Effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.” Arthritis & Rheumatism 62, no. 6 (n.d.): 1803–12. https://doi.org/10.1002/art.27434.
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  - Becker, Mara. “May Thurner Syndrome.” Consultant for Pediatricians 8, no. 6 (n.d.): 236–37.

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