Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.
Glucagon is historically described as the counterregulatory hormone to insulin, induced by fasting/hypoglycemia to raise blood glucose through action mediated in the liver. However, it is becoming clear that the biology of glucagon is much more complex and extends beyond hepatic actions to exert control on glucose metabolism. We discuss the inconsistencies with the canonical view that glucagon is primarily a hyperglycemic agent driven by fasting/hypoglycemia and highlight the recent advances that have reshaped the metabolic role of glucagon. These concepts are placed within the context of both normal physiology and the pathophysiology of disease and then extended to discuss emerging strategies that incorporate glucagon agonism in the pharmacology of treating diabetes.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Liver
- Insulin
- Hypoglycemia
- Humans
- Glucagon
- Endocrinology & Metabolism
- Diabetes Mellitus
- Blood Glucose
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Liver
- Insulin
- Hypoglycemia
- Humans
- Glucagon
- Endocrinology & Metabolism
- Diabetes Mellitus
- Blood Glucose
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences