Current Appointments & Affiliations
Associate Professor in Medicine
·
2024 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Associate Research Professor in Pharmacology & Cancer Biology
·
2021 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of Duke Molecular Physiology Institute
·
2015 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Islet hormones at the intersection of glucose and amino acid metabolism.
Journal Article Nat Rev Endocrinol · March 7, 2025 The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted by islets, exert powerful contr ... Full text Link to item CiteGLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells.
Journal Article Peptides · May 2024 Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) are transmembrane receptors involved in insulin, glucagon and somatostatin secretion from the pancreatic islet. Therapeutic targeting of GLP1R and GIP ... Full text Link to item CiteGIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications.
Journal Article Cell Metab · September 5, 2023 The incretin system is an essential metabolic axis that regulates postprandial metabolism. The two incretin peptides that enable this effect are the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide 1 (GLP-1), which have cogn ... Full text Link to item CiteRecent Grants
Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Alpha- to Beta-Cell Communication in Health and Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Targeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemia
ResearchMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027View All Grants
Education, Training & Certifications
York University in Toronto (Canada) ·
2010
Ph.D.