https://orcid.org/0000-0003-4358-6331
Current Duke Appointments & Affiliations
Associate Professor in Medicine
·
2025 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Associate Research Professor in Pharmacology & Cancer Biology
·
2021 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of Duke Molecular Physiology Institute
·
2015 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Scholarly Works
Primary cilia regulate GLP-1 signaling in pancreatic β cells.
Journal article Mol Metab · May 2026 Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are mainstay therapies for diabetes and obesity, acting in part by enhancing glucose-dependent insulin secretion. While the primary cilium is a known signaling compartment for certain G-protein coupled r ... Full text Link to item CiteGLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
Journal article Nature · May 2026 There are increasing numbers of effective drugs to improve obesity-linked metabolic dysfunction; GLP-1R-GIPR co-agonism is effective in the management of obesity and type 2 diabetes1,2, and lanifibranor-a nuclear-acting small-molecule triple agonist of PPA ... Full text Link to item CiteGlucagon promotes net hepatic glycogen repletion following meal ingestion.
Journal article JCI Insight · April 22, 2026 Insulin and glucagon are described as having opposing actions on hepatic glycogen metabolism. However, here we showed that their coordinated action promoted glycogen turnover and meal glucose storage. In mice, pharmacological doses of insulin or glucagon f ... Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Metabolic Actions of Glucagon
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2030Regulation of Adipose Tissue Plasticity by Pericyte GIPR
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2030View All Grants
Education
York University in Toronto (Canada) ·
2010
Ph.D.