Skip to main content

Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.

Publication ,  Journal Article
Merino, J; Dashti, HS; Li, SX; Sarnowski, C; Justice, AE; Graff, M; Papoutsakis, C; Smith, CE; Dedoussis, GV; Lemaitre, RN; Wojczynski, MK ...
Published in: Mol Psychiatry
December 2019

Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10-6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

December 2019

Volume

24

Issue

12

Start / End Page

1920 / 1932

Location

England

Related Subject Headings

  • White People
  • Receptors, Retinoic Acid
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Obesity
  • Nutrients
  • Middle Aged
  • Membrane Proteins
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Merino, J., Dashti, H. S., Li, S. X., Sarnowski, C., Justice, A. E., Graff, M., … Tanaka, T. (2019). Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry, 24(12), 1920–1932. https://doi.org/10.1038/s41380-018-0079-4
Merino, Jordi, Hassan S. Dashti, Sherly X. Li, Chloé Sarnowski, Anne E. Justice, Misa Graff, Constantina Papoutsakis, et al. “Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.Mol Psychiatry 24, no. 12 (December 2019): 1920–32. https://doi.org/10.1038/s41380-018-0079-4.
Merino, Jordi, et al. “Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.Mol Psychiatry, vol. 24, no. 12, Dec. 2019, pp. 1920–32. Pubmed, doi:10.1038/s41380-018-0079-4.
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE, Dedoussis GV, Lemaitre RN, Wojczynski MK, Männistö S, Ngwa JS, Kho M, Ahluwalia TS, Pervjakova N, Houston DK, Bouchard C, Huang T, Orho-Melander M, Frazier-Wood AC, Mook-Kanamori DO, Pérusse L, Pennell CE, de Vries PS, Voortman T, Li O, Kanoni S, Rose LM, Lehtimäki T, Zhao JH, Feitosa MF, Luan J, McKeown NM, Smith JA, Hansen T, Eklund N, Nalls MA, Rankinen T, Huang J, Hernandez DG, Schulz C-A, Manichaikul A, Li-Gao R, Vohl M-C, Wang CA, van Rooij FJA, Shin J, Kalafati IP, Day F, Ridker PM, Kähönen M, Siscovick DS, Langenberg C, Zhao W, Astrup A, Knekt P, Garcia M, Rao DC, Qi Q, Ferrucci L, Ericson U, Blangero J, Hofman A, Pausova Z, Mikkilä V, Wareham NJ, Kardia SLR, Pedersen O, Jula A, Curran JE, Zillikens MC, Viikari JS, Forouhi NG, Ordovás JM, Lieske JC, Rissanen H, Uitterlinden AG, Raitakari OT, Kiefte-de Jong JC, Dupuis J, Rotter JI, North KE, Scott RA, Province MA, Perola M, Cupples LA, Turner ST, Sørensen TIA, Salomaa V, Liu Y, Sung YJ, Qi L, Bandinelli S, Rich SS, de Mutsert R, Tremblay A, Oddy WH, Franco OH, Paus T, Florez JC, Deloukas P, Lyytikäinen L-P, Chasman DI, Chu AY, Tanaka T. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2019 Dec;24(12):1920–1932.

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

December 2019

Volume

24

Issue

12

Start / End Page

1920 / 1932

Location

England

Related Subject Headings

  • White People
  • Receptors, Retinoic Acid
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Obesity
  • Nutrients
  • Middle Aged
  • Membrane Proteins
  • Male
  • Humans