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Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.

Publication ,  Journal Article
Singh, J; Schupf, N; Boudreau, R; Matteini, AM; Prasad, T; Newman, AB; Liu, Y; Christensen, K; Kammerer, CM
Published in: Am J Epidemiol
December 1, 2015

One method by which to identify fundamental biological processes that may contribute to age-related disease and disability, instead of disease-specific processes, is to construct endophenotypes comprising linear combinations of physiological measures. Applying factor analyses methods to phenotypic data (2006-2009) on 28 traits representing 5 domains (cognitive, cardiovascular, metabolic, physical, and pulmonary) from 4,472 US and Danish individuals in 574 pedigrees from the Long Life Family Study (United States and Denmark), we constructed endophenotypes and assessed their relationship with mortality. The most dominant endophenotype primarily reflected the physical activity and pulmonary domains, was heritable, was significantly associated with mortality, and attenuated the association of age with mortality by 24.1%. Using data (1997-1998) on 1,794 Health, Aging and Body Composition Study participants from Memphis, Tennessee, and Pittsburgh, Pennsylvania, we obtained strikingly similar endophenotypes and relationships to mortality. We also reproduced the endophenotype constructs, especially the dominant physical activity and pulmonary endophenotype, within demographic subpopulations of these 2 cohorts. Thus, this endophenotype construct may represent an underlying phenotype related to aging. Additional genetic studies of this endophenotype may help identify genetic variants or networks that contribute to the aging process.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

December 1, 2015

Volume

182

Issue

11

Start / End Page

926 / 935

Location

United States

Related Subject Headings

  • United States
  • Motor Activity
  • Mortality
  • Male
  • Lung
  • Longevity
  • Humans
  • Health Status
  • Female
  • Epidemiology
 

Citation

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Singh, J., Schupf, N., Boudreau, R., Matteini, A. M., Prasad, T., Newman, A. B., … Kammerer, C. M. (2015). Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study. Am J Epidemiol, 182(11), 926–935. https://doi.org/10.1093/aje/kwv143
Singh, Jatinder, Nicole Schupf, Robert Boudreau, Amy M. Matteini, Tanushree Prasad, Anne B. Newman, YongMei Liu, Kaare Christensen, and Candace M. Kammerer. “Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.Am J Epidemiol 182, no. 11 (December 1, 2015): 926–35. https://doi.org/10.1093/aje/kwv143.
Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, et al. Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study. Am J Epidemiol. 2015 Dec 1;182(11):926–35.
Singh, Jatinder, et al. “Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study.Am J Epidemiol, vol. 182, no. 11, Dec. 2015, pp. 926–35. Pubmed, doi:10.1093/aje/kwv143.
Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, Liu Y, Christensen K, Kammerer CM. Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study. Am J Epidemiol. 2015 Dec 1;182(11):926–935.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

December 1, 2015

Volume

182

Issue

11

Start / End Page

926 / 935

Location

United States

Related Subject Headings

  • United States
  • Motor Activity
  • Mortality
  • Male
  • Lung
  • Longevity
  • Humans
  • Health Status
  • Female
  • Epidemiology